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Thick-skinned Contractional Salt Structures in the Kuqa Depression,the Northern Tarim Basin:Constraints from Physical Experiments 被引量:16
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作者 YU Yixin TANG Liangjie +3 位作者 YANG Wenjing JIN Wenzheng PENG Gengxin LEI Ganglin 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2008年第2期327-333,共7页
Thick-skinned contractional salt structures are widely developed in the western Kuqa depression, northern Tarim basin. To understand the mechanisms that govern the development of these structures, physical experiments... Thick-skinned contractional salt structures are widely developed in the western Kuqa depression, northern Tarim basin. To understand the mechanisms that govern the development of these structures, physical experiments are conducted and the results show that they are largely governed by the activities of basement faults and the forming of paleo-uplifts and basement slopes. The model materials in this study are dry sand, vaseline and plasticene (or hard foam), simulating the suprasalt, salt, and subsalt layers respectively. The experiments show that, due to the activities of basement faults and the forming of the paleo-uplifts, salt bodies usually accumulate and thicken significantly on the middle top of the paleo-uplifts which are constrained by the pre-exiting boundary faults. The development of large-scale thrust faults and salt nappes is favored by the basement slops with larger dips. The experiments also conclude that differential structural deformation could occur between the subsalt and suprasalt layers because of the presence of salt layers. Their geometries and the locations of structural highs are different, despite of the great similarities in the uplifted areas. The pierced salt diapir is not observed in the experiments, which indicates that the contractional shortening does not effectively accelerate the development of the salt diapir. 展开更多
关键词 thick-skinned contraction basement structures salt structures physical modeling Kuqa depression
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Relationship between skin fold thickness and insulin resistance in the essential hypertensive patients in Vietnam 被引量:4
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作者 Toan C Nguyen Khoa TA Pham +3 位作者 Quyen TL Do Cuong T Nguyen Diep D Nguyen Vinh G Le Cong D Nguyen 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2005年第4期228-232,共5页
Background Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thic... Background Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thickness and insulin resistance then developed a formula to estimate the insulin resistance index according to the skin fold thickness in the essential hypertensive patients. Subjects and Methods Medical records of 80 patients (37 males, 43 females) were reviewed and the data were tabulated. Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0 ?9.2 years. The insulin resistance index was calculated following the Homeostasis Model Assessment (HOMA) formula. Results Compared with the group with BMI < 23 kg/m2, the group with BMI≥23 kg/m2 had higher fasting insulin concentration (8.85±4.97 pmol/L vs 15.60±8.70 pmol/L, P<0.001 ) and higher insulin resistance index in ( 2.15±1,24 vs 3.76±2.22, P<0.001). No significant difference in fasting plasma insulin concentration, insulin resistance index between male and female was observed (P > 0.05). There was a positive correlation between skin fold thickness and the fasting insulin concentration and insulin resistance index. The skin fold thickness at point A8 had the best coefficient correlated with fasting plasma insulin(r=0.79, P < 0.001) and insulin resistance index (r= 0.79, P < 0.001). A formula to estimate the insulin resistance index by skin fold thickness at point A8 as: Insulin resistance index = 0.12×[skin fold thickness at A8 point (mm)] - 1. Conclusion: In the essential hypertensive patients, the formula to estimate insulin resistance index as 0.12×[skin fold thickness at A8 point (mm)]-1 may predict accurately the level of insulin resistance. (J Geriatr Cardiol 2005; 2(4):228-232 ) 展开更多
关键词 skin FOLD thickness INSULIN resistance HYPERTENSION
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Determination of the neutron skin thickness from interaction cross section and charge-changing cross section for B,C,N,O,F isotopes 被引量:2
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作者 Xiu-Fang Li De-Qing Fang Yu-Gang Ma 《Nuclear Science and Techniques》 SCIE CAS CSCD 2016年第3期153-158,共6页
The effective neutron and proton root-meansquare radius of stable and unstable nuclei(^(12-15,17)B,^(12-20)C,^(14-21)N,^(16-24)O and ^(18-21,23-26)F) were deduced from the charge-changing cross section,σ_(cc),and the... The effective neutron and proton root-meansquare radius of stable and unstable nuclei(^(12-15,17)B,^(12-20)C,^(14-21)N,^(16-24)O and ^(18-21,23-26)F) were deduced from the charge-changing cross section,σ_(cc),and the interaction cross sections,σ_I,by using a statistical abrasion-ablation model calculation.The extracted proton radii are in good agreement with the data from the Atomic Data and Nuclear Data Tables within the errors.Furthermore,we can observe that the neutron skin thickness increases monotonously with the increasing neutron number in these isotopes,which is consistent with the systematical trend of theoretical calculations. 展开更多
关键词 中子皮厚度 作用截面 同位素 变化截面 电荷 均方根半径 测定 不稳定核
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Skin fold thickness at abdomen:a simple anthropometric measurement may compliment metabolic syndrome definition in patients with normal waist circumference 被引量:2
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作者 Toan C Nguyen Thai Q Ngo +3 位作者 Son V Nguyen Hieu T Luong Khoa TA Pham Cong D Nguyen 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2006年第2期85-92,共8页
Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF a... Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF at A8 point (SFA8) on Erdheim diagram(MetSSFA8) in essential hypertensive patients. Subjects and Methods Medical records of 268 essential hypertensive patients (126males and 122 females) were analyzed, including 210 non-diabetic patients (NDM group) and 58 patients with diabetes (DM group).The mean age was 61.4 ± 9.9 and 59.0 ± 11.0 years, respectively. The control group consisted of 90 non-diabetic, non-hypertensive patients with a mean age of 58.0 ± 11.3 years. The proposed MetSSFA8 definition included SFA8 specific values ( ≥30 mm in female and ≥27 mm in male) and at least two of the following: raised triglyceride levels ( ≥1.7 mmol/L), or specific treatment for this lipid abnormality; raised blood pressure (SBP≥130 mmHg and/or DBP≥85 mmHg), or treatment of previously diagnosed hypertension;reduced HDL-cholesterol (< 1.03 mmol/L in men, <1.29 mmol/L in women), or specific treatment for this lipid abnormality; raised fasting plasma glucose (≥5.6 mmol/l), or previously diagnosed DM. Metabolic Syndrome by the National Cholesterol Education Program and International Diabetes Federation definitions were determined with abdominal obesity defined by Asia-Pacific criteria for waist circumference (NCEPA and IDFA). Results The percentage of MetS as defined by NCEPA, IDFA and MetSSFA8 in NDM group was lower than that of NCEPA, IDFA and MetSSFA8 in DM group [OR=7.7 (95%CI, 2.9-20.2) and 2.5 (95%CI, 1.4-4.8) and 2.7(95%CI, 1.3-5.6), respectively] and higher than that of the control group [OR=53.3 (95%CI, 16.7-170.6), 5.8 (95%CI, 2.6-13.2) and18.8 (95%CI, 7.3-48.7), respectively]. The percentage of MetS by NCEPA, IDFA and MetSSFA8 in males in NDM group was lower than the percentage of MetS by NCEPA, IDFA and MetSSFA8 in females in NDM group (50.8% and 77.9%, P< 0.001; 15,9% and 67.2%, P< 0.001; 60.3% and 73.8%, P <0.05, respectively). In subjects with normal WC or both normal WC and BMI, the percentage of MetS by SFAS was higher than that the percentage of MetS by NCEPA (36.9% and 50.8%, P< 0.05 and 36.0% and 51.0%, P< 0.05).The sensitivity, specificity, false positive rate, positive predictive value, negative predictive value of MetSSFA8 assessed with NCEPA definitions were 0.87, 0.73, 0.27, 0.79 and 0.82, respectively. There was a close agreement between MetSSFA8 and NCEPA (The coefficient of Kapa was 0.60, P< 0.001). Conclusions The MetSSFA8 definition was developed which may be useful in order to define and manage MetS in patients with normal WC or normal weight. 展开更多
关键词 skin FOLD thickness METABOLIC syndrome hypertension
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A possible experimental observable for the determination of neutron skin thickness 被引量:4
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作者 马春旺 傅瑶 +5 位作者 方德清 马余刚 蔡翔舟 郭威 田文栋 王宏伟 《Chinese Physics B》 SCIE EI CAS CSCD 2008年第4期1216-1222,共7页
The dependence between neutron skin thickness and neutron abrasion cross section (σnabr) for neutron-rich nuclei is investigated within the framework of the statistical abrasion ablation model. Assuming that the de... The dependence between neutron skin thickness and neutron abrasion cross section (σnabr) for neutron-rich nuclei is investigated within the framework of the statistical abrasion ablation model. Assuming that the density distributions for proton and neutron are of Fermi-type, and adjusting the diffuseness parameter of neutron density distribution in the droplet model, we find out the good linear correlation between the neutron skin thickness and the abrasion cross section σnabr for neutron-rich nuclei. The uncertainty of neutron skin thickness determined from σnabr is very small. It is suggested that σnabr can be used as a new experimental observable to extract the neutron skin thickness for neutronrich nucleus. The scaling behaviours between neutron skin thickness and σnabr, separately, for isotopes of ^26-35Na, ^44-56Ar, ^48-60Ca, ^67-78Ni are also investigated. 展开更多
关键词 neutron skin thickness neutron abrasion cross section statistical abrasion ablation model
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Exploring the sensitivity of α-decay half-life to neutron skin thickness for nuclei around ^(208)Pb 被引量:2
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作者 Niu Wan Chang Xu Zhong-Zhou Ren 《Nuclear Science and Techniques》 SCIE CAS CSCD 2017年第2期44-48,共5页
Based on the newest experimentally extracted nuclear density distributions for double-magic nucleus208Pb(Tarbert et al. in Phys Rev Lett 112:242502, 2014),the sensitivity of α-decay half-life to nuclear skin thicknes... Based on the newest experimentally extracted nuclear density distributions for double-magic nucleus208Pb(Tarbert et al. in Phys Rev Lett 112:242502, 2014),the sensitivity of α-decay half-life to nuclear skin thickness is explored in the vicinity of the shell closure region around208 Pb, i.e., isotopes of Z ? 82 and isotones of N ? 126.With the two-parameter Fermi(2PF) density distributions and an analytically derived formula, the α-decay half-life is found to be closely related to the magnitude of nuclear skin thickness. For a decays to the Z ? 82 isotopes, the α-decay half-life is found to decrease with the increasing neutron skin thickness, while the opposite behavior is found for a decays to the N ? 126 isotones. Therefore, it could be a possible way to extract the nuclear skin thickness from measured α-decay half-lives. 展开更多
关键词 Density distribution NEUTRON skin thickness DENSITY-DEPENDENT cluster model a-decay HALF-LIFE
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Reconstruction of massive skin avulsion of the scrota and penis by combined application of dermal regeneration template(Pelnac) and split-thickness skin graft with vacuum-assisted closure: A case report 被引量:1
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作者 Jia-Jie Fang Peng-Fei Li +3 位作者 Jia-Jun Wu Hai-Ying Zhou Li-Ping Xie Hui Lu 《World Journal of Clinical Cases》 SCIE 2019年第24期4349-4354,共6页
BACKGROUND Although skin avulsions to male external genitalia are rare, they can be both physically and psychologically traumatic. Thus, the necessity for judicious management poses significant challenges to surgeons ... BACKGROUND Although skin avulsions to male external genitalia are rare, they can be both physically and psychologically traumatic. Thus, the necessity for judicious management poses significant challenges to surgeons in order to avoid potential permanent disabilities. We report a case of massive penoscrotal skin avulsion and a composite graft was creatively applied to cover the defect which achieved good results. We believe that this case is of great reference value for fellow surgeons.CASE SUMMARY A 52-year-old male presented with massive traumatic avulsion of the penile and scrotal skin following mishandling of an electric drill. The avulsed skin was missing. The patient was diagnosed with massive skin avulsion of external genitalia. Following initial complete debridement of devitalized or infected tissues, Pelnac dermal substitute was secured to the defect with the assistance of negative-pressure wound closure. In the final step, the silicone layer of Pelnac was removed and a split-thickness skin graft was applied. The defect had healed at the two-month follow-up. The patient now has normal erections and satisfactory sexual function.CONCLUSION Our experience with this wound repair demonstrated that the combination of a dermal regeneration template and a split-thickness skin graft with vacuumassisted closure is a safe, well-tolerated and efficient solution for the reconstruction of massive penoscrotal skin defects. 展开更多
关键词 Artificial dermis Dermal regeneration template Massive skin defect Penoscrotal defect Split-thickness skin graft Case report
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A simple alternative technique for harvesting split thickness skin grafts
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作者 Leonidas Pavlidis Manousos-Georgios Pramateftakis +2 位作者 Nikolaos Costogloudis Georgia-Alexandra Spyropoulou Efterpi Demiri 《World Journal of Surgical Procedures》 2013年第2期4-7,共4页
AIM: To assess the use of a simple split skin graft harvesting technique, requiring only a scalpel and a swab.METHODS: During the last 8 mo, we operated on a consecutive series of 52 patients(30 males, 22 females) wit... AIM: To assess the use of a simple split skin graft harvesting technique, requiring only a scalpel and a swab.METHODS: During the last 8 mo, we operated on a consecutive series of 52 patients(30 males, 22 females) with a mean age of 60 years(33-80). We used the technique we present in order to cover small skin defects. All procedures were performed under local anesthesia. Thirty-seven patients underwent bedside surgery, 8 patients were operated on in the outpatient department and the remaining 7 had their graft harvested in the operating room. After antiseptic preparation of the donor site, the margins of the graft were drawn by the use of a surgical marker. A No 15 scalpel was used for the graft elevation, under constant traction with a moist swab.RESULTS: All procedures were completed successfully without immediate complications. The patients tolerated the procedure well. The mean operative time was 15 min. Twenty-four donor sites were left to heal by secondary intention, whereas 28 were sutured with interrupted 3/0 silk sutures in order to heal by primary intention. All 24 sites that were left to heal by secondary intention healed completely in approximately 14 d. For the sites that were sutured, the sutures were removed on the 10 th postoperative day. Out of the 52 operated cases, 6 patients(11%) developed complications. In 4 patients, the split thickness skin grafts were partially lost, whereas in 2 patients the grafts were completely lost. Wound dehiscence was observed in 2 patients, which were treated with local antiseptic and antibiotic therapy.CONCLUSION: The skin graft technique described is simple, costless and effective and can be performed even on an outpatient basis, without the need for special equipment. 展开更多
关键词 skin GRAFT skin DEFECT SPLIT thickness skin reconstruction DERMATOME Tissue HARVESTING
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A new formula for screening metabolic syndrome in Asians:skin fold thickness at A8 point on Erdheim diagram and waist circumference
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作者 Toan C Nguyen Thai Q Ngo +3 位作者 Khoa TA Pham Son V Nguyen Hieu T Luong Cong D Nguyen 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2007年第1期32-41,共10页
Background and objectives Recent studies have shown that abdominal obesity is an important component for the diagnosis of metabolic syndrome (MS) and MS is a high risk factor for cardiovascular disease and diabetes me... Background and objectives Recent studies have shown that abdominal obesity is an important component for the diagnosis of metabolic syndrome (MS) and MS is a high risk factor for cardiovascular disease and diabetes mellitus. The aim of this study was to develop a new formula for screening and diagnosis of MS using the waist circumference (WC) and skin fold thickness at the point A8 (SFA8) on the Erdheim diagram. Methods A total of 358 essential hypertensive patients (189 male and 169 female) with a mean age of 59.0±9.7 years were included; 151 healthy people (79 male, 72 female) with a mean age of 57.3±12.1 years (similar to hypertensive patients) who were non-hypertensive and non-diabetic served as a control group. All subjects had no evidence of hepatic, renal, or endocrine disease as determined by history, physical examination and screening blood tests. Height, weight, WC, SFA8, blood pressure (BP), fasting plasma glucose, HDL-cholesterol and triglyceride levels were measured in all subjects. Abdominal obesity measured by WC using the Asia-Pacific criteria (IDFA) was applied for meeting the MS definition. The normal value of SFA8 was measured in the non- MS group. Relationships between SFA8 and systolic BP, diastolic BP, fasting plasma glucose, HDL-cholesterol and triglyceride levels were calculated in the control group. A new formula was developed according to high SFA8 and high WC. Results The normal value of SFA8 in non-MS group was 23.6±7.2 mm in male and 26.5±4.6 mm in female, respectively. The value of SFA8 in MS group was 36.7± 7.4 mm in male and 38.9 ± 8.1 mm in female, respectively. The value of WC in MS group and non-MS group were 92.5±3.0 cm and 79.4±6. 1 cm in male and 86.3±6.4 cm and 74.7±5.4 cm in female, respectively. There was a correlation between SFA8 and systolic BP, diastolic BP, fasting plasma glucose, HDL-cholesterol and triglyceride in control group (the correlation coefficients were 0.29, 0.23, 0.25, -0.31 and 0.46, respectively, P < 0.01). A new formula for MS was suggested as high WC (≥ 90 cm in male, ≥ 80 cm in female) + high SFA8 (≥ 30 mm). The sensitivity, specificity, false positive rate, false negative rate, positive predictive value, and negative predictive value of the new formula assessed with the IDFA definition were 94%, 93%, 7%, 6%, 92% and 95%, respectively. The percentage of all patients who met the criteria for MS by conventional definition was 46.2%. The percentage of all patients who met the criteria by the new definition was 47.0%. There was no difference between the prevalence percentage of the MS according to new criteria and the IDFA criteria in all patients, in male and in female, respectively (P > 0.05). Conclusion This new formula for MS might be useful for easy screening. The advantage over current criteria is the lack of need for laboratory testing. 展开更多
关键词 WAIST CIRCUMFERENCE skin FOLD thickness metabolic syndrome
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Process of Microcellular Propellants with Adjustable Skin Thickness
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作者 YING Sanjiu CHEN Xiru LUO Yuanxiang 《Defence Technology(防务技术)》 SCIE EI CAS 2013年第1期70-74,共5页
Microcellular propellants show a vast applicable prospect due to their special shell-pore structure. The effects of saturation pressure and desorption time on skin thickness are studied. The skin thickness is observed... Microcellular propellants show a vast applicable prospect due to their special shell-pore structure. The effects of saturation pressure and desorption time on skin thickness are studied. The skin thickness is observed and measured using scanning electron microscope (SEM). The results show that the skin thickness decreases when saturation pressure increases from 15 MPa to 30 MPa. In contrast, the skin thickness increases as the desorption time changes from 2 min to 20 min.Therefore, the microcellular propellants with adjustable skin thickness can be obtained under the variable process conditions such as saturation pressure and desorption time. 展开更多
关键词 materials experiment microcellular propellant skin thickness saturation pressure desorption time supercritical CO2 fluid
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Somatotypological Features of the Skin Fat Fold Thickness in Ethnic Kyrgyz Women
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作者 Kyialbek Sakibaev Kanykei Zhanybek Kyzy +7 位作者 Nazgul Tashmatova Svetlana Klochkova Ibragim Atabaev Dmitrii Nikityuk Zhypargul Abdullaeva Lazokatkhan Dzhumaeva Nataliya Alexeeva Ishenbek Satylganov 《Forensic Medicine and Anatomy Research》 2021年第1期1-9,共9页
The purpose of this study was to determine the thickness of skin and fat folds in Kyrgyz women of various ages, taking into account their somatotypological profile. Using the method of complex anthropometry, including... The purpose of this study was to determine the thickness of skin and fat folds in Kyrgyz women of various ages, taking into account their somatotypological profile. Using the method of complex anthropometry, including the determination of the values of 21 anthropometric parameters, the physical status of 1028 Kyrgyz women of different age groups was studied youth (16 - 20 years old 310 girls), mature age (1st period, 21 - 35 years old 308 women;2nd period, 36 - 55 years 410 women) living in Osh, Kyrgyzstan. For somatotyping, we used the scheme of constitutional diagnostics. Seven somatotypes distinguished within three constitutional groups. The subcutaneous fat was measured by caliperometry. Statistical processing carried out using the statistical programs Microsoft Excel and the STATISTICA package (v. 6.0). To determine the reliability of the differences between the indicators, the Student’s test was used (p < 0.05). The results demonstrate that within each somatotype there are broad changes in the studied anthropometric indicator. Thus, the thickness of the skin and fat folds is the smallest in women of asthenic, athletic and stenoplastic (p < 0.05), and the largest in representatives of the euriplastic and pycnic somatotypes (p < 0.05). Thus, indicators of physical status in adolescence and adulthood in women have a pronounced somatotypological specificity. These materials on the physical development and constitutional and typological characteristics of the studied population of women applicable for a personalized approach in the context of a relative norm. 展开更多
关键词 Somatotypological Features Fat Fold skin thickness ANTHROPOMETRIC Indicators
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A Prospective, Within-Patient Controlled Study to Compare the Ability of the Non Adherent Drawtex®Hydroconductive Dressing to a Transparent Polyurethane Film Dressing (Standard of Care) on the Healing of Split-Thickness Skin Graft Donor Sites
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作者 Barend H.Van den Bergh Deirdré Kruger +2 位作者 Jonathan Kourie Steve Moeng Martin C.Robson 《Surgical Science》 2018年第7期210-221,共12页
Background: Dressing of split-thickness skin graft donor sites can be traumatic for the patient. The most advanced and expensive dressings have been compared to the most basic of dressings, with little or no consensus... Background: Dressing of split-thickness skin graft donor sites can be traumatic for the patient. The most advanced and expensive dressings have been compared to the most basic of dressings, with little or no consensus and an unpersuasive level of evidence. We aimed to determine the efficacy of the locally manufactured non-adherent, hydroconductive Drawtex? dressing and compare it to our current standard-of-care dressing, a thin transparent polyurethane film, in the healing of split-thickness donor sites. Methods: This prospective, within-patient controlled study included 27 adult participants, each with two split-thickness skin donor sites. The 54 donor site wounds were compared with regard to time to re-epithelialisation, perceived pain and healed wound quality. Results: By day 5, complete healing of donor site wounds, defined as >90% of epithelialized surface, was significantly higher in the hydroconductive dressing group compared to the polyurethane film group (22.2% and 3.7%, respectively;p < 0.0001). The hydroconductive dressing-treated donor site wounds were significantly less painful at 24-hours, 48-hours and 7-days post-operatively, and had fewer complications and superior wound healing quality. Conclusion: We have demonstrated that the relatively cheap and readily available dressing made locally in South Africa, Drawtex? is at least as safe, and potentially superior in wound healing, when compared to our current standard-of-care dressing. 展开更多
关键词 RE-EPITHELIALIZATION PROSPECTIVE Studies Wound HEALING Split-thickness skin Graft Donor Site Hydroconductive DRESSING Pain
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Rigorous Electromagnetic Modeling of a Micro Strip Line Incorporating a Flat and Thick Metallic Conductor Based on the Skin Effect Phenomenon
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作者 Rafika Mejri Taoufik Aguili 《Open Journal of Metal》 2022年第1期1-9,共9页
In most studies of microstrip circuits, the majority of researchers assume that the microstrip structures studied have flat metallic conductors of finite widths but without thickness. But in reality these types of str... In most studies of microstrip circuits, the majority of researchers assume that the microstrip structures studied have flat metallic conductors of finite widths but without thickness. But in reality these types of structures integrate metallic copper conductors of different thicknesses. If we neglect this thickness we introduce error in the electrical parameters of the microstrip structure, which affects the effective permittivity, the characteristic impedance, the adaptation of the circuit, the resonance frequency, etc. Given the importance of this parameter (thickness of the metal of micro rubon structures), rigorous electromagnetic modeling of the thick micro rubon line based on the skin effect phenomenon (In fact at high frequency the skin effect phenomenon occurs and the current only flows on the periphery of the conductor) has been proposed to improve the studied electric model and ensure the increase in the precision of the analysis method used: Wave concept iterative process. The good agreement between the simulated and published data justifies the improvement of the model. 展开更多
关键词 Micro Strip Line thick Conductor WCIP skin Effect Phenomenon
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外源性碱性成纤维细胞生长因子促进大鼠创面愈合的机制
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作者 李振超 杜喜玲 +2 位作者 韩志新 牛大伟 樊昌伟 《中国组织工程研究》 CAS 北大核心 2025年第11期2243-2251,共9页
背景:深入揭示外源性碱性成纤维细胞生长因子促进创面愈合的分子机制。目的:探讨外源性碱性成纤维细胞生长因子对大鼠创面修复中巨噬细胞表型转换和肉芽再生的影响。方法:(1)体外细胞实验:分为正常对照组、低剂量碱性成纤维细胞生长因... 背景:深入揭示外源性碱性成纤维细胞生长因子促进创面愈合的分子机制。目的:探讨外源性碱性成纤维细胞生长因子对大鼠创面修复中巨噬细胞表型转换和肉芽再生的影响。方法:(1)体外细胞实验:分为正常对照组、低剂量碱性成纤维细胞生长因子组、高剂量碱性成纤维细胞生长因子组以及碱性成纤维细胞生长因子+丙戊酸组,其中低、高剂量碱性成纤维细胞生长因子组细胞培养基中分别添加100,200μg/L碱性成纤维细胞生长因子,碱性成纤维细胞生长因子+丙戊酸组细胞培养基中添加200μg/L碱性成纤维细胞生长因子和20 mmol/L Notch1/Jagged1激动剂丙戊酸。通过EdU实验、划痕实验、小管生成实验检测碱性成纤维细胞生长因子对人脐静脉内皮细胞增殖、迁移和血管新生的影响。(2)体内动物实验:SD大鼠按照随机数字表法分为模型组、低剂量碱性成纤维细胞生长因子组、高剂量碱性成纤维细胞生长因子组以及碱性成纤维细胞生长因子+丙戊酸组,构建大鼠全层皮肤缺损开放性创面模型,其中低、高剂量碱性成纤维细胞生长因子组皮下注射100,200μg/L碱性成纤维细胞生长因子,碱性成纤维细胞生长因子+丙戊酸组大鼠皮下注射200μg/L碱性成纤维细胞生长因子的同时腹腔注射10 mg/kg丙戊酸。给药7,14 d检测大鼠创面的愈合率;TUNEL检测创面组织中的细胞凋亡情况;酶联免疫吸附实验检测大鼠血清中丙二醛、超氧化物歧化酶、肿瘤坏死因子α和白细胞介素10水平;免疫荧光检测创面组织中巨噬细胞的表型转换情况;免疫组化检测创面组织中增殖细胞核抗原、CD31和血管内皮生长因子的表达;Western blot法检测创面组织中Notch1、Jagged1的表达。结果与结论:(1)与正常对照组相比,碱性成纤维细胞生长因子能明显促进人脐静脉内皮细胞的增殖、迁移和血管新生,并且具有剂量依赖性;(2)与模型组相比,碱性成纤维细胞生长因子能明显促进创面的愈合,下调创面组织中的细胞凋亡率;降低大鼠血清中丙二醛和肿瘤坏死因子α水平,升高超氧化物歧化酶和白细胞介素10水平;促使创面组织中巨噬细胞向M2型转换,上调创面组织中增殖细胞核抗原、CD31和血管内皮生长因子的表达;抑制创面组织中Notch1、Jagged1的表达,并且均具有剂量依赖性。丙戊酸可部分逆转碱性成纤维细胞生长因子对创面愈合的促进作用。结果表明,碱性成纤维细胞生长因子能明显促进创面愈合与肉芽再生以及诱导巨噬细胞向M2型转换,这可能与调控Notch1/Jagged1信号有关。 展开更多
关键词 碱性成纤维细胞生长因子 全层皮肤缺损 创面 巨噬细胞表型转换 肉芽再生 NOTCH1 JAGGED1
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皮肤至椎板距离和皮下脂肪厚度对微创腰椎减压术后的影响
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作者 孙莹莹 李玉静 孟婧文 《颈腰痛杂志》 2024年第4期673-677,共5页
目的探讨皮肤至椎板距离(skr-to-laminal distme,SLD)和皮下脂肪厚度对微创腰椎减压术后的影响。方法选择2021年1月至2023年6月在该院接受微创腰椎减压术的173例患者作为研究对象,收集患者SLD距离和皮下脂肪厚度数据,分别根据中位值分... 目的探讨皮肤至椎板距离(skr-to-laminal distme,SLD)和皮下脂肪厚度对微创腰椎减压术后的影响。方法选择2021年1月至2023年6月在该院接受微创腰椎减压术的173例患者作为研究对象,收集患者SLD距离和皮下脂肪厚度数据,分别根据中位值分为低值组和高值组,观察两组患者术前、住院及出院资料差异。结果高SLD距离患者与低SLD距离患者的体质量指数(body mass index,BMI)、肥胖、年龄、ASA分级、高血压、糖尿病、饮酒等比较,差异存在统计学意义(P<0.05);两组患者性别、心脏病、脑血管疾病、慢性肾脏病、吸烟、手术类型、相邻节段病变、住院时间、即时并发症、住院并发症、出院并发症、总并发症、术前ODI、术后1年ODI、术前腰痛VAS、术后1年腰痛VAS、术前腿痛VAS、术后1年腿痛VAS比较,差异均无统计学意义(P>0.05)。高皮下脂肪厚度患者和低皮下脂肪厚度患者的BMI、肥胖、年龄、ASA分级、高血压、糖尿病、饮酒比较,差异存在统计学意义(P<0.05);两组患者性别、心脏病、脑血管疾病、慢性肾脏病、吸烟、手术类型、相邻节段病变、住院时间、即时并发症、住院并发症、出院并发症、总并发症、术前ODI、术后1年ODI、术前腰痛VAS、术后1年腰痛VAS、术前腿痛VAS和术后1年腿痛VAS比较,差异均无统计学意义(P>0.05)。Pearson相关性分析显示,SLD距离和皮下脂肪厚度与BMI均存在显著相关性(r=0.703、0.712,P<0.05)。结论手术部位局部软组织厚度对腰椎微创减压术的临床结果无显著影响。 展开更多
关键词 微创腰椎减压术 皮下脂肪厚度 皮肤至椎板距离 并发症
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乳腺癌改良根治术后皮瓣坏死的危险因素分析
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作者 李慧 赵雪 马晓鑫 《中国烧伤创疡杂志》 2024年第3期210-213,共4页
目的分析探讨乳腺癌改良根治术后皮瓣坏死的危险因素。方法选取2021年1月至2022年2月河南科技大学第一附属医院收治的92例拟行乳腺癌改良根治术治疗的乳腺癌患者作为研究对象,收集患者年龄、乳腺癌分期、病灶部位、肿瘤长径、病理分型... 目的分析探讨乳腺癌改良根治术后皮瓣坏死的危险因素。方法选取2021年1月至2022年2月河南科技大学第一附属医院收治的92例拟行乳腺癌改良根治术治疗的乳腺癌患者作为研究对象,收集患者年龄、乳腺癌分期、病灶部位、肿瘤长径、病理分型、皮瓣厚度、皮瓣张力、包扎压力、是否合并糖尿病、术后是否发生皮瓣坏死等临床资料,并依据术后皮瓣坏死发生情况将其分为正常组与坏死组,多因素Logistic回归分析乳腺癌改良根治术后皮瓣坏死的危险因素。结果92例乳腺癌患者中乳腺癌改良根治术后出现皮瓣坏死30例(3261%),设为坏死组;未出现皮瓣坏死62例(6739%),设为正常组。单因素分析结果显示,坏死组皮瓣薄、皮瓣张力高、包扎过紧、合并糖尿病的患者比例均明显高于正常组(χ^(2)=6550、6753、6418、6332,P=0010、0009、0011、0012);多因素Logistic回归分析结果显示,皮瓣薄、皮瓣张力高、包扎过紧以及合并糖尿病是乳腺癌改良根治术后皮瓣坏死的独立危险因素(95%CI为1313~4533、1059~2640、1124~4277、1180~3899,P=0005、0028、0022、0013)。结论皮瓣薄、皮瓣张力高、包扎过紧以及合并糖尿病是乳腺癌改良根治术后皮瓣坏死的独立危险因素。 展开更多
关键词 乳腺癌 改良根治术 皮瓣坏死 危险因素 加压包扎 皮瓣厚度 皮瓣张力
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高温对不同厚皮甜瓜品种种子萌发的影响及其耐热性综合评价
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作者 杨君妍 闫淼 +5 位作者 吴海波 杨文莉 王豪杰 毛建才 翟文强 李俊华 《新疆农业科学》 CAS CSCD 北大核心 2024年第6期1386-1396,共11页
【目的】研究高温对厚皮甜瓜种子萌发的影响以及不同厚皮甜瓜品种间耐高温能力的差异,为较耐高温厚皮甜瓜品种的筛选和厚皮甜瓜的育苗提供理论依据。【方法】以耐热性不同的5个新疆主栽厚皮甜瓜品种纳斯密、黄皮9818、新密14号(新红心脆... 【目的】研究高温对厚皮甜瓜种子萌发的影响以及不同厚皮甜瓜品种间耐高温能力的差异,为较耐高温厚皮甜瓜品种的筛选和厚皮甜瓜的育苗提供理论依据。【方法】以耐热性不同的5个新疆主栽厚皮甜瓜品种纳斯密、黄皮9818、新密14号(新红心脆)、黄梦脆和卡拉克赛(伽师瓜)为材料,设4个温度(28(CK)、35、40和50℃)处理,对比厚皮甜瓜种子萌发阶段的发芽势、发芽率、发芽指数、活力指数,以28和50℃芽苗样本测定超氧化物歧化酶(SOD)、过氧化物酶(POD)、过氧化氢酶(CAT)活性、丙二醛(MDA)和脯氨酸(Pro)含量,研究高温对不同厚皮甜瓜品种种子萌发和生理指标的影响,并分析相关指标和评价综合耐热性。【结果】5个厚皮甜瓜品种种子在28℃下能够正常萌发及生长,且发芽比较整齐;在35℃下,能使甜瓜种子更快萌发,但发芽过速易徒长,长势不整齐;在40℃下,种子萌发效果与35℃类似,生长开始受到轻微抑制且徒长加速,但不足以区分品种间的耐热性差异;在50℃下,延缓甜瓜种子的萌发,萌发后胚根逐渐腐烂,高温抑制作用明显且品系间的发芽能力差异显著。50℃下,耐热性好的品种抗氧化酶活性升高,而耐热性较差的品种抗氧化酶活性降低,其中SOD、POD较CAT发挥了更大作用,MDA增幅与耐热性成反比,脯氨酸增幅与耐热性成正比。【结论】5个厚皮甜瓜品种可划分为耐热型、热敏感型2个不同的耐热等级,耐热型:黄梦脆、纳斯密;热敏感型:黄皮9818、新密14号、卡拉克赛。黄梦脆、纳斯密、黄皮98183个厚皮甜瓜品种种子萌发期耐热性优于新密14号、卡拉克赛。 展开更多
关键词 厚皮甜瓜 高温胁迫 种子萌发 综合评价
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多技术联合治愈毛囊闭锁三联征1例报告
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作者 陈琳 何华清 +2 位作者 王世才 李杰辉 刘明 《中国烧伤创疡杂志》 2024年第5期351-354,357,共5页
给予2022年6月2日广西中医药大学第一附属医院收治的1例严重毛囊闭锁三联征(FOT)患者在抑制毛囊角化及皮脂分泌、减轻毛囊闭锁与抗生素抗感染等治疗的基础上,头部及胸背部创面于脓肿切开引流术后行湿润烧伤膏药纱换药治疗,腋窝处创面于... 给予2022年6月2日广西中医药大学第一附属医院收治的1例严重毛囊闭锁三联征(FOT)患者在抑制毛囊角化及皮脂分泌、减轻毛囊闭锁与抗生素抗感染等治疗的基础上,头部及胸背部创面于脓肿切开引流术后行湿润烧伤膏药纱换药治疗,腋窝处创面于病灶去顶外置搔刮术后行湿润烧伤膏药纱条引流治疗,臀部创面于根治性切除术、负压封闭引流、刃厚皮片移植术后行湿润烧伤膏换药治疗,入院后42 d所有创面均基本愈合;出院后随访4个月,愈后皮肤未见结节及脓肿复发,且无明显特殊不适。 展开更多
关键词 根治性切除术 负压封闭引流 刃厚皮片移植 湿润烧伤膏 毛囊闭锁三联征
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减施化肥配施EM菌剂对厚皮甜瓜生长及果实性状的影响
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作者 陈宝玲 刘文君 +3 位作者 周建辉 张曼 黄凤婵 黄孙答 《蔬菜》 2024年第5期58-62,共5页
为探讨减施化肥配施EM菌剂对厚皮甜瓜生长和果实性状的影响,以常规施肥(每667 m^(2)施用复合肥50 kg、有机肥500 kg、硫酸钾20 kg、钙镁磷肥20 kg)为对照,设置EM菌剂替代化肥方案(每667 m^(2)施用EM菌剂20 L,复合肥30 kg,有机肥500 kg,... 为探讨减施化肥配施EM菌剂对厚皮甜瓜生长和果实性状的影响,以常规施肥(每667 m^(2)施用复合肥50 kg、有机肥500 kg、硫酸钾20 kg、钙镁磷肥20 kg)为对照,设置EM菌剂替代化肥方案(每667 m^(2)施用EM菌剂20 L,复合肥30 kg,有机肥500 kg,硫酸钾20 kg,钙镁磷肥20 kg),比较分析减施化肥配施EM菌剂对不同厚皮甜瓜品种生长发育、果实性状及品质的影响。结果表明:施用EM菌后桂蜜12号最大株高、茎粗、叶片SPAD值分别为215.00 cm、9.93 mm、39.17,均显著高于对照;果实性状除腔长(11.38 cm)、腔宽(6.74 cm)比对照显著减少外,单瓜质量、产量、果肉硬度、果长、果宽、果肉厚、果脐肉厚和可溶性固形物含量均显著高于对照。施用EM菌后北甜1号株高、茎粗均大于对照,但不同时期差异性不同;最大株高、茎粗、叶片SPAD值和叶面积分别为193.67 cm、10.44 mm、37.62、990.38 cm^(2),与对照均无显著差异,果肉硬度、果长、果宽、中心可溶性固形物均比对照显著增加,而腔长、腔宽均比对照显著减少。综上,EM菌剂部分替代化肥方案能促进厚皮甜瓜植株生长、产量提高与品质改善,但对不同甜瓜品种的影响效果有所不同,对桂蜜12号甜瓜的促进作用更明显。 展开更多
关键词 EM菌剂 厚皮甜瓜 生长 果实性状
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15G针头打孔自体中厚皮片对四肢深度烧伤患者的影响
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作者 杨陆涛 曹青 +1 位作者 何霞飞 潘拥军 《中国医学创新》 CAS 2024年第17期123-128,共6页
目的:探讨15G针头打孔制备自体中厚皮片对四肢深度烧伤患者瘢痕愈合情况及肢体活动功能恢复的影响。方法:回顾性选取2021年1月—2023年5月于九江市第一人民医院就诊的60例四肢深度烧伤患者,依据所行移植手术方式不同分为研究组和对照组... 目的:探讨15G针头打孔制备自体中厚皮片对四肢深度烧伤患者瘢痕愈合情况及肢体活动功能恢复的影响。方法:回顾性选取2021年1月—2023年5月于九江市第一人民医院就诊的60例四肢深度烧伤患者,依据所行移植手术方式不同分为研究组和对照组,每组30例,其中对照组仅予以常规中厚皮片加压移植治疗,研究组予以15G针头打孔制备自体中厚皮片加压移植治疗,两组均干预至出院,追踪随访6个月。比较两组术后瘢痕愈合情况、瘢痕评分、肢体活动功能、术后疼痛程度、生活质量,并统计术后并发症例数。结果:研究组瘢痕愈合时间、住院时间均较对照组短,移植成活率较对照组高,差异均有统计学意义(P<0.05)。术后6个月,研究组温哥华瘢痕评定量表(VSS)评分均低于对照组,Fugl-Meyer评分高于对照组,差异均有统计学意义(P<0.05);研究组术后1、2周视觉模拟法评分(VAS)评分均低于对照组,差异均有统计学意义(P<0.05);研究组健康调查简表(SF-36)各维度评分均高于对照组,差异均有统计学意义(P<0.05)。结论:15G针头打孔制备自体中厚皮片能明显促进四肢深度烧伤患者瘢痕愈合,改善瘢痕状态,同时帮助肢体活动功能恢复,减轻术后创面疼痛,提高生活质量水平。 展开更多
关键词 15G针头打孔 自体中厚皮片 四肢深度烧伤 瘢痕愈合
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