Hypoglycemic Effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi Green Tea and Their Compatibility on Mice

[Objectives]To explore the hypoglycemic effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi green tea and their compatibility on mice,so as to provide more options for the adjuvant treatment of diabetes and improve the comprehensive utilization value of Guixi green tea.[Methods]After being fed adaptively for 7 d,60 SPF-grade male mice were intraperitoneally injected with alloxouracil(180 mg/kg)to induce hyperglycemia model,from which 35 mice with a successful model were selected.They were randomly divided into 5 groups(Danshen group,green tea group,compatible group,positive control group and blank control group),with 7 animals in each group.The mice in all groups were administered according to the dose of 200 mg/kg once a day for 15 d.After the last administration,their body weight was measured on the 15 th day after fasting for 12 h,and their fasting blood glucose was measured by tail clipping.[Results]After modeling,the mice in each group showed typical hyperglycemia symptoms,namely obvious polydipsia,polyphagia,polyuria and weight loss.Compared with the blank control group,Danshen group and green tea group had obvious hypoglycemic effect(P<0.05),and compatible group had significant hypoglycemic effect(P<0.01).Compared with the blank control group,the weight loss of diabetic mice could also be inhibited in green tea group and compatible group(P<0.05).[Conclusions]Danshen,Guixi green tea and their compatibility had the effect of lowering blood sugar,among which the compatible group had the most obvious effect.

Effects of Radix Puerariae, Radix Rehmanniae and Their Compatibility on Blood Glucose and Blood Lipids in Mice

[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly.

Based on the Advantages of Acupuncture and Moxibustion Therapy, the Multiple Exploration of the Correlation between the Meridians and the Circulatory System of the Nervous System

The meridians,nervous system,and circulatory system are important components of tra‐ditional Chinese medicine and modern medicine.The meridians have a high degree of consistency with the distribution of the nervous and circulatory systems in modern medi‐cine,and are closely related in the process of disease treatment.Therefore,people often confuse the three.Based on the great advantages of acupuncture and moxibustion in the treatment of nervous system and circulatory system diseases,the author has made diver‐sified exploration on its relevance in terms of origin,physiological anatomy,physiological function and clinical application.It is believed that meridians have their relative indepen‐dence,and the nervous and circulatory systems cannot completely replace meridians.However,meridians are closely related to the nervous and circulatory systems,and in clinical practice,meridians can be combined with the nervous and circulatory systems to guide the treatment of diseases.

Construction and Research Progress of the Chinese Meridian Project in 2022–2023

The Chinese Meridian Project(CMP)is a major national science and technology infrastructure constructed in two steps.The first phase of the CMP has been operating for more than a solar cycle.From 2022 to 2023,utilizing the monitoring data collected by the CMP,scientists made major breakthroughs in fields of ionosphere,middle and upper atmosphere,and coupling between layers.The construction of the second phase of the CMP is nearly finished,and the project is expected to operate as a whole in 2025 after national acceptance of the second phase.The whole project was built in an architecture of so-called“One Chain,Three Networks and Four Focuses”.It is promising to make a three-dimensional observation of the whole solar-terrestrial space.The science community is looking forward to the great contribution of the CMP to space weather and space physics research.

A New Class of Simple,General and Efficient Finite Volume Schemes for Overdetermined Thermodynamically Compatible Hyperbolic Systems

In this paper,a new efficient,and at the same time,very simple and general class of thermodynamically compatiblefinite volume schemes is introduced for the discretization of nonlinear,overdetermined,and thermodynamically compatiblefirst-order hyperbolic systems.By construction,the proposed semi-discrete method satisfies an entropy inequality and is nonlinearly stable in the energy norm.A very peculiar feature of our approach is that entropy is discretized directly,while total energy conservation is achieved as a mere consequence of the thermodynamically compatible discretization.The new schemes can be applied to a very general class of nonlinear systems of hyperbolic PDEs,including both,conservative and non-conservative products,as well as potentially stiff algebraic relaxation source terms,provided that the underlying system is overdetermined and therefore satisfies an additional extra conservation law,such as the conservation of total energy density.The proposed family offinite volume schemes is based on the seminal work of Abgrall[1],where for thefirst time a completely general methodology for the design of thermodynamically compatible numerical methods for overdetermined hyperbolic PDE was presented.We apply our new approach to three particular thermodynamically compatible systems:the equations of ideal magnetohydrodynamics(MHD)with thermodynamically compatible generalized Lagrangian multiplier(GLM)divergence cleaning,the unifiedfirst-order hyperbolic model of continuum mechanics proposed by Godunov,Peshkov,and Romenski(GPR model)and thefirst-order hyperbolic model for turbulent shallow waterflows of Gavrilyuk et al.In addition to formal mathematical proofs of the properties of our newfinite volume schemes,we also present a large set of numerical results in order to show their potential,efficiency,and practical applicability.

Network pharmacology to decipher the mechanism of Danggui Longhui Wan against chronic myeloid leukemia

Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative disorder.The Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain unclear.In this study,we gathered 794 constituents,1249 drug targets,1654 disease genes and 129 intersection genes.GO and KEGG were used to analyze the function of these genes.Compatibility of prescription study showed that monarch drug,minister drug,assistant and guide drug played a synergistic role in the treatment of CML.In addition,we obtained 20 hub genes and 12 key components.Molecular docking indicated that the main compounds and core proteins had good binding ability.The results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK,PI3K/AKT,FoxO and p53 signaling pathways.

Solution of the Matrix Second Semi-Tensor Product Equation A ∘ l X ∘ l B=C

In this paper, the solution of the matrix second semi-tensor product equation A∘lX∘lB=Cis studied. Firstly, the solvability of the matrix-vector second semi-tensor product equation is investigated. At the same time, the compatibility conditions, the sufficient and necessary conditions and the specific solution methods for the matrix solution are given. Secondly, we further consider the solvability of the second semi-tensor product equation of the matrix. For each part, several examples are given to illustrate the validity of the results.

Enhancing the compatibility of the amyloid-dye hybrid nanostructure for improved photo-biocatalysis

Artificial photosynthesis is significant for renewable energy generation,sustainable development,and environmental protection.Dye-protein hybrids are promising for developing photosynthesis mimics(e.g.,photo-biocatalysis),but their performances are far lower than the plant photosystems,partially because of the incompatibility between dye and the protein matrix that limits excited state electron transfer of the included dyes.Here,using ThT-insulin amyloid assembly as a model system,we proposed that increasing the dye-protein compatibility could lead to the improved photo-biocatalytic performance.A ThT derivative,ThTPD,was designed with the same electron acceptor but extended π-conjugated donor structure.When integrated into the insulin amyloid,the extended π-conjugated donor structure allowed increased binding affinity and energy with the amyloid matrix,thus better electron transport to the mediator to drive the photocatalytic reaction.Meanwhile,compared with ThT, ThTPD exhibited improved light absorption and longer excited state lifetime.The photo-biocatalytic performance of ThTPD-insulin amyloid was greatly improved as compared with that of ThT in reduced nicotinamide adenine dinucleotide(NADH) regeneration.When integrating with NADH-dependent L-glutamate reductase,the efficiency of the ThTPD-insulin amyloid hybrid was 2.8-fold higher than that of ThT in glutamate generation,showing promising feature in biocatalytic solar-to-chemical conversion.

Exploring the compatibility theory of traditional Chinese medicine formulae:the disassembled prescriptions study

Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their therapeutic targets remain ambiguous.This largely limits the correct use and modernization of TCM formulas clinically.The study of disassembled prescriptions is important for investigating the compatibility theory of Chinese medicines.By dissecting the mechanisms of TCM formulae,the compatibility principles of some well-known formulae,such as Realgar-Indigo naturalis,have been elucidated to a certain extent.In this review,several common methods of disassembled prescription studies are summarized,including those of single herb or mineral,sub-prescription,active ingredients or effective parts,large formulae,and systems pharmacology studies,as well as the methods of grouping based on the properties or efficacy of Chinese medicines,in order to provide evidence for formulae study.Moreover,some challenges to be addressed in disassembled prescriptions studies have been identified in this review.

Compatibility mechanism of Chinese medicine formula:state of the art and perspectives

Traditional Chinese medicine(TCM)has been practiced in China and surrounding countries for thousands of years and has gradually attracted the attention of Western countries.After reasonable compatibility,TCMs could play the key role of enhancing efficacy and reducing toxicity,which has significant therapeutic advantages in the treatment of complex diseases in clinical practice.While the TCM compatibility is not the simple addition of drugs.Under the appropriate dosage ratio,multiple TCMs can play a synergistic role to realize the overall regulation of TCM treatment.Therefore,it is of critical essential to study the compatibility of TCM formula to promote TCM modernization,new drug development and clinical application.Recently,under the guidance of TCM theory,many researches on the composition,pharmacodynamic activity and pharmacokinetic properties of TCM formula have emerged by integrating new technologies and new methods,revealing the scientific connotation of the compatibility of TCM formula from different perspectives and levels.This paper introduces the research progress of compatibility rules from different levels of compatibility,compatibility for synergistic enhancement and detoxification,and application of cutting-edge technology,with representative cases,in order to provide ideas and references for further study on TCM compatibility.

Forty-five Cases of Apoplexy Treated by Electroacupuncture at the Points of Yin Meridians

Forty-five cases of apoplexy were treated by electroacupuncture only at the points of Yin Meridians (i.e. the Hand- and Foot-Taiyin Meridians), and the other 30 cases as the controls were treated only at the points of Yang Meridians (i.e. the Hand- and Foot-Yangming Meridians). The total effective rate was 91.1% in the former and 86.7% in the latter, with no statistically significant difference between the two groups, indicating that acupuncture only at the points of Yin-Meridians is also an effective therapy for apoplexy.

The Channel Branches & Network Vessels on the Tianhui Lacquered Meridian Figurine——Taking the Heart-Regulated Channel as an Example

Along with the surge of unearthed medical literature and cultural relics in recent years,a network of channels in the system of medical conduit vessels(meridians) during the early Western Han dynasty has become much clearer gradually.In it,the increasing number of channel branches,network vessels and needle insertion holes(acupoints) is an important feature of the development of channel medicine during the Western Han dynasty.This is not only a reflection of the expanding requirements of the theoretical system of the main trunk channels and other vessels,but also an inevitable result of the continuous enrichment and accumulation of clinical experience.This article integrates the information about channel branches,network vessels,inscriptions,dots and further relics on the Tianhui(天回) Lacquered Meridian Figurine to compare the unearthed literature of the channel genre with the transmitted classical literature about acupuncture.The “Heart-Regulated Channel” in Medical Manuscripts on Bamboo Slips from Tianhui(《天回医简》) serves as an example to explain the occurrence,development and changes of the channel branches and network vessels in the early system of medical channels.

Evaluation of Compatibilizers for Improving Compatibility between Waste Vegetable Oil and Aged Asphalt

Modifying agents 2,2-Bis(4-glycidyloxyphenyl)propane(2BPE)and dibutyl phthalate(DBP)were selected to enhance the compatibility.By using molecular simulation software(Materials Studio,MS),nine systems were constructed,including molecular models of aged asphalt and WVO monomers with 2BPE and/or DBP.The solubility parameters,Flory-Huggins parameters,and interaction energies of these systems were calculated to determine the impact of 2BPE and DBP on the compatibility of WVO and aged asphalt.Results showed that the addition of 2BPE and DBP reduced the difference in the solubility parameters between WVO and aged asphalt,thus improving the compatibility between WVO and aged asphalt.Additionally,using a combination of 2BPE and DBP in both aged asphalt and rejuvenator was found to be more effective than using either 2BPE or DBP alone.Finally,it was determined that evaluating the compatibility of WVO and aged asphalt using Van der Waals potential and non-bonding energy as evaluation indicators was more accurate than using electrostatic potential energy.

Scientific exploration and hypotheses concerning the meridian system in traditional Chinese medicine

The meridian theory is an important component of traditional Chinese medicine,playing a crucial role in disease diagnosis,treatment,and health preservation.Serving as the media for the effects of acupuncture,moxibustion,herbal medicine,and acupressure massage,meridians exert undeniable impact on the human body.However,the essence of meridians remains a topic of debate.Recent research has primarily focused on their anatomical structures,leading to numerous hypotheses.Simultaneously,other researchers have approached this subject from an energetic perspective,discovering information interactions within the meridian system.These findings suggest that meridians possess both physical and information dimensions,indicating that a singular approach to their study is insufficient.To bridge this gap,a shift from purely structural research toward an exploration of the information aspects of meridians is necessary.By integrating this information approach with traditional meridian theory,it may be possible to develop a new,modernized meridian theory that is aligned with contemporary concepts,making it more accessible and applicable in clinical settings.

STUDY ON THE STARCH GRAFTED ACRYLATE MONOMERS AND ITS COMPATIBILITY FOR THE BLEND SYSTEM OF STARCH AND POLYETHYLENE

By means of initiation of the high temperature and shearing stress of an extruder,we synthesized the graft copolymer of starch with acrylate monomers based on the simple dry method.The effects of reaction conditions on graft copolymerization were discussed. Grafted starch used as a compatibilizer for the blend system of starch and polyethylene was further investigated. The results indicate that grafted starch as a compatibilizer can improve the mechanical properties and rheologic properties of the blend of starch and polyethylene.

Diversified and compatible web APIs recommendation based on game theory in IoT

With the ever-increasing popularity of Internet of Things(IoT),massive enterprises are attempting to encapsulate their developed outcomes into various lightweight Web Application Programming Interfaces(APIs)that can be accessible remotely.In this context,finding and writing a list of existing Web APIs that can collectively meet the functional needs of software developers has become a promising approach to economically and easily develop successful mobile applications.However,the number and diversity of candidate IoT Web APIs places an additional burden on application developers’Web API selection decisions,as it is often a challenging task to simultaneously ensure the diversity and compatibility of the final set of Web APIs selected.Considering this challenge and latest successful applications of game theory in IoT,a Diversified and Compatible Web APIs Recommendation approach,namely DivCAR,is put forward in this paper.First of all,to achieve API diversity,DivCAR employs random walk sampling technique on a pre-built“API-API”correlation graph to generate diverse“API-API”correlation subgraphs.Afterwards,with the diverse“API-API”correlation subgraphs,the compatible Web APIs recommendation problem is modeled as a minimum group Steiner tree search problem.A sorted set of multiple compatible and diverse Web APIs are returned to the application developer by solving the minimum group Steiner tree search problem.At last,a set of experiments are designed and implemented on a real dataset crawled from www.programmableweb.com.Experimental results validate the effectiveness and efficiency of our proposed DivCAR approach in balancing the Web APIs recommendation diversity and compatibility.

Electrochemical synthesis of FeN_(x) doped carbon quantum dots for sensitive detection of Cu^(2+) ion

A novel strategy was developed to fabricate FeNx-doped carbon quantum dots(Fe-N-CQDs)to detect Cu^(2+) ions selectively as a fluorescence probe.The Fe-N-CQDs were synthesized by an efficient electrolysis of a carbon cloth electrode,which was coated with monoatomic ironanchored nitrogen-doped carbon(Fe-N-C).The obtained Fe-N-CQDs emitted blue fluorescence and possessed a quantum yield(QY)of 7.5%.An extremely wide linear relationship between the Cu^(2+) concentration and the fluorescence intensity was obtained in the range from 100 nmol L^(-1) to 1000 nmol L^(-1)(R^(2)=0.997),and the detection limit was calculated as 59 nmol L^(-1).Moreover,the Fe-N-CQDs demonstrated wide range pH compatibility between 2 and 13 due to the coordination between pyridine nitrogen and Fe^(3+),which dramatically reduced the affection of the protonation and deprotonation process between H^(+) and Fe-N-CQDs.It is notable that the Fe-N-CQDs exhibited a rapid response in Cu^(2+) detection,where stable quenching can be completed in 7 s.The mechanism of excellent selective detection of Cu^(2+) was revealed by energy level simulation that the LUMO level of Fe-N-CQDs(-4.37 eV)was close to the redox potential of Cu^(2+),thus facilitating the electron transport from Fe-N-CQDs to Cu^(2+).

A leap by the rise of solid-state electrolytes for Li-air batteries

Li-air batteries have attracted extensive attention because of their ultrahigh theoretical energy density. However, the potential safety hazard of flammable organic liquid electrolytes hinders their practical applications. Replacing liquid electrolytes with solidstate electrolytes(SSEs) is expected to fundamentally overcome the safety issues. In this work, we focus on the development and challenge of solid-state Li-air batteries(SSLABs). The rise of different types of SSEs, interfacial compatibility and verifiability in SSLABs are presented. The corresponding strategies and prospects of SSLABs are also proposed. In particular, combining machine learning method with experiment and in situ(or operando)techniques is imperative to accelerate the development of SSLABs.

The Compatibility of Pragmatic Twist and Rhetoric

It is universally believed that Rhetoric is an expressive way of language, while pragmatic twist(Deliberate misinterpretation) isthe understanding phenomenon, which is not a rhetorical device but a cognitive activity in nature. The two can't be placed on a par witheach other. However, we find that the two aren't incompatible at all. The second speaker(S2) captures the rhetorical device in the firstspeaker(S1)'s utterance, and distorts the original meaning to achieve S2's communicative goal.

Analytical study of silane-based and wax-based additives on the interfacial bonding characteristics between natural rubber modified binder and different aggregate types

The modification of asphalt binder with natural rubber latex(NR)significantly improves the rutting and fatigue resistance of asphalt mixtures.However,NR-modified binder is prone to low workability and wettability due to its high viscosity.Therefore,this research focuses on examining the influences of silane and wax-based additives on the wettability of natural rubber-modified binders and the binder-aggregates adhesion performances.In this study,experimental and analytical approaches were used.The contact angles of asphalt binder were measured using a goniometer through the sessile drop method with three solvents:deionised water,formamide,and glycerol.The Cþþalgorithm was adopted to compute the surface free energy(SFE)elements of the asphalt binder.Analytical methods were employed to analyse the results based on the Young-Dupre equation,followed by linear regression to establish a correlation between the compatibility ratio(CR)and the SFE components.The results inferred that modified asphalt binders with additives possessed improved moisture resistance,wherein dry work adhesion values were less than 210 mJ/m^(2)under granite interfaces,whereas the limestone interface exhibited higher dry adhesion values of 340 mJ/m^(2)and below.Similar performance results were observed under wet adhesion conditions;with granite wet adhesive values observed below 120 mJ/m^(2),while limestone wet adhesion values were ascertained below 180 mJ/m^(2)for all tested samples and conditions.According to the spread–ability coefficient results,the limestone interface has greater spread-ability than granite interfaces.Meanwhile,compatibility ratio values indicated better compatibility of 1.9 or higher for tested samples under granite interfaces,whereas compatibility values of 1.7 and below were observed under limestone interfaces.