Osteoporosis has become a serious health problem throughout the world which is associated with an increased risk of bone fractures and mortality among the people of middle to old ages.Diabetes is also a major health p...Osteoporosis has become a serious health problem throughout the world which is associated with an increased risk of bone fractures and mortality among the people of middle to old ages.Diabetes is also a major health problem among the people of all age ranges and the sufferers due to this abnormality increasing day by day.The aim of this review is to summarize the possible mechanisms through which diabetes may induce osteoporosis.Diabetes mellitus generally exerts its effect on different parts of the body including bone cells specially the osteoblast and osteoclast,muscles,retina of the eyes,adipose tissue,endocrine system specially parathyroid hormone(PTH) and estrogen,cytokines,nervous system and digestive system.Diabetes negatively regulates osteoblast differentiation and function while positively regulates osteoclast differentiation and function through the regulation of different intermediate factors and thereby decreases bone formation while increases bone resorption.Some factors such as diabetic neuropathy,reactive oxygen species,Vitamin D,PTH have their effects on muscle cells.Diabetes decreases the muscle strength through regulating these factors in various ways and ultimately increases the risk of fall that may cause bone fractures.展开更多
A good beginning grasps the audience's attention,arouses their interest,and presents the gist of your speech,while a good ending reinforces your stance,creates a sense of completeness and leaves the listeners spac...A good beginning grasps the audience's attention,arouses their interest,and presents the gist of your speech,while a good ending reinforces your stance,creates a sense of completeness and leaves the listeners space for further thinking.展开更多
Diabetic muscle infarction(DMI) refers to spontaneous ischemic necrosis of skeletal muscle among people with diabetes mellitus, unrelated to arterial occlusion. People with DMI may have coexisting end-stage renal dise...Diabetic muscle infarction(DMI) refers to spontaneous ischemic necrosis of skeletal muscle among people with diabetes mellitus, unrelated to arterial occlusion. People with DMI may have coexisting end-stage renal disease(ESRD) but little is known about its epidemiology and clinical outcomes in this setting. This scoping review seeks to investigate the characteristics, clinical features, diagnostic evaluation, management and outcomes of DMI among people with ESRD. Electronic database (Pub Med/MEDLINE, CINAHL, SCOPUS and and EMBASE) searches were conducted for ("diabetic muscle infarction" or "diabetic myonecrosis") and("chronic kidney disease" or "renal impairment" or "dialysis" or "renal replacement therapy" or "kidney transplant ") from January 1980 to June 2017. Relevant cases from reviewed bibliographies in reports retrieved were also included. Data were extracted in a standardized form. A total of 24 publications with 41 patients who have ESRD were included. The mean age at the time of presentation with DMI was 44.2 years. Type 2 diabetes was present in 53.7% of patients while type 1 in 41.5%. In this cohort, 60.1% were receiving hemodialysis, 21% on peritoneal dialysis and 12.2% had kidney transplantation. The proximal lower limb musculature was the most commonly affected site. Muscle pain and swelling were the most frequent manifestation on presentation. Magnetic resonance imaging (MRI) provided the most specific findings for DMI. Laboratory investigation findings are usually non-specific. Non-surgical therapy is usually used in the management of DMI. Short-term prognosis of DMI is good but recurrence occurred in 43.9%. DMI is an uncommon complication in patients with diabetes mellitus, including those affected by ESRD. In comparison with unselected patients with DMI, the characteristics and outcomes of those with ESRD are generally similar. DMI may also occur inkidney transplant recipients, including pancreas-kidney transplantation. MRI is the most useful diagnostic investigation. Non-surgical treatment involving analgesia, optimization of glycemic control and initial bed rest can help to improve recovery rate. However, recurrence of DMI is relatively frequent.展开更多
Percutaneous coronary intervention is a well-established technique used to treat coronary artery disease,but the risk of coronary artery in-stent restenosis following percutaneous coronary intervention is still high.P...Percutaneous coronary intervention is a well-established technique used to treat coronary artery disease,but the risk of coronary artery in-stent restenosis following percutaneous coronary intervention is still high.Previous studies revealed that high mobility group protein B1(HMGB1)plays a critical role in neointima formation.In this study,we aimed to investigate the role of glycyrrhizic acid(GA),an HMGB1 inhibitor,in the process of neointima formation and the potential mechanisms.We investigated the role of GA in neointima formation through an iliac artery balloon injury model in rabbits.Proliferation,migration,and phenotype transformation of human vascular smooth muscle cells(VSMCs)were observed.Besides,infl ammation and receptor for advanced glycosylation end products(RAGE)signaling pathways were studied.The results indicate that GA attenuated neointima formation and downregulated HMGB1 expression in injured artery in rabbits.HMGB1 promoted proliferation,migration,and phenotype transformation through the activation of RAGE signaling pathways in VSMCs,and blockade of HMGB1 by GA(1,10,and 100μM)could attenuate those processes and reduce proliferation of human VSMCs.In conclusion,the HMGB1 inhibitor GA might be useful to treat proliferative vascular diseases by downregulating RAGE signaling pathways.Our results indicate a new and promising therapeutic agent for restenosis.展开更多
Let D be a digraph. A subset S of V (D) is a stable set if every pair of vertices in S is non-adjacent in D. A collection of disjoint paths is a path partition of D, if every vertex in V (D) is in exactly one path of ...Let D be a digraph. A subset S of V (D) is a stable set if every pair of vertices in S is non-adjacent in D. A collection of disjoint paths is a path partition of D, if every vertex in V (D) is in exactly one path of . We say that a stable set S and a path partition are orthogonal if each path of contains exactly one vertex of S. A digraph D satisfies the α-property if for every maximum stable set S of D, there exists a path partition such that S and are orthogonal. A digraph D is α-diperfect if every induced subdigraph of D satisfies the α-property. In 1982, Berge proposed a characterization for α-diperfect digraphs in terms of forbidden anti-directed odd cycles. In 2018, Sambinelli, Silva and Lee proposed a similar conjecture. A digraph D satisfies the Begin-End-property or BE-property if for every maximum stable set S of D, there exists a path partition such that 1) S and are orthogonal and 2) for each path P ∈ , either the start or the end of P belongs to S. A digraph D is BE-diperfect if every induced subdigraph of D satisfies the BE-property. Sambinelli, Silva and Lee proposed a characterization for BE-diperfect digraphs in terms of forbidden blocking odd cycles. In this paper, we verified both conjectures for 3-anti-circulant digraphs. We also present some structural results for α-diperfect and BE-diperfect digraphs.展开更多
肌少症是一种与年龄相关的以肌肉质量与肌肉力量下降和/或体能下降为特征的疾病。晚期糖基化终末产物(advanced glycation end products, AGEs)是蛋白质、脂质或核酸等物质与还原糖的游离羰基经重排、裂解等一系列反应形成的糖基化产物...肌少症是一种与年龄相关的以肌肉质量与肌肉力量下降和/或体能下降为特征的疾病。晚期糖基化终末产物(advanced glycation end products, AGEs)是蛋白质、脂质或核酸等物质与还原糖的游离羰基经重排、裂解等一系列反应形成的糖基化产物的总称。AGEs可能通过非酶糖化交联、与受体结合等途径加速肌少症的发生。AGEs对肌少症以及肌肉功能和身体活动能力都具有重要影响,本文就AGEs与肌少症及其参数的研究进展进行综述,为减缓老年人躯体功能的下降以及肌少症的预防与康复提供新思路。展开更多
文摘Osteoporosis has become a serious health problem throughout the world which is associated with an increased risk of bone fractures and mortality among the people of middle to old ages.Diabetes is also a major health problem among the people of all age ranges and the sufferers due to this abnormality increasing day by day.The aim of this review is to summarize the possible mechanisms through which diabetes may induce osteoporosis.Diabetes mellitus generally exerts its effect on different parts of the body including bone cells specially the osteoblast and osteoclast,muscles,retina of the eyes,adipose tissue,endocrine system specially parathyroid hormone(PTH) and estrogen,cytokines,nervous system and digestive system.Diabetes negatively regulates osteoblast differentiation and function while positively regulates osteoclast differentiation and function through the regulation of different intermediate factors and thereby decreases bone formation while increases bone resorption.Some factors such as diabetic neuropathy,reactive oxygen species,Vitamin D,PTH have their effects on muscle cells.Diabetes decreases the muscle strength through regulating these factors in various ways and ultimately increases the risk of fall that may cause bone fractures.
文摘A good beginning grasps the audience's attention,arouses their interest,and presents the gist of your speech,while a good ending reinforces your stance,creates a sense of completeness and leaves the listeners space for further thinking.
文摘Diabetic muscle infarction(DMI) refers to spontaneous ischemic necrosis of skeletal muscle among people with diabetes mellitus, unrelated to arterial occlusion. People with DMI may have coexisting end-stage renal disease(ESRD) but little is known about its epidemiology and clinical outcomes in this setting. This scoping review seeks to investigate the characteristics, clinical features, diagnostic evaluation, management and outcomes of DMI among people with ESRD. Electronic database (Pub Med/MEDLINE, CINAHL, SCOPUS and and EMBASE) searches were conducted for ("diabetic muscle infarction" or "diabetic myonecrosis") and("chronic kidney disease" or "renal impairment" or "dialysis" or "renal replacement therapy" or "kidney transplant ") from January 1980 to June 2017. Relevant cases from reviewed bibliographies in reports retrieved were also included. Data were extracted in a standardized form. A total of 24 publications with 41 patients who have ESRD were included. The mean age at the time of presentation with DMI was 44.2 years. Type 2 diabetes was present in 53.7% of patients while type 1 in 41.5%. In this cohort, 60.1% were receiving hemodialysis, 21% on peritoneal dialysis and 12.2% had kidney transplantation. The proximal lower limb musculature was the most commonly affected site. Muscle pain and swelling were the most frequent manifestation on presentation. Magnetic resonance imaging (MRI) provided the most specific findings for DMI. Laboratory investigation findings are usually non-specific. Non-surgical therapy is usually used in the management of DMI. Short-term prognosis of DMI is good but recurrence occurred in 43.9%. DMI is an uncommon complication in patients with diabetes mellitus, including those affected by ESRD. In comparison with unselected patients with DMI, the characteristics and outcomes of those with ESRD are generally similar. DMI may also occur inkidney transplant recipients, including pancreas-kidney transplantation. MRI is the most useful diagnostic investigation. Non-surgical treatment involving analgesia, optimization of glycemic control and initial bed rest can help to improve recovery rate. However, recurrence of DMI is relatively frequent.
基金National Natural Science Foundation of China project 81600248(to Z.Zhu)Hunan Provincial Natural Science Foundation of China project 2018JJ3744(to Z.Zhu).
文摘Percutaneous coronary intervention is a well-established technique used to treat coronary artery disease,but the risk of coronary artery in-stent restenosis following percutaneous coronary intervention is still high.Previous studies revealed that high mobility group protein B1(HMGB1)plays a critical role in neointima formation.In this study,we aimed to investigate the role of glycyrrhizic acid(GA),an HMGB1 inhibitor,in the process of neointima formation and the potential mechanisms.We investigated the role of GA in neointima formation through an iliac artery balloon injury model in rabbits.Proliferation,migration,and phenotype transformation of human vascular smooth muscle cells(VSMCs)were observed.Besides,infl ammation and receptor for advanced glycosylation end products(RAGE)signaling pathways were studied.The results indicate that GA attenuated neointima formation and downregulated HMGB1 expression in injured artery in rabbits.HMGB1 promoted proliferation,migration,and phenotype transformation through the activation of RAGE signaling pathways in VSMCs,and blockade of HMGB1 by GA(1,10,and 100μM)could attenuate those processes and reduce proliferation of human VSMCs.In conclusion,the HMGB1 inhibitor GA might be useful to treat proliferative vascular diseases by downregulating RAGE signaling pathways.Our results indicate a new and promising therapeutic agent for restenosis.
文摘Let D be a digraph. A subset S of V (D) is a stable set if every pair of vertices in S is non-adjacent in D. A collection of disjoint paths is a path partition of D, if every vertex in V (D) is in exactly one path of . We say that a stable set S and a path partition are orthogonal if each path of contains exactly one vertex of S. A digraph D satisfies the α-property if for every maximum stable set S of D, there exists a path partition such that S and are orthogonal. A digraph D is α-diperfect if every induced subdigraph of D satisfies the α-property. In 1982, Berge proposed a characterization for α-diperfect digraphs in terms of forbidden anti-directed odd cycles. In 2018, Sambinelli, Silva and Lee proposed a similar conjecture. A digraph D satisfies the Begin-End-property or BE-property if for every maximum stable set S of D, there exists a path partition such that 1) S and are orthogonal and 2) for each path P ∈ , either the start or the end of P belongs to S. A digraph D is BE-diperfect if every induced subdigraph of D satisfies the BE-property. Sambinelli, Silva and Lee proposed a characterization for BE-diperfect digraphs in terms of forbidden blocking odd cycles. In this paper, we verified both conjectures for 3-anti-circulant digraphs. We also present some structural results for α-diperfect and BE-diperfect digraphs.
文摘肌少症是一种与年龄相关的以肌肉质量与肌肉力量下降和/或体能下降为特征的疾病。晚期糖基化终末产物(advanced glycation end products, AGEs)是蛋白质、脂质或核酸等物质与还原糖的游离羰基经重排、裂解等一系列反应形成的糖基化产物的总称。AGEs可能通过非酶糖化交联、与受体结合等途径加速肌少症的发生。AGEs对肌少症以及肌肉功能和身体活动能力都具有重要影响,本文就AGEs与肌少症及其参数的研究进展进行综述,为减缓老年人躯体功能的下降以及肌少症的预防与康复提供新思路。
