Mode locking can be effectively achieved by using the thermo-optic effects in the whispering gallery mode(WGM)optical microcavity,without the help of external equipment.Therefore,it has the advantages of small size,lo...Mode locking can be effectively achieved by using the thermo-optic effects in the whispering gallery mode(WGM)optical microcavity,without the help of external equipment.Therefore,it has the advantages of small size,low integration costs,and self-locking,which shows great potential for application.However,the conventional single-channel microcavity thermal-locking method that relies solely on internal thermal balance will inevitably be disturbed by the external environment.This limitation affects the locking time and stability.Therefore,in this paper,we propose a new method for closed-loop thermal locking of a dual-channel microcavity.The thermal locking of the signal laser and the thermal regulation of the control laser are carried out respectively by synchronously drawing a dual-path tapered fiber.The theoretical model of the thermal dynamics of the dual-channel microcavity system is established,and the influence of the control-laser power on the thermal locking of the signal laser is confirmed.The deviation between the locking voltage of the signal laser and the set point value is used as a closed-loop feedback parameter to achieve long-term and highly stable mode locking of the signal laser.The results show that in the 2.63 h thermal-locking test,the locking stability is an order of magnitude higher than that of the single tapered fiber.This solution addresses the issue of thermal locking being disrupted by the external environment,and offers new possibilities for important applications such as spectroscopy and micro-optical sensor devices.展开更多
As Moore’s law approaching its end,electronics is hitting its power,bandwidth,and capacity limits.Photonics is able to overcome the performance limits of electronics but lacks practical photonic register and flexible...As Moore’s law approaching its end,electronics is hitting its power,bandwidth,and capacity limits.Photonics is able to overcome the performance limits of electronics but lacks practical photonic register and flexible control.Combining electronics and photonics provides the best of both worlds and is widely regarded as an important post-Moore’s direction.For stability and dynamic operations considerations,feedback tuning of photonic devices is required.For silicon photonics,the thermooptic effect is the most frequently used tuning mechanism due to the advantages of high efficiency and low loss.However,it brings new design requirements,creating new design challenges.Emerging applications,such as optical phased array,optical switches,and optical neural networks,employ a large number of photonic devices,making PCB tuning solutions no longer suitable.Electronic-photonic-converged solutions with compact footprints will play an important role in system scalability.In this paper,we present a unified model for thermo-optic feedback tuning that can be specialized to different applications,review its recent advances,and discuss its future trends.展开更多
A highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor based on a multi-pass cell(MPC)with dense spot pattern and a novel quartz tuning fork(QTF)with low resonance frequency is reported in this manu...A highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor based on a multi-pass cell(MPC)with dense spot pattern and a novel quartz tuning fork(QTF)with low resonance frequency is reported in this manuscript.An erbi-um-doped fiber amplifier(EDFA)was employed to amplify the output optical power so that the signal level was further enhanced.The optical path length(OPL)and the ratio of optical path length to volume(RLV)of the MPC is 37.7 m and 13.8 cm^(-2),respectively.A commercial QTF and a self-designed trapezoidal-tip QTF with low frequency of 9461.83 Hz were used as the detectors of the sensor,respectively.The target gas selected to test the performance of the system was acetylene(C2H2).When the optical power was constant at 1000 mW,the minimum detection limit(MDL)of the C2H2-LITES sensor can be achieved 48.3 ppb when using the commercial QTF and 24.6 ppb when using the trapezoid-al-tip QTF.An improvement of the detection performance by a factor of 1.96 was achieved after replacing the commer-cial QTF with the trapezoidal-tip QTF.展开更多
Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the pr...Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.展开更多
Radio frequency quadrupoles(RFQs),which are crucial components of proton injectors,significantly affect the performance of proton accelerator facilities.An RFQ with a high frequency of 714 MHz dedicated to compact pro...Radio frequency quadrupoles(RFQs),which are crucial components of proton injectors,significantly affect the performance of proton accelerator facilities.An RFQ with a high frequency of 714 MHz dedicated to compact proton injectors for medi-cal applications is designed in this study.The RFQ is designed to accelerate proton beams from 50 keV to 4 MeV within a short length of 2 m and can be matched closely with the downstream drift tube linac to capture more particles through a preliminary optimization.To develop an advanced RFQ,challenging techniques,including fabrication and tuning method,must be evaluated and verified using a prototype.An aluminium prototype is derived from the conceptual design of the RFQ and then redesigned to confirm the radio frequency performance,fabrication procedure,and feasibility of the tuning algorithm.Eventually,a new tuning algorithm based on the response matrix and least-squares method is developed,which yields favorable results based on the prototype,i.e.,the errors of the dipole and quadrupole components reduced to a low level after several tuning iterations.Benefiting from the conceptual design and techniques obtained from the prototype,the formal mechanical design of the 2-m RFQ is ready for the next manufacturing step.展开更多
With the rapid development of large megawatt wind turbines,the operation environment of wind turbine towers(WTTs)has become increasingly complex.In particular,seismic excitation can create a resonance response and cau...With the rapid development of large megawatt wind turbines,the operation environment of wind turbine towers(WTTs)has become increasingly complex.In particular,seismic excitation can create a resonance response and cause excessive vibration of the WTT.To investigate the vibration attenuation performance of the WTT under seismic excitations,a novel passive vibration control device,called a prestressed tuned mass damper(PS-TMD),is presented in this study.First,a mathematical model is established based on structural dynamics under seismic excitation.Then,the mathematical analytical expression of the dynamic coefficient is deduced,and the parameter design method is obtained by system tuning optimization.Next,based on a theoretical analysis and parameter design,the numerical results showed that the PS-TMD was able to effectively mitigate the resonance under the harmonic basal acceleration.Finally,the time-history analysis method is used to verify the effectiveness of the traditional pendulum tuned mass damper(PTMD)and the novel PS-TMD device,and the results indicate that the vibration attenuation performance of the PS-TMD is better than the PTMD.In addition,the PS-TMD avoids the nonlinear effect due to the large oscillation angle,and has the potential to dissipate hysteretic energy under seismic excitation.展开更多
In this paper,we introduce a novel Multi-scale and Auto-tuned Semi-supervised Deep Subspace Clustering(MAS-DSC)algorithm,aimed at addressing the challenges of deep subspace clustering in high-dimensional real-world da...In this paper,we introduce a novel Multi-scale and Auto-tuned Semi-supervised Deep Subspace Clustering(MAS-DSC)algorithm,aimed at addressing the challenges of deep subspace clustering in high-dimensional real-world data,particularly in the field of medical imaging.Traditional deep subspace clustering algorithms,which are mostly unsupervised,are limited in their ability to effectively utilize the inherent prior knowledge in medical images.Our MAS-DSC algorithm incorporates a semi-supervised learning framework that uses a small amount of labeled data to guide the clustering process,thereby enhancing the discriminative power of the feature representations.Additionally,the multi-scale feature extraction mechanism is designed to adapt to the complexity of medical imaging data,resulting in more accurate clustering performance.To address the difficulty of hyperparameter selection in deep subspace clustering,this paper employs a Bayesian optimization algorithm for adaptive tuning of hyperparameters related to subspace clustering,prior knowledge constraints,and model loss weights.Extensive experiments on standard clustering datasets,including ORL,Coil20,and Coil100,validate the effectiveness of the MAS-DSC algorithm.The results show that with its multi-scale network structure and Bayesian hyperparameter optimization,MAS-DSC achieves excellent clustering results on these datasets.Furthermore,tests on a brain tumor dataset demonstrate the robustness of the algorithm and its ability to leverage prior knowledge for efficient feature extraction and enhanced clustering performance within a semi-supervised learning framework.展开更多
In order to improve the seismic performance of adjacent buildings,two types of tuned inerter damper(TID)damping systems for adjacent buildings are proposed,which are composed of springs,inerter devices and dampers in ...In order to improve the seismic performance of adjacent buildings,two types of tuned inerter damper(TID)damping systems for adjacent buildings are proposed,which are composed of springs,inerter devices and dampers in serial or in parallel.The dynamic equations of TID adjacent building damping systems were derived,and the H2 norm criterion was used to optimize and adjust them,so that the system had the optimum damping performance under white noise random excitation.Taking TID frequency ratio and damping ratio as optimization parameters,the optimum analytical solutions of the displacement frequency response of the undamped structure under white noise excitation were obtained.The results showed that compared with the classic TMD,TID could obtain a better damping effect in the adjacent buildings.Comparing the TIDs composed of serial or parallel,it was found that the parallel TIDs had more significant advantages in controlling the peak displacement frequency response,while the H2 norm of the displacement frequency response of the damping system under the coupling of serial TID was smaller.Taking the adjacent building composed of two ten-story frame structures as an example,the displacement and energy collection time history analysis of the adjacent building coupled with the optimum design parameter TIDs were carried out.It was found that TID had a better damping effect in the full-time range compared with the classic TMD.This paper also studied the potential power of TID in adjacent buildings,which can be converted into available power resources during earthquakes.展开更多
Sentence classification is the process of categorizing a sentence based on the context of the sentence.Sentence categorization requires more semantic highlights than other tasks,such as dependence parsing,which requir...Sentence classification is the process of categorizing a sentence based on the context of the sentence.Sentence categorization requires more semantic highlights than other tasks,such as dependence parsing,which requires more syntactic elements.Most existing strategies focus on the general semantics of a conversation without involving the context of the sentence,recognizing the progress and comparing impacts.An ensemble pre-trained language model was taken up here to classify the conversation sentences from the conversation corpus.The conversational sentences are classified into four categories:information,question,directive,and commission.These classification label sequences are for analyzing the conversation progress and predicting the pecking order of the conversation.Ensemble of Bidirectional Encoder for Representation of Transformer(BERT),Robustly Optimized BERT pretraining Approach(RoBERTa),Generative Pre-Trained Transformer(GPT),DistilBERT and Generalized Autoregressive Pretraining for Language Understanding(XLNet)models are trained on conversation corpus with hyperparameters.Hyperparameter tuning approach is carried out for better performance on sentence classification.This Ensemble of Pre-trained Language Models with a Hyperparameter Tuning(EPLM-HT)system is trained on an annotated conversation dataset.The proposed approach outperformed compared to the base BERT,GPT,DistilBERT and XLNet transformer models.The proposed ensemble model with the fine-tuned parameters achieved an F1_score of 0.88.展开更多
As the realm of enterprise-level conversational AI continues to evolve, it becomes evident that while generalized Large Language Models (LLMs) like GPT-3.5 bring remarkable capabilities, they also bring forth formidab...As the realm of enterprise-level conversational AI continues to evolve, it becomes evident that while generalized Large Language Models (LLMs) like GPT-3.5 bring remarkable capabilities, they also bring forth formidable challenges. These models, honed on vast and diverse datasets, have undoubtedly pushed the boundaries of natural language understanding and generation. However, they often stumble when faced with the intricate demands of nuanced enterprise applications. This research advocates for a strategic paradigm shift, urging enterprises to embrace a fine-tuning approach as a means to optimize conversational AI. While generalized LLMs are linguistic marvels, their inability to cater to the specific needs of businesses across various industries poses a critical challenge. This strategic shift involves empowering enterprises to seamlessly integrate their own datasets into LLMs, a process that extends beyond linguistic enhancement. The core concept of this approach centers on customization, enabling businesses to fine-tune the AI’s functionality to fit precisely within their unique business landscapes. By immersing the LLM in industry-specific documents, customer interaction records, internal reports, and regulatory guidelines, the AI transcends its generic capabilities to become a sophisticated conversational partner aligned with the intricacies of the enterprise’s domain. The transformative potential of this fine-tuning approach cannot be overstated. It enables a transition from a universal AI solution to a highly customizable tool. The AI evolves from being a linguistic powerhouse to a contextually aware, industry-savvy assistant. As a result, it not only responds with linguistic accuracy but also with depth, relevance, and resonance, significantly elevating user experiences and operational efficiency. In the subsequent sections, this paper delves into the intricacies of fine-tuning, exploring the multifaceted challenges and abundant opportunities it presents. It addresses the technical intricacies of data integration, ethical considerations surrounding data usage, and the broader implications for the future of enterprise AI. The journey embarked upon in this research holds the potential to redefine the role of conversational AI in enterprises, ushering in an era where AI becomes a dynamic, deeply relevant, and highly effective tool, empowering businesses to excel in an ever-evolving digital landscape.展开更多
We present a 1 × 4 Y-branch digital optical switch in which S-bend variable optical attenuators are integrated. The S-bend waveguides, which are always introduced to connect the switch and the standard fiber arra...We present a 1 × 4 Y-branch digital optical switch in which S-bend variable optical attenuators are integrated. The S-bend waveguides, which are always introduced to connect the switch and the standard fiber array, are made use of and designed as variable optical attenuators. A compact device with low crosstalk and larger branching-angle is obtained. The device is fabricated on the thermo-optic polymer materials,and the performance of the device is measured. With an applied driving power of less than 200mW, the device has a low crosstalk of less than - 35dB at a wavelength of 1.55 μm.展开更多
A 1.55μm Fabry-Perot (F-P) thermo-optical t unable filter is fabricated.The cavity is made of amorphous silicon (a-Si) layer grown by electron-beam evaporation technique.Due to the excellent thermo-optical property o...A 1.55μm Fabry-Perot (F-P) thermo-optical t unable filter is fabricated.The cavity is made of amorphous silicon (a-Si) layer grown by electron-beam evaporation technique.Due to the excellent thermo-optical property of a-Si,the refractive index of the F-P cavity will be changed by heating;the transmittance resonant peak will therefore shift substantially.The measured tuning rang is 12nm, FWHM (full-width-at-half-maximum) of the transmissi on peak is 9nm,and heating efficiency is 0.1K/mW.The large FWHM is mainly due to th e non-ideal coating deposition and mirror undulation.Possible improvements to increase the efficiency of heating are suggested.展开更多
High-rise buildings are usually considered as flexible structures with low inherent damping. Therefore, these kinds of buildings are susceptible to wind-induced vibration. Tuned Mass Damper(TMD) can be used as an ef...High-rise buildings are usually considered as flexible structures with low inherent damping. Therefore, these kinds of buildings are susceptible to wind-induced vibration. Tuned Mass Damper(TMD) can be used as an effective device to mitigate excessive vibrations. In this study, Artificial Neural Networks is used to find optimal mechanical properties of TMD for high-rise buildings subjected to wind load. The patterns obtained from structural analysis of different multi degree of freedom(MDF) systems are used for training neural networks. In order to obtain these patterns, structural models of some systems with 10 to 80 degrees-of-freedoms are built in MATLAB/SIMULINK program. Finally, the optimal properties of TMD are determined based on the objective of maximum displacement response reduction. The Auto-Regressive model is used to simulate the wind load. In this way, the uncertainties related to wind loading can be taken into account in neural network’s outputs. After training the neural network, it becomes possible to set the frequency and TMD mass ratio as inputs and get the optimal TMD frequency and damping ratio as outputs. As a case study, a benchmark 76-story office building is considered and the presented procedure is used to obtain optimal characteristics of the TMD for the building.展开更多
超高层建筑是现代城市建设的重要标志之一,其高度已经超过了传统建筑的极限。然而,随着建筑高度不断增加,地震的破坏力也越来越强,超高层建筑面临着更加严峻的安全挑战。因此,研究超高层建筑防震支撑系统技术非常重要,Tuned Mass Damper...超高层建筑是现代城市建设的重要标志之一,其高度已经超过了传统建筑的极限。然而,随着建筑高度不断增加,地震的破坏力也越来越强,超高层建筑面临着更加严峻的安全挑战。因此,研究超高层建筑防震支撑系统技术非常重要,Tuned Mass Damper(TMD)是一种被广泛研究和应用的超高层建筑防震支撑系统技术,TMD最初是在20世纪60年代提出的,最早应用于桥梁上,后来,TMD被引入到建筑领域,并得到广泛的应用。通过精确调节质量、阻尼和弹性等参数来削弱地震引起的建筑物减震效应,从而减少了建筑物因地震造成的损害和崩塌的风险.展开更多
In this paper, we designed a thermo-optic variable optical attenuator (VOA) based on quartz substrate, which consists of a Mach-Zehnder interferometer (MZI) and a thin film heater above the phase-modulation arm. The t...In this paper, we designed a thermo-optic variable optical attenuator (VOA) based on quartz substrate, which consists of a Mach-Zehnder interferometer (MZI) and a thin film heater above the phase-modulation arm. The transmission properties of the waveguide and attenuation characteristics of the device have been simulated by beam propagation method (BPM), and the simulated results illustrated that the designed VOA had good performance.展开更多
Since 2019,the coronavirus disease-19(COVID-19)has been spreading rapidly worldwide,posing an unignorable threat to the global economy and human health.It is a disease caused by severe acute respiratory syndrome coron...Since 2019,the coronavirus disease-19(COVID-19)has been spreading rapidly worldwide,posing an unignorable threat to the global economy and human health.It is a disease caused by severe acute respiratory syndrome coronavirus 2,a single-stranded RNA virus of the genus Betacoronavirus.This virus is highly infectious and relies on its angiotensin-converting enzyme 2-receptor to enter cells.With the increase in the number of confirmed COVID-19 diagnoses,the difficulty of diagnosis due to the lack of global healthcare resources becomes increasingly apparent.Deep learning-based computer-aided diagnosis models with high generalisability can effectively alleviate this pressure.Hyperparameter tuning is essential in training such models and significantly impacts their final performance and training speed.However,traditional hyperparameter tuning methods are usually time-consuming and unstable.To solve this issue,we introduce Particle Swarm Optimisation to build a PSO-guided Self-Tuning Convolution Neural Network(PSTCNN),allowing the model to tune hyperparameters automatically.Therefore,the proposed approach can reduce human involvement.Also,the optimisation algorithm can select the combination of hyperparameters in a targeted manner,thus stably achieving a solution closer to the global optimum.Experimentally,the PSTCNN can obtain quite excellent results,with a sensitivity of 93.65%±1.86%,a specificity of 94.32%±2.07%,a precision of 94.30%±2.04%,an accuracy of 93.99%±1.78%,an F1-score of 93.97%±1.78%,Matthews Correlation Coefficient of 87.99%±3.56%,and Fowlkes-Mallows Index of 93.97%±1.78%.Our experiments demonstrate that compared to traditional methods,hyperparameter tuning of the model using an optimisation algorithm is faster and more effective.展开更多
In the last years,axonal conductance of action potential trains became a novel subject of study,changing the view of axons,from a static cable-like compartment to a more complex and dynamic system(Debanne et al.,2011)...In the last years,axonal conductance of action potential trains became a novel subject of study,changing the view of axons,from a static cable-like compartment to a more complex and dynamic system(Debanne et al.,2011).Axonal computation,indeed,is canonically constituted by the action of voltage-gated ion channels,such as the classic Na+and K+channels,but recent studies demonstrated that it can be modulated by the action of other ion channel pumps,and metabolic factors(Byczkowicz et al.,2019;Zang and Marder.展开更多
This paper reports that the thermo-optic coefficient (dn/dT) as well as thermal expansion coefficients (β) of DR1/PMMA polymer film are measured for both TE (transversal electric) and TM (transversal magnetic...This paper reports that the thermo-optic coefficient (dn/dT) as well as thermal expansion coefficients (β) of DR1/PMMA polymer film are measured for both TE (transversal electric) and TM (transversal magnetic) polarizations by using an attenuated total reflection configuration at the wavelengths of 832nm. The thermo-optic coefficients of DR1/PMMA are negative and as high as the order of 10^-4/℃. The influences of dopant concentration, poling process and photobleaching process on the thermo-optic properties of DR1/PMMA are also investigated.展开更多
基金Project supported by the National Key Research and Development Program of China(Grant No.2022YFB3203400)the National Natural Science Foundation of China(Grant Nos.U21A20141,62273314,and 51821003)+1 种基金the Fundamental Research Program of Shanxi Province(Grant No.202303021223001)Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement(Grant No.201905D121001)。
文摘Mode locking can be effectively achieved by using the thermo-optic effects in the whispering gallery mode(WGM)optical microcavity,without the help of external equipment.Therefore,it has the advantages of small size,low integration costs,and self-locking,which shows great potential for application.However,the conventional single-channel microcavity thermal-locking method that relies solely on internal thermal balance will inevitably be disturbed by the external environment.This limitation affects the locking time and stability.Therefore,in this paper,we propose a new method for closed-loop thermal locking of a dual-channel microcavity.The thermal locking of the signal laser and the thermal regulation of the control laser are carried out respectively by synchronously drawing a dual-path tapered fiber.The theoretical model of the thermal dynamics of the dual-channel microcavity system is established,and the influence of the control-laser power on the thermal locking of the signal laser is confirmed.The deviation between the locking voltage of the signal laser and the set point value is used as a closed-loop feedback parameter to achieve long-term and highly stable mode locking of the signal laser.The results show that in the 2.63 h thermal-locking test,the locking stability is an order of magnitude higher than that of the single tapered fiber.This solution addresses the issue of thermal locking being disrupted by the external environment,and offers new possibilities for important applications such as spectroscopy and micro-optical sensor devices.
基金This work was supported by the National Key Research and Development Program of China(No.2018YFA0704400).
文摘As Moore’s law approaching its end,electronics is hitting its power,bandwidth,and capacity limits.Photonics is able to overcome the performance limits of electronics but lacks practical photonic register and flexible control.Combining electronics and photonics provides the best of both worlds and is widely regarded as an important post-Moore’s direction.For stability and dynamic operations considerations,feedback tuning of photonic devices is required.For silicon photonics,the thermooptic effect is the most frequently used tuning mechanism due to the advantages of high efficiency and low loss.However,it brings new design requirements,creating new design challenges.Emerging applications,such as optical phased array,optical switches,and optical neural networks,employ a large number of photonic devices,making PCB tuning solutions no longer suitable.Electronic-photonic-converged solutions with compact footprints will play an important role in system scalability.In this paper,we present a unified model for thermo-optic feedback tuning that can be specialized to different applications,review its recent advances,and discuss its future trends.
基金National Natural Science Foundation of China(Grant Nos.62335006,62022032,62275065,and 61875047)Key Laboratory of Opto-Electronic Information Acquisition and Manipulation(Anhui University),Ministry of Education(Grant No.OEIAM202202)Fundamental Research Funds for the Central Universities(Grant No.HIT.OCEF.2023011).
文摘A highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor based on a multi-pass cell(MPC)with dense spot pattern and a novel quartz tuning fork(QTF)with low resonance frequency is reported in this manuscript.An erbi-um-doped fiber amplifier(EDFA)was employed to amplify the output optical power so that the signal level was further enhanced.The optical path length(OPL)and the ratio of optical path length to volume(RLV)of the MPC is 37.7 m and 13.8 cm^(-2),respectively.A commercial QTF and a self-designed trapezoidal-tip QTF with low frequency of 9461.83 Hz were used as the detectors of the sensor,respectively.The target gas selected to test the performance of the system was acetylene(C2H2).When the optical power was constant at 1000 mW,the minimum detection limit(MDL)of the C2H2-LITES sensor can be achieved 48.3 ppb when using the commercial QTF and 24.6 ppb when using the trapezoid-al-tip QTF.An improvement of the detection performance by a factor of 1.96 was achieved after replacing the commer-cial QTF with the trapezoidal-tip QTF.
基金supported by the STI 2030-Major Projects 2022ZD0208500(to DY)the National Natural Science Foundation of China,Nos.82072011(to YX),82121003(to DY),82271120(to YS)+2 种基金Sichuan Science and Technology Program,No.2022ZYD0066(to YS)a grant from Chinese Academy of Medical Science,No.2019-12M-5-032(to YS)the Fundamental Research Funds for the Central Universities,No.ZYGX2021YGLH219(to KC)。
文摘Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.
基金This work was supported by National Natural Science Foundation of China(No.12222513).
文摘Radio frequency quadrupoles(RFQs),which are crucial components of proton injectors,significantly affect the performance of proton accelerator facilities.An RFQ with a high frequency of 714 MHz dedicated to compact proton injectors for medi-cal applications is designed in this study.The RFQ is designed to accelerate proton beams from 50 keV to 4 MeV within a short length of 2 m and can be matched closely with the downstream drift tube linac to capture more particles through a preliminary optimization.To develop an advanced RFQ,challenging techniques,including fabrication and tuning method,must be evaluated and verified using a prototype.An aluminium prototype is derived from the conceptual design of the RFQ and then redesigned to confirm the radio frequency performance,fabrication procedure,and feasibility of the tuning algorithm.Eventually,a new tuning algorithm based on the response matrix and least-squares method is developed,which yields favorable results based on the prototype,i.e.,the errors of the dipole and quadrupole components reduced to a low level after several tuning iterations.Benefiting from the conceptual design and techniques obtained from the prototype,the formal mechanical design of the 2-m RFQ is ready for the next manufacturing step.
基金Fundamental Research Funds for the National Natural Science Foundation of China under Grant No.52078084the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0623)+2 种基金the 111 project of the Ministry of Educationthe Bureau of Foreign Experts of China under Grant No.B18062China Postdoctoral Science Foundation under Grant No.2021M690838。
文摘With the rapid development of large megawatt wind turbines,the operation environment of wind turbine towers(WTTs)has become increasingly complex.In particular,seismic excitation can create a resonance response and cause excessive vibration of the WTT.To investigate the vibration attenuation performance of the WTT under seismic excitations,a novel passive vibration control device,called a prestressed tuned mass damper(PS-TMD),is presented in this study.First,a mathematical model is established based on structural dynamics under seismic excitation.Then,the mathematical analytical expression of the dynamic coefficient is deduced,and the parameter design method is obtained by system tuning optimization.Next,based on a theoretical analysis and parameter design,the numerical results showed that the PS-TMD was able to effectively mitigate the resonance under the harmonic basal acceleration.Finally,the time-history analysis method is used to verify the effectiveness of the traditional pendulum tuned mass damper(PTMD)and the novel PS-TMD device,and the results indicate that the vibration attenuation performance of the PS-TMD is better than the PTMD.In addition,the PS-TMD avoids the nonlinear effect due to the large oscillation angle,and has the potential to dissipate hysteretic energy under seismic excitation.
基金supported in part by the National Natural Science Foundation of China under Grant 62171203in part by the Jiangsu Province“333 Project”High-Level Talent Cultivation Subsidized Project+2 种基金in part by the SuzhouKey Supporting Subjects for Health Informatics under Grant SZFCXK202147in part by the Changshu Science and Technology Program under Grants CS202015 and CS202246in part by Changshu Key Laboratory of Medical Artificial Intelligence and Big Data under Grants CYZ202301 and CS202314.
文摘In this paper,we introduce a novel Multi-scale and Auto-tuned Semi-supervised Deep Subspace Clustering(MAS-DSC)algorithm,aimed at addressing the challenges of deep subspace clustering in high-dimensional real-world data,particularly in the field of medical imaging.Traditional deep subspace clustering algorithms,which are mostly unsupervised,are limited in their ability to effectively utilize the inherent prior knowledge in medical images.Our MAS-DSC algorithm incorporates a semi-supervised learning framework that uses a small amount of labeled data to guide the clustering process,thereby enhancing the discriminative power of the feature representations.Additionally,the multi-scale feature extraction mechanism is designed to adapt to the complexity of medical imaging data,resulting in more accurate clustering performance.To address the difficulty of hyperparameter selection in deep subspace clustering,this paper employs a Bayesian optimization algorithm for adaptive tuning of hyperparameters related to subspace clustering,prior knowledge constraints,and model loss weights.Extensive experiments on standard clustering datasets,including ORL,Coil20,and Coil100,validate the effectiveness of the MAS-DSC algorithm.The results show that with its multi-scale network structure and Bayesian hyperparameter optimization,MAS-DSC achieves excellent clustering results on these datasets.Furthermore,tests on a brain tumor dataset demonstrate the robustness of the algorithm and its ability to leverage prior knowledge for efficient feature extraction and enhanced clustering performance within a semi-supervised learning framework.
基金This research was funded by the Natural Science Research Project of Higher Education Institutions in Anhui Province(Grant No.2022AH040045)the Anhui Provincial Natural Science Foundation(Grant No.2008085QE245)the Project of Science and Technology Plan of Department of Housing and Urban-Rural Development of Anhui Province(Grant No.2021-YF22).
文摘In order to improve the seismic performance of adjacent buildings,two types of tuned inerter damper(TID)damping systems for adjacent buildings are proposed,which are composed of springs,inerter devices and dampers in serial or in parallel.The dynamic equations of TID adjacent building damping systems were derived,and the H2 norm criterion was used to optimize and adjust them,so that the system had the optimum damping performance under white noise random excitation.Taking TID frequency ratio and damping ratio as optimization parameters,the optimum analytical solutions of the displacement frequency response of the undamped structure under white noise excitation were obtained.The results showed that compared with the classic TMD,TID could obtain a better damping effect in the adjacent buildings.Comparing the TIDs composed of serial or parallel,it was found that the parallel TIDs had more significant advantages in controlling the peak displacement frequency response,while the H2 norm of the displacement frequency response of the damping system under the coupling of serial TID was smaller.Taking the adjacent building composed of two ten-story frame structures as an example,the displacement and energy collection time history analysis of the adjacent building coupled with the optimum design parameter TIDs were carried out.It was found that TID had a better damping effect in the full-time range compared with the classic TMD.This paper also studied the potential power of TID in adjacent buildings,which can be converted into available power resources during earthquakes.
文摘Sentence classification is the process of categorizing a sentence based on the context of the sentence.Sentence categorization requires more semantic highlights than other tasks,such as dependence parsing,which requires more syntactic elements.Most existing strategies focus on the general semantics of a conversation without involving the context of the sentence,recognizing the progress and comparing impacts.An ensemble pre-trained language model was taken up here to classify the conversation sentences from the conversation corpus.The conversational sentences are classified into four categories:information,question,directive,and commission.These classification label sequences are for analyzing the conversation progress and predicting the pecking order of the conversation.Ensemble of Bidirectional Encoder for Representation of Transformer(BERT),Robustly Optimized BERT pretraining Approach(RoBERTa),Generative Pre-Trained Transformer(GPT),DistilBERT and Generalized Autoregressive Pretraining for Language Understanding(XLNet)models are trained on conversation corpus with hyperparameters.Hyperparameter tuning approach is carried out for better performance on sentence classification.This Ensemble of Pre-trained Language Models with a Hyperparameter Tuning(EPLM-HT)system is trained on an annotated conversation dataset.The proposed approach outperformed compared to the base BERT,GPT,DistilBERT and XLNet transformer models.The proposed ensemble model with the fine-tuned parameters achieved an F1_score of 0.88.
文摘As the realm of enterprise-level conversational AI continues to evolve, it becomes evident that while generalized Large Language Models (LLMs) like GPT-3.5 bring remarkable capabilities, they also bring forth formidable challenges. These models, honed on vast and diverse datasets, have undoubtedly pushed the boundaries of natural language understanding and generation. However, they often stumble when faced with the intricate demands of nuanced enterprise applications. This research advocates for a strategic paradigm shift, urging enterprises to embrace a fine-tuning approach as a means to optimize conversational AI. While generalized LLMs are linguistic marvels, their inability to cater to the specific needs of businesses across various industries poses a critical challenge. This strategic shift involves empowering enterprises to seamlessly integrate their own datasets into LLMs, a process that extends beyond linguistic enhancement. The core concept of this approach centers on customization, enabling businesses to fine-tune the AI’s functionality to fit precisely within their unique business landscapes. By immersing the LLM in industry-specific documents, customer interaction records, internal reports, and regulatory guidelines, the AI transcends its generic capabilities to become a sophisticated conversational partner aligned with the intricacies of the enterprise’s domain. The transformative potential of this fine-tuning approach cannot be overstated. It enables a transition from a universal AI solution to a highly customizable tool. The AI evolves from being a linguistic powerhouse to a contextually aware, industry-savvy assistant. As a result, it not only responds with linguistic accuracy but also with depth, relevance, and resonance, significantly elevating user experiences and operational efficiency. In the subsequent sections, this paper delves into the intricacies of fine-tuning, exploring the multifaceted challenges and abundant opportunities it presents. It addresses the technical intricacies of data integration, ethical considerations surrounding data usage, and the broader implications for the future of enterprise AI. The journey embarked upon in this research holds the potential to redefine the role of conversational AI in enterprises, ushering in an era where AI becomes a dynamic, deeply relevant, and highly effective tool, empowering businesses to excel in an ever-evolving digital landscape.
文摘We present a 1 × 4 Y-branch digital optical switch in which S-bend variable optical attenuators are integrated. The S-bend waveguides, which are always introduced to connect the switch and the standard fiber array, are made use of and designed as variable optical attenuators. A compact device with low crosstalk and larger branching-angle is obtained. The device is fabricated on the thermo-optic polymer materials,and the performance of the device is measured. With an applied driving power of less than 200mW, the device has a low crosstalk of less than - 35dB at a wavelength of 1.55 μm.
文摘A 1.55μm Fabry-Perot (F-P) thermo-optical t unable filter is fabricated.The cavity is made of amorphous silicon (a-Si) layer grown by electron-beam evaporation technique.Due to the excellent thermo-optical property of a-Si,the refractive index of the F-P cavity will be changed by heating;the transmittance resonant peak will therefore shift substantially.The measured tuning rang is 12nm, FWHM (full-width-at-half-maximum) of the transmissi on peak is 9nm,and heating efficiency is 0.1K/mW.The large FWHM is mainly due to th e non-ideal coating deposition and mirror undulation.Possible improvements to increase the efficiency of heating are suggested.
文摘High-rise buildings are usually considered as flexible structures with low inherent damping. Therefore, these kinds of buildings are susceptible to wind-induced vibration. Tuned Mass Damper(TMD) can be used as an effective device to mitigate excessive vibrations. In this study, Artificial Neural Networks is used to find optimal mechanical properties of TMD for high-rise buildings subjected to wind load. The patterns obtained from structural analysis of different multi degree of freedom(MDF) systems are used for training neural networks. In order to obtain these patterns, structural models of some systems with 10 to 80 degrees-of-freedoms are built in MATLAB/SIMULINK program. Finally, the optimal properties of TMD are determined based on the objective of maximum displacement response reduction. The Auto-Regressive model is used to simulate the wind load. In this way, the uncertainties related to wind loading can be taken into account in neural network’s outputs. After training the neural network, it becomes possible to set the frequency and TMD mass ratio as inputs and get the optimal TMD frequency and damping ratio as outputs. As a case study, a benchmark 76-story office building is considered and the presented procedure is used to obtain optimal characteristics of the TMD for the building.
文摘超高层建筑是现代城市建设的重要标志之一,其高度已经超过了传统建筑的极限。然而,随着建筑高度不断增加,地震的破坏力也越来越强,超高层建筑面临着更加严峻的安全挑战。因此,研究超高层建筑防震支撑系统技术非常重要,Tuned Mass Damper(TMD)是一种被广泛研究和应用的超高层建筑防震支撑系统技术,TMD最初是在20世纪60年代提出的,最早应用于桥梁上,后来,TMD被引入到建筑领域,并得到广泛的应用。通过精确调节质量、阻尼和弹性等参数来削弱地震引起的建筑物减震效应,从而减少了建筑物因地震造成的损害和崩塌的风险.
文摘In this paper, we designed a thermo-optic variable optical attenuator (VOA) based on quartz substrate, which consists of a Mach-Zehnder interferometer (MZI) and a thin film heater above the phase-modulation arm. The transmission properties of the waveguide and attenuation characteristics of the device have been simulated by beam propagation method (BPM), and the simulated results illustrated that the designed VOA had good performance.
基金partially supported by the Medical Research Council Confidence in Concept Award,UK(MC_PC_17171)Royal Society International Exchanges Cost Share Award,UK(RP202G0230)+6 种基金British Heart Foundation Accelerator Award,UK(AA\18\3\34220)Hope Foundation for Cancer Research,UK(RM60G0680)Global Challenges Research Fund(GCRF),UK(P202PF11)Sino-UK Industrial Fund,UK(RP202G0289)LIAS Pioneering Partnerships Award,UK(P202ED10)Data Science Enhancement Fund,UK(P202RE237)Guangxi Key Laboratory of Trusted Software,CN(kx201901).
文摘Since 2019,the coronavirus disease-19(COVID-19)has been spreading rapidly worldwide,posing an unignorable threat to the global economy and human health.It is a disease caused by severe acute respiratory syndrome coronavirus 2,a single-stranded RNA virus of the genus Betacoronavirus.This virus is highly infectious and relies on its angiotensin-converting enzyme 2-receptor to enter cells.With the increase in the number of confirmed COVID-19 diagnoses,the difficulty of diagnosis due to the lack of global healthcare resources becomes increasingly apparent.Deep learning-based computer-aided diagnosis models with high generalisability can effectively alleviate this pressure.Hyperparameter tuning is essential in training such models and significantly impacts their final performance and training speed.However,traditional hyperparameter tuning methods are usually time-consuming and unstable.To solve this issue,we introduce Particle Swarm Optimisation to build a PSO-guided Self-Tuning Convolution Neural Network(PSTCNN),allowing the model to tune hyperparameters automatically.Therefore,the proposed approach can reduce human involvement.Also,the optimisation algorithm can select the combination of hyperparameters in a targeted manner,thus stably achieving a solution closer to the global optimum.Experimentally,the PSTCNN can obtain quite excellent results,with a sensitivity of 93.65%±1.86%,a specificity of 94.32%±2.07%,a precision of 94.30%±2.04%,an accuracy of 93.99%±1.78%,an F1-score of 93.97%±1.78%,Matthews Correlation Coefficient of 87.99%±3.56%,and Fowlkes-Mallows Index of 93.97%±1.78%.Our experiments demonstrate that compared to traditional methods,hyperparameter tuning of the model using an optimisation algorithm is faster and more effective.
文摘In the last years,axonal conductance of action potential trains became a novel subject of study,changing the view of axons,from a static cable-like compartment to a more complex and dynamic system(Debanne et al.,2011).Axonal computation,indeed,is canonically constituted by the action of voltage-gated ion channels,such as the classic Na+and K+channels,but recent studies demonstrated that it can be modulated by the action of other ion channel pumps,and metabolic factors(Byczkowicz et al.,2019;Zang and Marder.
基金Project supported by the National Science Foundation of China (Grant No 60237010) and Exploring Foundation of National High-Tech ICF Committee of China (Grant No 2003AA84tslT).
文摘This paper reports that the thermo-optic coefficient (dn/dT) as well as thermal expansion coefficients (β) of DR1/PMMA polymer film are measured for both TE (transversal electric) and TM (transversal magnetic) polarizations by using an attenuated total reflection configuration at the wavelengths of 832nm. The thermo-optic coefficients of DR1/PMMA are negative and as high as the order of 10^-4/℃. The influences of dopant concentration, poling process and photobleaching process on the thermo-optic properties of DR1/PMMA are also investigated.