Hibernoma is a rare tumor containing prominent brown adipocytes that resemble normal brown fat.Brown fat(versus white fat) is predominantly found in hibernating mammals and infants.Brown fat adipocytes contain a highe...Hibernoma is a rare tumor containing prominent brown adipocytes that resemble normal brown fat.Brown fat(versus white fat) is predominantly found in hibernating mammals and infants.Brown fat adipocytes contain a higher number of small lipid droplets and a much denser concentration of mitochondria.The tumor can occur in a variety of locations however the extremities,followed by the head and neck,have been the most common sights.All variants of hibernoma described have followed a benign course with the majority presenting as a small,lobulated,nontender lesions.We present a case of a giant hibernoma arising from the pleura which invaded the intra and extra-thoracic chest.展开更多
背景与目的:原发性胸壁尤因肉瘤(primary Ewing sarcoma of the thoracic wall,PEST)是发生在胸壁或胸腔的罕见骨外尤因肉瘤。PEST患者生存期短,预后差,复发率高。PEST发病原因未明,发展迅速,早诊断、早治疗是提高患者生存率的有效手段...背景与目的:原发性胸壁尤因肉瘤(primary Ewing sarcoma of the thoracic wall,PEST)是发生在胸壁或胸腔的罕见骨外尤因肉瘤。PEST患者生存期短,预后差,复发率高。PEST发病原因未明,发展迅速,早诊断、早治疗是提高患者生存率的有效手段。本研究通过收集PEST病例,探讨其临床病理学特征、治疗方法及预后,以提高临床对该病的认识及诊疗水平。方法:回顾性分析2018—2023年苏州大学附属第一医院收治的及文献报道的共21例PEST患者的临床资料、病理学特征、治疗及随访结果,采用Kaplan-Meier法计算年龄与累积生存率的关系。结果:全组PEST患者男女比例为13∶8,左右胸比例为6∶15,中位年龄为20岁,平均年龄为28岁,中位肿瘤直径为8.0 cm,平均肿瘤直径为18.1 cm。65.2%患者同侧胸腹痛,47.6%患者侵犯同侧肋骨伴胸腔积液。病理学检查符合肿瘤特征,瘤细胞呈紧密成片或小叶状分布的蓝色小圆细胞,100%CD99弥漫强阳性,80%波形蛋白(vimentin)阳性。苏州大学附属第一医院收治的2例患者荧光原位杂交(fluorescence in situ hybridization,FISH)检测可见EWSR1分离信号,二代测序(next-generation sequencing,NGS)可见EWSR1-FLI1融合。2例患者术前接受新辅助化疗,10例术后接受放化疗,5例仅接受放化疗,1例仅接受手术治疗,3例无手术资料。全组患者随访时间为3~38个月,7例失访。患者的发病年龄与累积生存率呈正相关,平均生存时间为19.98个月,中位生存时间为13.00个月。结论:PEST多见于年轻男性,易发生于右胸,肿物常大于8 cm,大部分病例可通过病理形态学、免疫表型初诊,FISH或NGS行EWSR1基因检测可提供精确诊断。PEST患者预后极差,累积生存率与发病年龄呈正相关,手术、放疗及化疗为PEST的主要治疗手段。展开更多
The objective of this study is to investigate the hemodynamics in patient-specific thoracic aortic aneurysm and discuss the reason for formation of aortic plaque.A 3-Dimensional pulsatile blood flow in thoracic aorta ...The objective of this study is to investigate the hemodynamics in patient-specific thoracic aortic aneurysm and discuss the reason for formation of aortic plaque.A 3-Dimensional pulsatile blood flow in thoracic aorta with a fusiform aneurysm and 3 main branched vessels was studied numerically with the average Reynolds number of 1399 and the Womersley number of 19.2.Based on the clinical 2-Dimensional CT slice data,the patient-specific geometry model was constructed using medical image process software.Unsteady,incompressible,3-Dimensional Navier-Stokes equations were employed to solve the flow field.The temporal distributions of hemodynamic variables during the cardiac cycle such as streamlines,wall shear stresses in the arteries and aneurysm were analyzed. Growth and rupture mechanisms of thoracic aortic aneurysm in the patient can be analyzed based on patient-specific model and hemodynamics simulation.展开更多
Chest wall reconstruction after rib resection is essential to ensuring chest wall stability, avoiding flail chest and pulmonary hernia, and improving pulmonary function. Traditionally, a synthetic mesh and a musculocu...Chest wall reconstruction after rib resection is essential to ensuring chest wall stability, avoiding flail chest and pulmonary hernia, and improving pulmonary function. Traditionally, a synthetic mesh and a musculocutaneous flap have been used to bridge the chest wall defect. However, a risk of secondary prosthesis infection exists. Acellular dermal collagen mesh implants (Permacol™) are indicated for the reconstruction and reformation of human soft connective tissue. A case of a complex chest wall reconstruction after rib resection for osteomyelitis due to staphylococcus aureus infection in a malnourished, immunosuppressed, and methadone-addicted patient is presented. The patient underwent a left posterolateral thoracotomy and chest wall resection, involving three ribs and the soft tissues overlying an infected cutaneous fistula. The chest wall was reconstructed using a 28 × 18 cm piece of porcine sterile acellular dermal collagen mesh. A successful chest wall repair was achieved with no incisional herniation and with complete mesh incorporation, allowing physiologic respiratory movements. A typical wound seroma developed and resorbed over the following months. There was no infection. In conclusion, this case report suggests that Permacol™surgical implant can be used successfully as an alternative to synthetic mesh in reconstruction of an infected chest wall.展开更多
文摘Hibernoma is a rare tumor containing prominent brown adipocytes that resemble normal brown fat.Brown fat(versus white fat) is predominantly found in hibernating mammals and infants.Brown fat adipocytes contain a higher number of small lipid droplets and a much denser concentration of mitochondria.The tumor can occur in a variety of locations however the extremities,followed by the head and neck,have been the most common sights.All variants of hibernoma described have followed a benign course with the majority presenting as a small,lobulated,nontender lesions.We present a case of a giant hibernoma arising from the pleura which invaded the intra and extra-thoracic chest.
文摘背景与目的:原发性胸壁尤因肉瘤(primary Ewing sarcoma of the thoracic wall,PEST)是发生在胸壁或胸腔的罕见骨外尤因肉瘤。PEST患者生存期短,预后差,复发率高。PEST发病原因未明,发展迅速,早诊断、早治疗是提高患者生存率的有效手段。本研究通过收集PEST病例,探讨其临床病理学特征、治疗方法及预后,以提高临床对该病的认识及诊疗水平。方法:回顾性分析2018—2023年苏州大学附属第一医院收治的及文献报道的共21例PEST患者的临床资料、病理学特征、治疗及随访结果,采用Kaplan-Meier法计算年龄与累积生存率的关系。结果:全组PEST患者男女比例为13∶8,左右胸比例为6∶15,中位年龄为20岁,平均年龄为28岁,中位肿瘤直径为8.0 cm,平均肿瘤直径为18.1 cm。65.2%患者同侧胸腹痛,47.6%患者侵犯同侧肋骨伴胸腔积液。病理学检查符合肿瘤特征,瘤细胞呈紧密成片或小叶状分布的蓝色小圆细胞,100%CD99弥漫强阳性,80%波形蛋白(vimentin)阳性。苏州大学附属第一医院收治的2例患者荧光原位杂交(fluorescence in situ hybridization,FISH)检测可见EWSR1分离信号,二代测序(next-generation sequencing,NGS)可见EWSR1-FLI1融合。2例患者术前接受新辅助化疗,10例术后接受放化疗,5例仅接受放化疗,1例仅接受手术治疗,3例无手术资料。全组患者随访时间为3~38个月,7例失访。患者的发病年龄与累积生存率呈正相关,平均生存时间为19.98个月,中位生存时间为13.00个月。结论:PEST多见于年轻男性,易发生于右胸,肿物常大于8 cm,大部分病例可通过病理形态学、免疫表型初诊,FISH或NGS行EWSR1基因检测可提供精确诊断。PEST患者预后极差,累积生存率与发病年龄呈正相关,手术、放疗及化疗为PEST的主要治疗手段。
基金supported by the National Natural Science Foundation of China(Grant Nos.10972016 and 10872013)Natural Science Foundation of Beijing (Grant Nos.3092004 and 3092005)
文摘The objective of this study is to investigate the hemodynamics in patient-specific thoracic aortic aneurysm and discuss the reason for formation of aortic plaque.A 3-Dimensional pulsatile blood flow in thoracic aorta with a fusiform aneurysm and 3 main branched vessels was studied numerically with the average Reynolds number of 1399 and the Womersley number of 19.2.Based on the clinical 2-Dimensional CT slice data,the patient-specific geometry model was constructed using medical image process software.Unsteady,incompressible,3-Dimensional Navier-Stokes equations were employed to solve the flow field.The temporal distributions of hemodynamic variables during the cardiac cycle such as streamlines,wall shear stresses in the arteries and aneurysm were analyzed. Growth and rupture mechanisms of thoracic aortic aneurysm in the patient can be analyzed based on patient-specific model and hemodynamics simulation.
文摘Chest wall reconstruction after rib resection is essential to ensuring chest wall stability, avoiding flail chest and pulmonary hernia, and improving pulmonary function. Traditionally, a synthetic mesh and a musculocutaneous flap have been used to bridge the chest wall defect. However, a risk of secondary prosthesis infection exists. Acellular dermal collagen mesh implants (Permacol™) are indicated for the reconstruction and reformation of human soft connective tissue. A case of a complex chest wall reconstruction after rib resection for osteomyelitis due to staphylococcus aureus infection in a malnourished, immunosuppressed, and methadone-addicted patient is presented. The patient underwent a left posterolateral thoracotomy and chest wall resection, involving three ribs and the soft tissues overlying an infected cutaneous fistula. The chest wall was reconstructed using a 28 × 18 cm piece of porcine sterile acellular dermal collagen mesh. A successful chest wall repair was achieved with no incisional herniation and with complete mesh incorporation, allowing physiologic respiratory movements. A typical wound seroma developed and resorbed over the following months. There was no infection. In conclusion, this case report suggests that Permacol™surgical implant can be used successfully as an alternative to synthetic mesh in reconstruction of an infected chest wall.
