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Fractal analysis of major faults and fractal dimension of lineaments in the Indo-Gangetic Plain on a regional scale
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作者 Vipin Chauhan Jagabandhu Dixit 《Earthquake Science》 2024年第2期107-121,共15页
The Indo-Gangetic Plain(IGP)is one of the most seismically vulnerable areas due to its proximity to the Himalayas.Geographic information system(GIS)-based seismic characterization of the IGP was performed based on the... The Indo-Gangetic Plain(IGP)is one of the most seismically vulnerable areas due to its proximity to the Himalayas.Geographic information system(GIS)-based seismic characterization of the IGP was performed based on the degree of deformation and fractal dimension.The zone between the Main Boundary Thrust(MBT)and the Main Central Thrust(MCT)in the Himalayan Mountain Range(HMR)experienced large variations in earthquake magnitude,which were identified by Number-Size(NS)fractal modeling.The central IGP zone experienced only moderate to low mainshock levels.Fractal analysis of earthquake epicenters reveals a large scattering of earthquake epicenters in the HMR and central IGP zones.Similarly,the fault fractal analysis identifies the HMR,central IGP,and south-western IGP zones as having more faults.Overall,the seismicity of the study region is strong in the central IGP,south-western IGP,and HMR zones,moderate in the western and southern IGP,and low in the northern,eastern,and south-eastern IGP zones. 展开更多
关键词 geospatial analysis fractal modeling seismicity pattern fractal dimension
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Cosmological Model in Four Time and Four Space Dimensions
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作者 Juan Antonio Nieto 《Journal of Applied Mathematics and Physics》 2024年第3期829-840,共12页
We develop a cosmological model in a physical background scenario of four time and four space dimensions ((4+4)-dimensions or (4+4)-universe). We show that in this framework the (1+3)-universe is deeply connected with... We develop a cosmological model in a physical background scenario of four time and four space dimensions ((4+4)-dimensions or (4+4)-universe). We show that in this framework the (1+3)-universe is deeply connected with the (3+1)-universe. We argue that this means that in the (4+4)-universe there exists a duality relation between the (1+3)-universe and the (3+1)-universe. 展开更多
关键词 Cosmological model (4+4)-dimensions Duality Symmetry
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基于24Model-D-ISM的地铁站火灾疏散影响因素研究
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作者 孙世梅 张家严 《中国安全科学学报》 CAS CSCD 北大核心 2024年第4期153-159,共7页
为预防地铁站火灾事故,深入了解地铁站火灾人员疏散影响因素间的内在联系与层次结构,基于第6版“2-4”模型(24Model)分析63起地铁站火灾疏散事故,充分考虑各个因素之间的交互作用,提取19个影响地铁站人员疏散的关键因素,建立地铁站火灾... 为预防地铁站火灾事故,深入了解地铁站火灾人员疏散影响因素间的内在联系与层次结构,基于第6版“2-4”模型(24Model)分析63起地铁站火灾疏散事故,充分考虑各个因素之间的交互作用,提取19个影响地铁站人员疏散的关键因素,建立地铁站火灾人员疏散影响因素指标体系;采用算子客观赋权法(C-OWA)改进决策试验与评价实验法(DEMATEL),确定地铁站火灾人员疏散的重要影响因素;在此基础上,采用解释结构模型(ISM)分析各个因素间的层次结构及相互作用路径,构建地铁站火灾人员疏散影响因素的多级递阶结构模型。研究结果表明:疏散引导、恐慌从众行为、人员拥挤为地铁站火灾人员疏散的关键影响因素;地铁站火灾人员疏散受表层因素、中间层因素、深层因素共同作用的影响,其中,疏散教育与培训、设施维护与检查、疏散预案等因素是根源影响因素,重视根源影响因素的改善有利于从本质上预防和控制事故的发生。 展开更多
关键词 “2-4”模型(24model) 决策试验与评价实验法(DEMATEL) 解释结构模型(ISM) 地铁站 火灾疏散 影响因素
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DEVELOPMENT OF A HYBRID MODEL FOR THREE-DIMENSIONAL GIS 被引量:14
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作者 SHI Wenzhong 《Geo-Spatial Information Science》 2000年第2期6-12,共7页
This paper presents a hybrid model for three_dimensional Geographical Information Systems which is an integration of surface_ and volume_based models.The Triangulated Irregular Network (TIN) and octree models are inte... This paper presents a hybrid model for three_dimensional Geographical Information Systems which is an integration of surface_ and volume_based models.The Triangulated Irregular Network (TIN) and octree models are integrated in this hybrid model.The TIN model works as a surface_based model which mainly serves for surface presentation and visualization.On the other hand,the octree encoding supports volumetric analysis.The designed data structure brings a major advantage in the three_dimensional selective retrieval.This technique increases the efficiency of three_dimensional data operation. 展开更多
关键词 混合三维的模型 听模型 octree 模型 GIS
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A three-dimensional semi-implicit unstructured grid finite volume ocean model 被引量:10
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作者 WANG Zhili GENG Yanfen 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2013年第1期68-78,共11页
A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal d... A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal direction and z-level grid in the vertical direction. The three-dimensional model is discretized by the semi-implicit finite-volume method, in that the free-surface and the vertical diffusion are semi-implicit, thereby removing stability limitations associated with the surface gravity wave and vertical diffusion terms. The remaining terms in the momentum equations are discretized explicitly by an integral method. The partial cell method is used for resolving topography, which enables the model to better represent irregular topography. The model has been tested against analytical cases for wind and tidal oscillation circulation, and is applied to simulating the tidal flow in the Bohal Sea. The results are in good agreement both with the analytical solutions and measurement results. 展开更多
关键词 three-dimensional model finite volume unstructured grid SEMI-IMPLICIT z-level grid
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The study on three-dimensional numerical model and fronts of the Jiulong Estuary and the Xiamen Bay 被引量:3
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作者 LUO Zhibin PAN Weiran +1 位作者 LI Li ZHANG Guorong 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2012年第4期55-64,共10页
Applying the methods of on-site observation and dynamic model, the research on the fronts at the Jiulong Estuary has been carried out, during which spatial and temporal distribution, dynamic characteristics and format... Applying the methods of on-site observation and dynamic model, the research on the fronts at the Jiulong Estuary has been carried out, during which spatial and temporal distribution, dynamic characteristics and formation mechanism of salinity fronts are analyzed and discussed. The research shows that the estuarine fronts mainly lie in the area from the Jiyu Islet to the Haimen Island, outside of Yuweizai to Hulishan cross-section, the near coast of Yuweizai and the south of the Songyu-Gulangyu Channel. The fronts in the former two regions are formed directly by plume, while the one near the coast of Yuweizai is a tidal intrusion front caused by flood current and the one at the south of the Songyu-Gulangyu Channel is the result of current shear transformation. Under normal circumstances, fresh water of the Jiulong River mainly influences the inside of the Xiamen Bay, and when it is in typhoon seasons, plume front can affect the Taiwan Strait and has an effect on the biogeochemical Drocesses in the strait. 展开更多
关键词 Jiulong Estuary Xiamen Bay three-dimensional numerical model FRONTS
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Risk Assessment of Coal Mine Water Hazard Based on Three-Dimensional Model of Geology and Underground Space 被引量:1
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作者 Kai Zhang~1,Ming Huang~1,Bin Tang~2,Fan Cui~1 1.Laboratory of Coal Resources and Mine Safety,China University of Mining and Technology,Beijing 100083,China. 2.China Water Investment Co.Ltd,Beijing 100053,China 《地学前缘》 EI CAS CSCD 北大核心 2009年第S1期279-279,共1页
Mine safety have top-five disasters,which including the water,gas,fire,dust and geological dynamic disaster.The coal mine water disaster is one of the important factors which restricted the development of China’s coa... Mine safety have top-five disasters,which including the water,gas,fire,dust and geological dynamic disaster.The coal mine water disaster is one of the important factors which restricted the development of China’s coal production.It is showed by statistics that 60%of mine accidents are affected by groundwater,which not only result in the production losses,casualties and a variety of 展开更多
关键词 DISASTER risk assessment THREE-dimensionAL model of GEOLOGY and UNDERGROUND space emergency RESCUE
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Model-based Predictive Control for Spatially-distributed Systems Using Dimensional Reduction Models 被引量:3
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作者 Meng-Ling Wang Ning Li Shao-Yuan Li 《International Journal of Automation and computing》 EI 2011年第1期1-7,共7页
In this paper, a low-dimensional multiple-input and multiple-output (MIMO) model predictive control (MPC) configuration is presented for partial differential equation (PDE) unknown spatially-distributed systems ... In this paper, a low-dimensional multiple-input and multiple-output (MIMO) model predictive control (MPC) configuration is presented for partial differential equation (PDE) unknown spatially-distributed systems (SDSs). First, the dimension reduction with principal component analysis (PCA) is used to transform the high-dimensional spatio-temporal data into a low-dimensional time domain. The MPC strategy is proposed based on the online correction low-dimensional models, where the state of the system at a previous time is used to correct the output of low-dimensional models. Sufficient conditions for closed-loop stability are presented and proven. Simulations demonstrate the accuracy and efficiency of the proposed methodologies. 展开更多
关键词 Spatially-distributed system principal component analysis (PCA) time/space separation dimension reduction model predictive control (MPC).
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Three-dimensional forward modeling for magnetotelluric sounding by finite element method 被引量:3
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作者 童孝忠 柳建新 +3 位作者 谢维 徐凌华 郭荣文 程云涛 《Journal of Central South University》 SCIE EI CAS 2009年第1期136-142,共7页
A finite element algorithm combined with divergence condition was presented for computing three-dimensional(3D) magnetotelluric forward modeling. The finite element equation of three-dimensional magnetotelluric forwar... A finite element algorithm combined with divergence condition was presented for computing three-dimensional(3D) magnetotelluric forward modeling. The finite element equation of three-dimensional magnetotelluric forward modeling was derived from Maxwell's equations using general variation principle. The divergence condition was added forcedly to the electric field boundary value problem, which made the solution correct. The system of equation of the finite element algorithm was a large sparse, banded, symmetric, ill-conditioned, non-Hermitian complex matrix equation, which can be solved using the Bi-CGSTAB method. In order to prove correctness of the three-dimensional magnetotelluric forward algorithm, the computed results and analytic results of one-dimensional geo-electrical model were compared. In addition, the three-dimensional magnetotelluric forward algorithm is given a further evaluation by computing COMMEMI model. The forward modeling results show that the algorithm is very efficient, and it has a lot of advantages, such as the high precision, the canonical process of solving problem, meeting the internal boundary condition automatically and adapting to all kinds of distribution of multi-substances. 展开更多
关键词 电场 三维大地电磁模拟技术 计算方法 有限元方法 变分原理
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A Three-dimensional Heterogeneous Mass Transfer Model for the Absorption of Gas into Multiphase System 被引量:1
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作者 蔡旺锋 张丹 +1 位作者 许春建 周明 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2005年第6期717-725,共9页
一个三维的异构的传质模型被建议在气体吸收上调查驱散的粒子的改进。计算本地、全面的改进因素的策略被建议。而不是一个全球格子,合成重叠格子被采用,它简化三维的模型方程的安装和解决方案。驱散的粒子停顿,粒子大小,搬运部件的... 一个三维的异构的传质模型被建议在气体吸收上调查驱散的粒子的改进。计算本地、全面的改进因素的策略被建议。而不是一个全球格子,合成重叠格子被采用,它简化三维的模型方程的安装和解决方案。驱散的粒子停顿,粒子大小,搬运部件的液体固体分配系数,典型接触时间,和在粒子 andgas 液体之间的最短的距离连接,这被发现在吸收上有主要影响改进因素。气体吸收和在液膜的搬运部件的径向扩散上的 particle-particleinteraction 我们与多粒子模拟再学习。建议模型相当从文学预言了试验数据很好。 展开更多
关键词 多项体系气体吸收 三维非均传质模型 复合重叠格 增加因子 气液界面
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Three-Dimension Mathematical Model of Total Phosphor in the Reservoir and Application 被引量:2
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作者 NIEJing YANGTian-xing LIUXiao-duan 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2004年第3期294-298,共5页
Taking the transport of total phosphor pollutants in the Beijing Miyun reservoir for example,we have obtained three dimensional distributing regularity of total phosphor pollutants by the calculation of the linear int... Taking the transport of total phosphor pollutants in the Beijing Miyun reservoir for example,we have obtained three dimensional distributing regularity of total phosphor pollutants by the calculation of the linear interpolation value of each point between horizontal layers. The credibility analysis in allusion to this method was carried out and the programming scheme for realizing this method was set forth. 展开更多
关键词 Water body Total phosphor Three dimensional mathematical model
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Three-Dimensional Model Test for Port Engineering with Multi-Directional Waves 被引量:1
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作者 Yu Yuxiu Liu Shuxue Professor, State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology (DUT), Dalian 116024 Assistant Researcher, State Key Laboratory of Coastal and Offshore Engineering, DUT, Dalian 116024 《China Ocean Engineering》 SCIE EI 1994年第1期51-66,共16页
-The necessity of using irregular waves, especially multi- directional waves to conduct three-dimensional model tests for port engineering and the test method are described in this paper through an example of model te... -The necessity of using irregular waves, especially multi- directional waves to conduct three-dimensional model tests for port engineering and the test method are described in this paper through an example of model test for a port. The test results show that a deep navigation channel has a large effect on the waves in front of the breakwater near the port entrance and on the wave condition in the port. 展开更多
关键词 port engineering three-dimensional model test irregular waves multi-directional waves
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THREE-DIMENSIONAL MATHEMATICAL MODEL AND ITS APPLICATION IN THE NEIGHBORHOOD OF THE THREE GORGES RESERVOIR DAM IN THE YANGTZE RIVER 被引量:1
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作者 方红卫 Wolfgang Rodi 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2002年第3期235-243,共9页
The calculation of flow and sediment transport is one of the most important tasks in river engineering. The task is particularly difficult because a number of complex physical phenomena should be accounted for more re... The calculation of flow and sediment transport is one of the most important tasks in river engineering. The task is particularly difficult because a number of complex physical phenomena should be accounted for more realistically in a model with a predictive power. Three-dimensional calculations of river flow and suspended sediment transport are performed in this paper with application in the Three Gorges Reservoir in the Yangtze River. A period of 76 years after the dam is built is simulated and the results are compared with laboratory measurements obtained by Tsinghua University whereby the model is verified and calibrated. Generally speaking, the calculated results agree well with the experiments, demonstrating that the present model can be used for flow and sediment transport prediction in rivers. 展开更多
关键词 three-dimensional mathematical model sediment transport Three Gorges Project (TGP)
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A Novel Three-Dimensional Mouse Embryonic Implantation Model In Vitro 被引量:2
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作者 SONG Yu-xuan CAO Bin-yun 《Agricultural Sciences in China》 CAS CSCD 2007年第1期115-120,共6页
To regenerate three-dimensional endometrium in vitro as a novel model for studying the mechanism of implantation of embryos, the luminal epithelial cells and stromal cells of the rabbit uterus were separated and cultu... To regenerate three-dimensional endometrium in vitro as a novel model for studying the mechanism of implantation of embryos, the luminal epithelial cells and stromal cells of the rabbit uterus were separated and cultured in vitro. The type Ⅰ mouse tail collagen was used as scaffolding material. The stromal cells were inoculated in the type I mouse tail collagen, and the luminal epithelial cells were inoculated on the type i mouse tall collagen to regenerate the endometrium in vitro. The regenerated endometrium was cultured in DMEM-F/12 media containing 100 nmol L^-1 progesterone, 10 nM β-estradiol, and 10% fetal bovine serum (FBS) for 3 d. The media were then replaced with CZB containing 100 nM progesterone, 10 nmol L-1 β-estradiol, and 10% FBS, and the mouse blastulas were co-cultured with it. The results of scanning electronic micrography showed that the epithelial cells on the surface of the reconstructed endometrium were covered with numerous slender microvilli and some epithelial cells protruded pinopodes. After culturing for 12 h with the mouse blastula, the shedding, attachment, and implantation of the blastula were observed. The blastula can escape from zona pellucida and attach to the three-dimensional endometrium and is then implanted into it. This study showed that the reconstructed three-dimensional endometrium can serve as a robust embryo implantation model in vitro. 展开更多
关键词 three-dimensional endometrium EMBRYO IMPLANTATION model in vitro
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Numerical Simulation of Saline Intrusion and Purging in Long SeaOutfalls with Three-Dimensional Model 被引量:1
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作者 吴玮 严忠民 吴龙华 《China Ocean Engineering》 SCIE EI 2006年第2期279-288,共10页
Saline intrusion into marine sewage ouffalls will greatly decrease the efficiency of sewage disposal. In order to investigate the mechanisms of this flow, in this paper, a three-dimensional numerical model based on F... Saline intrusion into marine sewage ouffalls will greatly decrease the efficiency of sewage disposal. In order to investigate the mechanisms of this flow, in this paper, a three-dimensional numerical model based on FVM (Finite Volume Method) is established, The RNG κ-ε model is selected for turbulence modeling. The time-averaged vohtme fraction equations are introduced to simulate the stratification and inteffaeial exchange of sewage and seawater in outfalls. Validity of the established three-dimensional numerical model is evaluated by comparisons of numerical results with experimental data. With this three-dimensional numerical model, the internal flow characteristics in ouffalls for different sewage discharges are simulated. The results indicate that for a low sewage discharge, saline circulates in the outfall due to intrusion and both the inflowing momentum and the inteffaeial turbulent mixing are important mechanisms to extrude the saline. For a high sewage discharge, saline intrusion could be avoided. The inflow momentum is the main mechanism to extrude the saline and the inteffacial turbulent mixing is nut important relatively. Even at a high sewage discharge, the saline wedge would be retained in the main ouffall pipe after the risers are purged. It takes a long time for this saline wedge to be extruded by interracial turbulent mixing. 展开更多
关键词 sea outfalls saline intrusion saline purging three-dimensional numerical model experimental study
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Research on dynamic updating of three dimensional geological modeling based on the OO-Solid model 被引量:1
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作者 侯恩科 邓念东 +1 位作者 张志华 赵洲 《Journal of Coal Science & Engineering(China)》 2008年第3期420-424,共5页
The dynamic updating of the model included: the change of space border,addi- tion and reduction of spatial component (disappearing,dividing and merging),the change of the topological relationship and synchronous dynam... The dynamic updating of the model included: the change of space border,addi- tion and reduction of spatial component (disappearing,dividing and merging),the change of the topological relationship and synchronous dynamic updating of database.Firstly, arming at the deficiency of OO-Solid model in the aspect of dynamic updating,modeling primitives of OO-Solid model were modified.And then the algorithms of dynamic updating of 3D geological model with the node data,line data or surface data change were dis- cussed.The core algorithms was done by establishing space index,following the way of facing the object from bottom to top,namely the dynamic updating from the node to arc, and then to polygon,then to the face of the component and finally to the geological object. The research has important theoretical and practical values in the field of three dimen- sional geological modeling and is significant in the field of mineral resources. 展开更多
关键词 数字化煤矿 三维地质模式 煤炭开采 采煤方法
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Analysis of axial strain in one-dimensional loading by different models 被引量:2
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作者 G.Aryanpour M.Farzaneh 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2010年第5期745-753,共9页
Different phenomenological equations based on plasticity, primary creep (as a viscoplastic mechanism), secondary creep (as another viscoplastic mechanism) and different combinations of these equations are presente... Different phenomenological equations based on plasticity, primary creep (as a viscoplastic mechanism), secondary creep (as another viscoplastic mechanism) and different combinations of these equations are presented and used to describe the material inelastic deformation in uniaxial test. Agreement of the models with experimental results and with the theoretical concepts and physical realities is the criterion of choosing the most appropriate formulation for uniaxial test. A model is thus proposed in which plastic deformation, primary creep and secondary creep contribute to the inelastic deformation. However, it is believed that the hardening parameter is composed of plastic and primary creep parts. Accordingly, the axial plastic strain in a uniaxial test may no longer be considered as the hardening parameter. Therefore, a proportionality concept is proposed to calculate the plastic contribution of deformation. 展开更多
关键词 modelling Uniaxial test Plastic - Creep Strain hardening - Proportionality
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Development of a Percentile Based Three-dimensional Model of the Buttocks in Computer System 被引量:2
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作者 WANG Lijing HE Xueli LI Hongpeng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第3期633-640,共8页
There are diverse products related to human buttocks, which need to be designed, manufactured and evaluated with 3D buttock model. The 3D buttock model used in present research field is just simple approximate model s... There are diverse products related to human buttocks, which need to be designed, manufactured and evaluated with 3D buttock model. The 3D buttock model used in present research field is just simple approximate model similar to human buttocks. The 3D buttock percentile model is highly desired in the ergonomics design and evaluation for these products. So far, there is no research on the percentile sizing system of human 3D buttock model. So the purpose of this paper is to develop a new method for building three-dimensional buttock percentile model in computer system. After scanning the 3D shape of buttocks, the cloud data of 3D points is imported into the reverse engineering software(Geomagic) for the reconstructing of the buttock surface model. Five characteristic dimensions of the buttock are measured through mark-points after models being imported into engineering software CATIA. A series of space points are obtained by the intersecting of the cutting slices and 3D buttock surface model, and then are ordered based on the sequence number of the horizontal and vertical slices. The 1st, 5th, 50 th, 95 th, 99 th percentile values of the five dimensions and the spatial coordinate values of the space points are obtained, and used to reconstruct percentile buttock models. This research proposes a establishing method of percentile sizing system of buttock 3D model based on the percentile values of the ischial tuberosities diameter, the distances from margin to ischial tuberosity and the space coordinates value of coordinate points, for establishing the Nth percentile 3D buttock model and every special buttock types model. The proposed method also serves as a useful guidance for the other 3D percentile models establishment for other part in human body with characteristic points. 展开更多
关键词 three-dimensional percentile buttock model point-cloud
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Simulation-Based Construction of Three-Dimensional Process Model for Punching Cartridge Cases 被引量:1
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作者 Zhifang Wei Yechang Hu +1 位作者 Wu Lyu Jianzhong Gao 《Journal of Beijing Institute of Technology》 EI CAS 2018年第2期276-284,共9页
A method of constructing three-dimensional process model for the punching cartridge cases is presented based on DEFORM simulation analysis. Using DEFORM software,the finite element simulation models for the punching a... A method of constructing three-dimensional process model for the punching cartridge cases is presented based on DEFORM simulation analysis. Using DEFORM software,the finite element simulation models for the punching and forming process of cartridge cases are established,and the corresponding simulation result model of each intermediate procedure is obtained by continuously performing the forming process simulation. The simulation model cannot annotate size and process information due to poor interface between DEFORM software and CAD software. Thus,a 3D annotation module is developed with secondary development technology of UG NX software. Consequently,the final process model with dimension and process information is obtained. Then,with the current 3D process management system,the 3D punching and forming process design of cartridge cases can be completed further. An example is also provided to illustrate that the relative error between the simulation process model and the physical model is less than 2%,which proves the validity and reliability of the proposed method in this study. 展开更多
关键词 punching three-dimensional process model finite element simulation three-dimensional annotation
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Construction and Analysis of Three-dimensional Graphic Model of Single-chain Fv Derived from an Anti-human Placental Acidic Isoferritin Monoclonal Antibody by Computer 被引量:3
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作者 周春 沈关心 +4 位作者 朱慧芬 杨静 张悦 冯健南 沈倍奋 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2000年第1期23-25,共3页
Summary: A three-dimensional (3D) graphic model of a single-chain Fv (scFv) which was derived from an anti-human placental acidic isoferritin (PAF) monoclonal antibody (MAb) was construct- ed by a homologous protein... Summary: A three-dimensional (3D) graphic model of a single-chain Fv (scFv) which was derived from an anti-human placental acidic isoferritin (PAF) monoclonal antibody (MAb) was construct- ed by a homologous protein-predicting computer algorithm on Silicon graphic computer station. The structure, surface static electricity and hydrophobicity of scFv were investigated. Computer graphic modelling indicated that all regions of scFv including the linker, variable regions of the heavy (VH) and light (VL) chains were suitable. The VH region and the VL region were involved in composing the 'hydrophobic pocket'. The linker was drifted away VH and VL regions. The complementarity determining regions (CDRs) of VH and VL regions surrounded the 'hydrophobic pocket'. This study provides a theory basis for improving antibody affinity, investigating antibody structure and analyzing the functions of VH and VL regions in antibody activity. 展开更多
关键词 placental acidic isoferritin single-chain Fv three-dimensional structure com- puter modelling
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