Progress in neurorehabilitation research and the support by the National Natural Science Foundation of China from 2010 to 2022

The National Natural Science Foundation of China is one of the major funding agencies for neuro rehabilitation research in China.This study reviews the frontier directions and achievements in the field of neurorehabilitation in China and wo rldwide.We used data from the Web of Science Core Collection(WoSCC) database to analyze the publications and data provided by the National Natural Science Foundation of China to analyze funding information.In addition,the prospects for neurorehabilitation research in China are discussed.From 2010 to 2022,a total of 74,220 publications in neurorehabilitation were identified,with there being an overall upward tendency.During this period,the National Natural Science Foundation of China has funded 476 research projects with a total funding of 192.38 million RMB to support neuro rehabilitation research in China.With the support of the National Natural Science Foundation of China,China has made some achievements in neurorehabilitation research.Research related to neurorehabilitation is believed to be making steady and significant progress in China.

Aortic Dissection Research in China:Analysis of Studies Funded by the National Natural Science Foundation of China

Objective The National Natural Science Foundation of China(NSFC)has made great progress in promoting the development of aortic dissection research in recent years.This study aimed to examine the development and research status of aortic dissection research in China so as to provide references for future research.Methods The NSFC projects data from 2008 to 2019 were collected from the Internet-based Science Information System and other websites utilized as search engines.The publications and citations were retrieved by Google Scholar,and the impact factors were checked by the InCite Journal Citation Reports database.The investigator’s degree and department were identified from the institutional faculty profiles.Results A total of 250 grant funds totaling 124.3 million Yuan and resulting in 747 publications were analyzed.The funds in economically developed and densely populated areas were more than those in underdeveloped and sparsely populated areas.There was no significant difference in the amount of funding per grant between different departments’investigators.However,the funding output ratios of the grants for cardiologists were higher than those for basic science investigators.The amount of funding for clinical researchers and basic scientific researchers in aortic dissection was also similar.Clinical researchers were better in terms of the funding output ratio.Conclusion These results suggest that the medical and scientific research level of aortic dissection in China has been greatly improved.However,there are still some problems that urgently need to be solved,such as the unreasonable regional allocation of medical and scientific research resources,and the slow transition from basic science to clinical practice.

The 2010–2020 National Natural Science Foundation of China:Radiation Therapy

Objective This study explains the application number and funding rate of oncology projects undertaken by the National Natural Science Foundation of China(NSFC),with focus on tumor radiotherapy-related research over the past 11 years.Methods A stratified analysis was carried out on the application and funding status of tumor radiotherapy studies in different NSFC project categories,different research areas,and different tumor types.Research areas that required specific focus,such as immunology-related radiotherapy,multimodality imaging and radiomics,and post-radiotherapy organ injury,were separately analyzed.Results The status and development trends of various related research fields were studied,and the research results were presented with the support of the NSFC,in order to provide reference for future applications and funding allocations.Conclusion The number of applications for funding increases every year.Although the total number of funded projects has also increased every year,the funding rate has decreased year by year.Projects on radiotherapy and immunization have been at the forefront in recent years,and the funding rate for these projects increases yearly.

LIRR's Project of “Study on Spalling Mechanism Mechanism of Dense Refractory Castables by Rapid Heating-up” Being Obtained the Support from National Natural Natural Science Foundation of China

LIRR＇s Priject of ＂Research on Spalling Mechanism Due to Rapid Heating-up of Dense Refractory Castables＂ declared by Wang Zhanmin,vice-president of LIRR,will gain the fund support from National Natural Science Foundation of China in 2011.

RECIPIENTS OF THE 1995 NATIONAL SCIENCE FUNDS FOR OUTSTANDING YOUNGSTERS (I)

Chen Zhu Chen Zhu,molecular biologist. He obtained his Master’s Degree of Medical Sciences from Shanghai Second Medical University (SSMU)in 1981, and completed both his Ph.D. and postdoctoral study at Hopital Saint-Louis,Universite Pads ⅤⅡfrom 1985 to 1989. He worked as an Intern in the Department of Medicine in Shanghai Rui-Jin Hospital affiliated with SSMU from 1981 to 1984,as "Interne etranger des Hopitaux de Paris", Laboratoire Central d’Hematologie,Hopital Saint Louis from October 1984 to September 1985.He was Visiting Professor in the Division of Medical Oncology,Mount Sinai Center in New York from July 1991 to October 1991, and Visit Professor in l’Institut d’Hematologie, Hopital Saint-Louis

The Attention and Research of Domestic Academia on Public Cultural Service--Based on the Analysis of National Social Fund Project during Recent 20 Years

The construction of public cultural service is a practical way that safeguard people's basic cultural rights and interests,which is a upper design to construct a powerful culture of secialist country.It is of great significance to build a whole well-off society.The article is based on some cases of National Social Science Fund on the aspects of Public Cultural Service Project during 1994 to 2015 and put forward some advice and ideas in order to offer reference and lessens for the theoretical research and exploration of our country's Public Cultural Service.

Mapping scientific cooperation of the NSFC:A case study of Major International(Regional) Joint Research Program

International cooperations have played an important role in academic activities as more and more researchers endeavor to participate in joint research or exchange with partners aboard. Focused on projects of Major International(Regional) Joint Research Program of the Natural Science Foundation of China(NSFC) from 2003 to 2008, we have investigated the characteristics of the scientific cooperation by mapping the funded projects from the aspects of topics, affiliations and cooperative countries(regions), respectively.Moreover, it is demonstrated that issues related to nano technologies, genes and ecological environments have become the hot topics in the joint research of NSFC, and projects with issues of big science have been preferentially funded under the program’s guide posted every year. Moreover, most granted projects were undertaken by the minority of affiliations with the leading research capability, which is the same to partners abroad. The aggregation effect has been greatly improved with the bilateral or multilateral agreement signed with scientific organizations abroad, so has the competitive mechanism of scientific resources allocation.

FUNDAMENTAL RESEARCH IN NATURAL SCIENCE: SUPPORTING NATIONAL STRATEGY

The Central Committee of the Communist Party of China and the State Council have put forward "the strategy for revitalizing China through science and education" and decided to implement it with the turn of the century. All circles of the society and the broad masses of people i n China are unprecedentedly raising their scientific and technical awareness and so gradually reaching more and more common understanding of the role that fundamental research in natural science has been playing as a cornerstone in the implementation of "the strategy of revitalizing China through science and education".

Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin

Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi- cine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tan^s pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model es- tablishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxi- ety may be a result of Wen Dan Tan＇s regulation of Ghrelin-Ghrelin receptors.

Radiotherapy in combination with systemic therapies for brain metastases:current status and progress

Brain metastases(BMs)are the most common cause of intracranial neoplasms in adults with poor prognosis.Most BMs originate from lung cancer,breast cancer,or melanoma.Radiotherapy(RT),including whole brain radiotherapy(WBRT)and stereotactic radiation surgery(SRS),has been widely explored and is considered a mainstay anticancer treatment for BMs.Over the past decade,the advent of novel systemic therapies has revolutionized the treatment of BMs.In this context,there is a strong rationale for using a combination of treatments based on RT,with the aim of achieving both local disease control and extracranial disease control.This review focuses on describing the latest progress in RT as well as the synergistic effects of the optimal combinations of RT and systemic treatment modalities for BMs,to provide perspectives on current treatments.

Viewing the current situation of pig model application in China’s medical field from the application and funding of NSFC

Background:The National Natural Science Foundation of China(NSFC)is an important part of China’s innovation system.In the last decade,the pig has become more and more widely used in the field of medical science,especially in otology research.Objective:By analyzing and summarizing the funding information over recent years,we intend to identify the characteristics and trends of funding for research using pig models and provide references for future development.Material and methods:This is a comprehensive analysis of features in funding for research projects involving pig models by the NSFC in the past 10 years,with a focus on projects in the field of otolaryngology/head and neck surgery.Results:Both the number and amount of funding provided by the NSFC for research involving pig models are on the rise with each passing year.Researchers at the PLA General Hospital have completed a number of studies using miniature pigs in cochlear morphology,electrophysiology,cochlear implantation,cochlear transcription analysis,gene therapy,inner ear disease modeling and Eustachian tube pathology modeling.Conclusion:Pigs as an ideal large mammal model are well suited in the current national basic research strategy in China,and can help further strengthen China’s leading position in basic research in the world.

2023年度地球科学部基金项目评审工作综述

本文总结了2023年度国家自然科学基金委员会地球科学部的评审工作,分析了地球科学部各类项目受理、评审和资助情况,梳理了深化科学基金改革实施情况,提出了下一年度科学基金工作思路。

2023年度工程与材料科学部基金项目评审工作综述

本文总结了2023年度国家自然科学基金委员会工程与材料科学部项目评审工作情况,对各类项目申请、受理、评审和资助情况进行了整理及分析,重点回顾了本年度工程与材料科学部深化科学基金改革新举措及实施成效,并提出了下一年度评审工作的思路及建议,以进一步提高工程与材料科学基础研究资助质量。

2023年度生命科学部科学基金项目评审工作综述

本文总结了2023年度生命科学部各类科学基金项目评审情况,梳理了本年度科学基金深化改革的实施情况,并提出下一年度项目评审的工作思路。

2022年NSFC心血管领域中、西医申请资助情况分析

系统梳理分析2022年国家自然科学基金心血管领域中、西医学面上项目、青年科学基金项目和地区科学基金项目3类常规项目的申请和资助情况、所涉及主要病种、研究热点和研究思路。结果显示,两个领域研究的主要病种相似,研究热点也基本一致。均以动脉粥样硬化、冠心病、心力衰竭、高血压、继发性心肌损伤和心律失常为主,主要开展表观遗传学、外泌体、细胞焦亡或铁死亡、细胞自噬、肠道微生物群以及线粒体功能方面的研究,思路呈现多样化的特点。但西医心血管领域的病种更为广泛,还包括心脏移植等中医心血管领域不涉及的病种。在科学问题导向和研究内容方面,中医心血管领域要求在中医药理论的指导下,以解决中医学科的关键科学问题为导向,体现中医药的特色。此外,研究热点只是探索科学问题的技术手段,应深入凝练科学问题,避免盲目追求结合研究热点反而缺乏了创新性思想和科学依据,鼓励原创性基础研究。

全媒体传播体系下出版深度融合发展研究

在全媒体传播体系建构纳入国家战略规划背景下,处于数字化浪潮中的中国出版业面临产销技术、业务模式、组织机构等多方面的冲突与转型。在完成从数字出版到融合出版的过渡后,出版深度融合成为当下我国出版业面向未来生态建设的全新趋势。本课题紧密结合数字化环境下的新出版传播体系,以全媒体传播视角审视出版产业的深度融合问题,探讨出版融合发展的理论框架,以传统出版转型为立足点,构建多维度、系统化、针对性的全媒体传播体系下出版深度融合发展的实践路径和生态保障体系。

新时代高校教育、科技、人才一体化布局与科学基金发展策略

在世界新一轮科技产业革命加速演进的背景下,教育、科技、人才“三位一体”统筹布局成为我国全面建设社会主义现代化国家的基础性和战略性支撑。高校是科技强国、人才强国、教育强国三大战略的交汇点,科学基金作为促进创新链—产业链—资金链—人才链—学科链深度融合的重要渠道和枢纽,在一体布局下面临新的要求和挑战。文章围绕如何“有力统筹教育、科技、人才工作”的关键问题,明确新时代高校在教育、科技、人才一体布局的定位、内涵和要求,挖掘教育优先、科技自强、人才引领的现实困境与发展前景,以期为科学基金发展提出有针对性的方案和建议。

某神经特色医疗机构2020—2023年申请神经系统领域国家自然科学基金项目同行评议意见分析及对策

目的了解首都医科大学附属北京天坛医院神经系统领域国家自然科学基金项目申请未获资助的原因并提出对策,为同行提供借鉴。方法采用内容分析法,对该医院2020—2023年申请国家自然科学基金神经系统领域未获资助的289项青年、面上项目的867人次同行评议意见进行归类整理分析。结果本文共分析了1219条未获资助原因,发现在未获资助的青年和面上项目中,存在问题提及率及比例排名前5位的依次为“研究方案不合理”(32.65%/85.12%)、“研究基础不足”(18.54%/54.33%)、“创新性不足”(15.67%/51.21%)、“立项依据不足”(8.37%/30.10%)、“科学及临床价值不足”(7.88%/28.72%),其中青年项目“创新性不足”(提及率:17.13%vs.13.84%;比例:53.75%vs.48.06%)、“细节问题”(提及率:6.50%vs.3.87%;比例:23.13%vs.15.50%)的提及率及比例略高于面上项目,“科学问题属性选择错误”的提及率(4.28%vs.4.06%)、“关键科学问题凝练不足”的比例(24.38%vs.23.26%)同样在青年项目中略高,但仅“细节问题”提及率在两类项目中的差异有统计学意义(χ^(2)=4.322,P=0.038)。专家意见一致性分析显示,3位专家意见完全一致且排名前3位的反馈意见与上述结果中的前3位一致。结论该医院未中标项目存在问题主要集中在“研究方案不合理”“研究基础不足”“创新性不足”3个方面。建议该医院通过开展多维度的申报培训、精细化辅导等方式帮助申请人完善方案设计,通过设立孵育基金、加强在研课题过程管理等渠道强化研究基础,通过促进学科交叉融合拓展研究领域和思路、提升源头创新能力等措施提高申请书质量及申请中标率。