Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification

Plant morphogenesis relies on precise gene expression programs at the proper time and position which is orchestrated by transcription factors(TFs)in intricate regulatory networks in a cell-type specific manner.Here we introduced a comprehensive single-cell transcriptomic atlas of Arabidopsis seedlings.This atlas is the result of meticulous integration of 63 previously published scRNA-seq datasets,addressing batch effects and conserving biological variance.This integration spans a broad spectrum of tissues,including both below-and above-ground parts.Utilizing a rigorous approach for cell type annotation,we identified 47 distinct cell types or states,largely expanding our current view of plant cell compositions.We systematically constructed cell-type specific gene regulatory networks and uncovered key regulators that act in a coordinated manner to control cell-type specific gene expression.Taken together,our study not only offers extensive plant cell atlas exploration that serves as a valuable resource,but also provides molecular insights into gene-regulatory programs that varies from different cell types.

Average Secrecy Capacity of the Reconfigurable Intelligent Surface-Assisted Integrated Satellite Unmanned Aerial Vehicle Relay Networks

Integrated satellite unmanned aerial vehicle relay networks(ISUAVRNs)have become a prominent topic in recent years.This paper investigates the average secrecy capacity(ASC)for reconfigurable intelligent surface(RIS)-enabled ISUAVRNs.Especially,an eve is considered to intercept the legitimate information from the considered secrecy system.Besides,we get detailed expressions for the ASC of the regarded secrecy system with the aid of the reconfigurable intelligent.Furthermore,to gain insightful results of the major parameters on the ASC in high signalto-noise ratio regime,the approximate investigations are further gotten,which give an efficient method to value the secrecy analysis.At last,some representative computer results are obtained to prove the theoretical findings.

Research on the Impact and Strategies of Rail Transit Network Integration in the Context of Metropolitan Area Development:A Case Study of the Wuhan Metropolitan Area

The metropolitan area is one of the key focal points in the construction and development of China’s new urbanization.Urban integration is an emerging trend in metropolitan areas.This paper explores the traffic demand characteristics and economic aspects of rail transit within metropolitan regions and argues that the construction of an integrated urban rail transit network is an effective approach to support their development.Rail transit in metropolitan areas offers both technical and economic advantages,improving the efficiency of time and space resource utilization,fostering economic cooperation,and ultimately contributing to an integrated development model.However,the integration of rail transit networks faces several challenges,including road network planning,technical standards,and operational organization.Using the Wuhan metropolitan area as a case study,this paper analyzes the challenges of rail transit network integration and proposes strategic solutions for development.

Synthesis and Scheduling of Optimal Batch Water-recycle Networks

This work develops an optimization-based methodology for the design and scheduling of batch water recycle networks. This task requires the identification of network configuration, fresh-water usage, recycle assignments from sources to sinks, wastewater discharge, and a scheduling scheme. A new source-tank-sink representation is developed to allow for storage and dispatch tanks. The problem is solved in stages by first eliminating scheduling constraints and determining minimum usage of fresh water and wastewater discharge. An iterative procedure is formulated to minimize the total annual cost of the system by trading off capital versus operating costs. The work overcomes limitations in previous literature work including restricted recycle within the same cycle, lumped balances that may not lead to feasible solutions, and unrealistic objective functions. A case study is solved to illustrate the usefulness of the devised procedure.

Precise integration methods based on the Chebyshev polynomial of the first kind

This paper introduces two new types of precise integration methods based on Chebyshev polynomial of the first kind for dynamic response analysis of structures, namely the integral formula method （IFM） and the homogenized initial system method （HISM）. In both methods, nonlinear variable loadings within time intervals are simulated using Chebyshev polynomials of the first kind before a direct integration is performed. Developed on the basis of the integral formula, the recurrence relationship of the integral computation suggested in this paper is combined with the Crout decomposed method to solve linear algebraic equations. In this way, the IFM based on Chebyshev polynomial of the first kind is constructed. Transforming the non-homogenous initial system to the homogeneous dynamic system, and developing a special scheme without dimensional expansion, the HISM based on Chebyshev polynomial of the first kind is able to avoid the matrix inversion operation. The accuracy of the time integration schemes is examined and compared with other commonly used schemes, and it is shown that a greater accuracy as well as less time consuming can be achieved. Two numerical examples are presented to demonstrate the applicability of these new methods.

The Impact of Delay in Software-Defined Integrated Terrestrial-Satellite Networks

Satellite communication networks have been evolving from standalone networks with ad-hoc infrastructures to possibly interconnected portions of a wider Future Internet architecture. Experts belonging to the fifth-generation(5 G) standardization committees are considering satellites as a technology to integrate in the 5 G environment. Software Defined Networking(SDN) is one of the paradigms of the next generation of mobile and fixed communications. It can be employed to perform different control functionalities, such as routing, because it allows traffic flow identification based on different parameters and traffic flow management in a centralized way. A centralized set of controllers makes the decisions and sends the corresponding forwarding rules for each traffic flow to the involved intermediate nodes that practically forward data up to the destination. The time to perform this process in integrated terrestrial-satellite networks could be not negligible due to satellite link delays. The aim of this paper is to introduce an SDN-based terrestrial satellite network architecture and to estimate the mean time to deliver the data of a new traffic flow from the source to the destination including the time required to transfer SDN control actions. The practical effect is to identify the maximum performance than can be expected.

Integration and development of energy and information network in the Pan-Arctic region

The Global Energy Interconnection is an important strategic approach used to achieve efficient worldwide energy allocation.The idea of developing integrated power,information,and transportation networks provides increased power interconnection functionality and meaning,helps condense forces,and accelerates the integration of global infrastructure.Correspondingly,it is envisaged that it will become the trend of industrial technological development in the future.In consideration of the current trend of integrated development,this study evaluates a possible plan of coordinated development of fiber-optic and power networks in the Pan-Arctic region.Firstly,the backbone network architecture of Global Energy Interconnection is introduced and the importance of the Arctic energy backbone network is confirmed.The energy consumption and developmental trend of global data centers are then analyzed.Subsequently,the global network traffic is predicted and analyzed by means of a polynomial regression model.Finally,in combination with the current construction of fiber-optic networks in the Pan-Arctic region,the advantages of the integration of the fiber-optic and power networks in this region are clarified in justification of the decision for the development of a Global Energy Interconnection scheme.

On the Motivation and Reasons of Popularity of Parody in Network Language From the Perspective of Conceptual Integration Theory

The Conceptual Integration Theory was first formally put forward in 1997 by Fauconnier and Turner. According to it, there is a conceptual blending network comprised of four mental spaces： Input space Ⅰ, Input space Ⅱ, generic space, and blended space. In the process of blending, common information or structures from input spaces are projected to the ＂generic space＂. Meanwhile, through partially cross-space mapping, those structures are selectively projected to the ＂blended space＂. By means of composition, completion, and elaboration, consequently ＂emergent structure＂ comes into being from the development of blending. This theory instantly became a fresh power in cognitive research field. With the rapid development of network technology and the popularization of the internet, network language makes tremendous progresses and spreads quickly, which reflects the social and cultural development. The uniqueness and effectiveness of network language creation, to a great extent, relies on various rhetorical devices, among which parody is frequently used and plays an important role. In recent years, studies about network language somehow concentrate a lot on the construction, word transformation, and features of network vocabulary, and cognitive analysis on the mechanism of parody in network language is rather limited and requires further exploration. This paper tends to probe into the motivation and the reasons ofparody＇s popularity in network language through some examples in light of Conceptual Integration Theory in hope of a better comprehension, appreciation, and application of parody in network language

Optimization Processes of Tangible and Intangible Networks through the Laplace Problems for Regular Lattices with Multiple Obstacles along the Way

A systematic approach is proposed to the theme of safety,reliability and global quality of complex networks(material and immaterial)by means of special mathematical tools that allow an adequate geometric characterization and study of the operation,even in the presence of multiple obstacles along the path.To that end,applying the theory of graphs to the problem under study and using a special mathematical model based on stochastic geometry,in this article we consider some regular lattices in which it is possible to schematize the elements of the network,with the fundamental cell with six,eight or 2(n+2)obstacles,calculating the probability of Laplace.In this way it is possible to measure the“degree of impedance”exerted by the anomalies along the network by the obstacles examined.The method can be extended to other regular and/or irregular geometric figures,whose union together constitutes the examined network,allowing to optimize the functioning of the complex system considered.

Reflection on the Development of Satellite Communications and the Integration with Terrestrial Mobile Communications

With the further reduction in cost and the increase in bandwidth, as well as the increase in internet applications, satellite communications are gradually shifting from a complementary role to becoming a fully integrated component of terrestrial communications networks. This paper firstly introduces the development of satellite communications, mobile communications and the global space-terrestrial integrated network. We then propose the functional architecture and network architecture for the integration of satellite communications and terrestrial mobile communications based on 5 G core networks. Finally, in order to support the network of the future, four key technologies are presented, a space-terrestrial integrated air interface design, a multi-band space-terrestrial integrated transmission waveform design, space-terrestrial integrated switching and routing technology, along with spectrum sharing and interference coordination technology, all necessary for the development of space-terrestrial integrated networks.

The Integration of Network Teaching and Chinese Art History Education in Colleges

Based on the network teaching model,this article briefly summarizes the development of Chinese art history education in universities,analyzes the importance of integrating network teaching in Chinese art history lessons,and explores the integration strategy.

Tapping Advantages and Expanding International and Domestic Networks for Further Integrating Jiangxi with the Rest of the World——Thriving Foreign Related Work in Jiangxi Province

"…enable Jiangxi to become the example of ecological civilization and pacesetter of building beautiful China,and realize the dream of a prosperous,harmonious and beautiful Jiangxi through our earnest efforts."Recent years have witnessed vigorous efforts made by the Provincial Foreign Affairs and Overseas Chinese

Early warning of core network capacity in space-terrestrial integrated networks

With the rapid development of low-orbit satellite com-munication networks both domestically and internationally,space-terrestrial integrated networks will become the future development trend.For space and terrestrial networks with limi-ted resources,the utilization efficiency of the entire space-terres-trial integrated networks resources can be affected by the core network indirectly.In order to improve the response efficiency of core networks expansion construction,early warning of the core network elements capacity is necessary.Based on the inte-grated architecture of space and terrestrial network,multidimen-sional factors are considered in this paper,including the number of terminals,login users,and the rules of users’migration during holidays.Using artifical intelligence(AI)technologies,the regis-tered users of the access and mobility management function(AMF),authorization users of the unified data management(UDM),protocol data unit(PDU)sessions of session manage-ment function(SMF)are predicted in combination with the num-ber of login users,the number of terminals.Therefore,the core network elements capacity can be predicted in advance.The proposed method is proven to be effective based on the data from real network.

Global Optimization for the Synthesis of Integrated Water Systems with Particle Swarm Optimization Algorithm

The problem of optimal synthesis of an integrated water system is addressed in this study, where water using processes and water treatment operations are combined into a single network such that the total cost of fresh water and wastewater treatment is globally minimized. A superstructure that incorporates all feasible design alterna- tives for wastewater treatment, reuse and recycle, is synthesized with a non-linear programming model. An evolutionary approach--an improved particle swarm optimization is proposed for optimizing such systems. Two simple examples are .Presented.to illustrate the global op.timization of inte.grated water networks using the proposed algorithm.

Integrative medicine:the guide line in women's reproductive health and the treatment of gynecological disease

Integrative medicine follows the principles in TCM that nature and human beings being correspondent with its holistic and dialectic views and explores the integrating point with theories and scientific data in modern medicine. During study on 16 gynecological diseases, the deficiency. In patients with pubertal uterine bleeding, ovulation is induced by acupuncture via decrease in central β-endorphin (β-EP) levels, which leads to the cure of anorexia nervosa by acupuncture via decrease in serum cortisol levels in early 1980s. These results in TCM lead to the idea that neuro-endocrine system is directly related to metabolic system which is also proved to be true in the treatment of polycystic ovary syndrome (PCOS) with or without hyperinsulinemia by two formulas (Yu's Tonifying Ricipe and Tian Gui Recipe,TGR) respectively according to differential diagnosis in TCM. Ovulation resulted with decrease in obesity, acanthosis nigricans, serum androgen, insulin, leptin and hyperthalamic neuropeptide Y (NPY), proopiomalanocortin (POMC) levels based on scientific data from both patients and an animal modal. It suggests that metabolic network, and the incidence of obesity, hypertension, diabetes and cancers of the endometrium and breast may be reduced among patients with PCOS in their future life while these recipes being taken long period. For perimenopausal syndrome, formula Geng Nian Chun (GNC)without increase in serum estrogen levels. In aging rats, it was found that GNC increased the ER and ERmRNA expressions in the ovarian axis and the spleen accompanying with increase in central β-EP, serotonin (5-HT) and peripheral interlutin-2 (IL-2) levels in aging rats without changes of estrogen levels. These data may refer to the release of symptoms in women with postmenopausal syndome. It suggests that GNC up-regulates the fading of neuro-endocrine-immune network. Prevention, alleviation of osteoporosis, cardiovascular disease and Alzheimer disease may be expected in aging women with long period taking GNC.

Method for Incorporation of Controllability in Heat Exchanger Network Synthesis by Integrating Mathematical Programming and Knowledge Engineering

A method for incorporation of controlling the heat exchanger networks with or without splits is proposed by integrating mathemati-cal programming and knowledge engineering. The simultaneous optimal mathematical model is established. This method can be practically used in the integration of large-scale heat exchanger networks, not only to synthesize automatically but also to satisfy the requirement of struc-tural controllability with more objective human intervention.

A Method for Solving Fredholm Integral Equations of the First Kind Based on Chebyshev Wavelets

In this paper, we suggest a method for solving Fredholm integral equation of the first kind based on wavelet basis. The continuous Legendre and Chebyshev wavelets of the first, second, third and fourth kind on [0,1] are used and are utilized as a basis in Galerkin method to approximate the solution of integral equations. Then, in some examples the mentioned wavelets are compared with each other.

Software-Defined Space-Air-Ground Integrated Network Architecture with the Multi-Layer Satellite Backbone Network

Under the background of the rapid development of ground mobile communication,the advantages of high coverage,survivability,and flexibility of satellite communication provide air support to the construction of space information network.According to the requirements of the future space information communication,a software-defined Space-Air-Ground Integrated network architecture was proposed.It consisted of layered structure satellite backbone network,deep space communication network,the stratosphere communication network and the ground network.The Space-Air-Ground Integrated network was supported by the satellite backbone network.It provided data relay for the missions such as deep space exploration and controlled the deep-space spacecraft when needed.In addition,it safeguarded the anti-destructibility of stratospheric communication and assisted the stratosphere to supplement ground network communication.In this paper,algorithm requirements of the congestion control and routing of satellite backbone protocols for heterogeneous users’services were proposed.The algorithm requirements of distinguishing different service objects for the deep space communication and stratospheric communication network protocols were described.Considering the realistic demand for the dynamic coverage of the satellite backbone network and node cost,the multi-layer satellite backbone network architecture was constructed.On this basis,the proposed Software-defined Space-Air-Ground Integrated network architecture could be built as a large,scalable and efficient communication network that could be integrated into space,air,and ground.

Feature and Tendency of Technology Transfer in Z-Park Patent Cooperation Network:From the Perspective of Global Optimal Path

Purpose:This study aims to provide a new framework for analyzing the path of technology diffusion in the innovation network at the regional level and industrial level respectively,which is conducive to the integration of innovation resources,the coordinated development of innovative subjects,and the improvement of innovation abilities.Design/methodology/approach:Based on the Z-Park patent cooperation data,we establish Inter-Enterprise Technology Transfer Network model and apply the concept of Pivotability to describe the key links of technology diffusion and quantify the importance of innovative partnerships.By measuring the topologically structural characteristics in the levels of branch park and the technosphere,this paper demonstrates how technology spreads and promotes overall innovation activities within the innovation network.Findings:The results indicate that:(1)Patent cooperation network of the Z-Park displays heterogeneity and the connections between the innovative subjects distribute extremely uneven.(2)Haidian park owns the highest pivotability in the IETTN model,yet the related inter-enterprise patent cooperation is mainly concentrated in its internal,failing to facilitate the technology diffusion across multiple branch parks.(3)Such fields as“electronics and information”and“advanced manufacturing”are prominent in the cross-technosphere cooperation,while fields such as“new energy”and“environmental protection technology”can better promote industrial integration.Research limitations:Only the part of the joint patent application is taken into account while establishing the patent cooperation network.The other factors that influence the mechanism of technology diffusion in the innovation network need to be further studied,such as financial capital,market competition,and personnel mobility,etc.Practical implications:The findings of this paper will provide useful information and suggestions for the administration and policy-making of high-tech parks.Originality/value:The value of this paper is to build a bridge between the massive amount of patent data and the nature of technology diffusion,and to develop a set of tools to analyze the nonlinear relations between innovative subjects.

Design and verification of a satellite-terrestrial integrated IP network model for the Global Energy Interconnection

In order to meet the pressing demand for wide-area communication required by the Global Energy Interconnection(GEI),accelerating the construction of satellite-terrestrial Integra怕d networks that can achieve network extension and seamless global coverage has become the focus of power communication tech no logy development.In this study,we propose a satellite-terrestrial integrated network model that can support interconnection and interoperation on the IP layer between the satellite system and the怕rrestrial segment of the existing power communication system.First,the composition and function of the satellite-terrestrial collaborative network are explained.Then,the IP-based protocol stack is described,and a typical applicati on experime nt is con ducted to illustrate the particular process of this protocol stack.Fin ally,a use case of IP interconn ection that depends on GEO satellite communication is detailed.The experime ntal study has showed that the satellite-terrestrial collaborative network can efficiently support various IP applications for the GEI.