Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis

Determination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have achieved.Adipose-derived mesenchymal stem cells(AD-MSC)are easily isolated and cultured for a long time before losing their stem cell characteristics,which are self-renewal and pluripotency.AD-MSC are mesenchymal stem cells that have pluripotent lineage characteristics.They are easily accessible,and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem cells.It is also HLA-DR negative and can be transplanted allogenically without the need for immunosuppression.These advantages have popularized its use in many fields including plastic reconstructive surgery.However,in the field of hepatology and liver transplantation,the progress is slower.AD-MSC have the potential to modulate inflammation,ameliorate ischemia-reperfusion injury,and support liver and biliary tract regeneration.These are very important for the treatment of various hepatobiliary diseases.Furthermore,the anti-inflammatory potential of these cells has paramount importance in the treatment of sepsis.We need alternative therapeutic approaches to treat end-stage liver failure.AD-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver transplantation.Here we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis.

EXPERIMENTAL RESEARCH AND DESIGN ON HEAT TRANSFER OF EVAPORATOR USED IN THE LARGE QUICK FREEZE PLANT

The evaporator is the main part of a quick-freeze equipment. There are many factors influencing the heat transfer coefficient of an evaporator. The most important factors among them are the fin shape, tube diameter, distance of fin space, frost, and velocity of air flow etc. They mainly influence the thermal efficiency of an evaporator, and therefore its thermal efficiency has direct relationship with the whole efficiency of the quick freeze plant. Evaporators with different structural types have different heat transfer efficiency, in order to obtain high efficiency structure of evaporator, 8 evaporator models with different fin shape, tube diameter and tube arrangement are analyzed and compared. The calculation results show that the integral waved fins, equilateral-triangle arranged small diameter tubes and varying fin-spacing has the highest heat transfer coefficient. The experimental result also shows that the evaporator with this type of structure has better thermal efficiency. The experimental result is in good agreement with the calculation result, it can instruct engineering design for usual designer. A real quick-freeze equipment is designed and put into production. The result shows that, compared with traditional domestic quick-freeze equipments, this equipment decreases by 40% in size and by 20% in energy consumption.

The Application of Cohesion and Coherence Theory in Advanced College English Teaching

In 1976,Halliday and Hassan put forward the concept of cohesion and coherence theory for the first time in their book English Cohesion and discussed five types of cohesion:reference,substitution,omission,conjunction and lexical cohesion.Some scholars enriched and expanded cohesion and coherence from the perspective of cohesion conditions,phonology,structural relations at the level of meaning and discourse.Predecessors pay much attention to the theoretical discussion,while from the perspective of the theoretical application,the cohesion and coherence theory is used for analyzing the advanced college English textbook to provide the guidance for teachers and students in teaching and learning-teachers can judge and adopt appropriate teaching methods according to the cohesion and coherence theory;Students can understand cohesion and coherence in the text as well as the influencing factors,and adequately use the cohesion and coherence mechanism in listening,speaking,reading and writing.

A theoretical analysis and its application of the second order EC' reactions at microelectrodes under steady-state conditions

With a new approach,the general current expressions of two typical second order catalytic reactions are obtained for disk,hemispherical and spherical microelectrodes under steady-state conditions.This approach is based on the concept of reaction layer.For the second order EC' reactions,we also discussed how it is possible to observe pseudo-first order or second order behavior.This consideration allows the study of the fast chemical reactions and systems where the bulk concentrations of the reactants are nearly equal.Regeneration of Fe^(3+)(EDTA) with H_2O_2 was selected as an example of a rapid catalytic reaction.