Cardiovascular sequelae in post-COVID-19 patients with moderate to severe CT severity score: A follow-up study

Objective:To study cardiovascular sequelae of post-COVID-19 patients with moderate to severe computed tomography(CT)severity score.Methods:A prospective,non-randomized,observational study was conducted on 100 post-COVID-19 patients with moderate to severe CT severity scores from January 2021 to December 2021.Fifty-nine were male[mean age(54.1±12.2)years]and 41 were female[mean age(46.9±15.1)years].Patients with previous cardiovascular disease,previous chronic lung disease,and pre-existing primary or secondary pulmonary hypertension were excluded.Patients were examined,and serial electrocardiogram and 2D echocardiography were performed to detect any cardiovascular abnormality.Results:Post-COVID-19 patients had persistent symptoms,the most common being fatigue(59%).Most of these symptoms were relieved on follow-up.A rise in systolic,diastolic blood pressure,and pulse rate was observed.The electrocardiographic evaluation revealed ST-T segment changes,sinus tachycardia,ventricular hypertrophy,and arrhythmias among a considerable number of patients.On echocardiography,left ventricular diastolic dysfunction was most common(43%).Pulmonary hypertension,as evidenced by elevated pulmonary artery systolic pressure,was seen in 15%of patients.Conclusions:The present findings reveal an increased incidence of cardiovascular complications after recovery from COVID-19 infection in those without pre-existing cardiovascular or chronic lung disease.

COVID-19对高等教育的影响及我们的应对——基于国际组织相关报告的回溯性分析

文章选择联合国教科文组织及国际大学协会两大与高等教育相关的国际组织作为研究案例,以高等教育与COVID-19相关的研究报告作为分析样本,深度解读COVID-19对高等教育的教学、研究、公平和包容、国际交流、行政管理方面的影响,总结高等教育机构在危机不同时期的应对策略。最后提出后疫情时代高等教育变革的主要方向,即以可持续发展视角观照高等教育发展,以更系统的眼光统筹高等教育治理,以数字化转型推动高等教育创新发展,以高等教育国际合作维护全球共同利益。

COVID-19 related biliary injury:A review of recent literature

Since its emergence in 2019,it has become apparent that coronavirus 2019(COVID-19)infection can result in multi systemic involvement.In addition to pulmonary symptoms,hepatobiliary involvement has been widely reported.Extent of hepatic involvement ranges from minor elevation in liver function tests(LFTs)to significant hepatocellular or cholestatic injury.In majority of cases,resolution of hepatic injury or improvement in LFTs is noted as patients recover from COVID-19 infection.However,severe biliary tract injury progressing to liver failure has been reported in patients requiring prolonged intensive care unit stay or mechanical ventilation.Due to the timing of its presentation,this form of progressive cholestatic injury has been referred to as COVID-19 cholangiopathy or post-COVID-19 cholangiopathy,and can result in devastating consequences for patients.COVID-19 cholangiopathy is recognized by dramatic elevation in serum alkaline phosphatase and bilirubin and radiologic evidence of bile duct injury.Cholangiopathy in COVID-19 occurs weeks to months after the initial infection and during the recovery phase.Imaging findings and pathology often resemble bile duct injury associated with primary or secondary sclerosing cholangitis.Etiology of COVID-19 cholangiopathy is unclear.Several mechanisms have been proposed,including direct cholangiocyte injury,vascular compromise,and cytokine release syndromes.This review summarizes existing data on COVID-19 cholangiopathy,including reported cases in the literature,proposed pathophysiology,diagnostic testing,and long-term implications.

Work Ability Index and Work Ability Score: A Comparation between both Scores in a Persistent COVID-19 Cohort

Aims: The present study aims to compare the assessment of work ability based on the use of the Work Ability Index (WAI) with another questionnaire base only on the use of WAI’s first item, termed as the “Work Ability Score” (WAS). Study design: A cohort of 384 Spanish workers included in a Post COVID-19 condition or persistent COVID-19 multicenter research was utilized. Place and Duration of Study: This cohort was enlisted in four hospitals (Hospital Universitario 12 de Octubre, Madrid;Hospital Universitario Virgen Macarena, Sevilla, Andalucía;Hospital Universitario Gregorio Marañón, Madrid and Complejo Asistencial Universitario de Salamanca, Castilla y León), since 2021 until 2022. Methodology: 384 Spanish workers (176 men and 208 women;aged 20 to 70 years) with Post COVID-19 condition or persistent COVID-19 were included. Descriptive analysis of primary scores was conducted. Given the non-normal distribution of data, the Mann-Whitney and Kruskal-Wallis tests were employed. Spearman and Kendall correlations were employed to assess the relationship between WAI and WAS, also used weighted Kappa to estimate the degree agreement between WAI and WAS. Logistic regression models were utilized to study determinants influencing WAI and WAS, categorized as poor or moderate. Results: WAI had an average score of 32.98 (SD = 10.28), whereas WAS had an average of 5.95 (SD = 2.77). Significant differences were observed in both WAI and WAS across the same variables. Strong and statistically significant correlations were evident between WAI and WAS (rs = 0.83, p < 0.001). All the variables used in the logistic regression model (gender, the sector employment, and previous chronic diseases) were statistically significant in both questionnaires. Conclusion: WAS questionnaire could be used as a tool for reliable assessment of work ability among Spanish workers with Post COVID-19 condition or Persistent CO-VID-19.

Pulmonary arterial hypertension confirmed by right heart catheterization following COVID-19 pneumonia: A case report and review of literature

BACKGROUND Pulmonary arterial hypertension(PAH)is a disease of the arterioles resulting in an increased resistance in pulmonary circulation with associated high pressures in the pulmonary arteries,causing irreversible remodeling of the pulmonary arterial walls.Coronavirus disease 2019(COVID-19)has been associated with development of new onset PAH in the literature leading to symptoms of dyspnea,cough and fatigue that persist in spite of resolution of acute COVID-19 infection.However,the majority of these cases of COVID related PAH were diagnosed using echocardiographic data or via right heart catheterization in mechanically ventilated patients.CASE SUMMARY Our case is the first reported case of COVID related PAH diagnosed by right heart catheterization in a non-mechanically ventilated patient.Right heart catheterization has been the gold standard for diagnosis of pulmonary hypertension.Our patient had right heart catheterization four months after her initial COVID-19 infection due to persistent dyspnea.CONCLUSION This revealed new onset PAH that developed following her infection with COVID-19,an emerging sequela of the infection.

Stressors in Nurse Students’ Formation in the New Normality Post COVID-19

Background: Mental health has been impaired and at risk due to the worldwide COVID-19 pandemic. The consequences due to confinement impacted every scenario, which directly influenced the daily routine of nurse students;in each setting students faced stressors that trigger fear, anxiety and others, since being in confinement learning of topics moved to the home, laboratory practices in hospitals were cancelled leaving the room that is uncertain up to their return to in-person activities. It is important to highlight the need for innovation and strengthening of theoretical-pedagogic aspects centered at the student’s context as a human being with their own needs and problems, who will interact with others in the continuous process of health-illness. Objective: the aim was to identify the stressors in the nurse students’ formation in the new normality post-COVID-19. Methods: Qualitative and phenomenological research with 27 participants aged 20 - 25 years, nurse students of a public university. The information collection was through four focal groups of 6-7 members each, data analysis was done according to Miles & Huberman after signed informed consent of each participant, and authorized by the chairperson of the Nurse’ career. Results: Category 1, Cumulative stressors with sub-categories 1.1 Uncertainty, 1.2 Isolation, 1.3 Invisibility, 1.4 Mockery, 1.5 Exclusion. Category 2, Expectancy states with sub-categories 2.1 Low self-esteem, 2.2 Insecurity, 2.3 Anxiety, 2.4 Depression, 2.5 Temporary leave, 2.6 Search for authenticity. Category 3, Internalization processes with sub-categories 3.1 Social rejection, 3.2 Self-censorship, 3.3 Discrediting, 3.4 Disempowerment. Category 4, Academic aspects affected with sub-categories 4.1 Deficient studying habits, 4.2 Deficient assimilations of knowledge, 4.3 Archived knowledge in the computer, 4.4 Absence of practice in previous semesters. Conclusion: Once identified the stressors in nurse students in the new normality post-COVID-19, it will allow the creation of settings that help in getting confidence for students, i.e., a safe surrounding promotes the development of abilities and competencies during formation, as well as recommendations of teachers in the classroom and laboratories that contribute to filling space that students perceive as empty, and to intensifying the companionship in clinical settings where students perceive most aggressiveness.

Study on Influence of the COVID-19 Epidemic on Tourism Consumption Structure in Shandong Province

At the end of 2019,the sudden outbreak of the COVID-19 epidemic brought great challenges to the world,and China's tourism industry suffered an unprecedented heavy blow.Exploring the impact of the epidemic on tourism consumption structure has become a research focus in the post-epidemic era.In this study,based on Shandong Tourism Statistics Handbook from 2018 to 2020,taking Shandong Province as an example,the changes of total tourism revenue and tourism consumption structure in Shandong Province before and after the COVID-19 epidemic were compared to predict the development of tourism in Shandong Province in the post-epidemic era and find out existing problems,and optimization paths were put forward for the development of tourism in Shandong Province in the post-epidemic era.

Adults with Congenital Heart Disease during the COVID-19 Era:One-Year Tertiary Center Experience

Background:Adult patients with congenital heart disease(ACHD)might be at high risk of Coronavirus disease-2019(COVID-19).This study aimed to report on a one-year tertiary center experience regards COVID-19 infection in ACHD patients.Methods:This is a one-year(March-2020 to March-2021)tertiary-center retrospective study that enrolled all ACHD patients;COVID-19 positive patients’medical records,and management were reported.Results:We recorded 542 patients,205(37.8%)COVID-19-positive,and 337(62.2%)COVID-19-negative patients.Palliated single ventricle and Eisenmenger syndrome patients were more vulnerable to COVID-19 infection(P<0.05*).Cardiovascular COVID-19 complications were arrhythmias in 47(22.9%)patients,heart failure in 39(19.0%)patients,cyanosis in 12(5.9%)patients,stroke/TIA in 5(2.4%)patients,hypertension and infective endocarditis in 2(1.0%)patients for each,pulmonary hypertension and pulmonary embolism in 1(0.5%)patient for each.11(5.4%)patients were managed with home isolation,147(71.7%)patients required antibiotics,32(15.6%)patients required intensive care unit(ICU),8(3.9%)patients required inotropes,7(3.4%)patients required mechanical ventilation,and 2(1.0%)patients required extracorporeal membrane oxygenation(ECMO).Thromboprophylaxis was given to all 46(22.4%)hospitalized patients.American College of Cardiology/American Heart Association classification revealed that complex lesions,and FC-C/D categories were more likely to develop severe/critical symptoms,that required mechanical ventilation and ECMO(P<0.05*).Mortality was reported in 3(0.6%)patients with no difference between groups(P=0.872).193(35.6%)patients were vaccinated.Conclusions:COVID-19 infection in ACHD patients require individualized risk stratification and management.Eisenmenger syndrome,single ventricle palliation,complex lesions,and FC-C/D patients were more vulnerable to severe/critical symptoms that required ICU admission,mechanical ventilation,and ECMO.The vaccine was mostly tolerable.

Evaluation of Sensitivity and Specificity of Direct Microscopical Examination of Suspected Mucor Mycosis Samples by Potassium Hydroxide (KOH) during Covid-19 Pandemic Era

Introduction: Mucormycosis is a common fungal infection in India even before the COVID-19 pandemic. The incidence of Mucor mycosis has entered public consciousness in response to an outbreak of cases in India during COVID-19 pandemic. Mortality is unacceptably high, reaching 80% in some case series. Prompt diagnosis is crucial because treatment initiation is time-critical due to the rapid progression of the infection. Direct KOH mount is a simple, rapid, inexpensive point-of-care test, which requires minimum technical aids. Interpretation of KOH smears requires some amount of experience. The present study was to evaluate the sensitivity and specificity of Direct Microscopical examination by KOH preparation of suspected Mucor mycosis samples taking the fungal culture as gold standard. Material and Methods: 230 samples were received in Microbiology Department from May 2021 to August 2021 from the patients suspected of Mucor mycosis. Samples were processed for KOH preparation using different concentrations of KOH like 20% and 40% till all tissues get digested. Samples were cultured also in Sabourauds dextrose agar (SDA) medium. Results of microscopy and culture were statistically analyzed using SPSS software version 23. Result: Sensitivity of KOH preparation was 67%, specificity was 87%. Positive predictive value was 76% and negative predictive value was 81% and accuracy was 80% when compared with the fungal culture. Discussion: Direct microscopic examinations using KOH preparation are the simplest, cheapest method used for the diagnosis of mycotic infections. This study is valuable in establishing a reliable method for early information on diagnosis of Mucor mycosis that may be crucial for determining appropriate therapy for the successful treatment of Mucor mycosis patients. Conclusion: KOH examination plays an important role in the diagnosis of Mucor mycosis suspected patients during COVID-19 pandemic era when compared with fungal culture which is a gold standard test in diagnosis of Fungal infection. It is the simplest and cheapest method that can be developed easily with minimal infrastructure or human resources in resource-limited countries during the COVID-19 era.

疫情之下全球教与学面临的挑战与应对之策——OECD《2020应对COVID-19教育指南》解析与思考

为了支持各国在疫情期间进行合理的教育决策,实施有效的教育应对措施,2020年4月1日,OECD联合哈佛大学研究生院发布了《2020应对COVID-19教育指南》。《指南》从学校、教师和学生三个层面,分析了各国教育系统所面临的共同挑战:学校难以保证学生的学习质量,缺乏数字化基础设施和有深度的多方合作;教师缺乏ICT能力和教师之间的深度合作,需要重构师生关系和创新教学设计;学生需要转变学习模式和调整心理健康状态,弱势学生群体的基本学习条件无法得到保障。为此,进一步提出了具体的教育应对策略:在宏观教育系统层面,建议设立专门的领导小组,制订指导性纲领,建立跨部门合作机制以及加强教育的公平性和包容性;在中观学校层面,建议整合校内外教学资源,建立日常沟通渠道以及加强跨校合作;在微观师生层面,建议提升教师的责任感和领导力,构建教师专业合作网络,鼓励师生共同探索创新性教学模式以及提升学生的自主学习能力。对《指南》进行深入解读和分析,有助于我们构建符合时代发展需求的“包容·合作·赋能”的教育新生态。

COVID-19后疫情时代的慢直播及其优化路径

新冠肺炎(COVID-19)疫情暴发两年来,慢直播作为一种新兴媒介及疫情防控信息传播工具,在实践方面取得了良好的效果。不同于传统的电视直播与网络直播,慢直播有着节奏舒缓、画面原生态以及受众自组织式互动的特性。但慢直播也存在着主题冗杂,缺乏社会价值,拍摄机位固定而使观众产生视觉疲劳,公众监督失焦消解议题严肃性和城市形象塑造单一等问题。只有不断实施技术升级、主题创新选择、内容深度挖掘,慢直播方可在COVID-19后疫情时代继续行稳致远,发挥更大的传播效应。

Assessment of Persistence Symptoms in Recovered COVID-19 Patients by Yorkshire Rehabilitation Scale (C19‐YRS): A Cross-Sectional Study from Qassim Region, Saudi Arabia

Background: Earlier back at the beginning of COVID-19, the acute phase of infection was variable from one patient to another causing different symptoms. However, many patients are still suffering from Post COVID-19 Syndrome. Hence, this study aimed to assess the persistence of symptoms in patients who recovered from COVID-19 in the Qassim Region, Saudi Arabia. Methodology: A descriptive cross-sectional study of 413 confirmed PCR test-positive covid-19 patients enrolled in this study from the Ministry of Health Electronic Surveillance System (HESN). The Yorkshire Rehabilitation Scale (C19-YRS) checklist was used to record patients’ symptoms, functioning, and disability. Data were analyzed by the SPSS program. Functional and patient-reported outcome measures were correlated with certain items from C19-YRS, the severity of symptoms. Its distribution-based methods were used for responsiveness over time. The scaling and targeting assumptions were satisfied, and internal consistency was high (Cronbach’s α = 0.843). Results: After 4 weeks of infection, 50% of patients reported persistent symptoms such as laryngeal complications, 43.8% Swallowing changes, 31.3% fatigue, 18.8% pain, 18.8% loss of appetite, 12.5% breathlessness, and 6.3% depression, Moreover, 18.8% of patients experienced reduced mobility. At the beginning of the COVID-19 infection, fever was the most common complaint 332 (80.4%), followed by 267 (64.6%) fatigue, and loss of smell 230 (55.7%). The severity of the breathlessness symptoms was exaggerated during the patients’ walking or climbing stairs. Patients who were admitted to an intensive care unit (n = 5) were significantly elderly (P Conclusion: The study examined the severity of post covid syndrome by patients’ responsiveness to the scale items in C19-YRS. The majority of COVID-19 symptoms were still present but significantly reduced after 4 weeks of infection. Follow-up and long-term management of physical and psychological symptoms of hospitalized and non-hospitalized patients are very important.

后疫情时代城市社区居住满意度评价体系的重构

城市社区居住满意度是评价与提升社区居住环境的重要标准之一。针对后疫情时代居住满意度评价体系与社区环境之间适配性不足的问题,研究梳理了后疫情时代相关文献研究与空间规划实践,从中提取新的影响因素作为“疫情补丁”,在整合原有居住满意度评价体系的基础上,重构具有“精度”与“尺度”的后疫情时代居住满意度评价体系。研究结果表明,后疫情时代的居住满意度评价体系可以从“社区—组团—单元—家宅”四个空间层级进行重构和落实,并提出空间维度支撑、社会要素调节与整体动态更新的优化策略。本研究结果为人民满意的城市社区的空间韧性提升和规划建设提供理论支撑与实践经验。

后疫情时代联合办公发展变化分析

联合办公在前疫情时代构建了一种以互信和核心价值共享为基础的灵活办公模式,受益于科学技术的进步、共享经济的崛起和新型工作组织出现的推动,以社区化、开放性和合作性为特点,快速发展并日益成为现代办公的重要方式。然而,随着新冠疫情的爆发和全球蔓延,联合办公空间在新冠疫情期间的发展,因远程办公的快速发展和防疫政策的实施而受到了巨大的阻碍。为保证联合办公空间的经营者对后疫情时代多变的需求和变化快速做出响应,联合办公的演进需要转向不同的模式,包括空间的可配置性、满足心理预期的隐私模式、更高效的协作模式和工作环境的数字化模式。

后新冠疫情时代广州市茶艺馆经营现状调查研究

为探明后疫情时代广州市茶艺馆的经营现状,以广州市11个区人气前五的茶艺馆为对象,以“大众点评”为信息收集途径,通过线上检索资料自行填写对茶艺馆经营者的问卷,再结合线上线下双线程向茶艺馆消费者有针对性地发放问卷。结果表明,设计风格上趋同严重。装修风格中,参考“现代新中式风格”的茶艺馆占比高达94%;在茶艺馆功能类型上,大多茶艺馆重视商务交流功能,70%的茶艺馆专门配备了电子屏等硬件设施;座位设置中,每家茶艺馆都设有包间;服务项目上,有个别茶艺馆关注到独立个体对茶饮及茶空间的需求,“一人行”等单人饮茶项目始露苗头。针对后疫情时代的广州市内茶艺馆的现状从经营者与消费者两个视角有针对性地提出未来发展建议,希望能加深对后疫情时代背景条件下广州茶艺馆经营现状的认识,同时为该地区茶艺馆的未来发展提供理论指导,并为后疫情时代其他城市茶艺馆的研究与发展等提供参考。

新型冠状病毒肺炎疫情中国防治政策变迁

自2020年世界卫生组织(World Health Organization,WHO)正式宣布新型冠状病毒肺炎疫情成为全球大流行之后,全球114个国家或区域受到不同程度的影响。后疫情时代的到来要求各国采取新的疫情防控措施,以应对未来可能出现的问题和挑战。为帮助我国在后疫情时代巩固几年来的防疫成果并获取更大的发展窗口,本文探析了全球疫情变化及各国主要防治政策的变化,总结归纳了我国疫情防治政策的发展变迁,提出适应我国国情的以家庭为核心的新型精准防控措施。

大学生后疫情时代心理问题与机制建设(综述)

在后疫情时代下,因疫情带来的不确定性和不安全感给学生造成持续的紧张、焦虑、恐慌,巨大的心理压力和心理困扰,也为高校心理育人工作提出严峻的挑战。为此,高校心理育人工作急需建立健全相应的机制体制,以确保心理育人工作具有制度保障,程序保障,组织保障和法律保障。实现路径包括创新心理育人协同机制,健全心理育人联动机制,改进心理异常和心理危机监测机制,健全心理危机干预机制,建立心理健康人才培养使用机制等。

后疫情时代职业院校开展混合式教学:现实困境与优化策略

党的二十大报告提出,要加快建设数字中国,纵向推进教育数字化。近年来,疫情反复频发,极大推动了网络教学的应用。混合式教学不仅能保障疫情下教学工作正常运行,也是数字化教育的重要形态。然而,由于线上教学管理难度较大,其教学效果一直饱受诟病。因此,如何通过构建“线上+线下”混合式教学模式,实现线上教学和线下教学的有机深度融合,在保证教学正常运行的同时,深度提升课堂教学质量,是当前急需解决的问题。基于此,从在线教学平台、教学过程设计、学生参与情况等方面,深度剖析后疫情时代职业院校实施混合式教学的现实困境,提出了“线上+线下”混合式教学的优化策略。

日本经济研究报告(一):跨越新冠冲击与后新冠时期的发展课题

新冠疫情全球卫生紧急状态已经结束,但是它给人类社会的冲击是深远的,需要进行认真总结。分析日本在新冠疫情时期经济与防疫之间的关系以及走向后疫情时期的经济特点,是值得研究的重要课题。本报告包括三个部分:首先,对日本疫情演变和防疫政策进行简要回顾和总结;其次,分析疫情时期下日本经济的衰退和复苏;再次,对日本应对疫情冲击实施的经济政策进行总结;最后,分析后疫情时期日本经济的走向。日本疫情时期的社会经济状况与政策的分析分两个时期展开,在疫情前期日本经济经历了疫情冲击下的大衰退及快速反转,这一时期防疫对策与经济政策之间的相互制约,使得景气刺激政策受到了制约。在疫情中后期日本的防疫政策更趋于灵活性,特别是在转向“与病毒共存”社会的条件下,疫情与经济复苏出现了并立的倾向,开始了向后疫情时期的过渡。新冠疫情对日本经济造成的冲击是多方面的,短期内在国内生产总值、服务制造业以及就业市场等领域均有不同程度的体现,长期而言,新冠疫情加剧了日本的少子老龄化问题,使得日本的人口结构问题更加深化和复杂。日本政府先后出台了三阶段的经济政策加以应对。随着后疫情时期的到来,日本的宏观经济开始转暖,无论是生产与消费,还是企业经营和工资收入水平均有不同程度的提高。但是物价高涨与通货膨胀苗头的出现,对日本的货币政策选择提出了挑战,在短期内仍然是制约日本经济发展的重要变量,因疫情而加深的少子老龄化问题是日本经济未来发展面临的重大结构性问题。今后的日本经济在短时间内难以发生重大的改变即完成重大结构调整和实现较高速度的增长,相反其发展内外部制约机制可能会更加复杂。

后疫情时代背景下混合式教学融入留学生汉语专业的探索

目的后疫情时代背景下对留学生汉语课程教学模式的探索。方法选择2021级临床医学本科专业留学生82名为研究对象,按照随机数字表法分为实验组和对照组,每组41名。实验组采取线上线下混合式教学,对照组采取传统教学。教学结束后,比较两组留学生的汉语考试总成绩,以及教学满意度调查结果。结果实验组留学生汉语考试总成绩明显高于对照组,差异有统计学意义(t=4.07,P<0.05);问卷调查结果显示,实验组留学生对教学活动设计、教学内容、互动行为以及学习成效这四个项目的满意度均高于对照组,差异均有统计学意义(χ^(2)分别=11.10、8.95、8.13、7.96,P均<0.05)。结论线上线下混合式教学能提高留学生的成绩和满意度,达到了预期效果。线上线下混合式教学是顺应社会潮流趋势下的创新和突破,为留学生汉语以及其他课程提供参考和借鉴。