An enantioselective Michael addition of ethyl 4,4,4-trifluoro-3-oxobutanoate to α,β-unsaturated ketone esters using a chiral alkyl-substituted thiourea catalyst is reported. Excellent levels of stereo-induction （up...An enantioselective Michael addition of ethyl 4,4,4-trifluoro-3-oxobutanoate to α,β-unsaturated ketone esters using a chiral alkyl-substituted thiourea catalyst is reported. Excellent levels of stereo-induction （up to 98% ee） under mild reaction conditions were obtained to afford the corresponding α-trifluoromethyldihydropyrans.展开更多
基金Project supported by the National Natural Science Foundation of China （No. 21032006）.
文摘An enantioselective Michael addition of ethyl 4,4,4-trifluoro-3-oxobutanoate to α,β-unsaturated ketone esters using a chiral alkyl-substituted thiourea catalyst is reported. Excellent levels of stereo-induction （up to 98% ee） under mild reaction conditions were obtained to afford the corresponding α-trifluoromethyldihydropyrans.
