BACKGROUND Although gastrointestinal(GI)cancers have been becoming a great public health concern in China,there is currently a lack of comprehensive literature on the overall burden and changing trends of GI cancers i...BACKGROUND Although gastrointestinal(GI)cancers have been becoming a great public health concern in China,there is currently a lack of comprehensive literature on the overall burden and changing trends of GI cancers in the working-age population.AIM To assess the burden of GI cancers and to examine the overall,age-and genderspecific trends among the working-age population in China from 1990 to 2019.METHODS Data were extracted from the Global Burden of Disease Study 2019.The burden of GI cancers was indicated by incidence,mortality,disability-adjusted life-years(DALYs),age-standardized incidence rate(ASIR),age-standardized mortality rate,and age-standardized DALYs rate.Trends in the burden of GI cancers from 1990 to 2019 were examined using annual percent change and average annual percent change with Joinpoint regression models.RESULTS For overall GI cancers,a declining trend was observed in the ASIR,age-standardized mortality rate,and agestandardized DALYs rate,with reductions of 0.74%,2.23%,and 2.22%,respectively,from 1999 to 2019 in the Chinese working-age population.However,an increasing trend was observed in the ASIR for overall GI cancers from 2016-2019.The number of either incident cases,mortality cases,and DALYs was higher for colon/rectum cancer and liver cancer in younger participants but lower for esophageal,gallbladder,biliary tract,pancreatic,and stomach cancer among older subjects.Moreover,sex disparity in the GI cancers burden was also examined over 30 years.CONCLUSION The total burden of GI cancers remained heavy among the working-age population in China,although declining trends were observed from 1999 to 2019.Disparities in the GI cancers burden existed between sexes,age groups,and cancer types.Population-based precision prevention strategies are needed to tackle GI cancers among working-age individuals,considering the age,sex,and cancer type disparities in China.展开更多
Simulation was used to investigate the effects of population structure and migration on metrics of pairwise shared ancestry. Random and hierarchical structures, or migration geometries, were examined. Compared to panm...Simulation was used to investigate the effects of population structure and migration on metrics of pairwise shared ancestry. Random and hierarchical structures, or migration geometries, were examined. Compared to panmictic populations, progress to all qualitative metrics of pairwise ancestry is delayed in structured populations. However, unless migration is very low, the time required is generally less than triple and often less than twice that required in a panmictic population of the same total size. Population structure also increases, to a similar degree, the time required for a population-wide most recent common ancestor (MRCA). As a result, the relationships between various qualitative metrics of pairwise shared ancestry and MRCA time are relatively unaffected by population structure. For example, the mean time to most recent shared ancestor (MRSA) with global sampling of pairs is 40% - 50% of the MRCA time for almost all simulated structures and migration levels. Quantitative pairwise genealogical overlap is strongly affected by population structure. With global sampling, pairwise quantitative overlap never approaches 1.0, as it does in panmictic populations;and instead eventually becomes stationary at much lower values. Possible implications of the present results for human pairwise shared ancestry are discussed. For globally sampled pairs, the longest time to most recent shared ancestor (MRSA) for humans is suggested to be approximately 2100 years before the present. If generation time is 30 years, then all humans are 69th, or closer, cousins. For people with recent European ancestry, the MRSA time may be only half as long, about 1000 years.展开更多
Using a theoretical model, this article concludes that age structures influence people's propensity to save and thereby influence their capital intensity. In the context that capital and labor are in a substitutional...Using a theoretical model, this article concludes that age structures influence people's propensity to save and thereby influence their capital intensity. In the context that capital and labor are in a substitutional relation, increased capital intensity may lead to a drop of labor income share. We perform empirical research with provincial-level data from 1990 to 2007 and have proved that the rising of the old dependency ratio and the decrease of the children dependency rate both contribute to the fall of labor income share. This assumption still holds true after the authors control the influences of other potential factors that may influence labor income share展开更多
An analytical solution is derived for the probability that a random pair of individuals from a panmictic population of size N will share ancestors who lived G generations previously. The analysis is extended to obtain...An analytical solution is derived for the probability that a random pair of individuals from a panmictic population of size N will share ancestors who lived G generations previously. The analysis is extended to obtain 1) the probability that a sample of size s will contain at least one pair of (G - 1)<sup>th</sup> cousins;and 2) the expected number of pairs of (G - 1)<sup>th</sup> cousins in that sample. Solutions are given for both monogamous and promiscuous (non-monogamous) cases. Simulation results for a population size of N = 20,000 closely approximate the analytical expectations. Simulation results also agree very well with previously derived expectations for the proportion of unrelated individuals in a sample. The analysis is broadly consistent with genetic estimates of relatedness among a sample of 406 Danish school children, but suggests that a different genetic study of a heterogenous sample of Europeans overestimates the frequency of cousin pairs by as much as one order of magnitude.展开更多
A realistic population density distribution scenario in conjunction with the spatial dynamic spectrum allocation (DSA) is taken into account to mitigate the spectrum wastage in terms of extra guard bands. For the in...A realistic population density distribution scenario in conjunction with the spatial dynamic spectrum allocation (DSA) is taken into account to mitigate the spectrum wastage in terms of extra guard bands. For the insertion of the extra guard bands, an efficient strategy based on self-assessment is applied to each victim cell individually and independently. Consequently, it is no more required to spread the extra guard band over the whole DSA region. Simulation results StlOW an improvement of 3% -4% in percentage of satisfied users for Universal Mobile Telecommunications System (UMTS) network and 4%-5% for Digital Video Broadcasting Terrestrial (DVB-T) network.展开更多
The citizenization of the population transferred from agriculture is an inevitable process for Chinese social transformation,and one of the core issues in the course of new urbanization. The core problem in citizeniza...The citizenization of the population transferred from agriculture is an inevitable process for Chinese social transformation,and one of the core issues in the course of new urbanization. The core problem in citizenization of the population transferred from agriculture lies in cost.Taking Chongqing as an example,this paper calculates the total citizenization cost to be 125038. 7 yuan for the population transferred from agriculture. Through field survey and research,this paper analyzes the current situation of citizenization cost sharing of the population transferred from agriculture in Chongqing,points out some problems in cost sharing such as inadequate governmental financial capacity,absence of business and lack of personal affordability,and finally brings forward the corresponding policy recommendations.展开更多
The most essential step in adjusting and improving the childbearing policy, the universal two-child policy will produce far-reaching impacts on the future development of China’s population. With its implementation, t...The most essential step in adjusting and improving the childbearing policy, the universal two-child policy will produce far-reaching impacts on the future development of China’s population. With its implementation, the country’s total population will peak later, the underage population and its proportion will increase substantially, the working-age population will experience a slower decline, and the aging of China’s population will be eased. However, the drop in the proportion of working-age people over the last 15 years has expedited the reduction of the demographic dividend, the elderly population will remain unaffected over the next 60 years, the aging of the population will continue to deepen, and at the same time, the increased child dependency burden will expand the overall dependency ratio.展开更多
Identical-by-descent(IBD)is a fundamental genomic characteristic in population genetics and has been widely used for population history reconstruction.However,limited by the nature of IBD,which could only capture the ...Identical-by-descent(IBD)is a fundamental genomic characteristic in population genetics and has been widely used for population history reconstruction.However,limited by the nature of IBD,which could only capture the relationship between two individuals/haplotypes,existing IBD-based history inference is constrained to two populations.In this study,we propose a framework by leveraging IBD sharing in multipopulation and develop a method,MatrixiBD,to reconstruct recent multi-population migration history.Specifically,we employ the structured coalescent theory to precisely model the genealogical process and then estimate the IBD sharing across multiple populations.Within our model,we establish a theoretical connection between migration history and IBD sharing.Our method is rigorously evaluated through simulations,revealing its remarkable accuracy and robustness.Furthermore,we apply MatrixiBD to Central and South Asia in the Human Genome Diversity Project and successfully reconstruct the recent migration history of three closely related populations in South Asia.By taking into account the IBD sharing across multiple populations simultaneously,MatrixlBD enables us to attain clearer and more comprehensive insights into the history of regions characterized by complex migration dynamics,providing a holistic perspective on intricate patterns embedded within the recent population migration history.展开更多
基金Nanjing Medical Science and Technique Development Foundation,No.YKK22195National Natural Science Foundation of China,No.52078254.
文摘BACKGROUND Although gastrointestinal(GI)cancers have been becoming a great public health concern in China,there is currently a lack of comprehensive literature on the overall burden and changing trends of GI cancers in the working-age population.AIM To assess the burden of GI cancers and to examine the overall,age-and genderspecific trends among the working-age population in China from 1990 to 2019.METHODS Data were extracted from the Global Burden of Disease Study 2019.The burden of GI cancers was indicated by incidence,mortality,disability-adjusted life-years(DALYs),age-standardized incidence rate(ASIR),age-standardized mortality rate,and age-standardized DALYs rate.Trends in the burden of GI cancers from 1990 to 2019 were examined using annual percent change and average annual percent change with Joinpoint regression models.RESULTS For overall GI cancers,a declining trend was observed in the ASIR,age-standardized mortality rate,and agestandardized DALYs rate,with reductions of 0.74%,2.23%,and 2.22%,respectively,from 1999 to 2019 in the Chinese working-age population.However,an increasing trend was observed in the ASIR for overall GI cancers from 2016-2019.The number of either incident cases,mortality cases,and DALYs was higher for colon/rectum cancer and liver cancer in younger participants but lower for esophageal,gallbladder,biliary tract,pancreatic,and stomach cancer among older subjects.Moreover,sex disparity in the GI cancers burden was also examined over 30 years.CONCLUSION The total burden of GI cancers remained heavy among the working-age population in China,although declining trends were observed from 1999 to 2019.Disparities in the GI cancers burden existed between sexes,age groups,and cancer types.Population-based precision prevention strategies are needed to tackle GI cancers among working-age individuals,considering the age,sex,and cancer type disparities in China.
文摘Simulation was used to investigate the effects of population structure and migration on metrics of pairwise shared ancestry. Random and hierarchical structures, or migration geometries, were examined. Compared to panmictic populations, progress to all qualitative metrics of pairwise ancestry is delayed in structured populations. However, unless migration is very low, the time required is generally less than triple and often less than twice that required in a panmictic population of the same total size. Population structure also increases, to a similar degree, the time required for a population-wide most recent common ancestor (MRCA). As a result, the relationships between various qualitative metrics of pairwise shared ancestry and MRCA time are relatively unaffected by population structure. For example, the mean time to most recent shared ancestor (MRSA) with global sampling of pairs is 40% - 50% of the MRCA time for almost all simulated structures and migration levels. Quantitative pairwise genealogical overlap is strongly affected by population structure. With global sampling, pairwise quantitative overlap never approaches 1.0, as it does in panmictic populations;and instead eventually becomes stationary at much lower values. Possible implications of the present results for human pairwise shared ancestry are discussed. For globally sampled pairs, the longest time to most recent shared ancestor (MRSA) for humans is suggested to be approximately 2100 years before the present. If generation time is 30 years, then all humans are 69th, or closer, cousins. For people with recent European ancestry, the MRSA time may be only half as long, about 1000 years.
文摘Using a theoretical model, this article concludes that age structures influence people's propensity to save and thereby influence their capital intensity. In the context that capital and labor are in a substitutional relation, increased capital intensity may lead to a drop of labor income share. We perform empirical research with provincial-level data from 1990 to 2007 and have proved that the rising of the old dependency ratio and the decrease of the children dependency rate both contribute to the fall of labor income share. This assumption still holds true after the authors control the influences of other potential factors that may influence labor income share
文摘An analytical solution is derived for the probability that a random pair of individuals from a panmictic population of size N will share ancestors who lived G generations previously. The analysis is extended to obtain 1) the probability that a sample of size s will contain at least one pair of (G - 1)<sup>th</sup> cousins;and 2) the expected number of pairs of (G - 1)<sup>th</sup> cousins in that sample. Solutions are given for both monogamous and promiscuous (non-monogamous) cases. Simulation results for a population size of N = 20,000 closely approximate the analytical expectations. Simulation results also agree very well with previously derived expectations for the proportion of unrelated individuals in a sample. The analysis is broadly consistent with genetic estimates of relatedness among a sample of 406 Danish school children, but suggests that a different genetic study of a heterogenous sample of Europeans overestimates the frequency of cousin pairs by as much as one order of magnitude.
基金The National High-Tech Research and Development Program of China ( No.2005AA123950)the National Science Foundation of China (No.90604035)
文摘A realistic population density distribution scenario in conjunction with the spatial dynamic spectrum allocation (DSA) is taken into account to mitigate the spectrum wastage in terms of extra guard bands. For the insertion of the extra guard bands, an efficient strategy based on self-assessment is applied to each victim cell individually and independently. Consequently, it is no more required to spread the extra guard band over the whole DSA region. Simulation results StlOW an improvement of 3% -4% in percentage of satisfied users for Universal Mobile Telecommunications System (UMTS) network and 4%-5% for Digital Video Broadcasting Terrestrial (DVB-T) network.
基金Supported by College Students'Innovative Training Project(201510-635072)
文摘The citizenization of the population transferred from agriculture is an inevitable process for Chinese social transformation,and one of the core issues in the course of new urbanization. The core problem in citizenization of the population transferred from agriculture lies in cost.Taking Chongqing as an example,this paper calculates the total citizenization cost to be 125038. 7 yuan for the population transferred from agriculture. Through field survey and research,this paper analyzes the current situation of citizenization cost sharing of the population transferred from agriculture in Chongqing,points out some problems in cost sharing such as inadequate governmental financial capacity,absence of business and lack of personal affordability,and finally brings forward the corresponding policy recommendations.
基金received grants from the National Natural Sciences Foundation as a major project(Project Approval No.:71490731)
文摘The most essential step in adjusting and improving the childbearing policy, the universal two-child policy will produce far-reaching impacts on the future development of China’s population. With its implementation, the country’s total population will peak later, the underage population and its proportion will increase substantially, the working-age population will experience a slower decline, and the aging of China’s population will be eased. However, the drop in the proportion of working-age people over the last 15 years has expedited the reduction of the demographic dividend, the elderly population will remain unaffected over the next 60 years, the aging of the population will continue to deepen, and at the same time, the increased child dependency burden will expand the overall dependency ratio.
基金supported by the Fundamental Research Funds for the Central Universities(2023JBMC011)the National Natural Science Foundation of China(NSFC)Grant(12271026)the Beijing Natural Science Foundation Grant(L222051).
文摘Identical-by-descent(IBD)is a fundamental genomic characteristic in population genetics and has been widely used for population history reconstruction.However,limited by the nature of IBD,which could only capture the relationship between two individuals/haplotypes,existing IBD-based history inference is constrained to two populations.In this study,we propose a framework by leveraging IBD sharing in multipopulation and develop a method,MatrixiBD,to reconstruct recent multi-population migration history.Specifically,we employ the structured coalescent theory to precisely model the genealogical process and then estimate the IBD sharing across multiple populations.Within our model,we establish a theoretical connection between migration history and IBD sharing.Our method is rigorously evaluated through simulations,revealing its remarkable accuracy and robustness.Furthermore,we apply MatrixiBD to Central and South Asia in the Human Genome Diversity Project and successfully reconstruct the recent migration history of three closely related populations in South Asia.By taking into account the IBD sharing across multiple populations simultaneously,MatrixlBD enables us to attain clearer and more comprehensive insights into the history of regions characterized by complex migration dynamics,providing a holistic perspective on intricate patterns embedded within the recent population migration history.