Stability analysis of intermittently jointed rock slopes based on the stepped failure mode

In practical engineering,due to the noncontinuity characteristics of joints in rock slopes,in addition to plane failure,stepped sliding failure may occur for intermittently jointed rock slopes.Especially for intermittently bedding jointed rock slopes,the correlation and difference in strength parameters between joints and rock bridges,along with the various failure modes and intermittency of rock bridges,contribute to the complexity of stepped failure modes and the unpredictability of failure regions.Based on the upper-bound limit analysis method and multi-sliders step-path failure mode,considering the shear and tensile failure of rock bridges and the weakened relationship between the strength parameters of rock bridges and jointed surfaces,by introducing the modified M-C failure criterion and the formula for calculating the energy consumption of tensile failure of rock bridges,two failure mechanisms are constructed to obtain the safety factor(F_(s))of intermittently jointed rock slopes.The sequential quadratic programming method is used to obtain the optimal upper-bound solution for F_(s).The influence of multiple key parameters(slope height H,horizontal distance L,Slope angleβ,shear strength parameters of the rock bridgeφr and cr,Dimensionless parameter u,weakening coefficients of the internal friction angle and cohesion between the rock bridges and joint surfaces Kφand Kc)on the stability analysis of intermittently jointed rock slopes under the shear failure mode of rock bridges as well as under the tensile failure mode is also explored.The reliability of the failure mechanisms is verified by comparative analysis with theoretical results,numerical results,and landslide cases,and the variation rules of F_(s)with each key parameter are obtained.The results show that F_(s) varies linearly withφr and cr of the rock bridge and with K_(φ)and K_(c),whereas F_(s)changes nonlinearly with H and L.In particular,with the increase in Kφand Kc,Fs increases by approximately 52.78%and 171.02%on average,respectively.For rock bridge tensile failure,F_(s) shows a nonlinearly positive correlation withφr,cr,Kφand Kc.In particular,with the increase in Kφand Kc,Fs increases by approximately 13%and 61.69%on average,respectively.Fs decreases rapidly with increasing slope gradientβand decreasing dimensionless parameterμ.When Kφand Kc are both less than 1.0,the stepped sliding surface occurs more easily than the plane failure surface,especially in the case of tensile failure of the rock bridge.In addition,rock slopes with higher strength parameters,taller heights,and greater weakening coefficients are prone to rock bridge tension failure with lower Fs,and more attention should be given to the occurrence of such accidents in actual engineering.

Understanding the Activity Performance of Comets 38P/Stephan-Oterma,64P/Swift-Gehrels and C/2017 M4(ATLAS)through Broadband Photometric Observations

In this work,we report observations of three comets:38P/Stephan-Oterma,64P/Swift-Gehrels,and C/2017 M4(ATLAS),conducted with the Nanshan one-meter wide-field telescope in 2018 August and November,and 2019January.We extracted morphological features through image enhancement techniques and calculated the dust activity parameter,Afρ,along with dust mass loss rates and coma color indices using broadband photometric data.Our morphological analysis uncovered a spectrum of dust characteristics among the observed comets,ranging from a significant twisted structure in comet 38P/Stephan-Oterma’s coma to the regular coma envelope surrounding comet 64P/Swift-Gehrels.The Afρvalues varied between 148.8±0.3 cm for 64P/Swift-Gehrels and1118.5±6.2 cm for C/2017 M4(ATLAS)(measured within a reference aperture radius ofρ=6″),indicating a range from moderate to high activity levels.Dust mass loss rates were estimated from 328.1 kg s^(-1)for comet 64P/Swift-Gehrels to 1395.5 kg s^(-1)for comet C/2017 M4(ATLAS).The color indices of comets 38P/Stephan-Oterma and C/2017 M4(ATLAS)closely resemble the average colors of active short-period comets and active longperiod comets,respectively.In contrast,64P/Swift-Gehrels exhibits a significantly bluer hue than typical Jupiter family comets.

Treatment of Vulvovaginal Candidiasis with A Strategy Based on Phototherapy (M.A.C.® Scar Acceleration Method)

Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAC® Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAC®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

Growth of the Earthworm Millsonia omodeoi and Its Capacity to Accumulate Five Heavy Metals (HM) in Soils along a Toll Highway in Côte d’Ivoire

The roads in correlation with the traffic linked to their existences are at the origin of the emission of numerous polluting substances likely to induce disturbances of the growth and the behavioral changes in the organisms living in their vicinities. The purpose of this study is to analyze the growth and capacity accumulation of a common earthworm species (Millsonia omodeoi) in Cu, Cr, Ni, Pb and Zn in soils along a main road called “Autoroute du Nord” in C?te d’Ivoire. Thus, the earthworms were harvested in soils from a distance of 0 m (just after the sidewalk) to a distance of 200 m from the toll highway and in a control soil sampled in Lamto reserve (C?te d’Ivoire). The study was carried out in the soil laboratory at the ecological station of Lamto reserve. The Ford-Walford technique was used to determine the model and parameters most appropriated for describing the growth of earthworms. A pairwise comparison of the growth parameters was carried out using the Kruskal-Wallis test with the STATISTICA 7.1 software. The heavy metals contained in the cultivated soils and earthworms were detected and quantified using a Scanning Electron Micro-scope (MEB FEG Supra 40 VP Zeiss) and an Atomic Absorption Spectrometer SPECTRA 110 (VARIAN). The capacity accumulation of heavy metals in earthworm was determined by the bioaccumulation factor (BAF) calculation. The results of this study showed that Gompertz is the most appropriated model to describe the growth of M. omodeoi. The life cycle of M. omodeoi shows that this earthworm adopts a K type demographic strategy. Cu is the most accumulated heavy metals in M. omodeoi, when Cr is the least accumulated. Concerning heavy metal content in the earthworms, it decreases while moving away from the pavement. These results highlight a possibility of choice of M. omodeoi as 1) indicators of heavy metals pollution and 2) target of biological organisms for environmental impact studies.

Simulating the Dynamics of Bimetallic Clusters Deposited onto a Surface Using Molecular Dynamics

This paper examines the interface development between a single crystalline Ag matrix and core-shell AgnCom nanoclusters that have been deposited with energies varying between 0.25 eV and 1.5 eV per atom using computer modeling techniques. Clusters undergo deformation as a result of the slowing down;they may also become epitaxial with the substrate and maintain their core-shell structure. A detailed analysis of the effects of the cluster-surface interaction is conducted over a realistic size and energy range, and a model is created to show how clusters accumulate. It is discovered that both the silver shells and the cobalt cluster cores exhibit limited epitaxy with the substrate, and that the contact produced is only a few atomic layers thick. The effect is higher for Ag shells than for Co cores, and it is not very energy dependent.

Effects of UV-B radiation and different light repair conditions on the early development of the tetraspores of Chondrus ocellatus Holm

The effects of exposure to UV-B radiation, 280-315 nm, and dark or dark repair conditions on the early development of Chondrus ocellatus Holm collected from Qingdao coast were studied under the laboratory condition. After being exposed to different doses [0, 36, 72, 108, 144 and 180 J/（m2.d）] of UV-B radiation, one treatment of tetraspores were put back to normal culture condition （PAR）, the other treatment were put into dark condition to repair for 2 h. During the cultivation, the diameter of the tetraspores were recorded every 4 d till the 50th day when vertical branches formed in all treatments. Then at the 50th day, CPDs, phycoerythrin, chlorophyll a and MAAs （Palythine and asterina-330） were measured. The results showed that low doses UV-B radiation could significantly accelerate the growth rate of the rate reduced gradually with UV-B radiation keep on tetraspores of C. ocellatus and the growth increasing. The variation trend of both the phycoerythrin and chlorophyll a concentration reduced significantly （P 〈0.05） once given the UV- B radiation. Under UV-B stress, the CPDs were induced, and the concentrations of CPDs were significant low in dark repair groups. The data of MAAs analyzed by LC/MS in the tetraspores of C. ocellatus suggested that there were two MAAs formed （palythine and asterina-330） after UV-B radiation induced, and low dose of UV-B irradiation could significantly induced the concentration of MAAs. From the growth and development state of the tetraspores, negative effects of UV-B radiation on the dark repair groups were more serious than PAR.

EFFECT OF DEPOSITIONS CONDITION ON THE MICROSTRUCTURE OF C/C MINICOMPOSITE

C/C minicomposites were manufactured by CVI with propylene as resource gas and Ar as diluent gas. Effects of deposition temperature, the flow rate of propylene and total system pressure on the microstructure of C/C minicomposites were investigated. Deposition conditions are as follows: deposition temperature ranging from 870℃ to 1000℃, the flow rate of propylene from 10 to 60 ml/min, and total system pressure from 3 to 16kPa. The results revealed: The deposit distributes non uniformly as increasing the deposition temperature or total system pressure. The effect of the flow rate of propylene on the distribution of deposit observes different principles at different deposition temperatures. If the deposition temperature rises to 900℃, the deposit distributes more non uniformly as increasing the flow rate of propylene. The morphology of deposit varies with deposition condition, such as smooth, droplet like or spike like. Deposition mechanism varies with deposition condition. It can be surface reaction nucleation and growth, heterogeneous nucleation of liquid droplet on carbon fiber or gas borne nuclei growth. With the principle of nuclei growth of crystal and the method of phenomenology, the changes of deposition mechanism and the morphology of pyrolytic carbon with deposition condition were explained successfully. The effect of deposition condition on deposit homogeneity stems from the effect of deposition condition on the CVI kinetics and the deposition mechanism of pyrolytic carbon.

Research on the real-time signal conditioning method for dispersion interferometer in HL-2M

A new CO2 laser dispersion interferometer has been developed in the HL-2 M tokamak to measure the electron density.In order to meet the needs of high-precision measurement,a data acquisition system with real-time signal conditioning(RSC)method is proposed.It can eliminate part of the impacts of environmental factors,such as mechanical vibration,light path changes,and plasma refraction effect during experiments.In harsh environments,the system can measure the line-integrated density with a high precision of 2×10^18 m^-2 with the RSC method.The system has been tested in a recent HL-2 A experimental campaign,and the results show that the RSC method plays an important role in the plasma electron density measurement.

Geochemistry of the Aptian bituminous limestones in Gümuü?hane area,Eastern Black Sea region:new insight into paleogeography and paleoclimate conditions

Aptian is characterized by widespread deposition of organic-rich sediment.The Aptian bitumen limestone horizon,which is thin decimetre-thick sequences,locally crops out in the Kircaova area,Eastern Black Sea Region(Eastern Pontides).They are well correlated with Aptian bitumen limestone in the other Tethys Reams.They are proposed as episodes of increased organic matter.However,background factors controlling organic matter enrichment are poorly known.In this study,we present new inorganic geochemistry,including trace elements,rare earth elements(REE),redox-sensitive elements(RSE),stable-isotopes(δ~(18)O andδ~(13)C),and total organic carbon(TOC).We integrated new geochemical data with existing stratigraphy,paleontology,and organic chemistry data to provide new insight into the depositional environment and paleoclimate conditions during Aptian.The lacustrine bitumen limestone(LBL)samples have variedδ~(13)C(ave.-1.45‰)andδ~(18)O(ave.-4.50‰).They possess distinct REE patterns,with an average of REE(ave.14.45 ppm)and Y/Ho(ave.35)ratios.In addition,they have variable Nd/YbN(0.28-0.81;ave.0.56)and Ce/Ce*(0.68-0.97;ave.0.86),and relatively high Eu^(*)/Eu(1.23-1.53;ave.1.35).They display seawater signatures with reduced oxygen conditions.The enrichment in RSE(Mo,Cu,Ni,and Zn)and the low Mo/TOC(0.70-3.69;ave.2.41)support a certain degree of water restriction.The high Sr/Ba,Sr/Cu,Ga/Rb,and K/Al records of the LBL facies suggest hot house climatic conditions.The sedimentary environment was probably an isolated basin that is transformed from the marine basin.In addition to depositional conditions,the regional parameters such as the climate,increased run-off period,nutrient levels,alkalinity level,and dominant carbonate producers favored the enrichment in organic matter of LBL facies.Thus,extreme greenhouse palaeoclimate conditions have an important role in organic matter enrichment in the isolated basin.Our results are conformable with the published data from marine,semi-restricted basin,and lacustrine settings in the different parts of the Tethys margin.Thus,this approach provides the first insight into the Aptian greenhouse paleo-climate conditions of the Eastern Black Sea Region,NE Turkey.

非线性M-C强度准则下预应力锚索加固边坡时效稳定性分析M-P法

拓展传统极限平衡方法在复杂条件下边坡稳定性分析中的适用性一直是岩土工程界的研究热点。众所周知,边坡岩土体剪切失效一般服从于非线性强度准则,而传统极限平衡方法仅适用于线性强度准则下边坡稳定性分析。此外,预应力锚索作为一种主动防护措施,可极大地即时提高边坡稳定性而被广泛应用于中、大型边坡工程加固。然而,在应力松弛、蠕变效应以及腐蚀环境影响下预应力锚索加固边坡稳定性时效特征往往被忽视。由此,基于Morgenstern-Price(M-P)法,嵌入非线性Mohr-Coulomb(M-C)强度准则,并融入应力松弛与蠕变效应下锚索预应力损失模型以及腐蚀环境下锚索性能劣化模型,从而,建立非线性强度准则下预应力锚索加固边坡安全系数时程表达式。进一步,为了解决非线性强度准则下隐式嵌套公式难以求解的问题,归零化条间法向力初始值,并应用迭代循环求解策略,在引入循环终止允许误差判别条件后,可实现边坡稳定性理论真实结果的逼近求解。经过后续算例对比分析,验证了所提方法的可行性和合理性,与此同时,还研究了不同预应力损失速率和不同锈蚀环境下预应力锚索加固边坡稳定性的时效变化规律。

Thermodynamics analysis and precipitation behavior of fine carbide in K416B Ni-based superalloy with high W content during creep

The precipitation behavior of carbide in K416 B superalloy was investigated by means of creep measurement and microstructure observation. The results show that nanometer M6 C particles discontinuously precipitate in the γ matrix or along the γ/γ′ interface of the alloy during high temperature tensile creep. Thereinto, the amount of fine M6 C carbide increases as creep goes on, and the coherent interfaces of M6 C phase precipitating from the γ matrix are {100} and {111} planes. The thermodynamics analysis indicates that the solubility of element carbon in the matrix decreases when the alloy is deformed by the axial tensile stress during creep, so as to cause the carbon segregating in the regions of stress concentration and combining with carbide-forming elements M（W, Co）, which promotes the fine M6 C carbide to precipitate from the γ matrix.

m1A/m5C/m6A/m7G调控基因预测胃癌预后及免疫关联性

目的基于m1A/m5C/m6A/m7G甲基化调控基因建立胃癌预后风险预测模型,并分析该模型与免疫的关联性。方法通过癌症基因组图谱(TCGA)-胃癌数据集筛选表达具有显著差异的m1A/m5C/m6A/m7G调控基因,通过单基因Cox回归分析和LASSO算法构建预后风险评分(risk score,RS)模型,使用Kaplan-Meier(K-M)统计进行RS模型验证,并应用细胞系进行RT-qPCR验证。利用单因素、多因素Cox回归分析建立nomogram模型。使用CIBERSORT算法和estimate包进行免疫关联性分析。结果建立了基于八个甲基化调控基因的预后RS模型,将胃癌患者分为高风险和低风险。这八个基因在胃癌细胞系中高表达(P<0.05)。在TCGA-胃癌训练集和GSE62254-验证集中,患者总生存率(OS)与分组状态之间存在显著相关性(P<0.001)。nomogram生存模型预测的1年(C-index=0.703)、3年(C-index=0.729)和5年(C-index=0.734)生存率与实际生存率的一致性较好。免疫关联性分析表明,与低风险患者组相比,高风险患者组免疫评分和免疫检查点相关基因的表达较高(P<0.05)。结论基于m1A/m5C/m6A/m7G调控基因的预后RS模型可预测胃癌预后并指导个体免疫治疗决策。

Fourth-Order Compact Formulation for the Resolution of Heat Transfer in Natural Convection of Water-Cu Nanofluid in a Square Cavity with a Sinusoidal Boundary Thermal Condition

In the present work, we numerically study the laminar natural convection of a nanofluid confined in a square cavity. The vertical walls are assumed to be insulated, non-conducting, and impermeable to mass transfer. The horizontal walls are differentially heated, and the low is maintained at hot condition (sinusoidal) when the high one is cold. The objective of this work is to develop a new height accurate method for solving heat transfer equations. The new method is a Fourth Order Compact (F.O.C). This work aims to show the interest of the method and understand the effect of the presence of nanofluids in closed square systems on the natural convection mechanism. The numerical simulations are performed for Prandtl number ( ), the Rayleigh numbers varying between and for different volume fractions varies between 0% and 10% for the nanofluid (water + Cu).

理想M-C材料强度评估判据与等效塑性应变

基于理想Mohr-Coulomb(M-C)屈服准则,该文提出了拉伸、压缩和剪切等效应力的概念及其公式,并给出了三个相应的强度评估条件.根据塑性功等效原则,分别导出了与上述等效应力共轭的拉伸、压缩等效塑性应变和等效塑性剪应变,探论了不同的摩擦因数下等效应变的变化特征.与Mises等效应变不同,所得到的M-C等效应变能够反映静水压力的影响,也可退化为简单应力状态.这些等效应力和等效应变概念都具有明确的物理意义,将能够应用于更准确、有效地评估拉、压性能不同材料的强度,对于用简单拉伸、压缩或剪切试验标定复杂应力状态下本构模型参数也具有直接应用价值.

Effect of Different Culture Conditions on Sporulation Quantity of Phytophthora capsici in Capsicum annuum L. var. dactylus M. in Xunhua

[Objective] The paper was to explore the effect of different culture conditions on sporulation quantity of Phytophthora capsici in Capsicum annuum L.var.dactylus M.in Xunhua.[Method] The effects of light hours,pH,medium and temperature on sporulation quantity during isolation and culture process of P.capsici were studied.[Result] The sporulation quantity of P.capsici under the conditions of 24 h/day light,pH 7.0,potato medium（PSA） and 30 ℃ was the largest,and pH,basal medium and temperature had greater impact on sporulation quantity.[Conclusion]The study laid foundation for the study on natural incidence condition of C.annuum in Xunhua.

C2M电商助力制造企业数字化升级的机理及路径

随着信息技术及我国经济社会的迅猛发展,互联网由消费互联网走向工业互联网,C2M电商模式脱颖而出,众多品牌制造企业纷纷结合C2M电商,助力企业的数字化升级。在升级机理上,C2M电商将消费者与生产制造企业实现端到端的直接互联,使得消费端到生产端的供应链数字化升级日新月异,纵向上下游节点数据打通共享,横向同类供应商多家接入,按业务不断延展,形成产业网链。品牌制造企业通过C2M电商,从消费端收集消费者的动态需求,到未来潮流产品预测,再到产品研发的数字化、产品的柔性化生产与产品营销数字化,连通并共享产业链上的大数据,为企业的生产经营数据赋能,创新商业模式,形成产业数字生态圈,不断创造新的价值,实现数字化升级。在升级路径上,依次从产品信息充分数字化、实施C2M电商全渠道数字化营销、产品研发设计的数字化、到采购生产销售物流全流程供应链的数字化升级,最终实现生产经营大数据为企业生产经营数据赋能。

儿童支原体肺炎检测中CRP、IgM、IgG、PCT指标的临床意义分析

目的探讨在儿童支原体肺炎检测中C反应蛋白(C-reactive Protein,CRP)、免疫球蛋白指标M(Immunoglobulin M,IgM)、免疫球蛋白指标G(IgG)、降钙素原(Procalcitonin,PCT)指标的临床意义。方法选取2019年11月—2022年4月赣榆区人民医院收治的支原体肺炎患儿120例作为观察组,并在同期体检健康儿童中选取120例作为对照组,均接受CRP、IgM、IgG、PCT等指标检测,根据其检测水平进行分析。结果观察组患儿的CRP为(15.35±3.08)mg/L、PCT为(0.66±0.11)ng/L,比对照组CRP的(4.08±0.72)mg/L、PCT(0.31±0.06)ng/L高,差异有统计学意义(t=39.031、30.599,P均<0.05);观察组中急性期患儿的CRP、PCT指标水平明显高于恢复期患儿指标水平,差异有统计学意义(P均<0.05);观察组患儿的IgM、IgG、IgE水平较对照组高,IgA水平较对照组低,差异有统计学意义(P均<0.05)。结论支原体肺炎患儿接受免疫球蛋白指标、CRP、PCT指标检测,其指标值可良好地反映患儿病情,IgA水平较低,其他指标均升高,因此对以上指标进行密切监测,为支原体肺炎疾病诊断、治疗提供数据参考。

C2M反向驱动的皮革服装定制模式研究

C2M模式是继B2B、B2C模式后兴起的一种基于工业互联网背景的新型商业模式,是以用户个性化消费需求反向驱动企业生产的制造模式,具有去中间环节的价格优势。为满足皮革服装消费的个性化需求,从皮革服装裁剪与制作工艺角度,分析了皮革服装行业引入C2M模式的可行性,提出了基于C2M反向驱动的皮革服装定制设计模式和工作流程,为皮革服装品牌转换经营模式,加速数字化智能定制平台转型升级,更好地满足顾客需求,获取新的利润空间提供了参考。

指数有界双连续n阶m次积分C群的指数公式

利用经典算子半群理论中的研究方法,基于指数有界双连续n阶m次积分C群和预解式的定义,给出指数有界双连续n阶m次积分C群与其预解式间积分的表示关系,得到指数有界双连续n阶m次积分C群的指数公式,从而推广了n阶m次积分C半群的相关结果,丰富了算子半群理论的研究内容.

P/M和W/C对磷酸镁水泥强度的影响分析

为探究磷镁比(P/M)及水灰比(W/C)对磷酸镁水泥强度的影响和作用机理,对其力学性能进行测试,并结合XRD、SEM和FT-IR等测试手段对其物相组成及微观形貌进行表征和分析。研究结果表明:W/C=0.15时,磷酸二氢钾掺量的降低会使磷酸镁水泥的各龄期抗压强度增强,P/M=1:4时其3 h强度超过30 MPa,而当掺量过高时,3 h强度低于20 MPa,其产物MgKPO_(4)·6H_(2)O(K-struvite)的生成量减少且试件存在开裂区域;W/C=0.25时,减少MgO的掺量可以提高磷酸镁水泥的强度,P/M=1:1.5时,3 h的抗压强度接近30 MPa,磷酸镁水泥的水化产物K-struvite形貌结晶完好且排列紧密。