Correlation between the neuroendocrine axis,microbial species,inflammatory response,and gastrointestinal symptoms in irritable bowel syndrome

BACKGROUND This study examines the complex relationships among the neuroendocrine axis,gut microbiome,inflammatory responses,and gastrointestinal symptoms in patients with irritable bowel syndrome(IBS).The findings provide new insights into the pathophysiology of IBS and suggest potential therapeutic targets for improving patient outcomes.AIM To investigate the interactions between the neuroendocrine axis,gut microbiome,inflammation,and gastrointestinal symptoms in patients with IBS.METHODS Patients diagnosed with IBS between January 2022 and January 2023 were selected for the study.Healthy individuals undergoing routine check-ups during the same period served as the control group.Data were collected on neuroendocrine hormone levels,gut microbiome profiles,inflammatory biomarkers,and gastrointestinal symptomatology to analyze their interrelations and their potential roles in IBS pathogenesis.RESULTS IBS patients exhibited significant dysregulation of the neuroendocrine axis,with altered levels of cortisol,serotonin,and neuropeptides compared to healthy controls.The gut microbiome of IBS patients showed reduced diversity and specific alterations in bacterial genera,including Bifidobacterium,Lactobacillus,and Faecalibacterium,which were associated with neuroendocrine disturbances.Additionally,elevated levels of inflammatory markers,such as C-reactive protein,interleukin-6,and tumor necrosis factor-α,were observed and correlated with the severity of gastrointestinal symptoms like abdominal pain,bloating,and altered bowel habits.CONCLUSION The findings suggest that targeting the neuroendocrine axis,gut microbiome,and inflammatory pathways may offer novel therapeutic strategies to alleviate symptoms and improve the quality of life in IBS patients.

The Relationship between Working Conditions and Adverse Health Symptoms of Employee in Solar Greenhouse

To determine the correlation between the working environment and the health status of employees in solar greenhouse, 1171 employees were surveyed. The results show the ＇Greenhouse diseases＇ are affected by many factors. Among general uncomforts, the morbidity of the bone and joint damage is the highest and closely related to labor time and age. Planting summer squash and wax gourd more easilv cause skin pruritus.

Spectrum-Effect Relationship Between High Performance Liquid Chromatography Fingerprints and Anticoccidial Activities of a Compound Chinese Medicine

Quality control and screening of active substances in traditional Chinese medicines have been performed using fingerprint analysis. The spectrum-effect relationship between chromatography fingerprints and efficacy of herbal drugs is considered as a potentially useful method for determining active ingredients in complex mixtures. The study was designed to develop a method for determining the bioactive components of a compound Chinese medicine called Tiefeng based on spectrum-effect relationships between high-performance liquid chromatography （HPLC） fingerprints and anticoccidial activities. Four peaks of the established HPLC fingerprint indicate the main bioactive components of this medicine. In addition, pharrnacodynamic atlas was defined and used to assess the anticoccidial activity of Tiefeng from different sources for the first time. We found that the level of anticoccidial activity of Tiefeng was consistent with the degree of similarity between the pharmacodynamic atlas and chromatogram of any sample. Furthermore, effect of this medicine was related with the main active constituents, along with the origin and the harvesting time.

Topology and Semantic Information Fusion Classification Network Based on Hyperspectral Images of Chinese Herbs

Most methods for classifying hyperspectral data only consider the local spatial relation-ship among samples,ignoring the important non-local topological relationship.However,the non-local topological relationship is better at representing the structure of hyperspectral data.This paper proposes a deep learning model called Topology and semantic information fusion classification network(TSFnet)that incorporates a topology structure and semantic information transmis-sion network to accurately classify traditional Chinese medicine in hyperspectral images.TSFnet uses a convolutional neural network(CNN)to extract features and a graph convolution network(GCN)to capture potential topological relationships among different types of Chinese herbal medicines.The results show that TSFnet outperforms other state-of-the-art deep learning classification algorithms in two different scenarios of herbal medicine datasets.Additionally,the proposed TSFnet model is lightweight and can be easily deployed for mobile herbal medicine classification.

A pilot study on the relationship between thyroid status and neuropsychiatric symptoms in patients with Alzheimer disease

Background Growing evidence links alternation of the thyroid function to the pathogenesis and progression of Alzheimer disease （AD）. However, only a few studies evaluate the association between thyroid hormone levels and neuropsychiatric manifestations in patients with AD. This study aimed to investigate the relationship of thyroid hormone levels and neuropsychiatric symptoms in euthyroid patients with AD. Methods Forty patients with AD （26 women and 14 men）, with no prior AD treatment within 4 weeks before study entry, were evaluated on their thyroid status （total triiodothyronine （TT3）,total thyroxine （TT4）, and thyroid-stimulating hormone （TSH）, cognition （Mini-Mental State Examination （MMSE） and Alzheimer＇s disease Assessment Scale-Cognitive Subscale （ADAS-cog）, neuropsychiatric symptoms （Neuropsychiatric Inventory （NPI） and depression （Hamilton Rating Scale for Depression （HAMD17）. The unique relationship between thyroid hormones and cognitive function and mood was examined with multivariate linear regression analyses. The thyroid status between the neuropsychiatric symptoms group and the non-neuropsychiatric symptoms group was examined with independent-samples t-test. Results In euthyroid AD patients with agitation and irritability has lower TSH serum level than those without these symptoms （t=-2.130, P 〈0.05; t=-2.657, P 〈0.05）; and core score of HAMD is significantly associated with the serum level of TSH （β=0.395, P 〈0.01）. There is no significant association between thyroid hormone levels and cognition （MMSE, ADAS-cog and its subscale score）.

Research ideas and strategies on the dose-effect relationship of traditional Chinese medicine prescriptions and herbs

We discuss here the complexity of the doses of traditional Chinese medicine(TCM) prescriptions and herbs from different viewpoints,including the heterogeneity of drug quality,the flexibility of prescriptions,and the diversity of drug effects.Then,the corresponding research ideas and strategies are proposed.We can reveal the actual situation of clinical doses based on in-depth "real-world study" of the safety and effectiveness of TCM prescriptions,create an analytical method for dose-effect relationships in accordance with the features of TCM,and reveal the correlated regular nature of the effectiveness and dosage of TCM prescriptions and herbs.

林谦教授从肝肾论治老年高血压的临床经验

现代中医学者大多从“眩晕”“头痛”“痰饮”的角度进行辨证论治来探讨高血压病。头为“诸阳之会”“清阳之府”,五脏六腑之精气皆上注于头,若气虚亏虚、阴阳失调、痰浊内阻、瘀血阻滞,致清窍失养,均可发为眩晕。林谦教授认为,本病的病因病机大约有4种:情志过极,忧思恼怒,致肝气郁结气滞化火;饮食不节,损伤脾胃,致湿浊中阻;先天不足或年老体衰致肝肾阴虚,阴不潜阳肝阳上亢;年老体虚或久病失养,损伤脾肾之阳,水湿不运,痰湿泛溢。林谦教授通过大量的临床实践经验,得出肝肾功能失调是老年高血压病的最常见基本病因病机,兼顾心、脾、肾、全身血管,以及情、气、血、瘀、痰等病理因素。治疗上以调肝补肾为主,兼顾“益气”“活血”“通络”“化痰”为辅,林谦教授自拟调肝补肾汤,临证兼顾个体辨证论治,临床治疗效果显著,病案举例2例。

儿童期创伤对成人抑郁的影响:功能失调性态度和人际关系的链式中介作用

目的:探讨功能失调性态度和人际关系在儿童期创伤与成年人抑郁关系中的链式中介效应。方法:采用儿童期创伤问卷简表、功能失调性态度量表、人际关系综合诊断量表、汉密尔顿抑郁量表对930名成年抑郁症患者进行调查。结果:儿童期创伤、功能失调性态度、人际关系及抑郁症状得分之间均呈两两显著性正相关;儿童期创伤可以对抑郁产生直接影响,也可以通过功能失调性态度和人际关系的独立中介作用及两者的链式中介作用间接影响抑郁,其中介效应分别占总效应的33.62%、5.88%、7.60%。结论:儿童期创伤不但可以直接影响成人抑郁,还可以通过功能失调性态度和人际关系的独立中介作用,以及功能失调性态度-人际关系之间的链式中介作用间接影响成人抑郁。

不同责任半规管BPPV与主诉症状关系分析

目的分析确诊良性阵发性位置性眩晕(BPPV)患者的位置性眩晕主诉特征,以及主诉症状与BPPV责任半规管定位诊断的相关性。方法对2022年2-3月因位置性眩晕就诊于该院患者100例完成详细病史问卷调查,以视频眼震图位置试验进行BPPV客观定位诊断,分析确定诊断BPPV与病史主诉的关系。结果100例患者中以坐起-躺下、左右翻身为眩晕主要主诉者分别为39、56例,两者分辨不清5例;位置试验阳性75例,其中BPPV确定诊断63例,其他前庭周围性眩晕12例。分析63例确定诊断BPPV患者的主诉症状,以坐起-躺下眩晕确诊垂直、水平半规管BPPV的灵敏度和特异度分别为70.7%和94.4%、5.6%和29.3%,以左右翻身眩晕确诊水平、垂直半规管BPPV的灵敏度和特异度分别为94.4%和70.7%、29.3%和5.6%。进一步分析63例BPPV患者其位置性眩晕的首发体位,以坐起-躺下者确诊垂直、水平半规管BPPV的灵敏度和特异度为76.9%和55.6%、44.4%和23.1%,左右翻身者确诊水平、垂直半规管BPPV的灵敏度和特异度为55.6%和76.9%、23.1%和44.4%。对30例可明确表述眩晕诱发较重体位侧别的BPPV患者进行分析,右侧位为较重侧13例,左侧位为较重侧17例,余33例对诱发眩晕的左右侧分别描述不清。结论位置性眩晕患者的主诉症状中,“坐起-躺下”和“左右翻身”性眩晕主诉分别对垂直、水平半规管BPPV诊断的灵敏度和特异度高,符合Ewald′s定律;而首发体位及症状较重的体位侧别,对BPPV责任半规管侧别定位诊断的灵敏度和特异度均不高。位置性眩晕患者主诉症状对BPPV快速筛查具有一定的临床价值,确定定位诊断要依靠位置试验。

家校共育视角下同伴侵害的影响因素探究:有调节的中介模型

为探索家校共育理念指导下家庭与学校对青少年同伴侵害的交互影响,构建一个有调节的中介模型,探讨亲子关系、师生关系、抑郁情绪对同伴侵害的影响。采用父母依恋问卷、师生关系量表简版、多维同伴侵害量表、流调中心抑郁量表简版对1710名5~8年级学生进行调查。结果显示:(1)亲子关系一方面直接影响同伴侵害,另一方面通过抑郁情绪间接影响同伴侵害;(2)师生关系对中介模型的三条路径均有调节作用,且扮演着不同角色。具体来说,师生关系能强化亲子关系对同伴侵害的保护作用,分担亲子关系对抑郁情绪的影响,缓冲抑郁情绪对同伴侵害的不良影响。研究证实了从家校共育的视角防治校园欺凌的可行性,建议校园欺凌专项治理活动要充分考虑到家庭与学校的交互作用,以最大程度上发挥两者的双保险作用。

重构本草——泽兰

通过古籍文献调研、中药现代研究进展及其研究成果的梳理,结合中医临床及中药学等学科领域内的专家学者的认识及应用经验,归纳出泽兰:主要功效为活血调经,祛瘀消痈,利水消肿。症靶为水肿、月经不调。现代药理研究发现泽兰及其有效成分具有改善肝肾功能、抗凝血、抗血栓、保护胃黏膜等作用。本品无毒,血虚无瘀者慎服,孕妇禁服。临床使用剂量为6~30 g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索泽兰用量与症靶的量效关系构建。

石蒜属植物花粉形态及分类研究

利用光学显微镜和扫描电镜对石蒜属(LycorisHerb.)13种植物的花粉形态进行了系统观察和比较分析。结果表明,石蒜属植物花粉形态均为两侧对称,赤道面观呈舟形或肾形,极面观为椭圆形或长椭圆形,具有单萌发槽或萌发沟,槽长几乎达两端;花粉的外壁具网状纹饰,可划分为粗网状纹饰和细网状纹饰两种类型;根据扫描电镜清楚观察到在网眼底壁及网脊上是否附有小乳突或小瘤状突起,又划分为无乳突粗网、乳突粗网和无乳突细网、乳突细网4个亚型。通过花粉形态特征结合其他性状的比较分析,对石蒜属植物的种间分类与系统演化关系进行了探讨。

复方冬元膏戒毒效应的实验研究

本研究观察中药制剂复方冬元膏对动物药物依赖性的影响。用逐次逐日增加吗啡注射剂量的方法造成大鼠及小鼠的吗啡依赖性模型后，又分别分为中药大、小剂量组，吗啡维持组，空白对照组；再给予腹腔注射纳洛酮催瘾，观察经不同药物处理后动物的戒断症状反应。结果表明：中药能明显抑制成瘾大鼠的戒断症状及成瘾小鼠的跳跃反应。主要症状积分值的降低与空白对照组相比有显著性差异（Ｐ＜０．０１），并能促进动物体重的恢复。中药的效应与剂量相关。

中药药性-功效关联分析的展望

性效关联即研究药性与功效之间的关联,一方面说明了性效之间存在何种关联及分析将面临对五味的关联分析的困难;另一方面提出了性效关联的研究方向主要应从具有特征性和使用价值的方面分析而不是一味的对号入座。

护患关系满意度与护士抑郁症状调查

目的调查护士的抑郁症状,探讨护士对护患关系的主观满意度与抑郁症状之间的关系。方法使用流行病调查中心用抑郁量表,采用自填调查问卷方式对7个市级医院护士进行抽样调查。结果被调查护士的护患关系得分平均(2.46±0.99)分;分别有28.58%、6.42%、5.79%的护士会有时、经常、总是对护患关系感到心烦。护士抑郁症状平均得分(18.40±8.33)分;63.35%的护士存在抑郁症状。经常或总是对护患关系感到烦恼的护士抑郁症状现患率为85.26%,而从来没有或偶尔感到烦恼的护士抑郁症状现患率为54.50%,二者比较差异具有统计学意义(P<0.01);护患关系评分与护士抑郁症状现患率之间呈正相关(r=0.979,P=0.004)。结论城市医院护士广泛存在抑郁症状,护士对护患关系的不满意与其抑郁症状密切相关。

368味兽用中药材的性味、归经、毒性与11种元素含量关系的研究

本文分析了３６８味兽用中药材１１种元素含量与其法定药性、药味、归经、毒性的关系。结果表明：各类药１１种元素总平含量是寒凉药＞平性药＞温热药、咸味药＞辛味药＞甘味药＞苦味药＞酸味药、肾经药＞肝经药＞大肠经药＞胆经药＞脾经药＞胃经药＞心经药＞肺经药＞小肠经药＞膀胱经药。统计发现，高Ｆｅ、高Ｍｎ、低Ｋ分别是寒凉药、温热药和平性药的元素谱征；咸味药含Ｆｅ、Ｚｎ、Ｎａ高而Ｌｉ低，辛味药含Ｚｎ、Ｃａ低，甘味药各元素无明显优劣之势，苦味药含Ｃａ高、Ｌｉ高，酸味药多数元素含量均低；高Ｍｎ、高Ｆｅ分别是肾经药和肝经药的元素特征；有毒药Ｃｕ、Ｎａ、Ｌｉ含量显著高于无毒药。作者认为，中药元素含量及谱征是影响中药性味。

巨桉人工林草本层优势种的种间关系及生态种组的划分

根据野外60个样方的调查数据,运用χ2检验、Jaccard指数和Spearman秩相关系数研究了巨桉人工林草本层16个优势种的种间关联和相关关系。结果表明,草本层优势种种间联结性不强,种间关系较为松散,种的分布相对独立,呈负联结趋势,群落还处于演替之中,物种的组成还会发生变化。研究种间关系时,种间关联结合种间相关得出的结果较好。根据分析结果将16个优势种划分为3个生态种组,生态种组内的种其资源利用方式和生态要求相似,而组间表现出明显的差异。生态种组的划分能为巨桉人工林林下草本层的管理提供理论依据。

应用HPLC图谱进行石蒜属种间关系与分类研究

利用高效液相色谱(HPLC)对石蒜属及其近缘植物中国水仙共17份样品的生物碱进行检测,以各样品生物碱色谱峰的相对保留时间为变量,采用SPSS12.0中的Q型聚类法,得到树形图。聚类分析结果显示,17份样品聚成3类:第Ⅰ类包括长筒石蒜、安徽石蒜、鹿葱、换锦花、中国石蒜、香石蒜、乳白石蒜、红蓝石蒜8个种;第Ⅱ类由石蒜、稻草石蒜、江苏石蒜、忽地笑、玫瑰石蒜、矮小石蒜组成;中国水仙单独成第Ⅲ类。聚类结果与传统分类结果有较好的一致性,并支持鹿葱、玫瑰石蒜、安徽石蒜杂交起源的观点。外形相似的忽地笑与中国石蒜,矮小石蒜与石蒜HPLC图谱明显有别,表现出较远化学亲缘关系。表明HPLC化学图谱可用于石蒜属及其近缘植物中国水仙的分类和鉴别研究,并为石蒜属植物指纹图谱研究和质量控制提供重要参考。

紫花苜蓿和马唐根的生物力学性能及相关因素的试验研究

选择固土护坡植物时,植物根的抗拉强度是一项重要的力学指标。对豆科的紫花苜蓿和禾本科的马唐根的抗拉力和纤维素含量的研究表明,根的抗拉强度和纤维素含量均与直径呈显著的负相关关系,根的抗拉强度与纤维素含量呈正相关关系,表明"木本植物根的抗拉强度、直径和纤维素含量关系"的研究结论在这两种草本植物上也同样适用。对紫花苜蓿和马唐根的抗拉强度与其"木质素/纤维素"之间关系的研究表明,两者呈负相关关系,证实纤维素含量对于维持根抗拉强度的作用大于木质素含量。研究发现,豆科紫花苜蓿根的应力-应变为对数函数关系,不符合胡克定律,马唐根的应力-应变关系的本构方程基本遵从胡克定律。直径愈小,紫花苜蓿和马唐根的应力—应变关系对应变率敏感程度愈高,根的极限延伸率愈大。另外,根的抗拉力和直径测试设备的改进,实验结果更准确可靠。这方面研究对揭示植物根系提高土壤抗冲击性和抗剪强度机理,更好地进行水土保持植物的选择和优化组合具有重要意义。

大学生依恋类型对心理健康的影响

目的：探讨大学生依恋类型和心理健康的关系。方法：以整群抽样的方式选取大学生676名；用关系问卷（RQ）、亲密关系经历量表（ECR）、症状自评量表（SCL-90）进行测查。结果：676名大学生中安全型依恋者占41．3％，轻视型占25．6％，倾注型占23．3％，害怕型占9．8％；除躯体化外，安全型和轻视型大学生的SCL-90量表总分和其他指标分均低于倾注型和／或害怕型，[如，总分（153．0±45．4）、（158．4±47．8）vs．（173．8±51．2）、（175．1±58．8），P〈0．001]，敌对得分安全型低于倾注型和害怕型[（1．7±0．6）vs．（1．8±0．6）、（1．9±0．9），P=0．027]；依恋回避与除敌对以外的其他心理健康指标呈正相关（r=0．14～0．17，P〈0．01）；依恋焦虑与SCL-90各指标呈不同程度的相关（r=0．24～0．47，P〈0．01）。结论：大学生的依恋类型对他们的心理健康水平产生影响，依恋焦虑与依恋回避越低心理健康水平越高。