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Synthesis of New Thiazine and Thiosemicarbazone Derivatives from D-Xylose
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作者 Xiao Ming JI He Ping SUN Hai Wei XU Hong Min LIU 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第12期1563-1565,共3页
1,2-O-Isopropylidene-5-O-p-toluenesulfonyl-α-D-erythro-pentofuranos-3-ulose 1 was treated with thiourea and aminothiourea to give a D-ribose derivative 2 bearing a 2-amino 1,3-thiazine ring and a thiosemicarbazone de... 1,2-O-Isopropylidene-5-O-p-toluenesulfonyl-α-D-erythro-pentofuranos-3-ulose 1 was treated with thiourea and aminothiourea to give a D-ribose derivative 2 bearing a 2-amino 1,3-thiazine ring and a thiosemicarbazone derivative 5, respectively. 2 was acylated with Ac20 and propandioic acid to afford two acylation derivatives 3 and 4, respectively. Reduction of 5 with NaBH4 in methanol produced a hydrothiosemicarbazone derivative 6. The absolute configuration of 2 was confirmed by X-ray crystallographic analysis. The structures of all products were elucidated by IR, NMR and HRMS spectra. 展开更多
关键词 THIOUREA aminothiourea thiazine D-XYLOSE synthesis.
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Crystal Structure and Conformation of an 2-Amino-1,3-thiazine Derivative
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作者 赵铭钦 邵惠芳 姬小明 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2008年第10期1240-1244,共5页
Thiazine sugar derivative 2 was synthesized and characterized by IR, NMR and H RMS, and its crystal structure was determined by X-ray diffraction analysis. The crystal is of monoclinic system (C16H24N2O8S2, Mr = 436... Thiazine sugar derivative 2 was synthesized and characterized by IR, NMR and H RMS, and its crystal structure was determined by X-ray diffraction analysis. The crystal is of monoclinic system (C16H24N2O8S2, Mr = 436.49) with space group P21, a = 10.311(2), b = 9.1198(18), c = 11.623(2)A, β = 109.47(3)°, V= 1030.4(4)A^3, Z= 2, Dc = 1.407 g/cm^3, F(000)= 460, μ= 0.303 mm^-1, the final R = 0.0437 and wR = 0.0561 for 1954 observed reflections (I 〉 2σ(I)). Nine hydrogen bonds were found. The absolute configuration of this molecule was confirmed by comparison with the original material. 展开更多
关键词 thiazine SUGAR synthesis X-ray crystallographic analysis
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Synthesis and Antitumor Activity of the Thiazoline and Thiazine Multithioether
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作者 Wei Wang Bing Zhao +1 位作者 Chao Xu Wenpeng Wu 《International Journal of Organic Chemistry》 2012年第2期117-120,共4页
A series of novel multithioether derivatives were synthesized by the combination of thiazoline and thiazine with dibro- mides and their structures were characterized by IR, 1H NMR, MS and elemental analysis. The synth... A series of novel multithioether derivatives were synthesized by the combination of thiazoline and thiazine with dibro- mides and their structures were characterized by IR, 1H NMR, MS and elemental analysis. The synthesized derivatives were tested for antitumor activity. 展开更多
关键词 THIAZOLINE thiazine Multithioether SYNTHESIS ANTITUMOR Activity
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A facile one-pot synthesis of functionalized thiazines in water 被引量:1
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作者 Faramarz Rostami-Charati Zinatossadat Hossaini +1 位作者 Masoumeh Moghimi Elaheh Kowsari 《Chinese Chemical Letters》 SCIE CAS CSCD 2012年第9期1007-1010,共4页
An efficient synthesis of thiazines from the three component reactions between dialkyl acetylenedicarboxylates, arylisothio- cyanates and N-nucleophiles at room temperature in water as the solvent is described.
关键词 One-pot reactions thiazineS Arylisothiocyanates Dialkyl acetylenedicarboxylates
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The Metabolism of Methylene Blue and Its Derivatives in Japanese Eel(Anguilla Japonica) 被引量:1
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作者 WANG Yali HUANG Xuanyun +4 位作者 DU Bingtan LV Xinmei SUN Jing ZHENG Ruizhou HU Kun 《Journal of Ocean University of China》 SCIE CAS CSCD 2020年第3期653-658,共6页
Methylene blue(MB) is commonly used in aquaculture as a fungicide and antidotes. This study was designed to explore the pharmacokinetics of MB in Japanese eel(Anguilla Japonica) immersed in 10 mg L^-1 and 20 mg L^-1 M... Methylene blue(MB) is commonly used in aquaculture as a fungicide and antidotes. This study was designed to explore the pharmacokinetics of MB in Japanese eel(Anguilla Japonica) immersed in 10 mg L^-1 and 20 mg L^-1 MB for 0.5 h. The concentrations of MB and its derivatives in the blood, liver, kidney, skin and muscle were determined by HPLC after immersion. The results showed that the changes of drug concentrations in Japanese eel were basically the same in different dose groups, showing a general trend of increasing at first and then decreasing, but the peak time was slightly different. The peak concentration of the drug was positively correlated with the dose level. The peak concentrations of MB in MB(20 mg L^-1) group, MB, azure A and azure B in the tissues of Japanese eel were significantly higher than those in MB(10 mg L^-1) group. Moreover, MB, azure A and azure B remained for a long time and could still be detected at 64 days, and azure C was not detected in tissues. 展开更多
关键词 methylene blue Anguilla japonica thiazine dye AQUACULTURE
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