BACKGROUND Gout and seronegative rheumatoid arthritis(SNRA)are two distinct inflammatory joint diseases whose co-occurrence is relatively infrequently reported.Limited information is available regarding the clinical m...BACKGROUND Gout and seronegative rheumatoid arthritis(SNRA)are two distinct inflammatory joint diseases whose co-occurrence is relatively infrequently reported.Limited information is available regarding the clinical management and prognosis of these combined diseases.CASE SUMMARY A 57-year-old woman with a 20-year history of joint swelling,tenderness,and morning stiffness who was negative for rheumatoid factor and had a normal uric acid level was diagnosed with SNRA.The initial regimen of methotrexate,leflunomide,and celecoxib alleviated her symptoms,except for those associated with the knee.After symptom recurrence after medication cessation,her regimen was updated to include iguratimod,methotrexate,methylprednisolone,and folic acid,but her knee issues persisted.Minimally invasive needle-knife scope therapy revealed proliferating pannus and needle-shaped crystals in the knee,indicating coexistent SNRA and atypical knee gout.After postarthroscopic surgery to remove the synovium and urate crystals,and following a tailored regimen of methotrexate,leflunomide,celecoxib,benzbromarone,and allopurinol,her knee symptoms were significantly alleviated with no recurrence observed over a period of more than one year,indicating successful management of both conditions.CONCLUSION This study reports the case of a patient concurrently afflicted with atypical gout of the knee and SNRA and underscores the significance of minimally invasive joint techniques as effective diagnostic and therapeutic tools in the field of rheumatology and immunology.展开更多
目的:探讨微创全瓷贴面配合数字化微笑设计(Digital smile design,DSD)技术修复前牙切缘切角缺损的美学效果。方法:选取2019年1月-2022年1月笔者医院接诊的78例前牙切缘切角缺损患者为研究对象,采用区组随机化法分为观察组(116颗患牙)...目的:探讨微创全瓷贴面配合数字化微笑设计(Digital smile design,DSD)技术修复前牙切缘切角缺损的美学效果。方法:选取2019年1月-2022年1月笔者医院接诊的78例前牙切缘切角缺损患者为研究对象,采用区组随机化法分为观察组(116颗患牙)和对照组(120颗患牙),每组39例。对照组采用微创全瓷贴面修复,观察组给予微创全瓷贴面联合DSD技术进行修复。比较两组患者治疗6个月后的满意度、美学效果[美国公共卫生署评估标准(United states public health service,USPHS)],对比治疗前后两组患者的红色美学指数、牙周健康指数[牙龈指数(Gingival index,GI)、牙菌斑指数(Plaque index,PLI)、龈沟出血指数(Sulcus bleeding index,SBI)]的变化。结果:治疗6个月后,两组美学效果各维度评级有显著差异,观察组治疗满意率、红色美学指数评分均显著高于对照组(P<0.05);治疗6个月后,两组GI、PLI、SBI均明显降低,且观察组显著低于对照组(P<0.05)。结论:微创全瓷贴面联合DSD技术修复前牙切缘切角缺损可有效改善牙齿美学效果,提高患者治疗满意度,适合临床推广。展开更多
目的分析膝关节微创技术及截骨术在膝关节骨病保膝治疗中的临床效果。方法回顾性选取龙岩人民医院于2020年9月—2023年12月收治的100例膝关节骨病患者的临床资料,根据治疗方案不同将其分为两组,每组50例。对照组实施传统膝关节置换术治...目的分析膝关节微创技术及截骨术在膝关节骨病保膝治疗中的临床效果。方法回顾性选取龙岩人民医院于2020年9月—2023年12月收治的100例膝关节骨病患者的临床资料,根据治疗方案不同将其分为两组,每组50例。对照组实施传统膝关节置换术治疗,研究组实施膝关节微创技术及截骨术治疗,比较两组的治疗效果。结果研究组治疗总有效率为98.00%,高于对照组的84.00%,差异有统计学意义(χ^(2)=4.369,P=0.036);研究组治疗后膝关节功能评定量表(Harris Hip Score,HSS)评分高于对照组,且视觉模拟评分(Visual Analog Scale,VAS)评分低于对照组,差异有统计学意义(P均<0.05);研究组手术耗时、术后下地时间、愈合时间均短于对照组,且术中失血量少于对照组,差异有统计学意义(P均<0.05);研究组并发症总发生率为4.00%,低于对照组的16.00%,差异有统计学意义(χ^(2)=4.000,P=0.046)。结论膝关节微创技术及截骨术治疗膝关节骨病的疗效确切,相比传统方法,能提高治疗有效率,促进患者的术后恢复,降低疼痛和并发症的发生率。展开更多
目的分析立体定向手术机器人(Robot of Stereotactic Assistant,ROSA辅助定向手术治疗高血压脑干出血的手术疗效。方法回顾性分析33例高血压脑干出血的病例资料,均经微创手术治疗,根据时间节点分为框架辅助组17例(2014年1月-2016年3月)...目的分析立体定向手术机器人(Robot of Stereotactic Assistant,ROSA辅助定向手术治疗高血压脑干出血的手术疗效。方法回顾性分析33例高血压脑干出血的病例资料,均经微创手术治疗,根据时间节点分为框架辅助组17例(2014年1月-2016年3月)与ROSA辅助组16例(2016年5月-10月)。结果 ROSA辅助组血肿清除率优于框架辅助组(P=0.031),ROSA辅助组手术时间与术后拔管时间均少于框架辅助组(分别为t=1.762,P<0.05;t=2.493,P<0.05)。框架辅助组术后再出血3例,颅内感染2例;ROSA辅助组无再出血和颅内感染,但两组差异无统计学意义(分别为P=0.125和P=0.258)。结论 ROSA辅助微创手术治疗高血压性脑干出血在血肿清除率、手术时间、术后拔管时间等方面,均优于框架立体定向辅助治疗,适用于高血压性脑干出血的超早期治疗。展开更多
基金Supported by Natural Science Foundation of Guangdong Province,No.2023A1515011213。
文摘BACKGROUND Gout and seronegative rheumatoid arthritis(SNRA)are two distinct inflammatory joint diseases whose co-occurrence is relatively infrequently reported.Limited information is available regarding the clinical management and prognosis of these combined diseases.CASE SUMMARY A 57-year-old woman with a 20-year history of joint swelling,tenderness,and morning stiffness who was negative for rheumatoid factor and had a normal uric acid level was diagnosed with SNRA.The initial regimen of methotrexate,leflunomide,and celecoxib alleviated her symptoms,except for those associated with the knee.After symptom recurrence after medication cessation,her regimen was updated to include iguratimod,methotrexate,methylprednisolone,and folic acid,but her knee issues persisted.Minimally invasive needle-knife scope therapy revealed proliferating pannus and needle-shaped crystals in the knee,indicating coexistent SNRA and atypical knee gout.After postarthroscopic surgery to remove the synovium and urate crystals,and following a tailored regimen of methotrexate,leflunomide,celecoxib,benzbromarone,and allopurinol,her knee symptoms were significantly alleviated with no recurrence observed over a period of more than one year,indicating successful management of both conditions.CONCLUSION This study reports the case of a patient concurrently afflicted with atypical gout of the knee and SNRA and underscores the significance of minimally invasive joint techniques as effective diagnostic and therapeutic tools in the field of rheumatology and immunology.
文摘目的:探讨微创全瓷贴面配合数字化微笑设计(Digital smile design,DSD)技术修复前牙切缘切角缺损的美学效果。方法:选取2019年1月-2022年1月笔者医院接诊的78例前牙切缘切角缺损患者为研究对象,采用区组随机化法分为观察组(116颗患牙)和对照组(120颗患牙),每组39例。对照组采用微创全瓷贴面修复,观察组给予微创全瓷贴面联合DSD技术进行修复。比较两组患者治疗6个月后的满意度、美学效果[美国公共卫生署评估标准(United states public health service,USPHS)],对比治疗前后两组患者的红色美学指数、牙周健康指数[牙龈指数(Gingival index,GI)、牙菌斑指数(Plaque index,PLI)、龈沟出血指数(Sulcus bleeding index,SBI)]的变化。结果:治疗6个月后,两组美学效果各维度评级有显著差异,观察组治疗满意率、红色美学指数评分均显著高于对照组(P<0.05);治疗6个月后,两组GI、PLI、SBI均明显降低,且观察组显著低于对照组(P<0.05)。结论:微创全瓷贴面联合DSD技术修复前牙切缘切角缺损可有效改善牙齿美学效果,提高患者治疗满意度,适合临床推广。
文摘目的分析膝关节微创技术及截骨术在膝关节骨病保膝治疗中的临床效果。方法回顾性选取龙岩人民医院于2020年9月—2023年12月收治的100例膝关节骨病患者的临床资料,根据治疗方案不同将其分为两组,每组50例。对照组实施传统膝关节置换术治疗,研究组实施膝关节微创技术及截骨术治疗,比较两组的治疗效果。结果研究组治疗总有效率为98.00%,高于对照组的84.00%,差异有统计学意义(χ^(2)=4.369,P=0.036);研究组治疗后膝关节功能评定量表(Harris Hip Score,HSS)评分高于对照组,且视觉模拟评分(Visual Analog Scale,VAS)评分低于对照组,差异有统计学意义(P均<0.05);研究组手术耗时、术后下地时间、愈合时间均短于对照组,且术中失血量少于对照组,差异有统计学意义(P均<0.05);研究组并发症总发生率为4.00%,低于对照组的16.00%,差异有统计学意义(χ^(2)=4.000,P=0.046)。结论膝关节微创技术及截骨术治疗膝关节骨病的疗效确切,相比传统方法,能提高治疗有效率,促进患者的术后恢复,降低疼痛和并发症的发生率。
