Objective:To study the expression and significance of ECP, 25-(OH)D3 and M2 receptors in children with acute attack of asthma.Methods: Seventy children with bronchial asthma who first visited our hospital from Septemb...Objective:To study the expression and significance of ECP, 25-(OH)D3 and M2 receptors in children with acute attack of asthma.Methods: Seventy children with bronchial asthma who first visited our hospital from September 2016 to September 2018 were divided into chronic persistence group, remission group and acute attack group. Thirty healthy children who underwent physical examination in our hospital were selected and divided into control group. The levels of ECP, 25-(OH) D3 and M2 receptors were analyzed by ELISA, and Pearson correlation analysis was performed.Results: Compared with the control group, the levels of ECP and M2 receptors in chronic persistence group, remission group and acute attack group increased, while the levels of 25-(OH)D3 decreased, with statistical difference (P<0.05). The levels of ECP and M2 receptors in acute attack group were higher than those in chronic persistence group, and the levels of 25-(OH)D3 were lower than those in chronic persistence group (P<0.05). The levels of ECP and M2 receptors in acute attack group were higher than those in remission group, and the levels of 25-(OH)D3 were lower than those in remission group (P<0.05). Compared with mild children, the levels of ECP and M2 receptors increased and 25-(OH)D3 decreased in moderate and severe children (P<0.05). Compared with moderate children, the levels of ECP and M2 receptors increased and 25-(OH)D3 decreased in severe children (P<0.05).There was a negative correlation between ECP and 25-(OH)D3 (r=-0.380, P=0.038);a negative correlation between 25-(OH)D3 and M2 receptor (r=-0.448,P=0.013);and a positive correlation between ECP and M2 receptor (r=0.450,P=0.013).Conclusions:The expression of ECP and M2 receptors increased during the acute attack of bronchial asthma in children, while the expression of 25-hydroxyvitamin D3 decreased during the acute attack of bronchial asthma in children. The correlation among ECP, 25-(OH) D3 and M2 receptors is significant in the clinical diagnosis of acute attack of bronchial asthma in children.展开更多
目的探讨孟鲁司特钠联合布地奈德混悬液对哮喘急性发作患儿C-反应蛋白,肺功能及临床疗效的影响。方法收集湖州市中心医院儿科收治的支气管哮喘急性发作的患儿46例,随机分为对照组和实验组,每组各23例,2组均给予常规抗感染治疗,对照组给...目的探讨孟鲁司特钠联合布地奈德混悬液对哮喘急性发作患儿C-反应蛋白,肺功能及临床疗效的影响。方法收集湖州市中心医院儿科收治的支气管哮喘急性发作的患儿46例,随机分为对照组和实验组,每组各23例,2组均给予常规抗感染治疗,对照组给予氯雷他定片5 mg,1次/天,口服;给予硫酸特布他林雾化液1 m L,2次/天,雾化吸入;实验组给予孟鲁司特钠咀嚼片4mg,1次/天,口服;给予布地奈德混悬液1 m L+硫酸特布他林雾化液1 m L,2次/天,雾化吸入。2组均治疗10 d,治疗结束后,对所有患儿的血清C反应蛋白(C-reactive protein,CRP)、肺功能及临床疗效进行检测。结果与对照组治疗后比较,实验组患儿的血清CRP水平较低(P<0.05);实验组患儿的第1秒用力呼气容积/用力肺活量比值(forced expiratory volume in one second/forced vital capacity,FEV1/FVC%)、最大呼气峰流速(peak expiratory flow,PEF)水平较高(P<0.05);实验组患儿的总有效率较高(P<0.05)。结论孟鲁司特钠联合布地奈德混悬液能够显著降低哮喘急性发作患儿血清CRP水平,改善肺功能,具有良好的临床疗效。展开更多
基金Key projects funded by the science and technology bureau of Chenzhou city(No.CZ2013065).
文摘Objective:To study the expression and significance of ECP, 25-(OH)D3 and M2 receptors in children with acute attack of asthma.Methods: Seventy children with bronchial asthma who first visited our hospital from September 2016 to September 2018 were divided into chronic persistence group, remission group and acute attack group. Thirty healthy children who underwent physical examination in our hospital were selected and divided into control group. The levels of ECP, 25-(OH) D3 and M2 receptors were analyzed by ELISA, and Pearson correlation analysis was performed.Results: Compared with the control group, the levels of ECP and M2 receptors in chronic persistence group, remission group and acute attack group increased, while the levels of 25-(OH)D3 decreased, with statistical difference (P<0.05). The levels of ECP and M2 receptors in acute attack group were higher than those in chronic persistence group, and the levels of 25-(OH)D3 were lower than those in chronic persistence group (P<0.05). The levels of ECP and M2 receptors in acute attack group were higher than those in remission group, and the levels of 25-(OH)D3 were lower than those in remission group (P<0.05). Compared with mild children, the levels of ECP and M2 receptors increased and 25-(OH)D3 decreased in moderate and severe children (P<0.05). Compared with moderate children, the levels of ECP and M2 receptors increased and 25-(OH)D3 decreased in severe children (P<0.05).There was a negative correlation between ECP and 25-(OH)D3 (r=-0.380, P=0.038);a negative correlation between 25-(OH)D3 and M2 receptor (r=-0.448,P=0.013);and a positive correlation between ECP and M2 receptor (r=0.450,P=0.013).Conclusions:The expression of ECP and M2 receptors increased during the acute attack of bronchial asthma in children, while the expression of 25-hydroxyvitamin D3 decreased during the acute attack of bronchial asthma in children. The correlation among ECP, 25-(OH) D3 and M2 receptors is significant in the clinical diagnosis of acute attack of bronchial asthma in children.
文摘目的探讨孟鲁司特钠联合布地奈德混悬液对哮喘急性发作患儿C-反应蛋白,肺功能及临床疗效的影响。方法收集湖州市中心医院儿科收治的支气管哮喘急性发作的患儿46例,随机分为对照组和实验组,每组各23例,2组均给予常规抗感染治疗,对照组给予氯雷他定片5 mg,1次/天,口服;给予硫酸特布他林雾化液1 m L,2次/天,雾化吸入;实验组给予孟鲁司特钠咀嚼片4mg,1次/天,口服;给予布地奈德混悬液1 m L+硫酸特布他林雾化液1 m L,2次/天,雾化吸入。2组均治疗10 d,治疗结束后,对所有患儿的血清C反应蛋白(C-reactive protein,CRP)、肺功能及临床疗效进行检测。结果与对照组治疗后比较,实验组患儿的血清CRP水平较低(P<0.05);实验组患儿的第1秒用力呼气容积/用力肺活量比值(forced expiratory volume in one second/forced vital capacity,FEV1/FVC%)、最大呼气峰流速(peak expiratory flow,PEF)水平较高(P<0.05);实验组患儿的总有效率较高(P<0.05)。结论孟鲁司特钠联合布地奈德混悬液能够显著降低哮喘急性发作患儿血清CRP水平,改善肺功能,具有良好的临床疗效。
