Objective:To determine the concentration and rate of decay of maternal IgG antibodies against measles prevalence in infants of vaccinated or naturally infected mothers and study initial measles immunization occurs in ...Objective:To determine the concentration and rate of decay of maternal IgG antibodies against measles prevalence in infants of vaccinated or naturally infected mothers and study initial measles immunization occurs in nine-month-old children.Methods:In total,401 pregnant women and the same number of their subsequent newborns were recruited in the Bavi district of Hanoi in 2016-2017;they were divided into two groups:Older women(born before 1985,n=201)and younger women(born after 1990,n=200).Samples were collected at five time-points;week 36 of pregnancy,birth(cord),and 3,6,and 9 months after birth.Measles-specific IgG antibody levels were recorded.Results:In total,77.06% of the 401 pregnant women were seropositive for measles-specific IgG antibodies.A significantly greater proportion of mothers aged 30 and older(88.06%)and their newborn(93.53%)were seropositive compared to the mothers aged 25 and younger(66.00%),and their newborn(72.00%)(P<0.001).The infants of older mothers had significantly higher geometric mean titres(GMT)of measles IgG antibodies than the infants of younger mothers(P<0.001)at all time-points of the study period.The proportion of measles IgG antibodies together with GMT decreased from 82.97%(506.96)at the age of three months to 23.19%(45.22)at the age of nine months.Conclusions:This study provides a profile of maternal antibodies against measles in Vietnamese infants and investigates the early susceptibility to measles in both the infants of vaccinated mothers and mothers with naturally acquired immunity.These data suggest that determining the appropriate age for measles vaccination is paramount for the elimination of measles in Vietnam.展开更多
目的了解赣州市2008年实施扩大国家免疫规划(National Expanded Program on Immunization,NEPI)后工作开展情况,评价全市NEPI实施效果,为进一步制定免疫规划策略提供科学依据。方法对NEPI前后(2007年和2015年)的政府投入、冷链设备装备...目的了解赣州市2008年实施扩大国家免疫规划(National Expanded Program on Immunization,NEPI)后工作开展情况,评价全市NEPI实施效果,为进一步制定免疫规划策略提供科学依据。方法对NEPI前后(2007年和2015年)的政府投入、冷链设备装备、专业人员构成、疫苗接种率、免疫规划针对传染病疫情资料等各个方面进行比较分析。结果 NEPI工作实施后,市县两级NEPI工作经费有了较大改善;市、县、乡三级免疫规划专职人员均有所增加,县管理人员、乡级人员普遍偏少,单位平均人数分别为3.37人、2.73人;人员学历、职称总体呈上升趋势,但无学历、职称人员比例较高,村医管理覆盖率下降。全市冷链设备有了极大的提升。NEPI新增疫苗及乙型肝炎疫苗首剂及时接种率比NEPI前有了很大的提高,除流行性腮腺炎外,其余免疫规划针对传染病发病率均显著下降,白喉、脊髓灰质炎无病例报告。结论赣州市NEPI工作取得了较大进展,免疫规划疫苗接种率维持在较高水平,免疫规划针对传染病发病率总体呈下降趋势。但面临基层政府投入不足,免疫规划专业人员缺乏、素质不高、不稳定等问题。展开更多
文摘Objective:To determine the concentration and rate of decay of maternal IgG antibodies against measles prevalence in infants of vaccinated or naturally infected mothers and study initial measles immunization occurs in nine-month-old children.Methods:In total,401 pregnant women and the same number of their subsequent newborns were recruited in the Bavi district of Hanoi in 2016-2017;they were divided into two groups:Older women(born before 1985,n=201)and younger women(born after 1990,n=200).Samples were collected at five time-points;week 36 of pregnancy,birth(cord),and 3,6,and 9 months after birth.Measles-specific IgG antibody levels were recorded.Results:In total,77.06% of the 401 pregnant women were seropositive for measles-specific IgG antibodies.A significantly greater proportion of mothers aged 30 and older(88.06%)and their newborn(93.53%)were seropositive compared to the mothers aged 25 and younger(66.00%),and their newborn(72.00%)(P<0.001).The infants of older mothers had significantly higher geometric mean titres(GMT)of measles IgG antibodies than the infants of younger mothers(P<0.001)at all time-points of the study period.The proportion of measles IgG antibodies together with GMT decreased from 82.97%(506.96)at the age of three months to 23.19%(45.22)at the age of nine months.Conclusions:This study provides a profile of maternal antibodies against measles in Vietnamese infants and investigates the early susceptibility to measles in both the infants of vaccinated mothers and mothers with naturally acquired immunity.These data suggest that determining the appropriate age for measles vaccination is paramount for the elimination of measles in Vietnam.
文摘目的了解赣州市2008年实施扩大国家免疫规划(National Expanded Program on Immunization,NEPI)后工作开展情况,评价全市NEPI实施效果,为进一步制定免疫规划策略提供科学依据。方法对NEPI前后(2007年和2015年)的政府投入、冷链设备装备、专业人员构成、疫苗接种率、免疫规划针对传染病疫情资料等各个方面进行比较分析。结果 NEPI工作实施后,市县两级NEPI工作经费有了较大改善;市、县、乡三级免疫规划专职人员均有所增加,县管理人员、乡级人员普遍偏少,单位平均人数分别为3.37人、2.73人;人员学历、职称总体呈上升趋势,但无学历、职称人员比例较高,村医管理覆盖率下降。全市冷链设备有了极大的提升。NEPI新增疫苗及乙型肝炎疫苗首剂及时接种率比NEPI前有了很大的提高,除流行性腮腺炎外,其余免疫规划针对传染病发病率均显著下降,白喉、脊髓灰质炎无病例报告。结论赣州市NEPI工作取得了较大进展,免疫规划疫苗接种率维持在较高水平,免疫规划针对传染病发病率总体呈下降趋势。但面临基层政府投入不足,免疫规划专业人员缺乏、素质不高、不稳定等问题。
