Study on Independent Supervision Function of Design Assurance System

The effective operation of a design assurance system cannot be achieved without the effective performance of the independent supervision function.As one of the core functions of the design assurance system,the purpose of the independent supervision function is to ensure that the system operates within the scope of procedures and manuals.At present,the function of independent supervision is a difficult and confusing issue for various original equipment manufacturers as well as suppliers,and there is an urgent requirement to put forward relevant requirements and form relevant methods.Based on the above mentioned objective,the basic requirements of the independent supervision function of design assurance system were studied,the problems and deficiencies in the organization,staffing,and methods existing in the current independent supervision function were analyzed,the improvement suggestions and measures for the performance of the independent supervision function from the aspects of the organization,staffing,procedures,and suppliers were put forward.The present work and conclusions provide guidance and direction for the effective operation of the design assurance system.

The Design for R＆D Performance Auditing System

Based on the definition of R＆D pcrformance auditing system, this paper analyzes the characteristics of the system. Then it designs the components of the R＆D performance auditing system and the procedure of its establishment.

Design and Implementation of Stud-farm Daily Management System Based on C/S Structure

In order to achieve the computerization and digitization of the daily system of stud-farm, the immunization system technology, racecourse health monitoring technologies and the stud-farm prevention technologies were combined to built the studfarm daily management system. By using Visual Studio 2008 and Microsoft Office Access 2003, an immunization information system was developed based on Client/Server structure and combined with the key immunization link of horses. The system included studfarm immune management and racecourse health monitoring system. The immune management contained immunization information input, the inquiry of immunization information, immunization statistics, immunization-reminding and system management. The racecourse health monitoring system included stud-farm monitoring, horses monitoring and inquiry and statistics of health monitoring. The software realized the analysis and tips of the daily information in stud-farm. The software could record the appropriate data and carry on the statistics. The stud-farm daily management system greatly improved the efficiency of the expanded program about immunization and horses＇ healthy rearing technique.

Immune Genetic Algorithm for Optimal Design

A computing model employing the immune and genetic algorithm (IGA) for the optimization of part design is presented. This model operates on a population of points in search space simultaneously, not on just one point. It uses the objective function itself, not derivative or any other additional information and guarantees the fast convergence toward the global optimum. This method avoids some weak points in genetic algorithm, such as inefficient to some local searching problems and its convergence is too early. Based on this model, an optimal design support system (IGBODS) is developed.IGBODS has been used in practice and the result shows that this model has great advantage than traditional one and promises good application in optimal design.

基于区块链技术的公共资源配置审计流程设计

公共资源配置规范化透明化成为一项关乎中国特色社会主义市场经济阳光化发展的重大课题,使得公共资源配置审计也逐渐成为重点审计工作之一。然而,我国当前的公共资源配置审计流程存在诸多困境,如公共资源配置审计流程效率低、审计证据质量低、审计监督局部化等。这些问题亟需改善。深入研究当前公共资源配置审计流程缺陷的改善路径,发现区块链技术的智能合约机制、密码学基础、梅克尔树结构等,能够解决公共资源配置审计流程存在的诸多问题。因此,研究设计基于区块链技术的公共资源配置审计流程,探索公共资源配置审计智能化的实现方法,将为我国推进公共资源配置审计智能化转变提供核心理论支撑。

自拟疏肝理气解郁汤对甲状腺癌术后患者的疗效观察

目的 探讨自拟疏肝理气解郁汤对甲状腺癌术后患者的疗效。方法 选取甲状腺癌术后患者85例,中医辨证为气郁痰阻证,随机数字表法分为研究组43例,对照组42例。对照组予以常规治疗(口服左甲状腺素钠片,并进行心理及健康行为指导),研究组在对照组基础上予以自拟疏肝理气解郁汤治疗,2组均治疗3个月。统计2组中医证候疗效,比较治疗前后中医证候积分、负性情绪[21项抑郁-焦虑-压力量表(DASS-21)评分]、免疫功能(CD4^(+)、CD8^(+)、CD3^(+)水平变化)。结果 研究期间研究组依从性差剔除1例,纳入42例;对照组自行退出1例,纳入41例。治疗后研究组主症、次症及舌脉积分低于对照组(P<0.05);治疗后研究组中医证候疗效总有效率(90.48%)高于对照组(73.17%)(P<0.05);治疗后研究组DASS-21评分低于对照组(P<0.05);治疗后研究组CD4^(+)、CD3^(+)水平高于对照组,CD8^(+)水平低于对照组(P<0.05)。结论 自拟疏肝理气解郁汤治疗甲状腺癌术后患者,可明显缓解患者临床症状,减轻负性情绪,调节免疫功能,提高临床疗效。

疫苗的结构基础和分子设计

[背景]结构疫苗学方法是逆向疫苗学的逻辑演进,其核心是利用保护性决定因子来有选择地设计抗原,进而重新设计和简化,以纳入疫苗组合中.该技术旨在开发创新性传染病疫苗和设计具有广谱保护的疫苗免疫原,尤其对于目前仍无疫苗能用于防控的艾滋病毒(HIV)、寨卡病毒、结核杆菌及多种耐药菌引发的严重威胁人类健康的传染病具有重大应用前景.[进展]目前重大传染病疫苗的研发困难主要集中在病原体抗原表位的变异性,然而随着利用结构生物学疫苗设计的初步成功,结构疫苗学技术在疫苗研发陷入困境的情况下展现出巨大的应用潜力.许多重要病原体如HIV、新型冠状病毒、流感病毒的抗体-抗原复合物结构得到解析,许多有潜力的候选抗原表位陆续被发现.本文主要介绍疫苗的结构基础和如何基于结构进行理性分子设计.[展望]如何将这些表位应用于抗原改造,设计出保护性集中的免疫原或疫苗是结构疫苗学下一步需要努力的目标.结构疫苗学结合现代计算和人工智能技术的应用,可为21世纪的医学和科技挑战提供前所未有的解决方案,疫苗研发领域有望实现重大飞跃.

国家审计赋能经济高质量发展:效应检验与机理分析

党的二十大报告中指出,实现高质量发展是中国式现代化的本质要求。国家审计作为国家治理的一项关键制度安排,对推动经济高质量发展,实现中国式现代化具有重要意义。选取2009—2020年30个省的面板数据为研究样本,探讨了国家审计对经济高质量发展的影响,以及市场化进程的中介效应,研究结果表明:国家审计通过预防、揭示和抵御职能的发挥对经济高质量发展起到了积极的促进作用,市场化进程是国家审计对经济高质量发展影响的重要传导机制;非沿海地区国家审计问责更为充分,经济监督职能发挥更为完善;沿海地区在市场化进程中取得的成果更为显著,对经济高质量发展的推动作用更强。国家审计机关需要发挥好经济监督职能且各地区应依据不同情况制定政策,确保经济高质量发展。

基于O-PIRTAS翻转课堂探讨我校《免疫与感染基础》模块教学新模式

《医学微生物学》和《医学免疫学》是我校《免疫与感染基础》模块化教学中的重要组成部分。其中,《细菌的感染与免疫》是连接《医学微生物学》与《医学免疫学》的桥梁章节。该章节主要介绍致病菌如何侵入机体导致感染,以及机体免疫系统如何抵抗细菌感染,通过学习可以帮助学生构建“感染-免疫”知识框架。然而,该章节内容庞杂,课程时长有限,传统教学模式难以帮助学生理清知识脉络,教学效果较差,急需进行变革。作者以《细菌的感染与免疫》章节为例,探讨基于通用教学环节(O-PIRTAS)翻转课堂模式下的《免疫与感染基础》模块教学改革,为后续教学改革提供宝贵的经验。

建筑设计企业构建内部控制体系的几点思考

内部控制体系不仅有助于规范企业的各项活动,保障财务安全,还能提高管理效率,增强合规性,降低风险。基于此,文章将深入探讨建筑设计企业构建内部控制体系的关键思考,从基本要素、目标要求到体系内容和保障措施,为读者揭示如何在竞争激烈的市场中确保企业稳健运营的重要策略。通过对内部控制的全面分析,建筑设计企业将能够更好地应对市场挑战,实现可持续长期的成功。

Multidisciplinary design optimization on production scale of underground metal mine

In order to ensure overall optimization of the underground metal mine production scale, multidisciplinary design optimization model of production scale which covers the subsystem objective function of income of production, safety and environmental impact in the underground metal mine was established by using multidisciplinary design optimization method. The coupling effects from various disciplines were fully considered, and adaptive mutative scale chaos immunization optimization algorithm was adopted to solve multidisciplinary design optimization model of underground metal mine production scale. Practical results show that multidisciplinary design optimization on production scale of an underground lead and zinc mine reflect the actual operating conditions more realistically, the production scale is about 1.25 Mt/a (Lead and zinc metal content of 160 000 t/a), the economic life is approximately 14 a, corresponding coefficient of production profits can be increased to 15.13%, safety factor can be increased to 5.4% and environmental impact coefficient can be reduced by 9.52%.

Risks of CRISPR Gene Editing and An Answer to Them

CRISPR gene editing is a technology used to edit genomes of a variety of organisms like bacteria,animals or even human beings.Curently,there are various criticism concerning CRISPR since the technology is still immature.It's important to address these concerns to ensure that CRISPR wouldm't cause harms to the society.The pupose of this investigation is to summarize methods which can be used to solve the risks and ethical issues regarding CRISPR through examining published researches in-depth To draw a conclusion,scientists can use anti-crispr protein to minimize the off-target effects.For immunity issues,scientists can employ immunosuppressive drugs or to use CRISPR in places where immune system cannot reach.What's more,given both legaland ethical hurdles,the problem of designer babies and bio-weapons are unlikely to happen.Therefore,although there are various concerns regarding CRISPR,scientists are figuring out ways to minimize the risks and to optimize the usage of the CRISPR.

Two Other Important Indicators for the Assessment of Eco Dwelling

The authors of this paper propose a practical way to assess the environmental and financial costs of the performance of a real engineering activity for the case of a dwelling/building. This estimation is based on two indicators: Energy consumption during the Life Cycle of the building, EcLC and Equivalent Uniform Annual Cost, EUAC, related in various ways within the Building Life Cycle. The first indicator is determined by the Material Selection Method (CES Eco-Selector Software). While second indicator, EUAC, is determined by means of the Method of Life Cycle Cost. Consideration of these indicators from the conceptual phase of the object (dwelling), minimizes the costs of implementation and usage of the dwelling while respecting the principles of environment sustainable development. A dwelling as a product may have an environmental label, containing these two environmental and financial indicators, determined to take into account the entire life cycle. Results confirm the validity of some of the most innovative technologies currently applied in buildings and support our proposal on their energy label change.

国家审计与城市创业活跃度

基于国家审计信息理论和免疫系统理论,以中国278个城市2009—2018年的面板数据为样本,分析国家审计对城市创业活跃度的影响。研究表明,国家审计监督治理能够显著提升城市创业活跃度,该结论在一系列稳健性检验后依然成立。机制分析发现,国家审计作为一项外部监督机制,能够改善地区政务、市场、金融和司法环境,进而提升城市创业活跃度。进一步,国家审计的治理效应在东部地区、规模较小城市以及高政府创新偏好的样本中更明显。研究结论印证了高质量审计监督能够有效保障经济社会高质量发展,切实将制度优势转化为治理效能,进而优化城市创业环境、提高城市创业活跃度。

复合型会计人才培养的“审计学”课程设计——基于新文科背景

新文科建设是国家对学科建设为适应新时代发展而提出的要求,是对文科学科内涵定位及人才培养模式的全新设想。在新文科建设背景下,打破学科边界、推动理论和实务的融合已经成为复合型会计人才培养的趋势。“审计学”作为会计人才培养的重要专业课程,具有较强的专业性和实操性,针对新文科背景下培养会计复合人才的要求,结合目前“审计学”课程教学现状和存在的问题,从教学目标、教学内容、教学手段、考核方式等方面较为系统地介绍了融合性课程设计方案。

利用NSGA-Ⅱ改进算法构建CLSC网络模型可行性初探

首先介绍CLSC网络和改进NSGA-Ⅱ算法,随后对改进算法进行效果测试,在此基础上,开展基于NSGA-Ⅱ改进算法构建CLSC网络模型的应用案例分析,分析结果证实了改进算法的实用性。

基于全寿命周期的隔震结构整体性优化

现行规范的抗震设防目标已经不能完全满足目前的结构抗震要求.作为现行规范的延续与发展,基于性能的抗震设计方法已逐步被人们所接受.成本-效益准则是基于性能抗震设计的一项重要原则.首先,根据基础隔震结构的设计特点,采用免疫遗传算法来研究基于成本-效益准则的隔震结构参数优化问题;其次,在隔震设计中同时考虑结构的初始造价、损失费用和维修费用,对隔震结构进行整体性的优化设计;最后,通过一个优化算例得到了造价最低的隔震结构布置方案,并验证了隔震结构比传统抗震结构在全寿命周期内更具优势.

免疫算法驱动的电路板可靠性协同优化方法

针对电路板可靠性设计优化模型求解效率低的问题,通过对电路板进行故障分析,构建基于故障物理的电路板可靠性优化模型;依据人工免疫系统理论,采用序列优化与可靠性评估方法,提出基于免疫算法的电路板多层级可靠性协同优化及模型求解方法。将该方法应用于典型电路板可靠性优化问题中,获得最优化设计方案,并与遗传、蚁群等算法进行对比分析,结果表明免疫算法具有收敛速度快,寻优能力强等优点。此外,协同优化策略的引入,减少了约37.2%的计算时间。因此,提出的免疫协同优化方法能够有效提高电路板可靠性优化模型的求解效率。

嵌入算法价值观:新闻生产算法系统的价值敏感设计研究

“算法转向”让新闻业面临一个现实问题,即如何将新闻价值观嵌入算法,让算法系统的价值观与媒体的价值观匹配。本文从技术哲学的“经验转向”和批判算法研究出发,探讨算法何以有价值观,并将价值敏感设计与“情境分析-价值观识别-技术转译-原型设计”的算法设计流程结合,提出将新闻价值观嵌入算法的具体机制,并对价值敏感设计进行省思,指出价值敏感设计嵌入的是有限度的价值观,价值敏感设计成功的关键在于利益相关者的协同参与,并提出透明性、可解释、可审计的价值敏感设计伦理原则。

生化免疫检验结果自动审核信息化系统构建及其验证研究

目的:设计并构建生化免疫检验结果自动审核信息化系统,促进审核系统的智能化及科学应用,提高检验结果的准确性。方法:参考《医疗质量管理办法》和《医学实验室质量和能力认可准则》(ISO15189),以及美国病理学会(CAP)清单以及《自动审核的应用指南》AUTO-IO等文件,构建适合临床检验工作的生化免疫检验结果自动审核信息化系统,以自动化流水线中间体软件为核心,整合实验室自动化系统(LAS)各功能模块、实验室信息系统(LIS)系列硬件、软件和医院信息系统(HIS),搭建生化免疫检验结果自动审核信息化系统。结果:在临床生化检验工作中应用生化免疫检验结果自动审核信息化系统,可实现对检验科样本的有效审核。应用系统后,检验科样本审核时间缩短,样本审核报告的准确性明显提高,整体提升了临床生化检验的工作效率。结论:生化免疫检验结果自动审核信息化系统的构建与应用明显提高了临床生化检验的工作质量,进一步保证样本审核报告的准确性。