Developing a highly scalable synthetic strategy for 5-amino-4-nitrobenzo[1,2-c:3,4-c']bis([1,2,5]oxadiazole)1,b-dioxide(CL-18)and investigating the influence of crystal engineering and positional isomerization on its safety and laser ignition performance

5-amino-4-nitrobenzo[1,2-c:3,4-c']bis([1,2,5]oxadiazole)1,6-dioxide(CL-18)exhibits significant potential as an initiating explosive.However,its current synthesis process remains non-scalable due to low yields and safety risks.In this study,we have developed a simple and safe synthetic route for CL-18.It was synthesized from 3,5-dihaloanisole in a four-step reaction with an overall yield exceeding 60%,surpassing all reported yields in the literature.Subsequently,recrystallization of CL-18 was successfully achieved by carefully selecting appropriate solvents and antisolvents to reduce its mechanical sensitivity.Ultimately,when DMF-ethanol was employed as the recrystallization solvent system,satisfactory product yield(>90%)and reduced mechanical sensitivity(IS=15 J;FS=216 N)were obtained.Additionally,CL-18 is derived from the rearrangement of oxygen atoms on i-CL-18 furoxan,and a comparative analysis of their physicochemical properties was conducted.The thermal stability of both compounds is similar,with onset decomposition temperatures recorded at 186 and 182℃respectively.Similarly,they exhibit 5 s breaking point temperatures of 236 and 237℃.Additionally,we present novel insights into the positional-isomerization-laser-ignition performance of CL-18 and its isomer i-CL-18 using laser irradiation for the first time.Remarkably,our findings demonstrate that i-CL-18 exhibits enhanced laser sensitivity,as it can be directly ignited by a 1064 nm wavelength laser,whereas CL-18 lacks this characteristic.

Estimation of Aqueous Solubility (-lgS_w) of All Polychlorinated Biphenyl (PCB) Congeners by Density Functional Theory and Position of Cl Substitution (NPCS) Method

Optimization calculations of 209 polychlorinated biphenyls （PCBs） were carried out at the B3LYP/6-31G^＊ level. It was found that there is significant correlation between the Cl substitution position and some structural parameters. Consequently, Cl substitution positions were taken as theoretical descriptors to establish a novel QSPR model for predicting –lgSw of all PCB congeners. The model achieved in this work contains four variables, of which r^2 = 0.9527, q^2 = 0.9490 and SD = 0.25 with large t values. In addition, the variation inflation factors （VIFs） of variables in this model are all less than 5.0, suggesting high accuracy of the –lgSw predicting model. And the results of cross-validation test and method validation also show that the model exhibits optimum stability and better predictive capability than that from the AM1 method.

Cone beam computed tomography-guided differences among registration methods for lung cancer and the effects of tumor position,treatment model,and tumor size on positioning errors

Objective To explore the differences in three different registration methods of cone beam computed tomography(CBCT)-guided down-regulated intense radiation therapy for lung cancer as well as the effects of tumor location,treatment mode,and tumor size on registration.Methods This retrospective analysis included 80 lung cancer patients undergoing radiotherapy in our hospital from November 2017 to October 2019 and compared automatic bone registration,automatic grayscale(t+r)registration,and automatic grayscale(t)positioning error on the X-,Y-,and Z-axes under three types of registration methods.The patients were also grouped according to tumor position,treatment mode,and tumor size to compare positioning errors.Results On the X-,Y-,and Z-axes,automatic grayscale(t+r)and automatic grayscale(t)registration showed a better trend.Analysis of the different treatment modes showed differences in the three registration methods;however,these were not statistically significant.Analysis according to tumor sizes showed significant differences between the three registration methods(P<0.05).Analysis according to tumor positions showed differences in the X-and Y-axes that were not significant(P>0.05),while the autopsy registration in the Z-axis showed the largest difference in the mediastinal and hilar lymph nodes(P<0.05).Conclusion The treatment mode was not the main factor affecting registration error in lung cancer.Three registration methods are available for tumors in the upper and lower lungs measuring<3 cm;among these,automatic gray registration is recommended,while any gray registration method is recommended for tumors located in the mediastinal hilar site measuring<3 cm and in the upper and lower lungs≥3 cm.

Two Generic Frameworks of Multiple Viewpoints Oriented Requirements Method and Their Comparison

Traditional requirements method has some problems when it is used for large distributed systems. Multiple viewpoints oriented requirements method (MVORM) is a new method for resolving these problems. This paper develops two generic formal frameworks of MVORM, framework based on refinement relation (FBRR) and framework based on implementation relation (FBIR). They are generic, because no assumptions are made about the development process or the formal description languages to be used. Three kinds of specification relations and three kinds of specification transformations are discussed over FBIR and FBRR. This paper also compares the equivalence between FBIR and FBRR. We point out that an equivalent FBIR can be found for any FBRR, but reverse transformation is not always possible. We think FBIR is better than FBRR on most cases.

DFT and Position of Cl Substitution (PCS) Methods Studies on n-Octanol/water Partition Coefficients (lgK_(ow)) and Aqueous Solubility (–lgS_w) of All PCDD Congeners

Optimized calculations of 75 PCDDs and their parent DD were carded out at the B3LYP/6-31G＊ level by density functional theory （DFT） method. The structural parameters were obtained and significant correlation between the C1 substitution position and some structural parameters was found. Consequently, the number of C1 substitution positions was taken as theoretical descriptors to establish two novel QSPR models for predicting lgKow and -lgSw of all PCDD congeners. The two models achieved in this work contain two variables （Na and Nβ）, of which r = 0.9312, 0.9965 and SD = 0.27, 0.12 respectively, and t values are all large. The variation inflation factors （VIF） of variables in the two models herein are both less than 5.0, suggesting high accuracy of the lgKow and -lgSw predicting models, and the results of cross-validation test also show that the two models exhibit optimum stability and good predictive power. By comparison, the correlation and predictive ability of the present work are more advantageous than those obtained using semi-empirical AM1 and GC-RI methods.

A Precision-Positioning Method for a High-Acceleration Low-Load Mechanism Based on Optimal Spatial and Temporal Distribution of Inertial Energy

High-speed and precision positioning are fundamental requirements for high-acceleration low-load mechanisms in integrated circuit （IC） packaging equipment. In this paper, we derive the transient nonlinear dynamicresponse equations of high-acceleration mechanisms, which reveal that stiffness, frequency, damping, and driving frequency are the primary factors. Therefore, we propose a new structural optimization and velocity-planning method for the precision positioning of a high-acceleration mechanism based on optimal spatial and temporal distribution of inertial energy. For structural optimization, we first reviewed the commonly flexible multibody dynamic optimization using equivalent static loads method （ESLM）, and then we selected the modified ESLM for optimal spatial distribution of inertial energy; hence, not only the stiffness but also the inertia and frequency of the real modal shapes are considered. For velocity planning, we developed a new velocity-planning method based on nonlinear dynamic-response optimization with varying motion conditions. Our method was verified on a high-acceleration die bonder. The amplitude of residual vibration could be decreased by more than 20% via structural optimization and the positioning time could be reduced by more than 40% via asymmetric variable velocity planning. This method provides an effective theoretical support for the precision positioning of high-acceleration low-load mechanisms.

On the Method of Multiplier-enlargement and Approximation of Unbounded Continuous Functions

By combining the classical appropriate functions “1, x, x 2” with the method of multiplier enlargement, this paper establishes a theorem to approximate any unbounded continuous functions with modified positive linear operators. As an example, Hermite Fejér interpolation polynomial operators are analysed and studied, and a general conclusion is obtained.

Preliminary Research on the Mathematical Methods and Order of Problems in the“Fungcheng”Chapter of Yang Hui's Mathematical Methods(1261 CE)

Yang Hui was one of the most important authors of mathematical works during the thirteenth century.Mathematical Methods Explaining in Detail The Nine Chapters(Xiangjie jiuzhang suanfa詳解九章算法,1261 CE)is the earliest extant work attributed to Yang Hui.From the thirteenth to the fifteenth century,this work played a crucial role in the circulation and popularization of The Nine Chapters on Mathematical Procedures(Jiuzhang suanshu九章算术).However,the only surviving printed edition of Mathematical Methods is incomplete and contains many mistakes obstructing contemporary researchers'understanding of this work.The "Fangcheng" chapter of The Nine Chapters deals with problems related to solving what today are known as simultaneous sets of linear equations.However,interpreting the text in this chapter of Mathematical Methods and recovering the mathematical practices relating to fangcheng are difficult.Through detailed textual and mathematical analyses,the author of this paper explains Yang Hufs understanding and practice relating to〃the fangcheng method"and"the method of the positive and the negative".This paper includes an appendix that provides a detailed translation of the ambiguous text relating to"the method of the positive and the negative"and gives reasons supporting the interpretation provided here.Yang Hufs understanding of the concepts of"positive"and"negative"and his practice relating to these two concepts may easily be confused with their apparent counterparts in modem mathematics.Also,careful analysis of the mathematical methods in this work reveal that the order of problems in Yang Hufs Reclassifications of Mathematical Methods Explaining in Detail The Nine Chapters([Xiangjie jiuzhang suanfa zuanlei詳解九章算法纂類],namely,the last section of Mathematical Methods)were rearranged according to commentaries to specific methods that appear in Mathematical Methods.Some textual clues referring to the zzprevious question"(qianwen前問)in certain commentaries of Mathematical Methods indeed reflect the order of problems in Reclassifications.Yang Hui made especially detailed commentaries on the problems that he arranged in a sequence that differs with respect to the original order of problems as they appear in the ancient classic work,The Nine Chapters.All these discoveries reveal and serve to prove a close relationship between Yang Hufs Mathematical Methods and his Reclassifications.

The method to evaluate the position error in graphic positioning technology

In the measurement of automobile body-in-white, it has been widely studied to position the twodimensional (2D) visual sensors with high precision. In this paper a graphic positioning method is proposed, a hollow tetrahedron is used for a positioning target to replace all the edges of a standard automobile body. A 2D visual sensor can be positioned through adjusting two triangles to be superposed on a screen of the computer, so it is very important to evaluate the superposition precision of the two triangles. Several methods are discussed and the least square method is adopted at last, it makes the adjustment more easy and intuitive with high precision.

Motion Regular Analysis and Its Simulation of the Rodless Drilling Unit's Guiding & Positioning Board

To analyze the stress of the guiding & positioning board and the effectiveness of the guiding & positioning device,according to guiding & positioning device's operational principle and structure,the guiding & positioning board's motion regular was analyzed by diagrammatical method based on 2 postulated conditions.Considering about the working conditions' change,simulations in 5 different kinds of working conditions were done to check the correctness of the motion regulars obtained by diagrammatical method.Simulation results prove that the motion regulars are right,the postulated conditions have no effect on the obtained motion regulars.According to the simulation results,the motion processs's characters were drawn out at the same time.

Crack stop holes in steel bridge decks:Drilling method and effects

Force analysis using a compact tension model, as recommended by ASTM, was carried out on a crack stop hole. The stress before, and after, drilling the hole was compared in terms of stress concentration and stress gradient. The optimum drilling location and diameter were studied through analysis of different locations and diameters. By analyzing the effects of flank holes and an additional hole, drilling advice was proposed and fatigue testing of the cracks in a steel bridge deck with a crack stop hole was conducted. The results show that the stress at the crack tip with a crack stop hole decreased, and the major principal stress around the hole was distributed accordingly. The optimum position of the crack stop hole centre was where the centre of the crack stop hole was situated behind the crack and the hole edge coincided with the crack tip. Therefore, hole diameters larger than 8 mm, or those weakening the section by 10%, were suggested as the best diameters. In terms of multi-hole crack stopping, a flank hole was not recommended. The optimum horizontal position of flank holes was at a distance of 1/4 of a single hole diameter from, and in front of, the single hole. Besides, the experiment showed that crack stop hole could only prevent cracks from growing and had no influence on crack growth rate.

GPS short-delay multipath estimation and mitigation based on least square method

The GPS multipath signal model is presented, which indicates that the coherent DLL outputs in multipath environment are the convolution between the ideal DLL outputs and the channel responses. So the channel responses can be estimated by a least square method using the observed curve of the DLL discriminator. In terms of the estimated multipath channels, two multipath mitigation methods are discussed, which are equalization filtering and multipath subtracting, respectively. It is shown, by computer simulation, that the least square method has a good performance in channels estimation and the multipath errors can be mitigated almost completely by either of the methods. However, the multipath subtracting method has relative small remnant errors than equalization filtering.

MULTIPLICITY AND CONCENTRATION BEHAVIOUR OF POSITIVE SOLUTIONS FOR SCHRDINGER-KIRCHHOFF TYPE EQUATIONS INVOLVING THE p-LAPLACIAN IN R^N

In this article, we study the multiplicity and concentration behavior of positive solutions for the p-Laplacian equation of SchrSdinger-Kirchhoff type -εpM（εp-N∫RN｜△u｜p）△pu＋v（x｜u｜p-2u=f（u）in RN, where △p is the p-Laplacian operator, 1 〈 p 〈 N, M ： R＋ → R＋ and V ： RN →R＋ are continuous functions, ε is a positive parameter, and f is a continuous function with subcritical growth. We assume that V satisfies the local condition introduced by M. del Pino and P. Felmer. By the variational methods, penalization techniques, and Lyusternik- Schnirelmann theory, we prove the existence, multiplicity, and concentration of solutions for the above equation.

Solving single-frequency phase ambiguity using parameter weights fitting and constrained equation ambiguity resolution methods

Based on the structural characteristics of the double-differenced normal equation, a new method was proposed to resolve the ambiguity float solution through a selection of parameter weights to construct an appropriate regularized matrix, and a singular decomposition method was used to generate regularization parameters. Numerical test results suggest that the regularized ambiguity float solution is more stable and reliable than the least-squares float solution. The mean square error matrix of the new method possesses a lower correlation than the variancecovariance matrix of the least-squares estimation. The size of the ambiguity search space is reduced and the search efficiency is improved. The success rate of the integer ambiguity searching process is improved significantly when the ambiguity resolution by using constraint equation method is used to determine the correct ambiguity integervector. The ambiguity resolution by using constraint equation method requires an initial input of the ambiguity float solution candidates which are obtained from the LAMBDA method in the new method. In addition, the observation time required to fix reliable integer ambiguities can he significantly reduced.

A NOTE ON THE UNIQUENESS AND THE NON-DEGENERACY OF POSITIVE RADIAL SOLUTIONS FOR SEMILINEAR ELLIPTIC PROBLEMS AND ITS APPLICATION

In this paper, we are concerned with the uniqueness and the non-degeneracy of positive radial solutions for a class of semilinear elliptic equations. Using detailed ODE anal- ysis, we extend previous results to cases where nonlinear terms may have sublinear growth. As an application, we obtain the uniqueness and the non-degeneracy of ground states for modified SchrSdinger equations.

Position and Velocity Time Delay for Suppression Vibrations of a Hybrid Rayleigh-Van der Pol-Duffing Oscillator

In this paper,we used time delay feedback to minimize the vibrations of a hybrid Rayleigh–van der Pol–Duffing oscillator.This system is a one-degree-offreedom containing the cubic and fifth nonlinear terms and an external force.We applied the multiple scales method to get the solution from first approximation.Graphically and numerically,we studied the system before and after adding time delay feedback at the primary resonance case(
ffi!).We used MATLAB program to simulate the efficacy of different parameters and the time delay on the main system.

Design and Implementation of Digital Fractional Order PID Controller Using Optimal Pole-Zero Approximation Method for Magnetic Levitation System

The aim of this paper is to employ fractional order proportional integral derivative(FO-PID)controller and integer order PID controller to control the position of the levitated object in a magnetic levitation system(MLS),which is inherently nonlinear and unstable system.The proposal is to deploy discrete optimal pole-zero approximation method for realization of digital fractional order controller.An approach of phase shaping by slope cancellation of asymptotic phase plots for zeros and poles within given bandwidth is explored.The controller parameters are tuned using dynamic particle swarm optimization(d PSO)technique.Effectiveness of the proposed control scheme is verified by simulation and experimental results.The performance of realized digital FO-PID controller has been compared with that of the integer order PID controllers.It is observed that effort required in fractional order control is smaller as compared with its integer counterpart for obtaining the same system performance.

Reliability of gas holdup measurements using the differential pressure method in a cyclone-static micro-bubble flotation column

Gas holdup is one of the key parameters in flotation process. Gas holdup as measured by a differential pressure method was investigated and the relative errors compared to the average gas holdup from the volume expansion method. The errors were used to establish optimum measurement positions. The results show that the measurement position should be in the middle of the column and in the region half way from the center to the wall (the half-radius). The gas holdup along the axial direction is lower at the bottom and higher at the top of the floatation column. The gas holdup along the radial direction is lower near the wall and higher near the center of the flotation column. The average gas holdup measure- ment can be replaced by regional gas holdup values.

A new modification of false position method based on homotopy analysis method

A new modification of false position method for solving nonlinear equations is presented by applying homotopy analysis method （HAM）. Some numerical illustrations are given to show the efficiency of algorithm.

Restraint on the Effect of Friction by Localization Method

The characterization of friction in control systems and its restraint by localization method are analyzed. The minimum velocity and position precision of control systems with friction are obtained analytically. The condition of global stability is given.