The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs

Neurotrophins：Neurotrophins are peptides or proteins that are known to regulate neuronal viability,development,and function Beyond synaptic plasticity,neurotrophins protect neurons from apoptosis and also promote neurogenesis to recover neuronal defici even in adulthood.

An Analysis on the Experience and Routines of Experimental Site of New-countryside Construction of Xianhong in Hubei

The paper tends to make an empirical analysis on the experimental site of new countryside construction of Xianhong in Hubei, pointing out that the inner and outer dependence on routines of experimental construction. The paper also puts forward the beneficial policies, focusing on the agricultural production and fostering professional farmers, to reduce much dependence on routines.

Xintiandi——A Perfect Blend of the Old and New

Shanghai is changing in a big way. Xintiandi-New Heaven and Earth-a development of restoredlow-rise houses called Shikumen, or "stone gate"buildings, stands as a perfect symbol of the newShanghai.

Contrast and Comparison Between the Old and New Bar Code for Commodity Management Measures

With the development of socialism market economy, the former Bar Code ForCommodity Management Measures (being called Old Measures for short hereafter) issued by the NationalBureau of Quality and Technical Supervision can not adapt to the requirement of managing for barcode for commodity. Therefore, for the purpose of standardize bar code for commodity managementstandard, ensuring its quality, speeding up the application of it in electronic business andcirculating field and accelerating the course of being a well informed country, a new Bar Code ForCommodity Management Measures (New Measures for short) has been issued by the General Administratorof Quality Supervision, Inspection and Quarantine of P.R. China (AQSIQ) on May 30th, 2005, and putinto force in October, 2005. At the same time, the Old Measures issued on July 3rd, 1998 has beenabolished.

Impact of Two-Way FDI on the Industrial Structure in Shandong Province Under the Background of “New and Old Kinetic Energy Conversion”

This paper uses the panel data of 17 cities in Shandong Province from 2003 to 2018 to construct a panel model to empirically study the impact of foreign direct investment(FDI)on the industrial structure.The results show that two-way investment,financial industry development,and policy variables have significant roles in promoting the advancement of the industrial structure in the province.In the future implementation of the“Going Global”strategy in Shandong Province,the cooperation between two-way investment and the financial industry should be strengthened,the level of regional financial development should be improved,and the impact of two-way investment on the optimization and upgrading of the industrial structure should be reinforced.

Nest-site selection by the white-tailed eagle and black stork–implications for conservation practice

Background:Nesting trees and habitat represent the key factor underpinning stand selection by forest-dwelling birds.While two large European species–the black stork(Ciconia nigra L.)and white-tailed eagle(Haliaaetus albicilla L.)–are known to require old,large trees for nesting,we sought to investigate further by comparing species requirements at the levels of the nesting tree,nesting stand,and landscape.This entailed a detailed examination of forest features within circles of radius 15 m surrounding 16 and 19 trees holding the nests of storks and eagles respectively.The same parameters were also checked in the vicinity of 50 randomly-selected mature trees.Results:Our results indicate different nesting preferences,with the eagles entirely confining themselves to Scots pine(Pinus sylvestris L.)–a species also chosen by black storks,which nevertheless regularly favour pedunculate oak(Quercus robur L.).Both species select trees of greater girth than the random ones,but white-tailed eagles choose to nest in the vicinity of patches of mature old stands with a loose canopy,to the extent that nesting trees and surrounding trees are of similar ages.In contrast,black storks prefer“veteran”trees with low-set crowns that are much older than any others in their vicinity.Nesting trees of the eagles are away from roads and close to lakes,while black storks do not avoid roads.Conclusions:As the ages of nesting trees of both species are greater than ages at final cutting in this region’s managed forest,silvicultural measures will need to be adjusted,with small patches of forest spared,or larger areas as“islands”of old-growth.Likewise,as tending and thinning are engaged in,certain trees with horizontal branches will need to remain,with relict trees also left untouched.As it happens,all of these recommendations are anyway key elements of close-to nature silviculture and multifunctional forestry.

Application of the Concept of“Endowing the Old with the New”in Urban Renewal

The renewal of ancient cities is an important part of the urban renewal work in China.However,there are few studies on the general historical ancient cities at the county level in China,and there is no guidance on the renewal path.Through the practice of the renewal design project of Suining County,Xuzhou City,it makes an exploratory study on the renewal concept and mode.It first interprets the connotation and implementation path of the renewal concept of“endowing the old with the new”.Based on the texture analysis of the ancient city of Suining,it finally determines the design theme that tracing the historical context of the ancient city.Using the renewal techniques such as“extraction-transformationactivation”,through the renewal strategies such as“building new space,shaping new landscape,inheriting new culture and pregnant with new environment”,it realizes the regeneration of urban historical context and meets the needs of residents'modern life,so as to provide reference and guidance for the renovation of general historical ancient cities at the county level in China.

The Personality Beauty Thought in New Accounts of Old Episodes

“New Accounts of Old Episodes”is a classic handed down in China,which reflects the personality image and charm of the scholars in the Wei and Jin dynasties with the original ecological narrative technique.The scholars of the Wei and Jin Dynasties were detached,facing the world with an aesthetic attitude beyond secular utilitarianism,etiquette,and real life,establish a graceful social stage of vulgarity,create a unique personality beauty,providing valuable ideological wealth for the cultivation of poetic spirit,poetic dwelling,aesthetic style,transcend personality,and wisdom.

LOOKING FOR THE NEW MJ? TRY THE OLD TD——“Old School”Duncan

The question was on the mind of every NBA fan last January: Whocould possibly be the next Michael Jordan? Turns out the answer wasn t thenew MJ after all. It was the old Tim Duncan. That s old as in... "old school." Duncan s game is built on solidfundamentals, hard work and team play. Just as Doctor Naismith intended. Of course, so was Jordan s game. MJ just preferred to play above therim for the first half-dozen years of his career. before he figured out the

Cognitive malingering assessed using event-related potential P300 evoked by the old-new task in the oddball paradigm

The P300, an endogenous subcomponent of the event-related potential, is thought to reflect cognitive processes. The event-related potential evoked by the old-new memory recognition task in the oddball paradigm is suitable for examining the neural processes involved in malingered neurocognitive deficits. Forty-four undergraduates were randomly assigned to a simulated malingering group and a truth-telling group, Another 22 patients with head injudes were enrolled as a control group. All participants completed the old-new memory recognition task in the oddball paradigm. The mean P300 amplitude of the simulated malingering group was significantly reduced compared with the truth-telling group （P 〈 0.01）, but was increased compared with the control group （P〈 0.01）. These results revealed that the P300, evoked by the old-new memory recognition task of the oddball paradigm, may be a helpful indicator for determining cognitive malingering.

Construction of Xi'an ecological old-age care community in the new urbanization

The new urbanization is an important carrier of ecological civilization construction, and ecological old-age care is the concrete manifestation of the perfect combination of the two, the proper meaning of the new urbanization connotation and an inevitable trend of its development. Based on the analysis of the connotation and relationship between the new urbanization and ecological old-age care, together with the current situation and existing problems of the current nursing institutions and ecological old-age care in Xi'an area, this paper discusses the major issues that should be noticed when constructing the ecological old-age care community in Xi'an and three main construction modes.

Solving an Age Old Problem A new law requires children to visit their aging parents

MORE than 10 years ago, the song Come Home As Often As You Can to See Your Parents became popular in China, reminding young people of their obli- gation to set aside their hectic lives and return to their hometowns to visit their aging parents. Today, the idea expressed in this song has been codified in Chinese law.

Insights into New Media Use by International Students: Implications for Cross-Cultural Adaptation Theory

The current study uses a longitudinal, mixed-method approach to investigate the role that new media, such as social networking sites and video chat, play in cross-cultural adaptation and international student friendship network development. Results indicate that international students significantly increase and adapt their new media use while abroad to communicate globally with their friends and family, and locally with their newly formed relationships. Furthermore, social networking site host national friends do not necessarily lead to the development of face-to-face host national friends;however, interaction with established face-to-face host national friends and friend groups via new media platforms leads to an increased understanding of host communication patterns. Finally, this study proposes that researchers who apply Kim’s [1] cross-cultural adaptation theory consider incorporating Host New Media Communication as a principal concept.

Planning and construction of Xiong’an New Area(city of over 5 million people):Contributions of China’s geologists and urban geology

China established Xiong’an New Area in Hebei Province in 2017,which is planned to accommodate about 5 million people,aiming to relieve Beijing City of the functions non-essential to its role as China’s capital and to expedite the coordinated development of the Beijing-Tianjin-Hebei region.From 2017 to 2021,the China Geological Survey(CGS)took the lead in multi-factor urban geological surveys involving space,resources,environments,and disasters according to the general requirements of“global vision,international standards,distinctive Chinese features,and future-oriented goals”in Xiong’an New Area,identifying the engineering geologic conditions and geologic environmental challenges of this area.The achievements also include a 3D engineering geological structure model for the whole area,along with“one city proper and five clusters”,insights into the ecology and the background endowment of natural resources like land,geothermal resources,groundwater,and wetland of the area before engineering construction,a comprehensive monitoring network of resources and environments in the area,and the“Transparent Xiong’an”geological information platform that is open,shared,dynamically updated,and three-dimensionally visualized.China’s geologists and urban geology have played a significant role in the urban planning and construction of Xiong’an New Area,providing whole-process geological solutions for urban planning,construction,operation and management.The future urban construction of Xiong’an New Area will necessitate the theoretical and technical support of earth system science(ESS)from various aspects,and the purpose is to enhance the resilience of the new type of city and to provide support for the green,low-carbon,and sustainable development of this area.

Translocator protein 18 kDa(TSPO): old dogma, new mice, new structure, and new questions for neuroprotection

The normal development and optimal functioning of the brain requires a vigilant immune surveillance system to detect and remove potential risk factors and prevent infection and tissue damage. Microglia are the resident immune cells and the frontline defenders responsible for the immune response of the brain. Resting microglia possess a ramified morphology with numerous thin processes that continuously sample the environment. In response to inflammatory signals, microglia become activated and transform their morphology into a thick, amoeboid-like shape. Activated microglia proliferate, tolerate to sites of iniurv,

Arginine: New and Exciting Developments for an“Old”Amino Acid

Arginine (2-amino-5-guanidino pentanoic acid) was shown in 1895 by Hedin to be present in the proteins of horn. Metabolic nitrogen balance studies, conducted in 1957 by Rose in human adults and in 1959 by Snyderman and coworkers in young infants, revealed that a dietary source of this amino acid was not an obligatory requirement for growth and maintenance of nitrogen homeostasis in healthy individuals. Hence, It was initially classified as a non-essential (dispensable) amino acid and, perhaps, for reasons of this classification arginine did not receivc the earlier atteniion it now deserves, in relation to an understanding of the nutritional biochemistry and physiology of its metabolism in humans subjects. However, there is currently a considerable interest in the cellular and tissue functions, as well as clinical, therapeutic significance, of arginine. In this paper we review the multiple functions of arginlne, including its role in the L-arginine-nitric oxide pathway,cellular regeneration, immune function, protein synthesis and protein breakdown. We then consider some in vivo aspects of the physiology of arginine metabolism, which varies greatly among eukaryotes, with particular reference to humans. Against this background, studies of arginine in the nutrition of humans under various pathophysiological conditions are reviewed briefly. Finally, a new, updated concept for the metabolic basis for the 'conditional essentiality' of arginine is proposed

Research on the Necessity of Building National-level Grape and Cherry Germplasm Resources Bank in Shandong Province

At present,the grape and cherry industries in Shandong are in the leading position in China and have driven the development of related high-end manufacturing industries such as wine,brandy,preserved fruit processing,fruit juice processing and health products. Therefore,vigorously developing the grape and cherry industries in Shandong Province and carrying out development and innovation are important parts of Shandong Province in responding to the strategy of national new and old kinetic energy conversion. However,currently the germplasm resources preserved in the fruit tree resources banks in China are only 45% of those in the US and 27. 2% of those in the EU. Moreover,the development of fruit trees resources banks in Shandong is relatively backward in China,and there is still no banks related with grape and cherry germplasm resources in Shandong. Therefore,importance can be attached to the agriculture,forestry,and animal husbandry to build germplasm resources banks for grape and cherry industries in Shandong Province. Building the national-level grape and cherry germplasm resources bank in Shandong Province can also promote the utilization of wild and farm germplasm resources in the future; advance the research on the genes related to disease resistance,stress resistance and quality of grapes and cherries; push forward the construction and development of cherry and grape mutants banks. It is conducive to the research on the agronomic traits of grapes and cherries,and can provide the parents resources for planting innovation and improving the quality of grapes and cherries,as well as promote the development and application of molecular markers of grapes and cherries,including the identification of lines and crossbreeding. Thereby,it cannot only promote the industry development,but also achieve the development of cultivation,breeding and basic research in an all-round way and the development of ＂ production,study and research＂ going side by side.