The simulation of salinity at different locations of a tidal river using physically-based hydrodynamic models is quite cumbersome because it requires many types of data, such as hydrological and hydraulic time series ...The simulation of salinity at different locations of a tidal river using physically-based hydrodynamic models is quite cumbersome because it requires many types of data, such as hydrological and hydraulic time series at boundaries, river geometry, and adjusted coefficients. Therefore, an artificial neural network (ANN) technique using a back-propagation neural network (BPNN) and a radial basis function neural network (RBFNN) is adopted as an effective alternative in salinity simulation studies. The present study focuses on comparing the performance of BPNN, RBFNN, and three-dimensional hydrodynamic models as applied to a tidal estuarine system. The observed salinity data sets collected from 18 to 22 May, 16 to 22 October, and 26 to 30 October 2002 (totaling 4320 data points) were used for BPNN and RBFNN model training and for hydrodynamic model calibration. The data sets collected from 30 May to 2 June and 11 to 15 November 2002 (totaling 2592 data points) were adopted for BPNN and RBFNN model verification and for hydrodynamic model verification. The results revealed that the ANN (BPNN and RBFNN) models were capable of predicting the nonlinear time series behavior of salinity to the multiple forcing signals of water stages at different stations and freshwater input at upstream boundaries. The salinity predicted by the ANN models was better than that predicted by the physically based hydrodynamic model. This study suggests that BPNN and RBFNN models are easy-to-use modeling tools for simulating the salinity variation in a tidal estuarine system.展开更多
Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor ...Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells.This study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I collagen.It also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and migration.Finally,it compares two-dimensional(2D)and 3D cultures.For comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D model.Besides,the two models yielded significantly different cell morphologies.Finally,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D model.These results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture systems.The developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.展开更多
Natural convection is a heat transfer mechanism driven by temperature or density differences,leading to fluid motion without external influence.It occurs in various natural and engineering phenomena,influencing heat t...Natural convection is a heat transfer mechanism driven by temperature or density differences,leading to fluid motion without external influence.It occurs in various natural and engineering phenomena,influencing heat transfer,climate,and fluid mixing in industrial processes.This work aims to use the Updated Lagrangian Particle Hydrodynamics(ULPH)theory to address natural convection problems.The Navier-Stokes equation is discretized using second-order nonlocal differential operators,allowing a direct solution of the Laplace operator for temperature in the energy equation.Various numerical simulations,including cases such as natural convection in square cavities and two concentric cylinders,were conducted to validate the reliability of the model.The results demonstrate that the proposed model exhibits excellent accuracy and performance,providing a promising and effective numerical approach for natural convection problems.展开更多
With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,...With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,fault throw analyzing,and balanced profile restoration,it is pointed out that the transtensional fault system in the Ziyang 3-D seismic survey consists of the northeast-trending F_(I)19 and F_(I)20 fault zones dominated by extensional deformation,as well as 3 sets of northwest-trending en echelon normal faults experienced dextral shear deformation.Among them,the F_(I)19 and F_(I)20 fault zones cut through the Neoproterozoic to Lower Triassic Jialingjiang Formation,presenting a 3-D structure of an“S”-shaped ribbon.And before Permian and during the Early Triassic,the F_(I)19 and F_(I)20 fault zones underwent at least two periods of structural superimposition.Besides,the 3 sets of northwest-trending en echelon normal faults are composed of small normal faults arranged in pairs,with opposite dip directions and partially left-stepped arrangement.And before Permian,they had formed almost,restricting the eastward growth and propagation of the F_(I)19 fault zone.The F_(I)19 and F_(I)20 fault zones communicate multiple sets of source rocks and reservoirs from deep to shallow,and the timing of fault activity matches well with oil and gas generation peaks.If there were favorable Cambrian-Triassic sedimentary facies and reservoirs developing on the local anticlinal belts of both sides of the F_(I)19 and F_(I)20 fault zones,the major reservoirs in this area are expected to achieve breakthroughs in oil and gas exploration.展开更多
Two-dimensional(2D)flume experiments are useful in investigating the performances of floating breakwaters(FBs),including hydrodynamic performances,motion responses,and mooring forces.Designing a reasonable gap between...Two-dimensional(2D)flume experiments are useful in investigating the performances of floating breakwaters(FBs),including hydrodynamic performances,motion responses,and mooring forces.Designing a reasonable gap between the flume wall and the FBs is a critical step in 2D flume tests.However,research on the effect of the gap on the accuracy of 2D FB experimental results is scarce.To address this issue,a numerical wave tank is developed using CFD to estimate the wave-FB interaction of a moored dual-cylindrical FB,and the results are compared to experimental data from a previously published work.There is good agreement between them,indicating that the numerical model is sufficiently accurate.The numerical model is then applied to explore the effect of gap diffraction on the performance of FBs in2D experiments.It was discovered that the nondimensional gap length L_(Gap)/W_(Pool)should be smaller than 7.5%to ensure that the relative error of the transmission coefficient is smaller than 3%.The influence of the gap is also related to the entering wave properties,such as the wave height and period.展开更多
BACKGROUND Esophageal cancer is one of the most common malignant tumors.The three-dimensional quality structure model is a quality assessment theory that includes three dimensions:Structure,process,and results.AIM To ...BACKGROUND Esophageal cancer is one of the most common malignant tumors.The three-dimensional quality structure model is a quality assessment theory that includes three dimensions:Structure,process,and results.AIM To investigate the effects of nursing interventions with three-dimensional quality assessment on the efficacy and disease management ability of patients undergoing esophageal cancer surgery.METHODS In this prospective study,the control group received routine nursing,and the intervention group additionally received a three-dimensional quality assessment intervention based on the above routine care.Self-efficacy and patient disease management abilities were evaluated using the General Self-Efficacy Scale(GSES)and Exercise of Self-Care Agency scale,respectively.IBM SPSS Statistics for Windows,version 17.0,was used for the data processing.RESULTS This study recruited 112 patients who were assigned to the control and experi-mental groups(n=56 per group).Before the intervention,there was no significant difference in GSES scores between the two groups(P>0.05).After the inter-vention,the GSES scores of both groups increased,with the experimental group showing higher values(P<0.05).At the time of discharge and three months after discharge,the scores for positive attitudes,self-stress reduction,and total score of health promotion in the experimental group were higher than those in the control group(P<0.05).CONCLUSION The implementation of a three-dimensional quality structure model for postoperative patients with esophageal cancer can effectively improve their self-management ability and self-efficacy of postoperative patients.展开更多
Aiming at the problems that the simulation accuracy which is reduced due to the simplification of the model,a three-dimensional simulation method based on solid modeling is being proposed.By analyzing the motion relat...Aiming at the problems that the simulation accuracy which is reduced due to the simplification of the model,a three-dimensional simulation method based on solid modeling is being proposed.By analyzing the motion relationship and positional relationship between the caries knife and the workpiece,the coordinate system of the caries machining was established.With the MATLAB software,the cutting edge model and the blade sweeping surface model of the boring cutter are sequentially established.Boolean operation is performed on the blade swept surface formed by the tooth cutter teeth with time t and the workpiece tooth geometry as well as the undeformed three-dimensional chip geometry model and the instantaneous cogging geometry model are obtained at different times.Through the compare between gear end face simulation tooth profile and the theoretical inner arc tooth profile,we verified the accuracy and rationality of the proposed method.展开更多
We combined domestic ground-based and satellite magnetic measurements to create a regional three-dimensional surface Spline(3DSS)gradient model of the main geomagnetic field over the Chinese continent.To improve the p...We combined domestic ground-based and satellite magnetic measurements to create a regional three-dimensional surface Spline(3DSS)gradient model of the main geomagnetic field over the Chinese continent.To improve the precision of the model,we considered the data gap between the ground and satellite data.We compared and analyzed the results of the Taylor polynomial,surface Spline,and CHAOS-6(the CHAMP,?rsted and SAC-C model of Earth’s magnetic field)gradient models.Results showed that the gradients in the south-north and east-west directions of the four models were consistent.The 3DSS model was able to express not only gradients at different altitudes,but also average gradients inside the research area.The two Spline models were able to capture more information on gradient anomalies than were the fitted models.Strong local anomalies were observed in northern Xinjiang,Beijing,and the junction area between Jiangsu and Zhejiang,and the total intensity F decreased whereas the altitude increased.The gradient decreased by 21.69%in the south-north direction and increased by 11.78%in the east-west direction.In addition,the altitude gradient turned from negative to positive while the altitude increased.The Spline model and the two fitted models differed mainly in the field sources they expressed and the modeling theory.展开更多
In this paper,we apply the method given in the paper“Zero relaxation time limits to a hydrodynamic model of two carrier types for semiconductors”(Mathematische Annalen,2022,382:1031–1046)to study the Cauchy problem...In this paper,we apply the method given in the paper“Zero relaxation time limits to a hydrodynamic model of two carrier types for semiconductors”(Mathematische Annalen,2022,382:1031–1046)to study the Cauchy problem for a one dimensional inhomogeneous hydrodynamic model of two-carrier types for semiconductors with the velocity relaxation.展开更多
Objective To evaluate the predictive validity of IRIS™(Intuitive Surgical®,Sunnyvale,CA,USA)as a planning tool for robot-assisted partial nephrectomy(RAPN)by assessing the degree of overlap with intraoperative ex...Objective To evaluate the predictive validity of IRIS™(Intuitive Surgical®,Sunnyvale,CA,USA)as a planning tool for robot-assisted partial nephrectomy(RAPN)by assessing the degree of overlap with intraoperative execution.Methods Thirty-one patients scheduled for RAPN by four experienced urologists were enrolled in a prospective study.Prior to surgery,urologists reviewed the IRIS™three-dimensional model on an iphone Operating System(iOS)app and completed a questionnaire outlining their surgical plan including surgical approach,and ischemia technique as well as confidence in executing this plan.Postoperatively,questionnaires assessing the procedural approach,clinical utility,efficiency,and effectiveness of IRIS™were completed.The degree of overlap between the preoperative and intraoperative questionnaires and between the planned approach and actual execution of the procedure was analyzed.Questionnaires were answered on a 5-point Likert scale and scores of 4 or greater were considered positive.Results Mean age was 65.1 years with a mean tumor size of 27.7 mm(interquartile range 17.5-44.0 mm).Hilar tumors consisted of 32.3%;48.4%of patients had R.E.N.A.L.nephrometry scores of 7-9.On preoperative questionnaires,the surgeons reported that in 67.7%cases they were confident that they can perform the procedure successfully,and on intraoperative questionnaires,the surgeons reported that in 96.8%cases IRIS™helped achieve good spatial sensation of the anatomy.There was a high degree of overlap between preoperative and intraoperative questionnaires for the surgical approach,interpreting anatomical details and clinical utility.When comparing plans for selective or off-clamp,the preoperative plan was executed in 90.0%of cases intraoperatively.Conclusion A high degree of overlap between the preoperative surgical approach and intraoperative RAPN execution was found using IRIS™.This is the first study to evaluate the predictive accuracy of IRIS™during RAPN by comparing preoperative plan and intraoperative execution.展开更多
In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare co...In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers.展开更多
In order to facilitate engineering design and coastal flooding protection, the potential storm surge induced by a typhoon is studied.Using an unstructured mesh, a coupled model which combines the advanced circulation ...In order to facilitate engineering design and coastal flooding protection, the potential storm surge induced by a typhoon is studied.Using an unstructured mesh, a coupled model which combines the advanced circulation ( ADCIRC ) hydrodynamic model and simulating waves nearshore ( SWAN ) model is applied to analyze the storm surge and waves on the coast of Jiangsu Province.The verifications of wind velocity, tidal levels and wave height show that this coupling model performs well to reflect the characteristics of the water levels and waves in the studied region.Results show that the effect of radiation stress on storm surge is significant, especially in shallow areas such as the coast of Jiangsu Province and the Yangtze estuary.By running the coupled model, the simulated potential flooding results can be employed in coastal engineering applications in the Jiangsu coastal area, such as storm surge warnings and extreme water level predictions.展开更多
The shear failure of intact rock under thermo-mechanical(TM)coupling conditions is common,such as in enhanced geothermal mining and deep mine construction.Under the effect of a continuous engineering disturbance,shear...The shear failure of intact rock under thermo-mechanical(TM)coupling conditions is common,such as in enhanced geothermal mining and deep mine construction.Under the effect of a continuous engineering disturbance,shear-formed fractures are prone to secondary instability,posing a severe threat to deep engineering.Although numerous studies regarding three-dimensional(3D)morphologies of fracture surfaces have been conducted,the understanding of shear-formed fractures under TM coupling conditions is limited.In this study,direct shear tests of intact granite under various TM coupling conditions were conducted,followed by 3D laser scanning tests of shear-formed fractures.Test results demonstrated that the peak shear strength of intact granite is positively correlated with the normal stress,whereas it is negatively correlated with the temperature.The internal friction angle and cohesion of intact granite significantly decrease with an increase in the temperature.The anisotropy,roughness value,and height of the asperities on the fracture surfaces are reduced as the normal stress increases,whereas their variation trends are the opposite as the temperature increases.The macroscopic failure mode of intact granite under TM coupling conditions is dominated by mixed tensileeshear and shear failures.As the normal stress increases,intragranular fractures are developed ranging from a local to a global distribution,and the macroscopic failure mode of intact granite changes from mixed tensileeshear to shear failure.Finally,3D morphological characteristics of the asperities on the shear-formed fracture surfaces were analyzed,and a quadrangular pyramid conceptual model representing these asperities was proposed and sufficiently verified.展开更多
This paper presents a hybrid model for three-dimensional Geographical Information Systems which is an integration of surface- and volume-based models. The Triangulated Irregular Network (TIN) and octree models are int...This paper presents a hybrid model for three-dimensional Geographical Information Systems which is an integration of surface- and volume-based models. The Triangulated Irregular Network (TIN) and octree models are integrated in this hybrid models. The TIN model works as a surface-based model which mainly serves for surface presentation and visualization. On the other hand, the octree encoding supports volumetric analysis. The designed data structure brings a major advantage in the three-dimensional selective retrieval. This technique increases the efficiency of three-dimensional data operation.展开更多
This paper presents the features of newly designed hydrodynamics test for the scaled model of 4500 m deepsea open-framed remotely operated vehicle (ROV), which is being researched and developed by Shanghai Jiao Tong...This paper presents the features of newly designed hydrodynamics test for the scaled model of 4500 m deepsea open-framed remotely operated vehicle (ROV), which is being researched and developed by Shanghai Jiao Tong University. Accurate hydrodynamics coefficients measurement and spatial modeling of ROV are significant for the maneuverability and control algorithm. The scaled model of ROV was constructed by 1:1.6. Hydrodynamics coefficients were measured through VPMM and LAHPMM towing test. And dynamics model was derived as a set of equations, describing nonlinear and coupled 5-DOF spatial motions. Rotation control motion was simulated to verify spatial model proposed. Research and application of hydrodynamics coefficients are expected to enable ROV to overcome uncertainty and disturbances of deepsea environment, and accomplish some more challengeable and practical missions.展开更多
The hydrodynamic forces and flow field of artificial reef models in steady flow were numerically investigated using the RNG κ-ε turbulent model. The numerical simulation results are consistent with results observed ...The hydrodynamic forces and flow field of artificial reef models in steady flow were numerically investigated using the RNG κ-ε turbulent model. The numerical simulation results are consistent with results observed by experimental means. A comparative study indicates that the corresponding errors of forces between calculated values and values observed in the experiment vary in the range of2.3%-11.2% and that the corresponding errors of velocities vary in the range of 1.3%-15.8%. The flow field numerical results show that upstream and vortices exist when the current passes over and through the surface of the reef model. This study suggests that the numerical simulation method can be applied to predict the forces and flow field associated with artificial reefs.展开更多
A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal d...A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal direction and z-level grid in the vertical direction. The three-dimensional model is discretized by the semi-implicit finite-volume method, in that the free-surface and the vertical diffusion are semi-implicit, thereby removing stability limitations associated with the surface gravity wave and vertical diffusion terms. The remaining terms in the momentum equations are discretized explicitly by an integral method. The partial cell method is used for resolving topography, which enables the model to better represent irregular topography. The model has been tested against analytical cases for wind and tidal oscillation circulation, and is applied to simulating the tidal flow in the Bohal Sea. The results are in good agreement both with the analytical solutions and measurement results.展开更多
Merits of the Fernandes model(Fernandes et al.1983)for two-phase slug flow in verticaltubes are reviewed in this paper.While predicting many macroscopic parameters of slug flow in verti-cal tubes,it fails to present c...Merits of the Fernandes model(Fernandes et al.1983)for two-phase slug flow in verticaltubes are reviewed in this paper.While predicting many macroscopic parameters of slug flow in verti-cal tubes,it fails to present correctly the trend that the average voidage in liquid slugs increases asthe rising velocity of Taylor bubbles is increased.It is also desirable to extend its application toelectrolyte systems, and to churn flow conditions.Based on the diagnostic analysis,the model equa-tion for gas entrainment by falling liquid film is reformulated and the influence of surface tension isalso accounted for.Development of the falling liquid film is recognized in the revised model in or-der to suit the case of short Taylor bubbles as well.The modified model predicts the variation of av-erage voidage in liquid slugs in good agreement with available experimental data.展开更多
Radius of ceramic cone can largely contribute into final solution of analytic models of penetration into ceramic/metal targets.In the present research,a modified model based on radius of ceramic cone was presented for...Radius of ceramic cone can largely contribute into final solution of analytic models of penetration into ceramic/metal targets.In the present research,a modified model based on radius of ceramic cone was presented for ceramic/aluminum targets.In order to investigate and evaluate accuracy of the presented analytic model,obtained results were compared against the results of the Florence’s analytic model and also against numerical modeling results.The phenomenon of impact onto ceramic/aluminum composites were modeled using smoothed particle hydrodynamics(SPH)implemented utilizing ABAQUS Software.Results indicated that,with increasing initial velocity and ceramic thickness and decreasing support layer thickness,the radius of ceramic cone decreases;this ends up increasing residual velocity of the projectile and penetration time and extending the area across which the pressure is distributed.These findings indicate enhanced levels of target energy absorption and the required energy for bending and tensioning the target.As such,it can be observed that,at the same thickness and areal density,the ceramic target has its efficiency enhanced with increasing ceramic thickness and decreasing the support layer thickness.Finally,the results revealed that the associated data with SPH confirm the modified analytic model at higher accuracy than the Florence’s analytic model.展开更多
A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model ...A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model tests are carried out to consider the effects of exciting wave directions and types. Based on the experimental results, two hydrodynamic force models derived from Morisen equation and Wake model are presented respectively. By use of hydrodynamic force models suitable for free spanning submarine pipelines under earthquakes, diseretized equations of motion are obtained and finite element models are established to analyze dynamic response of free spanning submarine pipeline subjected to multi-support seismic excitations. The comparison of numerical results with experimental results shows that the improved Morison and Wake hydrodynamic force models could satisfactorily predict dynamic response on the free spanning submarine pipelines subjected to earthquakes.展开更多
文摘The simulation of salinity at different locations of a tidal river using physically-based hydrodynamic models is quite cumbersome because it requires many types of data, such as hydrological and hydraulic time series at boundaries, river geometry, and adjusted coefficients. Therefore, an artificial neural network (ANN) technique using a back-propagation neural network (BPNN) and a radial basis function neural network (RBFNN) is adopted as an effective alternative in salinity simulation studies. The present study focuses on comparing the performance of BPNN, RBFNN, and three-dimensional hydrodynamic models as applied to a tidal estuarine system. The observed salinity data sets collected from 18 to 22 May, 16 to 22 October, and 26 to 30 October 2002 (totaling 4320 data points) were used for BPNN and RBFNN model training and for hydrodynamic model calibration. The data sets collected from 30 May to 2 June and 11 to 15 November 2002 (totaling 2592 data points) were adopted for BPNN and RBFNN model verification and for hydrodynamic model verification. The results revealed that the ANN (BPNN and RBFNN) models were capable of predicting the nonlinear time series behavior of salinity to the multiple forcing signals of water stages at different stations and freshwater input at upstream boundaries. The salinity predicted by the ANN models was better than that predicted by the physically based hydrodynamic model. This study suggests that BPNN and RBFNN models are easy-to-use modeling tools for simulating the salinity variation in a tidal estuarine system.
基金supported by the National Natural Science Foundation of China (No. 52275291)the Fundamental Research Funds for the Central Universitiesthe Program for Innovation Team of Shaanxi Province,China (No. 2023-CX-TD-17)
文摘Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells.This study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I collagen.It also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and migration.Finally,it compares two-dimensional(2D)and 3D cultures.For comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D model.Besides,the two models yielded significantly different cell morphologies.Finally,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D model.These results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture systems.The developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.
基金support from the National Natural Science Foundations of China(Nos.11972267 and 11802214)the Open Foundation of the Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics and the Open Foundation of Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment.
文摘Natural convection is a heat transfer mechanism driven by temperature or density differences,leading to fluid motion without external influence.It occurs in various natural and engineering phenomena,influencing heat transfer,climate,and fluid mixing in industrial processes.This work aims to use the Updated Lagrangian Particle Hydrodynamics(ULPH)theory to address natural convection problems.The Navier-Stokes equation is discretized using second-order nonlocal differential operators,allowing a direct solution of the Laplace operator for temperature in the energy equation.Various numerical simulations,including cases such as natural convection in square cavities and two concentric cylinders,were conducted to validate the reliability of the model.The results demonstrate that the proposed model exhibits excellent accuracy and performance,providing a promising and effective numerical approach for natural convection problems.
基金Supported by the Key Project of National Natural Science Foundation of China(42330810).
文摘With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,fault throw analyzing,and balanced profile restoration,it is pointed out that the transtensional fault system in the Ziyang 3-D seismic survey consists of the northeast-trending F_(I)19 and F_(I)20 fault zones dominated by extensional deformation,as well as 3 sets of northwest-trending en echelon normal faults experienced dextral shear deformation.Among them,the F_(I)19 and F_(I)20 fault zones cut through the Neoproterozoic to Lower Triassic Jialingjiang Formation,presenting a 3-D structure of an“S”-shaped ribbon.And before Permian and during the Early Triassic,the F_(I)19 and F_(I)20 fault zones underwent at least two periods of structural superimposition.Besides,the 3 sets of northwest-trending en echelon normal faults are composed of small normal faults arranged in pairs,with opposite dip directions and partially left-stepped arrangement.And before Permian,they had formed almost,restricting the eastward growth and propagation of the F_(I)19 fault zone.The F_(I)19 and F_(I)20 fault zones communicate multiple sets of source rocks and reservoirs from deep to shallow,and the timing of fault activity matches well with oil and gas generation peaks.If there were favorable Cambrian-Triassic sedimentary facies and reservoirs developing on the local anticlinal belts of both sides of the F_(I)19 and F_(I)20 fault zones,the major reservoirs in this area are expected to achieve breakthroughs in oil and gas exploration.
基金financially supported by China National Funds for Distinguished Young Scientists(Grant No.52025112)the Key Projects of the National Natural Science Foundation of China(Grant No.52331011)。
文摘Two-dimensional(2D)flume experiments are useful in investigating the performances of floating breakwaters(FBs),including hydrodynamic performances,motion responses,and mooring forces.Designing a reasonable gap between the flume wall and the FBs is a critical step in 2D flume tests.However,research on the effect of the gap on the accuracy of 2D FB experimental results is scarce.To address this issue,a numerical wave tank is developed using CFD to estimate the wave-FB interaction of a moored dual-cylindrical FB,and the results are compared to experimental data from a previously published work.There is good agreement between them,indicating that the numerical model is sufficiently accurate.The numerical model is then applied to explore the effect of gap diffraction on the performance of FBs in2D experiments.It was discovered that the nondimensional gap length L_(Gap)/W_(Pool)should be smaller than 7.5%to ensure that the relative error of the transmission coefficient is smaller than 3%.The influence of the gap is also related to the entering wave properties,such as the wave height and period.
文摘BACKGROUND Esophageal cancer is one of the most common malignant tumors.The three-dimensional quality structure model is a quality assessment theory that includes three dimensions:Structure,process,and results.AIM To investigate the effects of nursing interventions with three-dimensional quality assessment on the efficacy and disease management ability of patients undergoing esophageal cancer surgery.METHODS In this prospective study,the control group received routine nursing,and the intervention group additionally received a three-dimensional quality assessment intervention based on the above routine care.Self-efficacy and patient disease management abilities were evaluated using the General Self-Efficacy Scale(GSES)and Exercise of Self-Care Agency scale,respectively.IBM SPSS Statistics for Windows,version 17.0,was used for the data processing.RESULTS This study recruited 112 patients who were assigned to the control and experi-mental groups(n=56 per group).Before the intervention,there was no significant difference in GSES scores between the two groups(P>0.05).After the inter-vention,the GSES scores of both groups increased,with the experimental group showing higher values(P<0.05).At the time of discharge and three months after discharge,the scores for positive attitudes,self-stress reduction,and total score of health promotion in the experimental group were higher than those in the control group(P<0.05).CONCLUSION The implementation of a three-dimensional quality structure model for postoperative patients with esophageal cancer can effectively improve their self-management ability and self-efficacy of postoperative patients.
基金The National Natural Science Foundation of China (No.52165060,12272189)Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region: (NJYT23022)+2 种基金Science and Technology Projects of Inner Mongolia Autonomous Region: (2021GG0432)Central Guiding Local Science and Technology Development Plan (2022ZY0013)Basic research business fee project for universities directly under Inner Mongolia Autonomous Region (GXKY22046).
文摘Aiming at the problems that the simulation accuracy which is reduced due to the simplification of the model,a three-dimensional simulation method based on solid modeling is being proposed.By analyzing the motion relationship and positional relationship between the caries knife and the workpiece,the coordinate system of the caries machining was established.With the MATLAB software,the cutting edge model and the blade sweeping surface model of the boring cutter are sequentially established.Boolean operation is performed on the blade swept surface formed by the tooth cutter teeth with time t and the workpiece tooth geometry as well as the undeformed three-dimensional chip geometry model and the instantaneous cogging geometry model are obtained at different times.Through the compare between gear end face simulation tooth profile and the theoretical inner arc tooth profile,we verified the accuracy and rationality of the proposed method.
基金the support of the National Natural Science Foundation of China(Nos.41974073,41404053)the Macao Foundation and the pre-research project of Civil Aerospace Technologies(Nos.D020308 and D020303)+2 种基金funded by the National Space Administration of Chinathe opening fund of the State Key Laboratory of Lunar and Planetary Sciences(Macao University of Science and Technology,Macao Science and Technology Development Fund No.119/2017/A3)the Specialized Research Fund for State Key Laboratories,and the NUIST-UoR International Research Institute。
文摘We combined domestic ground-based and satellite magnetic measurements to create a regional three-dimensional surface Spline(3DSS)gradient model of the main geomagnetic field over the Chinese continent.To improve the precision of the model,we considered the data gap between the ground and satellite data.We compared and analyzed the results of the Taylor polynomial,surface Spline,and CHAOS-6(the CHAMP,?rsted and SAC-C model of Earth’s magnetic field)gradient models.Results showed that the gradients in the south-north and east-west directions of the four models were consistent.The 3DSS model was able to express not only gradients at different altitudes,but also average gradients inside the research area.The two Spline models were able to capture more information on gradient anomalies than were the fitted models.Strong local anomalies were observed in northern Xinjiang,Beijing,and the junction area between Jiangsu and Zhejiang,and the total intensity F decreased whereas the altitude increased.The gradient decreased by 21.69%in the south-north direction and increased by 11.78%in the east-west direction.In addition,the altitude gradient turned from negative to positive while the altitude increased.The Spline model and the two fitted models differed mainly in the field sources they expressed and the modeling theory.
基金supported by Zhejiang Province NSFC(LY20A010023 and LY22A010015)the NSFC(12071106)of China+1 种基金supported by the Natural Science Foundation of Jiangsu Province(BK20211293)the“Qing-Lan Engineering”Foundation of Jiangsu Higher Education Institutions。
文摘In this paper,we apply the method given in the paper“Zero relaxation time limits to a hydrodynamic model of two carrier types for semiconductors”(Mathematische Annalen,2022,382:1031–1046)to study the Cauchy problem for a one dimensional inhomogeneous hydrodynamic model of two-carrier types for semiconductors with the velocity relaxation.
文摘Objective To evaluate the predictive validity of IRIS™(Intuitive Surgical®,Sunnyvale,CA,USA)as a planning tool for robot-assisted partial nephrectomy(RAPN)by assessing the degree of overlap with intraoperative execution.Methods Thirty-one patients scheduled for RAPN by four experienced urologists were enrolled in a prospective study.Prior to surgery,urologists reviewed the IRIS™three-dimensional model on an iphone Operating System(iOS)app and completed a questionnaire outlining their surgical plan including surgical approach,and ischemia technique as well as confidence in executing this plan.Postoperatively,questionnaires assessing the procedural approach,clinical utility,efficiency,and effectiveness of IRIS™were completed.The degree of overlap between the preoperative and intraoperative questionnaires and between the planned approach and actual execution of the procedure was analyzed.Questionnaires were answered on a 5-point Likert scale and scores of 4 or greater were considered positive.Results Mean age was 65.1 years with a mean tumor size of 27.7 mm(interquartile range 17.5-44.0 mm).Hilar tumors consisted of 32.3%;48.4%of patients had R.E.N.A.L.nephrometry scores of 7-9.On preoperative questionnaires,the surgeons reported that in 67.7%cases they were confident that they can perform the procedure successfully,and on intraoperative questionnaires,the surgeons reported that in 96.8%cases IRIS™helped achieve good spatial sensation of the anatomy.There was a high degree of overlap between preoperative and intraoperative questionnaires for the surgical approach,interpreting anatomical details and clinical utility.When comparing plans for selective or off-clamp,the preoperative plan was executed in 90.0%of cases intraoperatively.Conclusion A high degree of overlap between the preoperative surgical approach and intraoperative RAPN execution was found using IRIS™.This is the first study to evaluate the predictive accuracy of IRIS™during RAPN by comparing preoperative plan and intraoperative execution.
基金supported by the National Natural Science Foundation of China under Grant[52077027]Liaoning Province Science and Technology Major Project[No.2020JH1/10100020].
文摘In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers.
基金The National Natural Science Foundation of China(No.51209040,51279134)the Natural Science Foundation of Jiangsu Province(No.BK2012341)+1 种基金the Fundamental Research Funds for the Central Universities(No.SJLX_0087)the Research Fund of Nanjing Hydraulic Research Institute(No.Y213012)
文摘In order to facilitate engineering design and coastal flooding protection, the potential storm surge induced by a typhoon is studied.Using an unstructured mesh, a coupled model which combines the advanced circulation ( ADCIRC ) hydrodynamic model and simulating waves nearshore ( SWAN ) model is applied to analyze the storm surge and waves on the coast of Jiangsu Province.The verifications of wind velocity, tidal levels and wave height show that this coupling model performs well to reflect the characteristics of the water levels and waves in the studied region.Results show that the effect of radiation stress on storm surge is significant, especially in shallow areas such as the coast of Jiangsu Province and the Yangtze estuary.By running the coupled model, the simulated potential flooding results can be employed in coastal engineering applications in the Jiangsu coastal area, such as storm surge warnings and extreme water level predictions.
基金supported by the National Natural Science Foundation of China(Grant No.51974173)the Natural Science Foundation of Shandong Province,China(Grant No.ZR2020QD122).
文摘The shear failure of intact rock under thermo-mechanical(TM)coupling conditions is common,such as in enhanced geothermal mining and deep mine construction.Under the effect of a continuous engineering disturbance,shear-formed fractures are prone to secondary instability,posing a severe threat to deep engineering.Although numerous studies regarding three-dimensional(3D)morphologies of fracture surfaces have been conducted,the understanding of shear-formed fractures under TM coupling conditions is limited.In this study,direct shear tests of intact granite under various TM coupling conditions were conducted,followed by 3D laser scanning tests of shear-formed fractures.Test results demonstrated that the peak shear strength of intact granite is positively correlated with the normal stress,whereas it is negatively correlated with the temperature.The internal friction angle and cohesion of intact granite significantly decrease with an increase in the temperature.The anisotropy,roughness value,and height of the asperities on the fracture surfaces are reduced as the normal stress increases,whereas their variation trends are the opposite as the temperature increases.The macroscopic failure mode of intact granite under TM coupling conditions is dominated by mixed tensileeshear and shear failures.As the normal stress increases,intragranular fractures are developed ranging from a local to a global distribution,and the macroscopic failure mode of intact granite changes from mixed tensileeshear to shear failure.Finally,3D morphological characteristics of the asperities on the shear-formed fracture surfaces were analyzed,and a quadrangular pyramid conceptual model representing these asperities was proposed and sufficiently verified.
文摘This paper presents a hybrid model for three-dimensional Geographical Information Systems which is an integration of surface- and volume-based models. The Triangulated Irregular Network (TIN) and octree models are integrated in this hybrid models. The TIN model works as a surface-based model which mainly serves for surface presentation and visualization. On the other hand, the octree encoding supports volumetric analysis. The designed data structure brings a major advantage in the three-dimensional selective retrieval. This technique increases the efficiency of three-dimensional data operation.
基金financially supported by the National High Technology Research and Development Program of China(863 Program,Grant No.2008AA092301)
文摘This paper presents the features of newly designed hydrodynamics test for the scaled model of 4500 m deepsea open-framed remotely operated vehicle (ROV), which is being researched and developed by Shanghai Jiao Tong University. Accurate hydrodynamics coefficients measurement and spatial modeling of ROV are significant for the maneuverability and control algorithm. The scaled model of ROV was constructed by 1:1.6. Hydrodynamics coefficients were measured through VPMM and LAHPMM towing test. And dynamics model was derived as a set of equations, describing nonlinear and coupled 5-DOF spatial motions. Rotation control motion was simulated to verify spatial model proposed. Research and application of hydrodynamics coefficients are expected to enable ROV to overcome uncertainty and disturbances of deepsea environment, and accomplish some more challengeable and practical missions.
基金Supported by the National High Technology Research and Development Program of China(863 Programs)(No.2006AA100301)Science and Technology Development Program of Shandong Province(No.2005GG3205102)
文摘The hydrodynamic forces and flow field of artificial reef models in steady flow were numerically investigated using the RNG κ-ε turbulent model. The numerical simulation results are consistent with results observed by experimental means. A comparative study indicates that the corresponding errors of forces between calculated values and values observed in the experiment vary in the range of2.3%-11.2% and that the corresponding errors of velocities vary in the range of 1.3%-15.8%. The flow field numerical results show that upstream and vortices exist when the current passes over and through the surface of the reef model. This study suggests that the numerical simulation method can be applied to predict the forces and flow field associated with artificial reefs.
基金The Major State Basic Research Program of China under contract No. 2012CB417002the National Natural Science Foundation of China under contract Nos 50909065 and 51109039
文摘A new three-dimensional semi-implicit finite-volume ocean model has been developed for simulating the coastal ocean circulation, which is based on the staggered C-unstructured non-orthogonal grid in the hor- izontal direction and z-level grid in the vertical direction. The three-dimensional model is discretized by the semi-implicit finite-volume method, in that the free-surface and the vertical diffusion are semi-implicit, thereby removing stability limitations associated with the surface gravity wave and vertical diffusion terms. The remaining terms in the momentum equations are discretized explicitly by an integral method. The partial cell method is used for resolving topography, which enables the model to better represent irregular topography. The model has been tested against analytical cases for wind and tidal oscillation circulation, and is applied to simulating the tidal flow in the Bohal Sea. The results are in good agreement both with the analytical solutions and measurement results.
文摘Merits of the Fernandes model(Fernandes et al.1983)for two-phase slug flow in verticaltubes are reviewed in this paper.While predicting many macroscopic parameters of slug flow in verti-cal tubes,it fails to present correctly the trend that the average voidage in liquid slugs increases asthe rising velocity of Taylor bubbles is increased.It is also desirable to extend its application toelectrolyte systems, and to churn flow conditions.Based on the diagnostic analysis,the model equa-tion for gas entrainment by falling liquid film is reformulated and the influence of surface tension isalso accounted for.Development of the falling liquid film is recognized in the revised model in or-der to suit the case of short Taylor bubbles as well.The modified model predicts the variation of av-erage voidage in liquid slugs in good agreement with available experimental data.
文摘Radius of ceramic cone can largely contribute into final solution of analytic models of penetration into ceramic/metal targets.In the present research,a modified model based on radius of ceramic cone was presented for ceramic/aluminum targets.In order to investigate and evaluate accuracy of the presented analytic model,obtained results were compared against the results of the Florence’s analytic model and also against numerical modeling results.The phenomenon of impact onto ceramic/aluminum composites were modeled using smoothed particle hydrodynamics(SPH)implemented utilizing ABAQUS Software.Results indicated that,with increasing initial velocity and ceramic thickness and decreasing support layer thickness,the radius of ceramic cone decreases;this ends up increasing residual velocity of the projectile and penetration time and extending the area across which the pressure is distributed.These findings indicate enhanced levels of target energy absorption and the required energy for bending and tensioning the target.As such,it can be observed that,at the same thickness and areal density,the ceramic target has its efficiency enhanced with increasing ceramic thickness and decreasing the support layer thickness.Finally,the results revealed that the associated data with SPH confirm the modified analytic model at higher accuracy than the Florence’s analytic model.
基金supported jointly by the National Natural Science Foundation of China and Korea Scienceand Engineering Foundation(Grant No.50811140341)
文摘A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model tests are carried out to consider the effects of exciting wave directions and types. Based on the experimental results, two hydrodynamic force models derived from Morisen equation and Wake model are presented respectively. By use of hydrodynamic force models suitable for free spanning submarine pipelines under earthquakes, diseretized equations of motion are obtained and finite element models are established to analyze dynamic response of free spanning submarine pipeline subjected to multi-support seismic excitations. The comparison of numerical results with experimental results shows that the improved Morison and Wake hydrodynamic force models could satisfactorily predict dynamic response on the free spanning submarine pipelines subjected to earthquakes.