Preventing brain aging by the artificial enforcement of the unfolded protein response:future directions

As the life expectancy of the world’s population increases,age-related diseases are emerging as one of the greatest problems facing modern society.The onset of dementia and neurodegenerative diseases is strictly dependent on aging as a major risk factor and has a profound impact on various aspects of the lives of individuals and their families.

Ascertaining the influences of auxiliary qubits on the Einstein–Podolsky–Rosen steering and its directions

Einstein–Podolsky–Rosen(EPR) steering is an example of nontrivial quantum nonlocality and characteristic in the non-classical world.The directivity(or asymmetry) is a fascinating trait of EPR steering,and it is different from other quantum nonlocalities.Here,we consider the strategy in which two atoms compose a two-qubit X state,and the two atoms are owned by Alice and Bob,respectively.The atom of Alice suffers from a reservoir,and the atom of Bob couples with a bit flip channel.The influences of auxiliary qubits on EPR steering and its directions are revealed by means of the entropy uncertainty relation.The results indicate that EPR steering declines with growing time t when adding fewer auxiliary qubits.The EPR steering behaves as damped oscillation when introducing more auxiliary qubits in the strong coupling regime.In the weak coupling regime,the EPR steering monotonously decreases as t increases when coupling auxiliary qubits.The increases in auxiliary qubits are responsible for the fact that the steerability from Alice to Bob(or from Bob to Alice) can be more effectively revealed.Notably,the introductions of more auxiliary qubits can change the situation that steerability from Alice to Bob is certain to a situation in which steerability from Bob to Alice is certain.

Stability assessment of tree ring growth of Pinus armandii Franch in response to climate change based on slope directions at the Lubanling in the Funiu Mountains,China

Global warming will affect growth strategies and how trees will adapt.To compare the response of tree radial growth to climate warming in different slope directions,samples of Pinus armandii Franch were collected and treering chronologies developed on northern and western slopes from the Lubanling in the Funiu Mountains.Correlation analyses showed that two chronologies were mainly limited by temperatures in the previous June–August and the combination of temperatures and moisture in the current May–July.The difference of the climate response to slopes was small but not negligible.Radial growth of the LBL01 site on the northern slope was affected by the combined maximum and minimum temperatures,while that of the LBL02 site was affected by maximum temperatures.With regards to moisture,radial growth of the trees on the north slope was influenced by the relative humidity in the current May–July,while on the western slope,it was affected by the relative humidity in the previous June–August,the current May–July and the precipitation in the current May–July.With the change in climate,the effects of the main limiting factors on growth on different slopes were visible to a certain extent,but the differences in response of trees on different slopes gradually decreased,which might be caused by factors such as different slope directions and the change in diurnal temperature range.These results may provide information for forest protection and ecological construction in this region,and a scientific reference for future climate reconstruction.

Stability assessment of tree ring growth of Pinus armandii Franch in response to climate change based on slope directions at the Lubanling in the Funiu Mountains,China

Global warming will affect growth strategies and how trees will adapt.To compare the response of tree radial growth to climate warming in different slope directions,samples of Pinus armandii Franch were collected and tree-ring chronologies developed on northern and western slopes from the Lubanling in the Funiu Mountains.Correlation analyses showed that two chronologies were mainly limited by temperatures in the previous June-August and the com-bination of temperatures and moisture in the current May-July.The difference of the climate response to slopes was small but not negligible.Radial growth of the LBLO1 site on the northern slope was affected by the combined maximum and minimum temperatures,while that of the LBLO2 site was affected by maximum temperatures.With regards to moisture,radial growth of the trees on the north slope was influenced by the relative humidity in the current May-July,while on the western slope,it was affected by the relative humidity in the previous June-August,the current May-July and the precipitation in the current May-July.With the change in climate,the effects of the main limiting factors on growth on different slopes were visible to a certain extent,but the differences in response of trees on different slopes gradually decreased,which might be caused by factors such as different slope directions and the change in diurnal temperature range.These results may provide information for forest protection and ecological construction in this region,and a scientific reference for future climate reconstruction.

Dialogue on standards:directions and difficulties of standardization discipline construction

To probe into the directions and difficulties of standardization discipline construction in China,China Standardization Press organized a pertinent dialogue on July 10.During the event,Yu Xinli,President of China Association for Standardization,was invited as the moderator.Several standardization experts including Song Mingshun,Mai Lyubo,Qiang Yi,Cao Lili,and Huang Manxue from the China Standardization Expert Committee and renowned universities and research institutes in the country were invited as guests to give their insightful views.

Protective benefits of HDPE board sand fences in an environment with variable wind directions on Gobi surfaces:wind tunnel study

The Golmud-Korla Railway in the Gobi area faces operational challenges due to sand hazards,caused by strong and variable winds.This study addresses these challenges by conducting wind tunnel tests to evaluate the protective benefits of High Density Polyethylene(HDPE)board sand fences,focusing on their orientation relative to various wind directions(referred to as'wind angle').This study found that the size of the low-velocity zone on the leeward side of the sand fences(LSF)expanded with an increase in the wind angle(WA).At 1H(the height of the sand fence)and 2H positions on the LSF,the wind speed profiles(WSP)exhibited a segmented logarithmic growth,constrained by Z=H at varying WAs.The efficacy of the sand fence in obstructing airflow escalated as WA increased.The size of the WA has a significant impact on the protective efficiency of HDPE board sand fences.Furthermore,compared to typical sandy surfaces,the rate of sand transport across the Gobi surface diminishes more slowly with height,attributed to the gravel's rebound effect.This phenomenon allows some sand particles to bypass the fences,rendering them less effective at blocking wind and trapping sand than in sandy environments.This paper offers scientific evidence supporting the practical use and enhancement of HDPE board sand fences in varied wind conditions.

Optimizing PID controller parameters for robust automatic voltage regulator system through indirect design approach-2

Automatic voltage regulators(AVR)are designed to manipulate a synchronous generator’s voltage level automatically.Proportional integral derivative(PID)controllers are typically used in AVR systems to regulate voltage.Although advanced PID tuning methods have been proposed,the actual voltage response differs from the theoretical predictions due to modeling errors and system uncertainties.This requires continuous fine tuning of the PID parameters.However,manual adjustment of these parameters can compromise the stability and robustness of the AVR system.This study focuses on the online self-tuning of PID controllers called indirect design approach-2(IDA-2)in AVR systems while preserving robustness.In particular,we indirectly tune the PID controller by shifting the frequency response.The new PID parameters depend on the frequency-shifting constant and the previously optimized PID parameters.Adjusting the frequency-shifting constant modifies all the PID parameters simultaneously,thereby improving the control performance and robustness.We evaluate the robustness of the proposed online PID tuning method by comparing the gain margins(GMs)and phase margins(PMs)with previously optimized PID parameters during parameter uncertainties.The proposed method is further evaluated in terms of disturbance rejection,measurement noise,and frequency response analysis during parameter uncertainty calculations against existing methods.Simulations show that the proposed method significantly improves the robustness of the controller in the AVR system.In summary,online self-tuning enables automated PID parameter adjustment in an AVR system,while maintaining stability and robustness.

Trending IC design directions in 2022

For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works.

Generative Learning in VLSI Design for Manufacturability: Current Status and Future Directions

With the continuous scaling of integrated circuit technologies,design for manufacturability(DFM)is becoming more critical,yet more challenging.Alongside,recent advances in machine learning have provided a new computing paradigm with promising applications in VLSI manufacturability.In particular,generative learning-regarded among the most interesting ideas in present-day machine learning-has demonstrated impressive capabilities in a wide range of applications.This paper surveys recent results of using generative learning in VLSI manufacturing modeling and optimization.Specifically,we examine the unique features of generative learning that have been leveraged to improve DFM efficiency in an unprecedented way;hence,paving the way to a new data-driven DFM approach.The state-of-the-art methods are presented,and challenges/opportunities are discussed.

基于Geomagic Design Direct的残缺数据实体重构

面向实物的逆向工程技术是近几年来研究和发展的热点,已广泛应用于产品设计、文物保护和零件修复等领域。报告了对模型的残缺表面数据进行曲面和实体重构的研究现状,以及结合正向和逆向建模软件进行实体模型重构的局限性。介绍了应用软件Geomagic Design Direct进行实体模型重构的优势以及对残缺表面数据实体模型重构的一般流程。提出了基于软件Geomagic Design Direct的特征识别与提取功能,对残缺表面数据进行实体重构的解决方案,并以某一零部件的残缺表面数据为例进行实体重构验证了该方案的可行性和便利性。

基于Geomagic Design Direct的截面特征提取与逆向建模

当前逆向工程已成为一种消化、吸收先进技术,实现产品的创新设计和快速开发的重要技术手段。随着各种特征技术的不断发展和引进,基于特征的逆向建模方法逐渐成为逆向工程新的发展方向。根据已有的建模方法,提出一种在二维草图模式下截面特征轮廓线提取与参数化设计的逆向建模新思路。并以Geomagic Design Direct软件为平台,实现了二维草图模式下特征轮廓线的提取与参数化再设计的逆向建模方法,为产品的快速建模和创新设计提供了一种新的途径。

Uniform Design for Optimizating Regeneration Shoots Directly from Tender Leaves and Plant Regeneration System of Rhododendron chrysanthum Pall.

[Objective] The experimental was aimed to screen the optimum regeneration shoot induction media and rooting media for tender leaves of Rhododendron chrysanthum Pall.[Method] The tender leaves of Rhododendron chrysanthum Pall were taken as explants to select the optimum bud induction media and rooting media through uniform design and the screening results were verified.[Result] The optimum media for regeneration shoot of Rhododendron chrysanthum Pall contained 1/4 MS,3.70 mg/L ZT, 0.02 mg/L IAA and 1.00 mg/L KT and its induction rate was 95.5% and the rooting media contained modified MS, 0.10 mg/L IAA and 0.07 mg/L NAA and its rooting rate was 98%. [Conclusion] Through this experiment, regeneration systems for regeneration shoot and regenerated plant from tender leaves of Rhododendron chrysanthum Pall were created successfully.

Design calculation of porous ceramics tube type dew point indirect evaporative cooler

To improve the wall surface hydrophilicity of a tube type indirect evaporative cooler,a new method adopting porous ceramics is proposed.This method realizes the combination of porous ceramics and the evaporative cooling technique.The design calculation of the porous ceramics tube type dew point indirect evaporative cooler are carried out from such aspects as the volumes and status parameters of the primary and secondary air,the cooler structure,the heat transfer of the solid porous ceramic tubes and the resistance of the cooler.The calculation results show that the design is reasonable.Finally,based on the design calculation,the porous ceramics tube type dew point indirect evaporative cooler is successfully manufactured.

The Precise Order and Singular Directions of Meromorphic Functions

The rnemmorphic functions of positive order(both finite positive order and infinite order) are discussed.First,the precise order and type function are given by using the characteristic function.Then some singular directions are defined and their existence is proved.

TOOTH CROWN DEFORMABLE DESIGN BASED ON DIRECT MANIPULATION OF FFD

A flexible and adaptable design method for the tooth crown is presented based on the direct manipulation of free-form deformation （FFD）. The correct shape of the tooth crown can be obtained by adding, modifying, and deleting constraint points or load points based on stretching and compressing operation. Finally, an example is given to illustrate the method to be efficient.

基于Geomagic Design Direct的正逆向混合建模创新设计

混合建模设计是正向设计与逆向设计的结合,提出了一种基于Geomagic Design Direct软件的正逆向混合建模的方法。通过数据采集、点云预处理、曲面重构,然后编辑曲面、实体特征造型以及参数化修改获得最终CAD模型。以游戏手柄模型为例,应用Geomagic Design Direct软件的强大功能对零件点云数据进行混合建模创新设计,实现了游戏手柄的快速还原以及对产品进行第二次创新。实验结果表明,通过Geomagic Design Direct软件实现混合建模技术,能高效的对原始模型进行创新设计。

水田动力底盘逆向建模与质心验证——基于Geomagic Design X

针对目前农业机械仿真和优化模型精度不高的问题,提出了一种构建精确模型的逆向建模方法。应用光学扫描仪采集点云数据,基于Geomagic Design X处理点云数据并重构零部件模型,在SolidWorks中完成水田动力底盘的装配。以VP6D-CQ型水田动力底盘为例,将测得的实际质心位置与所建的模型质心位置进行比较,并对提出的逆向建模方法进行了试验验证以及误差分析。结果表明:总质量、x坐标、y坐标、z坐标的误差值分别为4.55%、3.62%、2.23%、4.81%,误差值均在5%内。此方法可构建准确的三维模型,为后续仿真优化数据精确性奠定了基础,与传统的研发相比较,可缩短农业机械研发周期、降低设计成本。

Automatic IQ Phase Calibration Design in a 2.4GHz Direct Conversion Receiver

An automatic IQ phase calibration method implemented in a 2.4GHz direct conversion receiver is proposed. It uses a delay locked loop （DLL） with a proposed quadrature phase detector to greatly reduce the phase error. The receiver is fabricated in a 0.18μm CMOS process. Measurements show that the IQ phase error can be calibrated within 1°,which satisfies the system requirement.

App Designer辅助教学方法探索与实践——以软件无线电课程为例

软件无线电作为通信学科的必修课程,具有承上启下的重要作用。因课程原理抽象、理论公式复杂,学员在学习过程存在理解掌握难、实践应用难等问题。通过对当前软件无线电教学过程中存在的不足与困难进行分析,提出利用MATLAB App Designer辅助课程教学,从教学准备、课堂互动、自主实验、反馈提升四个方面开展课程教学改革。实践表明,该方法对于提升学员的工程思维、系统思维具有显著效果,同时可以增强学员理论联系实际的能力。

An evaluation of force-based design vs.direct displacement-based design of jointed precast post-tensioned wall systems

The unique features of jointed post-tensioned wall systems, which include minimum structural damage and re-centering capability when subjected to earthquake lateral loads, are the result of using unbonded post-tensioning to attach the walls to the foundation, along with employing energy dissipating shear connectors between the walls. Using acceptance criteria defined in terms of inter-story drift, residual drift, and floor acceleration, this study presents a multiplelevel performance-based seismic evaluation of two five-story unbonded post-tensioned jointed precast wall systems. The design and analysis of these two wall systems, established as the direct displacement-based and force-based solutions for a prototype building used in the PREcast Seismic Structural Systems （PRESSS） program, were performed at 60% scale so that the analysis model could be validated using the PRESSS test data. Both buildings satisfied the performance criteria at four levels of earthquake motions although the design base shear of the direct displacement-based jointed wall system was 50% of that demanded by the force-based design method. The study also investigated the feasibility of controlling the maximum transient inter-story drift in a jointed wall system by increasing the number of energy dissipating shear connectors between the walls but without significantly affecting its re-centering capability.