The purpose of this study was to evaluate whether the cranial and circumaxillary sutures react differently to maxillary expansion （ME） and alternate maxillary expansions and constrictions （Alt-MEC） in a rat model....The purpose of this study was to evaluate whether the cranial and circumaxillary sutures react differently to maxillary expansion （ME） and alternate maxillary expansions and constrictions （Alt-MEC） in a rat model. Twenty-two male Sprague-Dawley rats （6 weeks old） were used and divided into three groups. In ME group （n=9）, an expander was activated for 5 days. In Alt-MEC group （9 animals）, an al- ternate expansion and constriction protocol （5-day expansion and 5-day constriction for one cycle） was conducted for 2.5 cycles （25 days total）. The control group comprised 4 animals with no appliances used, each of two sacrificed on day 5 and day 25 respectively. Midpalatal suture expansion or constriction levels were assessed qualitatively and quantitatively by bite-wing X-rays and cast models. Distances between two central incisors and two maxillary first molars were measured on cast models after each activation. Circumaxillary sutures （midpalatal, maxillopalatine, premaxillary, zygomaticotemporal and frontonasal suture） in each group were characterized histologically. Results showed that midpalatal suture was wid- ened and restored after each expansion and constriction. At the end of activation, the widths between both central incisors and first molars in Alt-MEC group were significantly larger than those in ME group （P〈0.05）. Histologically, all five circumaxillary sutures studied were widened in multiple zones in Alt- MEC group. However, only midpalatal suture was expanded with cellular fibrous tissue filling in ME group. Significant osteoclast hyperplasia was observed in all circumaxillary sutures after alternate expan- sions and constrictions, but osteoclast count increase was only observed in midpalatal suture in ME group. These results suggested that cranial and circumaxillary sutures were actively reconstructed after Alt-MEC, while only midpalatal suture had active reaction after ME.展开更多
目的:通过锥体束CT研究上颌反复扩缩合并前方牵引对上气道不同部位的影响。方法:纳入安氏Ⅲ类9~12岁患者20例,在治疗前及上颌反复扩缩合并前方牵引后拍摄锥体束CT,使用Dolphin软件三维重建后测量上气道总体积、鼻咽、腭咽、舌咽、喉咽...目的:通过锥体束CT研究上颌反复扩缩合并前方牵引对上气道不同部位的影响。方法:纳入安氏Ⅲ类9~12岁患者20例,在治疗前及上颌反复扩缩合并前方牵引后拍摄锥体束CT,使用Dolphin软件三维重建后测量上气道总体积、鼻咽、腭咽、舌咽、喉咽各部分容积、分界面的截面积、最小横截面积等指标,使用SPSS 26.0软件进行数据分析。结果:上颌反复扩缩合并前方牵引治疗后上气道总容积、鼻咽容积、腭咽容积分别平均增加1385.39 mm 3(P=0.013)、546.74 mm 3(P=0.011)、768.03 mm 3(P=0.035);鼻咽和腭咽分界面面积增加73.79 mm 2(P=0.002)、横径增加1.41 mm(P=0.037)、矢状径增加1.52 mm(P=0.022);而舌咽、喉咽的容积、最小横截面积、分界面面积和分界面的横径、矢状径变化均无统计学意义(P>0.05)。结论:上颌反复扩缩合并前方牵引治疗可显著增大鼻咽、腭咽容积,对气道舌咽和喉咽段无明显影响。展开更多
基金supported by Peking University School of Stomatology Youth Scientific Research Fund of China(No.PKUSS20120113)
文摘The purpose of this study was to evaluate whether the cranial and circumaxillary sutures react differently to maxillary expansion （ME） and alternate maxillary expansions and constrictions （Alt-MEC） in a rat model. Twenty-two male Sprague-Dawley rats （6 weeks old） were used and divided into three groups. In ME group （n=9）, an expander was activated for 5 days. In Alt-MEC group （9 animals）, an al- ternate expansion and constriction protocol （5-day expansion and 5-day constriction for one cycle） was conducted for 2.5 cycles （25 days total）. The control group comprised 4 animals with no appliances used, each of two sacrificed on day 5 and day 25 respectively. Midpalatal suture expansion or constriction levels were assessed qualitatively and quantitatively by bite-wing X-rays and cast models. Distances between two central incisors and two maxillary first molars were measured on cast models after each activation. Circumaxillary sutures （midpalatal, maxillopalatine, premaxillary, zygomaticotemporal and frontonasal suture） in each group were characterized histologically. Results showed that midpalatal suture was wid- ened and restored after each expansion and constriction. At the end of activation, the widths between both central incisors and first molars in Alt-MEC group were significantly larger than those in ME group （P〈0.05）. Histologically, all five circumaxillary sutures studied were widened in multiple zones in Alt- MEC group. However, only midpalatal suture was expanded with cellular fibrous tissue filling in ME group. Significant osteoclast hyperplasia was observed in all circumaxillary sutures after alternate expan- sions and constrictions, but osteoclast count increase was only observed in midpalatal suture in ME group. These results suggested that cranial and circumaxillary sutures were actively reconstructed after Alt-MEC, while only midpalatal suture had active reaction after ME.
文摘目的:通过锥体束CT研究上颌反复扩缩合并前方牵引对上气道不同部位的影响。方法:纳入安氏Ⅲ类9~12岁患者20例,在治疗前及上颌反复扩缩合并前方牵引后拍摄锥体束CT,使用Dolphin软件三维重建后测量上气道总体积、鼻咽、腭咽、舌咽、喉咽各部分容积、分界面的截面积、最小横截面积等指标,使用SPSS 26.0软件进行数据分析。结果:上颌反复扩缩合并前方牵引治疗后上气道总容积、鼻咽容积、腭咽容积分别平均增加1385.39 mm 3(P=0.013)、546.74 mm 3(P=0.011)、768.03 mm 3(P=0.035);鼻咽和腭咽分界面面积增加73.79 mm 2(P=0.002)、横径增加1.41 mm(P=0.037)、矢状径增加1.52 mm(P=0.022);而舌咽、喉咽的容积、最小横截面积、分界面面积和分界面的横径、矢状径变化均无统计学意义(P>0.05)。结论:上颌反复扩缩合并前方牵引治疗可显著增大鼻咽、腭咽容积,对气道舌咽和喉咽段无明显影响。
