The aim of this study was to establish a control system for saccharification process using quality control charts. To achieve this goal, temperature, pH and brix were measured at 12 minutes intervals for 15 consecutiv...The aim of this study was to establish a control system for saccharification process using quality control charts. To achieve this goal, temperature, pH and brix were measured at 12 minutes intervals for 15 consecutive batches which took 2 hours each. The time variations for three process parameters were assessed to establish a good understanding of the saccharification process. The temperature varied between 58℃ and 62℃ while the pH decreased slowly due to oxidation, values of which varied between 5.7 and 5.0. Brix values increased linearly with time. The initial and final values of the three parameters varied from one batch to another. Of the three parameters, brix was not well represented on the quality control charts due to wide difference between initial and final values during saccharification. The final brix values varied between batches, from 10.6% to 11.6%. The control charts used in this study were X-bar and Range charts. The rules for interpreting control charts were implemented for both X-bar and R charts, results of which showed that the process was out of control, although some rules were not violated due to little number of batches studied. The values of for temperature and pH data (2.27℃ and 0.35, respectively) were lower compared to brix data (11.2%). The corresponding values of span between control limits, SP<sub>x</sub> and SP<sub>R</sub> for temperature and pH were also comparatively lower than those established from brix data. Due to larger values of for brix measurements, the corresponding control charts for brix were insensitive in identifying out-of-control points during saccharification process.展开更多
Background:Cancerous ascites is a common and severe complication that occurs in patients with late-stage malignant tumors.The prognosis of cancerous ascites is poor,clinical treatment is difficult and therapeutic outc...Background:Cancerous ascites is a common and severe complication that occurs in patients with late-stage malignant tumors.The prognosis of cancerous ascites is poor,clinical treatment is difficult and therapeutic outcome is disappointing.In the present study,tumor cell-derived vesicles were used as drug delivery vehicles that encapsulated a chemotherapeutic agent and were perfused into a patients’abdominal cavity to effectively kill the cancer cells in cancerous ascites.Pre-clinical data has demonstrated that tumor vesicles that carry low-dose chemotherapeutics can efficiently eliminate metastatic tumor cells in the abdominal cavity with minimal toxic or adverse effects.When combined,tumor cell-derived vesicles can sensitize tumor cells,which facilitates the entry of chemotherapeutics into tumor cells,thereby enhancing killing of tumor cells and limiting the risk of drug resistance.In this study,we designed a clinical trial to evaluate the safety and efficacy of intraperitoneal perfusion with tumor vesicle-encapsulated methotrexate for the treatment of cancerous ascites.Methods:Sixty patients with cancerous ascites were enrolled in this open,randomized and controlled clinical trial.Participants were randomly assigned a visit number and,according to their visiting order for which a random numerical table was used,were assigned to the trial group or the control group in a 1:1 ratio.The change in ascetic volume was used as the study outcome and adverse events were monitored during the entire length of the study.Conclusion:In this clinical trial,randomization and electronic case report forms were implemented.The trial indicated that tumor vesicle-encapsulated methotrexate was proposed to be a safe and effective method for treating malignant ascites.Our study may provide at the first time evidence for the clinical application of tumor vesicles in tumor therapy.展开更多
A process capability study is performed for the turning process on a general purpose center lathe in order to verify the process performance and machine ability to perform within specified tolerance limit. The process...A process capability study is performed for the turning process on a general purpose center lathe in order to verify the process performance and machine ability to perform within specified tolerance limit. The process and machine capability indices were measured to determine the process and machine adequacy for industrial application. The tolerance limits were obtained from the given nominal size of the shaft, using the basic hole system and 90 sample shafts were turned on the lathe machine to specification for varying spindle speed and feed rate of the lathe. Three (3) samples were randomly selected for the turning process of a combination of the spindle speed and feed rate as a subgroup size for a total subgroup of thirty (30). The diameters (representing the quality characteristics) were used to generate control charts and capability histogram for the process. The process is within statistical control but found incapable of meeting up to specification because the capability index (C<sub>p</sub>) measured was less than 1 and the machine capability for industrial application is not adequate.展开更多
文摘The aim of this study was to establish a control system for saccharification process using quality control charts. To achieve this goal, temperature, pH and brix were measured at 12 minutes intervals for 15 consecutive batches which took 2 hours each. The time variations for three process parameters were assessed to establish a good understanding of the saccharification process. The temperature varied between 58℃ and 62℃ while the pH decreased slowly due to oxidation, values of which varied between 5.7 and 5.0. Brix values increased linearly with time. The initial and final values of the three parameters varied from one batch to another. Of the three parameters, brix was not well represented on the quality control charts due to wide difference between initial and final values during saccharification. The final brix values varied between batches, from 10.6% to 11.6%. The control charts used in this study were X-bar and Range charts. The rules for interpreting control charts were implemented for both X-bar and R charts, results of which showed that the process was out of control, although some rules were not violated due to little number of batches studied. The values of for temperature and pH data (2.27℃ and 0.35, respectively) were lower compared to brix data (11.2%). The corresponding values of span between control limits, SP<sub>x</sub> and SP<sub>R</sub> for temperature and pH were also comparatively lower than those established from brix data. Due to larger values of for brix measurements, the corresponding control charts for brix were insensitive in identifying out-of-control points during saccharification process.
文摘Background:Cancerous ascites is a common and severe complication that occurs in patients with late-stage malignant tumors.The prognosis of cancerous ascites is poor,clinical treatment is difficult and therapeutic outcome is disappointing.In the present study,tumor cell-derived vesicles were used as drug delivery vehicles that encapsulated a chemotherapeutic agent and were perfused into a patients’abdominal cavity to effectively kill the cancer cells in cancerous ascites.Pre-clinical data has demonstrated that tumor vesicles that carry low-dose chemotherapeutics can efficiently eliminate metastatic tumor cells in the abdominal cavity with minimal toxic or adverse effects.When combined,tumor cell-derived vesicles can sensitize tumor cells,which facilitates the entry of chemotherapeutics into tumor cells,thereby enhancing killing of tumor cells and limiting the risk of drug resistance.In this study,we designed a clinical trial to evaluate the safety and efficacy of intraperitoneal perfusion with tumor vesicle-encapsulated methotrexate for the treatment of cancerous ascites.Methods:Sixty patients with cancerous ascites were enrolled in this open,randomized and controlled clinical trial.Participants were randomly assigned a visit number and,according to their visiting order for which a random numerical table was used,were assigned to the trial group or the control group in a 1:1 ratio.The change in ascetic volume was used as the study outcome and adverse events were monitored during the entire length of the study.Conclusion:In this clinical trial,randomization and electronic case report forms were implemented.The trial indicated that tumor vesicle-encapsulated methotrexate was proposed to be a safe and effective method for treating malignant ascites.Our study may provide at the first time evidence for the clinical application of tumor vesicles in tumor therapy.
文摘A process capability study is performed for the turning process on a general purpose center lathe in order to verify the process performance and machine ability to perform within specified tolerance limit. The process and machine capability indices were measured to determine the process and machine adequacy for industrial application. The tolerance limits were obtained from the given nominal size of the shaft, using the basic hole system and 90 sample shafts were turned on the lathe machine to specification for varying spindle speed and feed rate of the lathe. Three (3) samples were randomly selected for the turning process of a combination of the spindle speed and feed rate as a subgroup size for a total subgroup of thirty (30). The diameters (representing the quality characteristics) were used to generate control charts and capability histogram for the process. The process is within statistical control but found incapable of meeting up to specification because the capability index (C<sub>p</sub>) measured was less than 1 and the machine capability for industrial application is not adequate.
文摘在微波通信系统中,滤波器作为通信系统中不可缺少的微波无源器件,其性能指标直接影响整个通信系统的性能。与传统滤波器相比,微机电系统(Micro-Electro-Mechanical System,MEMS)滤波器具有集成度高、小型化等优点,其中腔体结构在RF MEMS滤波器中有着广泛的应用。感应耦合等离子刻蚀是实现三维腔体结构的关键技术,其刻蚀均匀性直接影响腔体滤波器的性能指标。过程控制监控(Process Control Monitoring,PCM)是MEMS工艺控制中的重要监控手段,利用自动测试系统,论述了用于自动测试的PCM图形,通过数据处理得到硅腔深度分布图,并拟合出硅腔深度和中心频率对应关系,反应了当前刻蚀的工艺能力,为后续产品设计、提高刻蚀均匀性及优化版图设计提供了数据支撑。
