Disparities in Prevalence and Determinants of Hypertension amongst Bamiléké Adults Residing in Two Different Agroecological Zones of Cameroon

Background: Cardiovascular diseases such as hypertension (HTN) are one of the main causes of death in Cameroon. This study aimed at assessing prevalence disparities and determinants of hypertension amongst Bamiléké adults residing in two different agroecological zones of Cameroon. Methods: A cross-sectional and descriptive survey was conducted among Bamiléké population living in the Highlands zone (Western region) and in the Monomodal Rainforest zone (Littoral region) of Cameroon from August 2016 to August 2017. Participants (962) were aged at least 20 years old. Data on sociodemographic, hemodynamic, anthropometric, and biochemical parameters and lifestyle of the participants were collected. Results: Results obtained revealed that 34.2% were hypertensive and those residing in the highland zone were more affected than those living in the monomodal rainforest zone (44.5% vs 22.9%). The different subtypes of HTN (Isolated systolic hypertension (14.1%), isolated diastolic hypertension (7.2%) and Systo-diastolic hypertension (23.3%)) were also more prevalent in the Highlands Zone. The most prevalent stage of HTN was pre-HTN (31.5%). However, people living in the monomodal rainforest zone were more affected by pre-HTN compared to Bamiléké living in the highland zone (33.6% vs. 29.6%). Results also showed that high consumption (≥ 3 times/week) of carbohydrate- and fat-rich foods, ageing, obesity, and marital status were associated with high blood pressure in both agroecological zones. Besides, secondary education (OR = 0.68;95% CI: 0.42 - 0.99) in the Highlands Zone and high (≥3 times/week) vegetable consumption (OR = 0.66;95% CI: 0.44 - 0.98) in the Monomodal Rainforest Zone had a protective effect on elevated blood pressure of population. Conclusion: There is a disparity in the prevalence of hypertension and some of its determinants among Bamiléké adults residing in different agroecological zones. This work highlights the need to advocate for local and ethno-cultural health policies to prevent, diagnose and manage hypertension.

Seroprevalence of <i>Brucella</i>Antibodies and Risk Factors Associated with Human Brucellosis in High-Risk Occupational Groups of the Noun Division in the West Region of Cameroon

Brucellosis is an anthropozoonotic disease with an important public health impact. Although the transmission of Brucella from animals to humans can occur in different epidemiological settings of sub-Saharan African countries, little data has been published on human brucellosis. This study aimed to detect Brucella antibodies and the risk factors associated to brucellosis among high-risk occupational groups of people in the Noun Division of Cameroon. For this study, a structured questionnaire was used to assess risk factors associated with human brucellosis. Thereafter, blood samples were collected from high-risk occupational groups of people in four villages. Plasma was extracted from each sample and Brucella antibodies were detected using Rose Bengal Plate Test (RBPT) and indirect Enzyme-Linked Immunosorbent Assay (i-ELISA). Of the 273 participants enrolled, the overall seroprevalence of Brucella antibodies was 12.45% with RBPT and 10.26% with i-ELISA test. This seroprevalence was significantly (P = 0.04;X2 = 9.73) higher among livestock herdsmen (15.8%), slaughterhouse workers (9.8%), butchers (4.8%), participants having no educational level (14.3%) and those experiencing above 5 years of risky activity (15%). Raw milk consumption (OR: 4.8;P = 0.001), no formal education (OR: 6.4;P = 0.03) and assistance of animal during parturition (OR: 7.2;P < 0.0001) appeared as factors that may increase the risk of Brucella infections. The detection of Brucella antibodies indicates the risk of human brucellosis in some groups of people of the Noun division. Consuming unpasteurized milk, participating in parturition and lacking knowledge on brucellosis appeared as risk factors associated with human brucellosis in western Cameroon. It raises the need of developing and implementing control measures for human and animal brucellosis.

HIV Infection in Pregnancy and the Risk of Gestational Hypertension and Preeclampsia

The objective of this study was to evaluate the association between HIV infection and hypertensive disorders of pregnancy, comparing the rates of preeclampsia and gestational hypertension in a HIV-infected pregnant group and in a HIV-negative control pregnant group matched for age and parity. Furthermore, we aimed to compare the rates of hypertensive disorders in a subgroup of HIV-positive and HIV-negative African-American Black women. Patients and Methods: This was a prospective observational cohort study conducted at two University Departments of Obstetrics and Gynecology, Salesi Hospital, Ancona, and Sant’Orsola Hospital, Bologna. The HIV-infected patients’ group consisted of 126 pregnant women;140 HIV-negative pregnant women matched for age and parity served as controls. Gestational hypertension and preeclampsia were diagnosed according to NHBPEP-ISSHP criteria. Categorical data were analyzed using the Fisher exact test. Statistical significance was set at a p value < 0.05. Results: Gestational hypertension and preeclampsia were diagnosed in 3 of 126 HIV-positive patients (2.38%) and in 14 of 140 HIV-negative patients (10%), with a relative risk of 0.24 (p = 0.0112). In the subgroup of African-American Black women, gestational hypertension and preeclampsia were diagnosed in 2 out of 43 HIV-positive (4.7%) and in 3 out of 18 HIV-negative patients (16.7%) with a relative risk of 0.28, not statistically significant (p = 0.1887). Conclusion: Pregnant women with HIV infection seem to be protected against gestational hypertension and preeclampsia and this protective effect remains also in a high risk population, such as African-American Black ethnic group. The effect is present independently from treatment received and virus copies. The lack of immune response present since the conception period should account for unopposed trophoblast invasion resulting in a better placentation.

Effect of Therapeutic Group Education on Adherence and Blood Pressure Control among Uncontrolled Hypertensive Patients in Sub Saharan Africa

Background: Hypertension is the leading cardiovascular risk factor worldwide, with the greatest burden in low-income settings. Blood pressure (BP) control is usually low resulting in high rates of uncontrolled patients and complications. Low awareness resulting in poor therapeutic adherence represents an important factor for insufficient blood pressure control in developing countries. Methods: This was a three months non-randomized control trial at the cardiology clinic of the Yaoundé Central Hospital. We included adults with essential and uncontrolled hypertension. The intervention consisted of group educative sessions every week focusing on knowledge of hypertension risk factors, complications, treatment, comorbidities, home self-monitoring of BP. Home blood pressure figures, drug compliance, and knowledge regarding hypertension were evaluated before and after. Results: 17 participants (8 women) with a mean age 56.2 ± 8.1 years. During intervention, mean SBP decreased by 30 mmHg while mean DBP drooped by 11 mmHg using home BP measures. Knowledge regarding hypertension, adherence and drug compliance increased by 36.5%, 88.2% and 81.4% respectively. Conclusion: Therapeutic group education resulted in a significant improvement in BP control amongst uncontrolled hypertensive patients in sub Saharan Africa.

Microalbuminuria in White and Black Hypertensive Nondiabetic Brazilian Patients

Microalbuminuria (MAU) is a predictor of cardiovascular mortality in patients with diabetes mellitus (DM) and hypertension (HTN) and also in an unselected population. The American Diabetes Association (ADA) and the National Kidney Foundation (NKF) define MAU as an albumin/creatinine ratio (ACR) between 30 and 300 μg/mg in both men and women. Aim: To evaluate the possible relationship among MAU, HTN and gender and ethnicity in Brazilian nondiabetic primary hypertensive patients. Design: Population-based study. Participants: Ninety-eight men and women, seventy-two black and twenty-six white nondiabetic primary hypertensive patients aged 20 years or older were selected. Forty healthy individuals, paired according to age, gender, and ethnics were used as controls. Methods: Early-morning midstream urine was used. Urinary albumin was spectrophotometrically measured with Coomassie Brillant Blue G-250. Creatinine was determined by a method based on Jaffe’s reaction. ACR (μg albumin/mg creatinine) was calculated. Data are expressed as medians. Results: ACR level was significantly higher in 98 hypertensive patients (38.00) than in 40 control individuals (23.00) (P < 0.001). ACR level was significantly higher in 48 hypertensive male (46.00) than in 50 hypertensive female (34.00) (P = 0.008). No significant effect of ethnicity on ACR levels between 26 hypertensive Whites (35.50) and 72 hypertensive Blacks (38.00) was observed (P = 0.978). Conclusions: The ACR level, significantly higher in hypertensive patients than in control individuals, supports data from the literature. To our knowledge, this is the first study demonstrating that the ACR level is significantly higher in men than in women. The lack of an ethnicity effect supports what was already asserted, namely, that in Brazil, at an individual level, color, as determined by physical evaluation, is a poor predictor of genomic African ancestry, as estimated by molecular markers.

互联网+微信群组健康教育对HDP患者产后自我管理能力及血压控制效果

目的:分析互联网+微信群组健康教育在妊娠期高血压(HDP)患者产后管理中的应用效果。方法:选取2022年4月-2023年3月于本院分娩的HDP患者92例,随机数字表法分为对照组46例(常规干预)和观察组46例(互联网+微信群组健康教育)。比较两组产后血压控制情况、自我管理能力、并发症发生情况及生活质量。结果:干预1、3个月时血压控制情况观察组(舒张压87.67±6.89、80.39±5.56,收缩压128.63±10.06、117.47±10.22)mmHg均优于对照组(91.36±8.66、84.37±7.61,133.54±11.29、124.26±10.66)mmHg,干预3个月时观察组自我管理行为测评量表情绪管理(22.56±3.68分)、饮食管理(36.34±2.41分)、用药管理(17.87±3.56分)、工作与休息管理(21.21±1.35分)评分及SF-36各维度评分均高于对照组高(20.44±4.45分、33.48±5.51分、16.38±2.44分、20.34±2.36分)(均P<0.05);干预期间观察组与对照组并发症发生率(2.2%、15.2%)未见差异(P>0.05)。结论:采用互联网+微信群组健康教育可增强HDP患者产后自我管理能力,有效控制血压,利于产后恢复与生活质量改善。

HMGB1介导细胞焦亡参与肺动脉高压小鼠肺血管重构的机制研究

目的探讨高迁移率族蛋白1(HMGB1)介导细胞焦亡参与肺动脉高压(PAH)小鼠肺血管重构的机制。方法将40只SD小鼠分为对照组、PAH组、PAH+HMGB1中和抗体(HMGB1 Ab)组、PAH+焦亡抑制剂(NSA)组,除对照组外的其余3组均采用低氧处理建立PAH模型,PAH+HMGB1 Ab组和PAH+NSA组再分别给予HMGB1 Ab、NSA处理,结束后,检测各组小鼠平均肺动脉压(mPAP)、右心室肥厚指数(RVHI),苏木精-伊红染色观察各组小鼠肺组织病理学变化情况并计算肺动脉血管壁厚度百分比(WT)及肺动脉管壁面积百分比(WA)。酶联免疫吸附试验检测各组小鼠血清中白细胞介素(IL)-1β、IL-18水平。免疫组化染色观察各组小鼠肺组织中消皮素D(GSDMD)表达。实时荧光定量PCR和蛋白质免疫印迹检测各组小鼠肺组织中HMGB1及核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)、凋亡相关斑点样蛋白(ASC)、含半胱氨酸的天冬氨酸蛋白水解酶-1(Caspase-1)、GSDMD表达。结果与对照组[(1.81±0.19)kPa、(0.27±0.03)]比较,PAH组小鼠mPAP和RVHI[(3.97±0.41)kPa、(0.41±0.04)]显著升高,差异有统计学意义(P<0.05)。与对照组比较,PAH组肺动脉血管壁明显增厚,血管平滑肌细胞增殖肥大;PAH+HMGB1 Ab组和PAH+NSA组肺动脉血管壁增厚程度较PAH组明显减轻。PAH组小鼠WT和WA[(42.06±4.38)%、(50.56±5.24)%]显著高于对照组[(23.64±2.46)%、(25.12±2.63)%],差异有统计学意义(P<0.05)。与对照组[(23.56±2.48)pg/mL、(22.68±2.32)pg/mL]比较,PAH组小鼠血清中IL-1β、IL-18水平[(94.51±9.62)pg/mL、(58.21±5.97)pg/mL]显著增加,差异有统计学意义(P<0.05)。与PAH组[(48.57±5.02)%]比较,PAH+HMGB1 Ab组和PAH+NSA组肺组织中GSDMD阳性率[(16.52±1.76)%、(14.62±1.59)%]显著降低,差异有统计学意义(P<0.05)。PAH组小鼠肺组织中HMGB1、NLRP3、ASC、Caspase-1、GSDMD蛋白表达显著高于对照组(P<0.05)。结论HMGB1中和抗体能够抑制细胞焦亡从而降低PAH小鼠肺动脉压力,改善肺血管重构。

贵州畲族农村老年人高血压患病情况及影响因素分析

目的了解贵州畲族农村老年人群的高血压患病情况及其影响因素。方法2022年7月采用多级整群单纯随机抽样方法对麻江县畲族乡村60岁以上老年人进行高血压流行病学调查,共调查560人,其中男222人,女338人,年龄(72.58±6.59)岁。调查内容包含高血压发病率、知晓率、治疗率、控制率和人口学相关指标、行为生活方式、反映体型的体格检查指标。采用χ^(2)检验,采用非条件logistic回归分析影响因素。结果贵州畲族农村老年人高血压患病率为55.71%(312/560),高血压知晓率、治疗率和控制率分别为72.44%(226/312)、51.92%(162/312)、21.79%(68/312)。非条件logistic回归分析结果显示,文化程度(OR=2.020,95%CI 1.265~3.224)、婚姻状况(OR=1.579,95%CI 1.280~1.947)、吸烟(OR=2.695,95%CI 1.578~4.604)、饮酒(OR=0.376,95%CI 0.238~0.593)、体重指数(OR=2.051,95%CI 1.464~2.875)、腰臀比(OR=1.737,95%CI 1.125~2.681)、家族史(OR=1.500,95%CI 1.223~1.838)、每日食盐量(OR=1.596,95%CI 1.077~2.366)均为影响贵州畲族农村老年人高血压患病的主要因素(均P<0.05)。结论贵州畲族农村老年人群高血压患病率高、治疗率和控制率低,应重点加强对高血压知识及可控因素预防的宣教,改变不良生活习惯,从而提高老年人健康水平。

Colorectal cancer screening: Modalities and adherence

In the last decade,several studies have explored various modalities and strategies for colorectal cancer(CRC)screening,taking into account epidemiological data,individual characteristics,and socioeconomic factors.In this editorial,we comment further on a retrospective study by Agatsuma et al published in the recent issue of the World Journal of Gastroenterology.Our focus is on screening trends,particularly in relation to efforts to improve the currently suboptimal uptake among the general population worldwide,aiming to enhance early diagnosis rates of CRC.There is a need to raise awareness through health edu-cation programs and to consider the use of readily available,non-invasive screening methods.These strategies are crucial for attracting screen-eligible populations to participate in first-line screening,especially those in high-or average-risk groups and in regions with limited resources.Liquid biopsies and biomarkers represent rapidly evolving trends in screening and diagnosis;however,their clinical relevance has yet to be standardized.

曲前列尼尔对肺动脉高压患者心肺功能及IL-6、HMGB1水平的影响

目的:探讨曲前列尼尔对肺动脉高压患者心肺功能及白细胞介素6(IL-6)、高迁移率族蛋白B1(HMGB1)水平的影响。方法:选取86例肺动脉高压患者为研究对象,根据治疗方式不同分为对照组和观察组,每组各43例。对照组患者予以波生坦口服治疗;观察组患者在对照组治疗基础上予以曲前列尼尔静脉泵注,疗程均为24周。对比两组患者治疗前后心功能等级变化情况和血浆N末端B型利钠肽原(NT-proBNP)水平、6 min步行距离(6MWD)、肺动脉收缩压(PASP)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、Borg呼吸困难指数(BDI)、血清IL-6和HMGB1水平及不良反应发生情况。结果:治疗后,观察组患者心功能等级优于对照组(P<0.05)。治疗后,两组患者血浆NT-proBNP水平及PASP、BDI均降低(P<0.05),且观察组低于对照组(P<0.05);FVC、FEV1、6MWD均升高(P<0.05),且观察组高于对照组(P<0.05);血清IL-6、HMGB1水平均降低(P<0.05),且观察组低于对照组(P<0.05);两组不良反应发生率无统计学差异(P>0.05)。结论:在波生坦基础上予以曲前列尼尔治疗肺动脉高压患者,可以更好改善心肺功能,抑制IL-6、HMGB1等促炎因子表达,减轻体内炎症反应,且安全性好。

白细胞介素1β基因-511C/T多态性与云南省彝族人群原发性高血压相关

目的探讨白细胞介素1β基因-511C/T多态性与云南省彝族人群原发性高血压的相关性。方法用PCR-RFLP技术对云南省晋宁县双河乡85例彝族原发性高血压患者(EH组)和106例彝族健康人(对照组)的白细胞介素1β基因-511C/T基因多态性进行检测,通过SPSS 27.0软件分析基因型频率和等位基因频率,并进行关联性分析。结果EH组中白细胞介素1β基因的突变位点511的CC、CT、TT基因型频率分布分别为18.82%、44.71%、36.47%,对照组中分别为5.66%、26.42%、67.92%。2组的基因型频率相比较,差异具有统计学意义(P<0.05)。EH组C、T等位基因频率分别为41.18%、58.82%,对照组C、T等位基因频率为18.87%、81.13%。等位基因在2组间的频率差异具有统计学意义(P<0.05)。分别计算男性和女性的基因型频率与等位基因频率,2者都具有统计学差异(P<0.05)。结论白细胞介素1β基因-511C/T多态性分布与云南省彝族人群原发性高血压发病存在相关性,是云南彝族原发性高血压的遗传易感基因。

乌拉地尔联合硫酸镁治疗妊娠高血压的临床效果

目的 观察乌拉地尔联合硫酸镁治疗妊娠高血压的临床效果。方法 选取2021年7月—2022年1月吉安市妇幼保健院收治的妊娠高血压患者60例,按随机数字表法分为单药治疗组与联合治疗组,各30例。单药治疗组在常规治疗基础上给予硫酸镁注射液治疗,联合治疗组在单药治疗组基础上加用盐酸乌拉地尔注射液治疗,2组均治疗7 d。比较2组临床疗效,治疗前后血压、血清学指标[高迁移率族蛋白B1(HMGB1)、同型半胱氨酸(Hcy)],不良反应。结果 联合治疗组总有效率高于单药治疗组(96.67%vs. 73.33%,χ^(2)=4.706,P=0.030)。治疗7 d后,2组收缩压、舒张压低于治疗前,且联合治疗组低于单药治疗组(P均<0.01);2组血清HMGB1、Hcy水平低于治疗前,且联合治疗组低于单药治疗组(P均<0.01)。联合治疗组不良反应总发生率与单药治疗组比较,差异无统计学意义(6.67%vs. 23.33%,χ^(2)=2.092,P=0.148)。结论 乌拉地尔联合硫酸镁治疗妊娠高血压效果确切,可显著降低患者血压,减轻血管内皮损伤程度,缓解炎性反应,提高机体代谢水平,且不增加药物不良反应。

Non-invasive assessment of esophageal varices:Status of today

With increasing burden of compensated cirrhosis,we desperately need noninvasive methods for assessment of clinically significant portal hypertension.The use of liver and spleen stiffness measurement helps in deferring unnecessary endoscopies for low risk esophageal varices.This would reduce cost and patient discomfort.However,these special techniques may not be feasible at remote areas where still we need only biochemical parameters.More prospective studies validating the non-invasive risk prediction models are definitely needed.

门诊新发高血压患者服药依从性轨迹及影响因素研究

目的探究门诊新发高血压患者服药依从性轨迹及其影响因素,为制定针对性干预措施提供参考。方法采用便利抽样法选取337例门诊新确诊的高血压患者为研究对象,应用Morisky服药依从性量表于确诊后4周、3个月、6个月和12个月进行4次调查,采用群组化轨迹模型分析患者服药依从性变化轨迹,并通过多分类logistic回归分析其影响因素。结果患者在4个时间点的服药依从性得分比较,差异无统计学意义(P>0.05)。服药依从性轨迹分为持续高依从性组(52.82%)、中等波动组(37.09%)及持续低依从性组(10.09%)3类。多分类logistic回归分析显示,与持续高依从组相比,年龄51~60岁、服药种类≥3种更易进入中等波动组(均P<0.05),年龄36~50岁、文化程度大专、家庭人均月收入<1000元更易进入持续低依从性组,社会支持有利于提高患者服药依从性(均P<0.05)。结论门诊新发高血压患者在确诊12个月内服药依从性轨迹呈现相对稳定性特征,但存在显著的群体异质性。医护人员应特别关注持续低服药依从性及依从性波动变化的患者,根据影响因素采取针对性干预措施,以提高患者服药依从性。

高迁移率族蛋白B1在临床相关疾病中的作用研究进展

高迁移率族蛋白B1(HMGB1)是由巨噬细胞释放的一种具有晚期促炎作用的核蛋白。近年来,HMGB1作为一种新型炎症因子,国内外学者均对其进行了广泛研究,发现其在许多疾病中均充当炎症介质,发挥细胞因子活性,从而参与机体损伤。该文主要对HMGB1在心血管系统、肾脏、肝脏及胰腺等相关疾病中的损伤作用,以及其可能的机制进行了综述,以便为临床诊断和研究相关疾病提供依据。

血清高迁移率族蛋白Bl、白细胞介素-6与高血压性脑出血患者神经内镜微创术后神经功能及预后的关系

目的探讨血清高迁移率族蛋白Bl(HMGB1)、白细胞介素-6(IL-6)水平与高血压性脑出血(HICH)患者神经内镜微创术后神经功能及预后的关系。方法选取2018年6月至2022年12月许昌市中心医院收治的336例HICH患者作为研究对象,根据神经内镜微创术后神经功能缺损程度分为轻型组、中型组及重型组,并根据术后预后状态分为预后良好组和预后不良组。分析HICH患者血清HMGB1、IL-6水平与美国国立卫生研究院卒中量表(NIHSS)评分的相关性及对预后的预测效能,探讨影响HICH患者预后的因素。结果HICH患者术后血清HMGB1、IL-6水平及NIHSS评分均低于术前,且二者与NIHSS评分均呈正相关;血清HMGB1和IL-6水平均随神经功能缺损程度的增加而升高,预后不良组患者术后血清HMGB1和IL-6水平均高于预后良好组;术中出血量、出血部位、出血破入脑室、术前格拉斯哥昏迷(GCS)评分、血肿清除率、NIHSS评分、HMGB1和IL-6均为HICH患者预后不良的危险因素;术后血清HMGB1和IL-6二者联合检测对患者预后的预测效能优于各自单独检测(Z_(二者联合-HMGB1)=2.236、Z_(二者联合-IL-6)=1.974,P=0.034、0.017)。结论HICH患者行神经内镜微创术后血清HMGB1、IL-6水平与其神经功能康复密切相关,二者联合检测对患者的预后状态具有预测效能。

ABO血型与幕上高血压脑出血的相关性研究

目的探讨ABO血型与幕上高血压脑出血的关系。方法分析常熟市中医院(常熟市新区医院)神经外科2018年1月—2022年12月诊断为幕上高血压脑出血患者的临床资料,按准入及排除标准,将其分为A型血(145例)、B型血(149例)、AB型血(50例)、O型血(135例),分析不同患者之间的差异。结果O型血患者血肿量与其他血型患者之间的差异存在统计学意义(P<0.05),O型血基底节出血患者的格拉斯哥预后评分与其他血型患者之间的差异存在统计学意义(P<0.05)。结论ABO血型中O型血患者发生幕上高血压脑出血后血肿量更大,其中基底节出血患者预后更差。

PDCA居家药学服务模式对大理白族高血压患者的管理效果评价

目的探讨PDCA居家药学服务模式对大理白族高血压患者的管理效果评价。方法选择2020年1—6月于大理大学第一附属医院门诊和住院治疗的106例白族原发性高血压患者,通过简单随机方法分为对照组与干预组,每组各53例。对照组接受常规药学服务;干预组采用PDCA法开展居家药学服务。观察两组患者干预前后生活质量、血压控制、用药依从性以及药物不良反应。结果开展居家药学服务干预后,干预组生活质量各项评定、血压控制以及用药依从率均优于对照组,差异有统计学意义(P<0.05);对照组药物不良反应总发生率高于干预组,差异有统计学意义(P<0.05)。结论采用PDCA法开展居家药学服务干预,能够显著提高白族高血压患者的生活质量和用药依从性,更好地控制血压并降低药物不良反应的发生。

间苯三酚联合益气养阴汤治疗HDP对患者血清HMGB1、TAC、MDA水平及分娩结局影响

目的:分析益气养阴汤联合间苯三酚治疗妊娠期高血压(HDP)对患者血清高迁移率蛋白-1(HMGB1)、总抗氧化能力(TAC)、丙二醛(MDA)水平及分娩结局影响。方法:选取2021年1月-2022年12月本院收治的HDP患者96例,按随机数字表法分为对照组(48例,给予间苯三酚治疗)和联合组(48例,在对照组基础上给予益气养阴汤治疗)。比较两组疗效、血清HMGB1、TAC、MDA水平、脂代谢指标、血压、不良反应及分娩结局。结果:治疗后联合治疗组总有效率(95.8%)高于对照组(77.1%),两组舒张压、收缩压、平均动脉压均低于治疗前且联合组低于对照组,两组血清HMGB1、MDA水平均低于治疗前且联合组(1.85±0.47mg/L、23.56±3.56μmol/L)低于对照组(3.36±0.82 mg/L、32.47±5.16μmol/L),两组TAC水平均升高且联合组(11.26±2.65U/ml)高于对照组(9.24±2.03U/ml),两组甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平均降低且联合组低于对照组,两组高密度脂蛋白胆固醇水平均上调且联合组高于对照组(均P<0.05)。联合组不良妊娠结局总发生率(8.3%)低于对照组(37.5%)(P=0.001),不良反应总发生率(6.3%)与对照组(12.5%)无差异(P=0.484)。结论:益气养阴汤联合间苯三酚治疗HDP,可更好控制患者血压水平,改善氧化应激和脂代谢水平,改善母婴结局,提高临床治疗效果,安全性好。

基于心理资本干预模型的团体护理干预对妊娠期高血压患者自我效能及妊娠结局的影响

目的回顾性分析基于心理资本干预模型的团体护理干预在妊娠期高血压(HDP)中的应用价值。方法收集本院174例HDP患者,按护理方法不同分为对照组(n=87)、观察组(n=87),对照组行常规护理,观察组在此基础上实施基于心理资本干预模型的团体护理干预。比较两组妊娠结局、血压水平[收缩压(SBP)、舒张压(DBP)]、积极心理资本、自我效能。结果干预2个月后,观察组产后出血、羊水过多发生率均低于对照组(P均<0.05);观察组SBP、DBP指标水平均低于对照组(P均<0.05);观察组积极心理资本评分、一般自我效能感量表(GSES)评分高于对照组(P均<0.05)。结论对HDP患者实施基于心理资本干预模型的团体护理干预,能提高积极心理资本、自我效能感,改善血压水平、妊娠结局。