Objective： To evaluate the efficacy of Bufei Yishen Granule （补肺益肾颗粒, BFYSG） combined with Shufei Tie （舒肺贴） acupoint sticking therapy on quality of life of patients with stable chronic obstructive pulmona...Objective： To evaluate the efficacy of Bufei Yishen Granule （补肺益肾颗粒, BFYSG） combined with Shufei Tie （舒肺贴） acupoint sticking therapy on quality of life of patients with stable chronic obstructive pulmonary disease （COPD）. Methods： A multi-center, double-blinded, double-dummy and randomized controlled method was adopted in this trial. A total of 244 patients were randomly assigned to a trial group and a control group according to the random number, each with 122 patients; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent form. In the trial group, patients were treated with BFYSG combined with ＂Shufei Tie＂ acupoint sticking therapy and sustained-release theophylline dummy, and in the control group patients were treated with oral sustained-release theophylline and BFYSG dummy combined with ＂Shufei Tie＂ acupoint sticking therapy dummy. The therapeutic course for two groups was 4 months and the follow-up was 6 months. The frequency and duration of acute exacerbation calculated by adding up each frequency and duration of acute exacerbation in treatment and follow-up time respectively, the quality of life measured by the World Health Organization Quality of Life （WHOQOL）-BREF scale and adult COPD quality of life （COPD-QOL） scale were observed. Results： Among the 244 enrolled patients, 234 were screened for full analysis set （FAS）; 221 were screened for per-protocol analysis set （PPS）. After 4-month treatment and 6-month follow-up there were differences between the trial group and the control group in frequency of acute exacerbation （FAS： P=0.013; PPS： P=0.046）; duration of acute exacerbation （FAS： P=0.005; PPS： P=0.006）; scores of physiological, psychological and environment aspects of the WHOQOL-BREF questionnaire （FAS： P=0.002, P=0.006, P=0.000; PPS： P=0.00, P=0.001, P=0.000）; scores of daily living ability, social activity, depression symptoms aspects of the COPD-QOL questionnaire （FAS： P=0.000, P=0.000, P=0.006; PPS： P=0.002, P=0.001, P=0.001）. Conclusion： BFYSG combinedwith acupoint sticking therapy could improve the quality of life of patients with stable COPD.展开更多
Objective To observe the effects of acupoint sticking therapy of different dosages and durations on the subjective and objective sleep indicators in insomnia patients.Methods Ninety-six patients with insomnia due to l...Objective To observe the effects of acupoint sticking therapy of different dosages and durations on the subjective and objective sleep indicators in insomnia patients.Methods Ninety-six patients with insomnia due to liver-Qi stagnation and spleen deficiency were divided into a high-dosage 7 d group(25 cases),a high-dosage 14 d group(22 cases),a low-dosage 7 d group(21 cases),and a low-dosage 14 d group(28 cases)using the random numbers generated in a stratified and stage-by-stage manner in combination with the visiting sequence.The four groups all received the same acupuncture treatment,but acupoint sticking therapy varied in dosage and duration.Before and after treatment,the actigraphic readings(total time in bed,total sleep time,sleep efficiency,number of wake bouts,length of wakes after asleep,and sleep latency),Pittsburgh sleep quality index(PSQI)score,and symptoms score of traditional Chinese medicine(TCM)were observed.A correlation analysis was conducted among the subjective and objective indicators.Results The PSQI score was positively correlated with the total time in bed and total sleep time(P<0.05).After treatment,the sleep latency,PSQI scores,and TCM symptoms scores changed significantly in the four groups(P<0.05).The total sleep time and sleep efficiency gained improvements after treatment in the high-dosage 14 d and low-dosage 14 d groups(P<0.05).The high-dosage acupoint sticking groups had longer total sleep time compared with the low-dosage groups of the same treatment duration(P<0.05).After treatment,the length of wakes after asleep,PSQI scores,and TCM symptoms scores were better in the 14 d groups than in the 7 d groups of the same acupoint sticking dosage(P<0.05).Conclusion Given the same acupuncture treatment,acupoint sticking therapy of different treatment durations produces different effects on the length of wakes after asleep,PSQI score,and TCM symptoms score in insomnia patients,and the 14-day acupoint sticking treatment is superior to the 7-day treatment.展开更多
目的观察针刺联合耳穴贴压治疗中风后失眠的临床疗效及其对患者脑血管血流速度的影响。方法将80例中风后失眠患者随机分为对照组(40例)和治疗组(40例),对照组口服艾司唑仑治疗,治疗组用针刺联合耳穴贴压治疗。观察治疗前后两组卒中专用...目的观察针刺联合耳穴贴压治疗中风后失眠的临床疗效及其对患者脑血管血流速度的影响。方法将80例中风后失眠患者随机分为对照组(40例)和治疗组(40例),对照组口服艾司唑仑治疗,治疗组用针刺联合耳穴贴压治疗。观察治疗前后两组卒中专用生存质量量表(stroke specific quality of life scale,SS-QOL)、爱泼沃斯嗜睡量表(Epworth sleepiness score,ESS)和匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)的评分变化;比较两组治疗前后睡眠质量相关指标[觉醒时长(wake after sleep onset,WASO)、睡眠潜伏时长(sleep-onset latency,SOL)和睡眠总时长(total sleep time,TST)]、脑血流速度(大脑前动脉、大脑中动脉和大脑后动脉)以及血清氧化应激指标[谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、丙二醛(malondialdehyde,MDA)和同型半胱氨酸(homocysteine,Hcy)]的水平。比较两组临床疗效和安全性。结果治疗组总有效率为90.0%,高于对照组的72.5%(P<0.05)。与对照组治疗后比较,治疗组治疗后SS-QOL评分和血清GSH-Px水平均升高(P<0.05),ESS和PSQI评分以及血清MDA和Hcy水平均降低(P<0.05),WASO和SOL都缩短(P<0.05),TST延长(P<0.05),大脑前动脉、中动脉和后动脉血流速加快(P<0.05)。治疗组不良反应发生率为2.5%,低于对照组的30.0%(P<0.05)。结论针刺联合耳穴贴压治疗中风后失眠可提高睡眠质量,改善脑血流速度和血清中氧化应激指标。展开更多
基金Supported by the Specific Research in Traditional Chinese Medicine Industry of State Administration of Traditional Chinese Medicine(No.200707018)
文摘Objective： To evaluate the efficacy of Bufei Yishen Granule （补肺益肾颗粒, BFYSG） combined with Shufei Tie （舒肺贴） acupoint sticking therapy on quality of life of patients with stable chronic obstructive pulmonary disease （COPD）. Methods： A multi-center, double-blinded, double-dummy and randomized controlled method was adopted in this trial. A total of 244 patients were randomly assigned to a trial group and a control group according to the random number, each with 122 patients; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent form. In the trial group, patients were treated with BFYSG combined with ＂Shufei Tie＂ acupoint sticking therapy and sustained-release theophylline dummy, and in the control group patients were treated with oral sustained-release theophylline and BFYSG dummy combined with ＂Shufei Tie＂ acupoint sticking therapy dummy. The therapeutic course for two groups was 4 months and the follow-up was 6 months. The frequency and duration of acute exacerbation calculated by adding up each frequency and duration of acute exacerbation in treatment and follow-up time respectively, the quality of life measured by the World Health Organization Quality of Life （WHOQOL）-BREF scale and adult COPD quality of life （COPD-QOL） scale were observed. Results： Among the 244 enrolled patients, 234 were screened for full analysis set （FAS）; 221 were screened for per-protocol analysis set （PPS）. After 4-month treatment and 6-month follow-up there were differences between the trial group and the control group in frequency of acute exacerbation （FAS： P=0.013; PPS： P=0.046）; duration of acute exacerbation （FAS： P=0.005; PPS： P=0.006）; scores of physiological, psychological and environment aspects of the WHOQOL-BREF questionnaire （FAS： P=0.002, P=0.006, P=0.000; PPS： P=0.00, P=0.001, P=0.000）; scores of daily living ability, social activity, depression symptoms aspects of the COPD-QOL questionnaire （FAS： P=0.000, P=0.000, P=0.006; PPS： P=0.002, P=0.001, P=0.001）. Conclusion： BFYSG combinedwith acupoint sticking therapy could improve the quality of life of patients with stable COPD.
文摘Objective To observe the effects of acupoint sticking therapy of different dosages and durations on the subjective and objective sleep indicators in insomnia patients.Methods Ninety-six patients with insomnia due to liver-Qi stagnation and spleen deficiency were divided into a high-dosage 7 d group(25 cases),a high-dosage 14 d group(22 cases),a low-dosage 7 d group(21 cases),and a low-dosage 14 d group(28 cases)using the random numbers generated in a stratified and stage-by-stage manner in combination with the visiting sequence.The four groups all received the same acupuncture treatment,but acupoint sticking therapy varied in dosage and duration.Before and after treatment,the actigraphic readings(total time in bed,total sleep time,sleep efficiency,number of wake bouts,length of wakes after asleep,and sleep latency),Pittsburgh sleep quality index(PSQI)score,and symptoms score of traditional Chinese medicine(TCM)were observed.A correlation analysis was conducted among the subjective and objective indicators.Results The PSQI score was positively correlated with the total time in bed and total sleep time(P<0.05).After treatment,the sleep latency,PSQI scores,and TCM symptoms scores changed significantly in the four groups(P<0.05).The total sleep time and sleep efficiency gained improvements after treatment in the high-dosage 14 d and low-dosage 14 d groups(P<0.05).The high-dosage acupoint sticking groups had longer total sleep time compared with the low-dosage groups of the same treatment duration(P<0.05).After treatment,the length of wakes after asleep,PSQI scores,and TCM symptoms scores were better in the 14 d groups than in the 7 d groups of the same acupoint sticking dosage(P<0.05).Conclusion Given the same acupuncture treatment,acupoint sticking therapy of different treatment durations produces different effects on the length of wakes after asleep,PSQI score,and TCM symptoms score in insomnia patients,and the 14-day acupoint sticking treatment is superior to the 7-day treatment.
文摘目的观察针刺联合耳穴贴压治疗中风后失眠的临床疗效及其对患者脑血管血流速度的影响。方法将80例中风后失眠患者随机分为对照组(40例)和治疗组(40例),对照组口服艾司唑仑治疗,治疗组用针刺联合耳穴贴压治疗。观察治疗前后两组卒中专用生存质量量表(stroke specific quality of life scale,SS-QOL)、爱泼沃斯嗜睡量表(Epworth sleepiness score,ESS)和匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)的评分变化;比较两组治疗前后睡眠质量相关指标[觉醒时长(wake after sleep onset,WASO)、睡眠潜伏时长(sleep-onset latency,SOL)和睡眠总时长(total sleep time,TST)]、脑血流速度(大脑前动脉、大脑中动脉和大脑后动脉)以及血清氧化应激指标[谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、丙二醛(malondialdehyde,MDA)和同型半胱氨酸(homocysteine,Hcy)]的水平。比较两组临床疗效和安全性。结果治疗组总有效率为90.0%,高于对照组的72.5%(P<0.05)。与对照组治疗后比较,治疗组治疗后SS-QOL评分和血清GSH-Px水平均升高(P<0.05),ESS和PSQI评分以及血清MDA和Hcy水平均降低(P<0.05),WASO和SOL都缩短(P<0.05),TST延长(P<0.05),大脑前动脉、中动脉和后动脉血流速加快(P<0.05)。治疗组不良反应发生率为2.5%,低于对照组的30.0%(P<0.05)。结论针刺联合耳穴贴压治疗中风后失眠可提高睡眠质量,改善脑血流速度和血清中氧化应激指标。
