Objective:To investigate the clinical effect of modified closed negative pressure suction technique combined with flap transplantation on the treatment of deep chronic refractory wounds.Methods:During March of 2015 to...Objective:To investigate the clinical effect of modified closed negative pressure suction technique combined with flap transplantation on the treatment of deep chronic refractory wounds.Methods:During March of 2015 to April of 2018,52 cases of patients with deep chronic refractory wounds were selected as research objects.They were divided into the control group and the treatment group by use of the random number table method,with 26 cases in each group.Among them,the control group was given conventional debridement combined with flap reconstruction,and the treatment group was treated with modified closed negative pressure suction technique combined with flap transplantation to observe the clinical effect.Results:(1)According to the analysis on the effect of flap transplantation,the excellent and good rate of the treatment group was 92.3%,and in the control group,it was 76.9%(p<0.05).(2)According to the statistics,the incidence of complications in the treatment group was lower than that in the control group(p<0.05).Conclusions:Modified closed negative pressure suction technique combined with flap transplantation has a good effect on the treatment of deep chronic refractory wounds with fewer complications.展开更多
Suction caisson foundations are often subjected to vertical uplift loads,but there are still no wide and spread engineering specifications on design and calculation method for uplift bearing capacity of suction caisso...Suction caisson foundations are often subjected to vertical uplift loads,but there are still no wide and spread engineering specifications on design and calculation method for uplift bearing capacity of suction caisson foundation.So it is important to establish an uplift failure criterion.In order to study the uplift bearing mechanism and failure mode of suction caisson foundation,a series of model tests were carried out considering the effects of aspect ratio,soil permeability and loading mode.Test results indicate that the residual negative pressure at the top of caisson is beneficial to enhance uplift bearing capacity.The smaller the permeability coefficient is,the higher the residual negative pressure will be.And the residual negative pressure is approximately equal to the water head that causes seepage in the caisson.When the load reaches the ultimate bearing capacity,both the top and bottom negative pressures are smaller than Su and both the top and bottom reverse bearing capacity factors are smaller than 1.0 in soft clay.Combined the uplift bearing characteristics of caisson in sandy soil and soft clay,the bearing capacity composition and the calculation method are proposed.It can provide a reference for the engineering design of suction caisson foundation under vertical load.展开更多
Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rate...Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot.展开更多
文摘Objective:To investigate the clinical effect of modified closed negative pressure suction technique combined with flap transplantation on the treatment of deep chronic refractory wounds.Methods:During March of 2015 to April of 2018,52 cases of patients with deep chronic refractory wounds were selected as research objects.They were divided into the control group and the treatment group by use of the random number table method,with 26 cases in each group.Among them,the control group was given conventional debridement combined with flap reconstruction,and the treatment group was treated with modified closed negative pressure suction technique combined with flap transplantation to observe the clinical effect.Results:(1)According to the analysis on the effect of flap transplantation,the excellent and good rate of the treatment group was 92.3%,and in the control group,it was 76.9%(p<0.05).(2)According to the statistics,the incidence of complications in the treatment group was lower than that in the control group(p<0.05).Conclusions:Modified closed negative pressure suction technique combined with flap transplantation has a good effect on the treatment of deep chronic refractory wounds with fewer complications.
基金the National Key Research and Development Program(Grant No.2017YFC0703408)the National Natural Science Foundation of China(Grant Nos.51678145 and 51478160)the Natural Science Foundation of Jiangsu Province(Grant No.BK20180155).
文摘Suction caisson foundations are often subjected to vertical uplift loads,but there are still no wide and spread engineering specifications on design and calculation method for uplift bearing capacity of suction caisson foundation.So it is important to establish an uplift failure criterion.In order to study the uplift bearing mechanism and failure mode of suction caisson foundation,a series of model tests were carried out considering the effects of aspect ratio,soil permeability and loading mode.Test results indicate that the residual negative pressure at the top of caisson is beneficial to enhance uplift bearing capacity.The smaller the permeability coefficient is,the higher the residual negative pressure will be.And the residual negative pressure is approximately equal to the water head that causes seepage in the caisson.When the load reaches the ultimate bearing capacity,both the top and bottom negative pressures are smaller than Su and both the top and bottom reverse bearing capacity factors are smaller than 1.0 in soft clay.Combined the uplift bearing characteristics of caisson in sandy soil and soft clay,the bearing capacity composition and the calculation method are proposed.It can provide a reference for the engineering design of suction caisson foundation under vertical load.
基金Research on in situ skin repair and regeneration based on micro-tissue engineering technology and 3D printing.(The National Key R&D Program of China,Grant Number 2019YFA0110503).The study on natural living micro-amniotic scaffolds to dynamic regulate immune inflammation and reconstruct wound repairing.(National Natural Science Foundation of China,Grant Number 81971836).The systemic study of miR-23b_24-1 cluster in the prevention and treatment of MODS caused by sepsis after burns.(National Natural Science Foundation of China,Grant Number 81930057).The experimental study on regulating the immune inflammatory microenvironment of burn wounds and promoting repair and regeneration based on micro-tissue engineering technology.(National Natural Science Foundation of China,Grant Number 81871559).
文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot.
