To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling(3D pc-ASL)in measuring cerebral blood flow(CBF)with different post-labeling delay time(PLD)in the resting...To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling(3D pc-ASL)in measuring cerebral blood flow(CBF)with different post-labeling delay time(PLD)in the resting state and the right finger taping state.Methods 3D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo(3D T1-FSPGR)sequence were applied to eight healthy subjects twice at the same time each day for one week interval.ASL data acquisition was performed with post-labeling delay time(PLD)1.5 seconds and 2.0 seconds in the resting state and the right finger taping state respectively.CBF mapping was calculated and CBF value of both the gray matter(GM)and white matter(WM)was automatically extracted.The reliability was evaluated using the intraclass correlation coefficient(ICC)and Bland and Altman plot.Results ICC of the GM(0.84)and WM(0.92)was lower at PLD 1.5 seconds than that(GM,0.88;WM,0.94)at PLD 2.0 seconds in the resting state,and ICC of GM(0.88)was higher in the right finger taping state than that in the resting state at PLD 1.5 seconds.ICC of the GM and WM was 0.71 and 0.78 for PLD 1.5 seconds and PLD 2.0 seconds in the resting state at the first scan,and ICC of the GM and WM was 0.83 and 0.79 at the second scan,respectively.Conclusion This work demonstrated that 3D pc-ASL might be a reliable imaging technique to measure CBF over the whole brain at different PLD in the resting state or controlled state.展开更多
Arterial spin labeling(ASL) is a magnetic resonance imaging technique for measuring tissue perfusion using a freely diffusible intrinsic tracer.As compared with other perfusion techniques,ASL offers several advantages...Arterial spin labeling(ASL) is a magnetic resonance imaging technique for measuring tissue perfusion using a freely diffusible intrinsic tracer.As compared with other perfusion techniques,ASL offers several advantages and is now available for routine clinical practice in many institutions.Its noninvasive nature and ability to quantitatively measure tissue perfusion make ASL ideal for research and clinical studies.Recent technical advances have increased its sensitivity and also extended its potential applications.This review focuses on some basic knowledge of ASL perfusion,emerging techniques and clinical applications in neuroimaging.展开更多
基金Supported by the Foundation for Medical and Health Sci&Tech Innovation Project of Sanya(2016YW37)the Special Financial Grant from China Postdoctoral Science Foundation(2014T70960)
文摘To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling(3D pc-ASL)in measuring cerebral blood flow(CBF)with different post-labeling delay time(PLD)in the resting state and the right finger taping state.Methods 3D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo(3D T1-FSPGR)sequence were applied to eight healthy subjects twice at the same time each day for one week interval.ASL data acquisition was performed with post-labeling delay time(PLD)1.5 seconds and 2.0 seconds in the resting state and the right finger taping state respectively.CBF mapping was calculated and CBF value of both the gray matter(GM)and white matter(WM)was automatically extracted.The reliability was evaluated using the intraclass correlation coefficient(ICC)and Bland and Altman plot.Results ICC of the GM(0.84)and WM(0.92)was lower at PLD 1.5 seconds than that(GM,0.88;WM,0.94)at PLD 2.0 seconds in the resting state,and ICC of GM(0.88)was higher in the right finger taping state than that in the resting state at PLD 1.5 seconds.ICC of the GM and WM was 0.71 and 0.78 for PLD 1.5 seconds and PLD 2.0 seconds in the resting state at the first scan,and ICC of the GM and WM was 0.83 and 0.79 at the second scan,respectively.Conclusion This work demonstrated that 3D pc-ASL might be a reliable imaging technique to measure CBF over the whole brain at different PLD in the resting state or controlled state.
文摘Arterial spin labeling(ASL) is a magnetic resonance imaging technique for measuring tissue perfusion using a freely diffusible intrinsic tracer.As compared with other perfusion techniques,ASL offers several advantages and is now available for routine clinical practice in many institutions.Its noninvasive nature and ability to quantitatively measure tissue perfusion make ASL ideal for research and clinical studies.Recent technical advances have increased its sensitivity and also extended its potential applications.This review focuses on some basic knowledge of ASL perfusion,emerging techniques and clinical applications in neuroimaging.
