Based on network pharmacology and molecular docking technology to explore the mechanism of Panax notoginseng in the treatment of membranous nephropathy

Objective:Based on network pharmacology and molecular docking technology to explore the mechanism of Professor Cao Enze's application of Panax notoginseng in the treatment of membranous nephropathy.Methods:TCMSP database was used to obtain the effective components and corresponding target information of Panax notoginseng,and Gene Cards database was used to obtain the disease target genes of membranous nephropathy.The intersection targets of the two were taken and the Venn diagram was drawn.The STRING database was used to obtain the protein interaction relationship,and the PPI network diagram was constructed by Cytoscape 3.9.1 software to screen out the core targets of Panax notoginseng in the treatment of membranous nephropathy.GO function and KEGG pathway enrichment analysis were performed using the David database to obtain the potential pathway of Panax notoginseng in the treatment of membranous nephropathy.Finally,Autodock software was used to verify the molecular docking of the main active components of the drug with the core targets.Results:A total of 7 effective components such as quercetin,ginsenoside rh2,Mandenol and Stigmasterol were retrieved,and 127 potential targets of Panax notoginseng in the treatment of membranous nephropathy were screened out.By PPI network topology analysis,23 core targets such as JUN,TP53,RELA,AKT1 and MAPK1 were screened out.GO functional enrichment analysis contained 703 biological processes,55 cell components and 121 molecular functions,and KEGG signal pathway enrichment analysis enriched 171 signal pathways.The results of molecular docking showed that there was a strong binding ability between the main core targets and the main components of Panax notoginseng.Conclusion:Through network pharmacology,it is concluded that Panax notoginseng treats membranous nephropathy through multiple targets and multiple pathways,which provides a theoretical basis for subsequent basic research.

Doctor Song Fuyin's Experience in Treating Hashimoto's Thyroiditis Based on Qi,Blood Essence and Spirit Syndrome Differentiation Stage Classification

The paper systematically summarizes the experience of Director Song Fuyin in treating Hashimoto's thyroiditis which is a typical emotional disease that causes obvious changes in organ morphology and endocrine and body fluid metabolism.It belongs to the category of psychosomatic diseases,and is the embodiment of a series of pathogenesis processes of qi disease,blood disease,essence disease and deformation in TCM theory.The whole course of the disease is dominated by the dialectical relationship of mutual influence,mutual control,mutual root and mutual use among the deity disease,qi disease,blood disease,essence and spiritual disease.Therefore,the treatment emphasizes the dialectical relationship based on qi,blood,essence and spirit.At the beginning,the treatment focuses on regulating qi and clearing heat and eliminating phlegm;at the middle stage,the treatment focuses on replenishing essence and promoting yang and eliminating wind and calming the deity;at the late stage,the treatment focuses on replenishing qi and eliminating phlegm and promoting collages.Flexible use of calming the spirits,regulating qi,dispersing essence,eliminating phlegm,promoting blood and other methods of stage classification treatment,can be targeted,improve the cure rate of the disease.This article aims to clarify the experience of Director Song Fuyin in treating Hashimoto's thyroiditis based on syndrome differentiation of qi,blood essence and spirit.

Professor LUO Zhijuan's experience in the treatment of infertility in elderly women

With the national second child policy, old-age fertility problem increasingly prominent, female fertility decline by the increase of age, so the incidence of infertility also will increase from the understanding of disease dialectical trichotomy therapy to summarize professor LUO Zhi-juan clinical experience infertility think the disease occurs mainly in kidney empty as this, liver and spleen viscera dysfunction to heart, wet phlegm and blood stasis as the main pathological product of common cause kidney - menstruation - ran ren - cell palace reproductive axis dysfunction and infertility.

Experience of the national-level old Chinese medicine expert Wu Zhengshi on syndrome differentiation and treatment of anaphylactoid purpura

This paper introduced and summarized the experience of the national-level old Chinese medicine expert Wu Zhengshi on syndrome differentiation and treatment of anaphylactoid purpura.Wu Zhengshi believes that blood-heat is the main cause of anaphylactoid purpura.When Qi is weak,the human body is attacked by external heat,resulting in the damage of the blood system,which lead to the anaphylactoid purpura.The blood is thermalized poison,which enters the vessel quickly and forces the blood to overflow the vessel,which develops for the purpura.According to the ancient book of Chinese medicine Jie Wei Yuan Sou(1550 C.E.),Wu Zhengshi put forward the treatment of relieving blood detoxification,heat and cooling blood,which achieved significant curative effects.

The experiences of Zheng-ping Bai in treating gastric cancer based on qi,phlegm,and stasis

This paper will introduce the clinical experiences of Professor Zheng-pingBai in treating gastric cancer.In his diagnosis and treatment of this disease,Professor Bai advocates the integration of disease,symptom,and syndrome differentiation,pointing out that gastric cancer is caused by the accumulation of phlegm-dampness and blood stasis in the stomach due to qi stagnation.Therefore,the basic pathogenic mechanism involves the loss of harmonious descent in the stomach.This implies that treatment should prioritize qi activity by calming the stomach and suppressing the abnormal ascent of qi,as well as emphasizing the elimination of phlegm and stasis,and this has achieved significant therapeutic efficacy.

Professor Yanping Bai’s experience in treating alopecia areata

To summarize and analyze Professor Bai Yanping’s clinical experience in treating alopecia areata.Prof.Bai thinks the etiology of alopecia areata is a combination of liver-kidney depletion,qi and blood deficiency,qi stagnation and blood stasis,always along with wind-heat,damp-heat,blood heat and insomnia.It is indispensable to enrich and nourish the liver and kidney,supplement and nourish the qi and blood,invigorate blood and dissolve stasis,and at the same time,the usage of messenger drug and plum-blossom needle is important and formula has to vary from person to person on the basis of commonality.

Professor Cheng Lan's Experience in Treating Endometriosis

Endometriosis is one of the refractory and common disease in gynaecology, which the main manifestations are dysmenorrhea and infertility. Professor Cheng considers it's the deficiency-excess mixing illness whose pathological base is blood stasis and root is the deficiency of Yin and Yang, Qi and blood. So in terms of treatment, Professor Cheng praises highly the way of strengthening the body resistance to eliminate pathogenic factors. Strengthening the body resistance and expelling evil at the same time can achieve the purpose of treatment. In the adjustment of Yin and Yang ,Qi and blood, Professor Cheng attaches importance to treating middle burner. On the treatment of dysmenorrhea, Professor Cheng is able to capture xuefu zhuyu decoction and bazhen decoction and pays attention to menstrual cycle therapy. In addition, Professor Cheng often uses jingui wenjing decoction for infertility and re-understands the decoction by meridians theory and circular motion theory. Furthermore, Professor Cheng's treatment in reserving follicle, promoting ovulation and developing follicle is distinctive by traditional Chinese medicine.

Brief Analysis of Treatment of Postpartum Body Pain by Professor Zhang Xiaofeng from the Viewpoint of “Liver Vital Deficiency and Yang Stagnation”

Postpartum body pain is a common gynecological disease in clinical setting.Its symptoms are complex and is difficult to treat.It is often treated in many ways but with poor results,which bring great pain to patients and their families.Professor Zhang Xiaofeng can effectively improve clinical treatment of this disease from the point of view of“liver vital deficiency and yang stagnation”.This paper mainly introduces the professional experience of Professor Zhang Xiaofeng in treating postpartum body pain.A clinical case was attached for reference as proof.

Summary on SHANG Hong-tao's Experience in Treating Alopecia of Spleen Deficiency with Shengyang Sanhuo Decoction (升阳散火汤)

Alopecia is a common but difficult miscellaneous disease in dermatology.Director SHANG Hong-tao believes that alopecia is often caused by exogenous cold or heat in daily life,internal damage of emotions and improper diet,leading to injury of spleen and stomach.So it can be treated with LI Dongyuan's Shengyang Sanhuo Decoction(升阳散火汤),which protects spleen and stomach.Here are 3 proved cases as evidence.

Professor Pei Ruixia's ExperienAce in Treating Diabetes with the"Harmony Method"

This paper introduces professor Pei Ruixia's experience in the treatment of diabetes with the"harmony method." Professor Pei believes that the pathogenic factors of diabetes are mainly divided into emotional and dietary factors,and the essence of diabetes are not in harmony of the human body.Thus,its treatment is to"make it harmonious."It is good to use the method of"clearing and harmonizing,"appropriately using Xiaochaihu decoction,paying attention to the compatibility of drugs,and taking care of spleen and stomach,as well as Qi.

Multi-target therapy for autoimmune hemolytic anemia under the guidance of traditional Chinese medicine pharmacology

Autoimmune hemolytic anemia(AIHA)is a rare and refractory acquired autoimmune disease.At present,western medicine treatment has obvious side effects,low drug sensitivity,easy to relapse and other problems.Multi-target treatment of autoimmune hemolytic anemia through the study of pharmacology of traditional Chinese medicine can effectively improve the clinical efficacy of autoimmune hemolytic anemia,and the price is low,worthy of promotion.This paper discusses the effects of traditional Chinese medicine on maintaining acid-base balance,alleviating liver and kidney function damage and immune collapse.

饶旺福治疗头痛临床经验撷萃

国医名师饶旺福教授认为风邪是导致头痛最重要的诱因,风又有外风和内风之别,“头为诸阳之会”,最易招致风邪,常常夹痰、夹瘀;风邪侵袭头部,久则损伤脑络,气血运行不畅,形成瘀滞。《素问·评热病论篇》有云:“邪之所凑,其气必虚”,故饶老治疗头痛常不忘久病必虚、久病必瘀的特点,善用川芎、防风、羌活、蔓荆子等风药,尤其善用全蝎、土鳖虫等虫类药以扫除入络之顽风痼疾。文章从理论与临床实际出发,总结饶旺福教授中医治疗头痛四十年临床经验,以飨同道。

刘鑫治疗咳嗽临证经验

刘鑫教授认为,咳嗽发病与肺、脾、肝功能失常密切相关,治疗时应注重调护正气、兼顾主次、因人制宜、治随证出,以止嗽散为主方,常随临床症状合用麻黄汤、三拗汤、麻黄杏仁甘草石膏汤、柴朴汤、二陈汤、三子养亲汤、千金苇茎汤、桑贝小陷胸汤、血府逐瘀汤等方,个性化用药,疗效显著。本文总结刘鑫教授治疗咳嗽经验,附验案一则。

周耀庭从“风湿毒热瘀”治疗IgA血管炎经验

本文总结周耀庭教授治疗IgA血管炎的经验。周教授认为IgA血管炎由风、湿、毒、热、瘀多病因致病,病因病机为风湿毒热、邪迫血溢、瘀血阻络,治以散风利湿、凉血解毒化瘀,创制“散风解毒凉血汤”收到较好疗效,为IgA血管炎的治疗提供新的思路。

陈如泉从肝脾肾论治桥本甲状腺炎合并甲减的经验

桥本甲状腺炎合并甲状腺功能减退症(简称甲减)是临床常见的甲状腺疾病,目前没有根治性的治疗方案,西医以甲状腺激素替代治疗为主,但存在剂量难以把控、有心脏方面的副作用等问题。而中医药治疗在缓解症状,调节免疫,提高患者生活质量上面有明显优势。文章总结了陈如泉教授治疗桥本甲状腺炎合并甲减的临证经验,陈如泉教授认为,肝脾肾功能失调是本病发生发展的主要因素,阳虚是主要结局,主张肝、脾、肾同治,从三脏的生理功能进行辨证用药,坚持病证结合,为中医治疗桥本甲状腺炎合并甲减提供借鉴与思路。

时毓民教授治疗小儿慢性咳嗽临证经验

时毓民教授认为,慢性咳嗽的病位在肺脾肾,其本质在于肺脾肾虚。文章从降中有宣以调气机、分别清解肺之余邪、活血化瘀贯穿始终、润肺止咳相佐为用、重视温阳滋肾纳气、益气滋阴固本善后六个方面总结时教授论治小儿慢性咳嗽的临证经验,并附验案一则。

名中医张剑勇教授治疗产后身痛经验

文章总结了广东省名中医张剑勇教授临床治疗产后身痛的经验。妇女生产致气血大亏,肝肾受损,筋骨失养,若兼外邪侵袭,留滞肌腠、筋骨等部位,阻滞气血运行则发为产后身痛,产后身痛常无特异性实验室指标,可能仅有炎症因子升高,故张教授采用中医治疗为法,强调以补益气血、疏肝、益肾、祛邪蠲痹为主,标本兼顾,内外合参,重视心理疏导,最终减轻患者病痛,提升生活质量。

基于整体观探讨国医大师周仲瑛运用升降散经验

总结国医大师周仲瑛教授运用升降散的临证经验。在气一元论的整体观指导下,认为升降散的组方体现整体观之义,配伍深谙整体观之旨。并将此方的配伍特点归纳为升降相因以调中焦郁结,辛开苦降以通三焦郁闭,表里双解以消内外郁滞。临床实践中对于呼吸系统类疾病、皮肤病等病机属“郁”者,不论“气郁”“火郁”“痰郁”,皆可灵活运用升降散辨证论治,随证加减。

李惠林基于肺主治节辨治甲亢经验

甲状腺功能亢进症是指甲状腺合成释放过多甲状腺激素,导致神经、消化、循环等系统兴奋性增高,且伴有代谢亢进及免疫异常的一种自身免疫性内分泌疾病。李教授认为该病发病与肺失治节密切相关,治疗上,在各个阶段均应注意调节肺的治节功能,通过疏风宣肺、理气化痰、滋阴清热、补益肺气等治法加强肺的治节作用,使气血顺畅,脏腑和谐,则该病自愈。

司国民教授基于气、血、水、毒理论辨治血管性痴呆

司国民教授临床治疗血管性痴呆,创新性地提出基于气、血、水、毒理论进行分期辨治。他认为,气、血、水生理上同源化生,病理上层叠递进,相互为患;血管性痴呆由虚到实,虚实同病,久之入络,化生浊毒;虚乃痴呆之本,痰浊瘀血为其标,治疗时应在除痰瘀等病浊的同时,注意扶正。