Exploring the pathogenesis of idiopathic granulomatous mastitis based on the prolactin theory

Prolactin(PRL),as a cytokine,plays a variety of multidirectional roles in immunity and inflammation.An autoimmune condition known as idiopathic granulomatous mastitis(IGM)involves many inflammatory cells and cytokines.PRL links neuroendocrine and immune systems and plays an active role in the inflammatory and immune processes.Based on the theory of PRL and combined with the latest research review at home and abroad,this paper aims to review the mechanism of action of PRL on IGM from the aspects of various inflammatory cells,cytokines and pathways,revealing the influence of PRL theory on IGM and the mechanism of action,so as to effectively control inflammation in the long-term.

Study on Language Harmony in China:Achievements,Deficiency and Prospect

Language harmony means that different languages and their dialects can coexist in harmony in the same society.It is not only a linguistic issue,but also a social phenomenon.As an independent branch of language study in China,language harmony study covers the following topics:The value of language harmony,the types of language harmony,the factors that affect language harmony,the construction path of language harmony,etc.The main research methods include:case study,a combination of synchronic and diachronic research and multidisciplinary research.Statistics results of relevant studies of language harmony in China show that,in the past fifteen years,the study of language harmony in China has grown and presents the following characteristics:The results are mainly papers(206 papers)and a few monographs(6 books);the initial stage is dominated by theoretical discussions;subsequently,the case study is in a dominant position;there are more case studies than theoretical studies in total;case study results focus on a few topics;case studies are still the current focus of study;the total number of results has shown a decreasing trend after 2008.Despite these recent findings,case studies of language harmony in China lack width and profundity,and its theoretical discussion still needs to be deepened and improved.

Discussion on Relationship Between Meridians and Viscera of Decreased Ovarian Reserve from the Perspective of"Preventive Treatment of Disease"by Acupuncture

Based on extensive historical data,clinical experience,and modern scientific research,we discuss the relationship between meridians and viscera of decreased ovarian reserve(OR)from the perspective of"preventive treatment of disease"by acupuncture.It is believed that the endogenous protection mechanism of acupuncture in"preventive treatment of disease"lies in harmonizing Yin and Yang and dredging meridians;stimulating righteousness and rejecting the evil outside;preventing disease;co-cultivating body and spirit,and regulating emotions.The incidence ofOR dysfunction is closely related to the uterus-related meridians and viscera.The mechanism of acupuncture treatment of OR dysfunction may be related to reproductive endocrine hormone levels,ovarian tissue morphology,immune system,granulosa cell apoptosis,and related signal transduction pathways.The clinical effect of acupuncture treatment of diminished OR is reflected in improving menstruation and ovulation;improving OR function,promoting pregnancy;improving local ovarian microenvironment;improving negative emotions,improving quality of life,and thus affecting pregnancy outcomes.This article summarizes the mechanism of action and clinical effect of acupuncture in the treatment of decreased OR function based on recent findings,analyzes the advantages and disadvantages of acupuncture in the treatment of disease,and provides the rationale for the clinical application of acupuncture in the treatment of decreased OR function.