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Prospects for the therapeutic development of umbilical cord bloodderived mesenchymal stem cells 被引量:4
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作者 Soyoun Um Jueun Ha +2 位作者 Soo Jin Choi Wonil Oh Hye Jin Jin 《World Journal of Stem Cells》 SCIE 2020年第12期1511-1528,共18页
Umbilical cord blood(UCB)is a primitive and abundant source of mesenchymal stem cells(MSCs).UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders.Despite the high lat... Umbilical cord blood(UCB)is a primitive and abundant source of mesenchymal stem cells(MSCs).UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders.Despite the high latent selfrenewal and differentiation capacity of these cells,the safety,efficacy,and yield of MSCs expanded for ex vivo clinical applications remains a concern.However,immunomodulatory effects have emerged in various disease models,exhibiting specific mechanisms of action,such as cell migration and homing,angiogenesis,anti-apoptosis,proliferation,anti-cancer,anti-fibrosis,anti-inflammation and tissue regeneration.Herein,we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies,and discuss the concerns regarding the safety and mass production issues in future applications. 展开更多
关键词 Umbilical cord blood Mesenchymal stem cell Stem cell therapy IMMUNOMODULATION Regenerative medicine therapeutic cell manufacturing processing
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