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Stream Surface Strip Element Method and Simulation of Three-Dimensional Deformation of Continuous Hot Rolled Strip 被引量:5
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作者 LIU Hong-min WANG Ying-rui 《Journal of Iron and Steel Research(International)》 SCIE EI CAS CSCD 2004年第2期18-24,共7页
A new method,the stream surface strip element method,for simulating the three-dimensional deformation of plate and strip rolling process was proposed.The rolling deformation zone was divided into a number of stream su... A new method,the stream surface strip element method,for simulating the three-dimensional deformation of plate and strip rolling process was proposed.The rolling deformation zone was divided into a number of stream surface(curved surface)strip elements along metal flow traces,and the stream surface strip elements were mapped into the corresponding plane strip elements for analysis and computation.The longitudinal distributions of the lateral displacement and the altitudinal displacement of metal were respectively constructed to be a quartic curve and a quadratic curve,of which the lateral distributions were expressed as the third-power spline function,and the altitudinal distributions were fitted in the quadratic curve.From the flow theory of plastic mechanics,the mathematical models of the three-dimensional deformations and stresses of the deformation zone were constructed.Compared with the streamline strip element method proposed by the first author of this paper,the stream surface strip element method takes into account the uneven distributions of stresses and deformations along altitudinal direction,and realizes the precise three-dimensional analysis and computation.The simulation example of continuous hot rolled strip indicates that the method and the model accord with facts and provide a new reliable engineering-computation method for the three-dimensional mechanics simulation of plate and strip rolling process. 展开更多
关键词 HOT-ROLLING STRIP PLATE three-dimensional deformation stream surface strip element method unit rolling pressure friction stress tension stress
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Experimental and measured research on three-dimensional deformation law of gas drainage borehole in coal seam 被引量:7
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作者 Hongbao Zhao Jinyu Li +3 位作者 Yihong Liu Yikuo Wang Tao Wang Hui Cheng 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2020年第3期397-403,共7页
Using self-researched gas drainage borehole stability dynamic monitoring device, three-dimensional deformation characteristics of borehole under steady vertical load were researched experimentally and systematically. ... Using self-researched gas drainage borehole stability dynamic monitoring device, three-dimensional deformation characteristics of borehole under steady vertical load were researched experimentally and systematically. This research indicated that under the action of steady loading, the mechanical deformation path of the simulated gas drainage borehole is gradually complicated, and the decay of the borehole circumferential strain is an important characterization of the prediction and early warning of borehole instability and collapse. The horizontal position of borehole occurs compressive strain, and the vertical of which occurs tensile strain under the action of vertical stress. At the initial stage of loading, the vertical strain is more sensitive than that in the horizontal direction. After a certain period of time, the horizontal strain is gradually higher than the vertical one, and the intersection of the borehole horizontal diameter and the hole wall is the stress concentration point. With the increase of the depth of hole, the strain shows a gradual decay trend as a whole, and the vertical strain decays more observably, but there is no absolute position correlation between the amount of strain decay and the increase in borehole depth,and the area within 1.5 times the orifice size is the borehole stress concentration zone. 展开更多
关键词 Gas drainage borehole Dynamic monitoring Strain-time curve three-dimensional deformation law
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Precise Three-Dimensional Deformation Retrieval in Large and Complex Deformation Areas via Integration of Offset-Based Unwrapping and Improved Multiple-Aperture SAR Interferometry:Application to the 2016 Kumamoto Earthquake 被引量:5
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作者 Won-Kyung Baek Hyung-Sup Jung 《Engineering》 SCIE EI 2020年第8期927-935,共9页
Conventional synthetic aperture radar(SAR)interferometry(InSAR)has been successfully used to precisely measure surface deformation in the line-of-sight(LOS)direction,while multiple-aperture SAR interferometry(MAI)has ... Conventional synthetic aperture radar(SAR)interferometry(InSAR)has been successfully used to precisely measure surface deformation in the line-of-sight(LOS)direction,while multiple-aperture SAR interferometry(MAI)has provided precise surface deformation in the along-track(AT)direction.Integration of the InSAR and MAI methods enables precise measurement of the two-dimensional(2D)deformation from an interferometric pair;recently,the integration of ascending and descending pairs has allowed the observation of precise three-dimensional(3D)deformation.Precise 3D deformation measurement has been applied to better understand geological events such as earthquakes and volcanic eruptions.The surface deformation related to the 2016 Kumamoto earthquake was large and complex near the fault line;hence,precise 3D deformation retrieval had not yet been attempted.The objectives of this study were to①perform a feasibility test of precise 3D deformation retrieval in large and complex deformation areas through the integration of offset-based unwrapped and improved multiple-aperture SAR interferograms and②observe the 3D deformation field related to the 2016 Kumamoto earthquake,even near the fault lines.Two ascending pairs and one descending the Advanced Land Observing Satellite-2(ALOS-2)Phased Array-type L-band Synthetic Aperture Radar-2(PALSAR-2)pair were used for the 3D deformation retrieval.Eleven in situ Global Positioning System(GPS)measurements were used to validate the 3D deformation measurement accuracy.The achieved accuracy was approximately 2.96,3.75,and 2.86 cm in the east,north,and up directions,respectively.The results show the feasibility of precise 3D deformation measured through the integration of the improved methods,even in a case of large and complex deformation. 展开更多
关键词 Synthetic aperture radar(SAR) Conventional SAR interferometry(InSAR) Multiple-aperture SAR interferometry(MAI) ALOS-2 PALSAR-2 3D deformation retrieval 2016 Kumamoto earthquake
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THREE-DIMENSIONAL DEFORMATION ALONG THE ALTYN TAGH FAULT ZONE AND UPLIFT OF THE ALTYN MOUNTAIN, NORTHERN TIBET
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作者 Li Haibing, Yang Jingsui, Xu Zhiqin, Zhang Jianxin, Wu Cailai,Shi Rendeng (Institute of Geology, Chinese Academy of Geological Sciences, 26 Baiwanzhuang Road, Beijing 100037, China,E\|mail: lihaibing@yeah.net yangjsui@public.bta.net.cn) 《地学前缘》 EI CAS CSCD 2000年第S1期257-258,共2页
he convergence between India and Eurasia is partly accommodated by motion of a few large blocks along strike\|slip faults. About 1800km long Altyn Tagh fault strikes in N60~80°E and allows the northeastward disp... he convergence between India and Eurasia is partly accommodated by motion of a few large blocks along strike\|slip faults. About 1800km long Altyn Tagh fault strikes in N60~80°E and allows the northeastward displacement of the Tibet plateau relative to the Tarim. The Altyn Tagh fault zone is a typical transpressional fault zone, characterized by blocks rotation and crustal shortening and vertical extrusion of blocks within the Altyn Tagh strike\|slip system. Differences of three\|dimensional deformation and configuration of the active structures are recognized at different segment of the Altyn Tagh fault zone.1\ Structural configuration of the Altyn Tagh fault zone\;In the Altyn Tagh strike\|slip fault zone, the assemblage pattern of the (active) faults is in the form of parallel plumes, especially in the eastern and the western segments of the Altyn Tagh fault zone. These plumes structures in the eastern segment are assembled by string\|like left lateral strike\|slip fault and broom\|like thrusting faults, and in the western segment by arc\|like left lateral strike\|slip faults along with thrusting faults and normal faults. In the middle segment of the Altyn Tagh fault zone, the structures are characterized by the string\|like left lateral strike\|slip faults in the center and reverse thrusting faults on the two sides. 展开更多
关键词 three\|dimensional deformation UPLIFT MOUNTAIN building t ranspression Altyn Tagh FAULT TIBET
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Geodetic constraints on contemporary three-dimensional crustal deformation in the Laji Shan—Jishi Shan tectonic belt 被引量:1
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作者 Wenquan Zhuang Duxin Cui +2 位作者 Ming Hao Shangwu Song Zhangjun Li 《Geodesy and Geodynamics》 EI CSCD 2023年第6期589-596,共8页
The Laji Shan—Jishi Shan tectonic belt(LJTB),located in the southern part of the northeastern Tibetan Plateau(NETP),is a tectonic window to reveal regional tectonic deformation in the NETP.However,its kinematics in t... The Laji Shan—Jishi Shan tectonic belt(LJTB),located in the southern part of the northeastern Tibetan Plateau(NETP),is a tectonic window to reveal regional tectonic deformation in the NETP.However,its kinematics in the Holocene remains controversial.We obtain the latest and dense horizontal velocity field based on data collected from our newly constructed and existing GNSS stations.Combined with fault kinematics from geologic observations,we analyze the crustal deformation characteristics along the LJTB.The results show that:(1)The Laji Shan fault(LJF)is inactive,and the northwest-oriented Jishi Shan fault(JSF)exhibits a significant dextral and thrust slip.(2)The transpression along the arc-shaped LJTB accommodates deformation transformation between the dextral Riyue Shan fault and the sinistral west Qinling fault.(3)With the continuous pushing of the Indian plate,internal strains in the Tibetan Plateau are continuously transferred in the northeast via the LJTB as they are gradually dissipated near the LJTB and translated into significant crustal uplift in these regions. 展开更多
关键词 Laji Shan-Jishi Shan tectonic belt three-dimensional crustal deformation Fault slip rate GNSS Velocity field
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Oxygen tension modulates cell function in an in vitro three-dimensional glioblastoma tumor model 被引量:1
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作者 Sen Wang Siqi Yao +8 位作者 Na Pei Luge Bai Zhiyan Hao Dichen Li Jiankang He J.Miguel Oliveira Xiaoyan Xue Ling Wang Xinggang Mao 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第3期307-319,共13页
Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor ... Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells.This study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I collagen.It also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and migration.Finally,it compares two-dimensional(2D)and 3D cultures.For comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D model.Besides,the two models yielded significantly different cell morphologies.Finally,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D model.These results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture systems.The developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology. 展开更多
关键词 HYPOXIA GLIOMA three-dimensional glioma model In vitro
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Application of GNSS-PPP on Dynamic Deformation Monitoring of Offshore Platforms 被引量:1
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作者 YU Li-na XIONG Kuan +3 位作者 GAO Xi-feng LI Zhi FAN Li-long ZHANG Kai 《China Ocean Engineering》 SCIE EI CSCD 2024年第2期352-361,共10页
The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe operation.Although Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has b... The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe operation.Although Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively low.Moreover,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains unclear.Hence,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore platforms.To address these concerns,vibration table tests with different amplitudes and frequencies are conducted.The results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with GNSS-RTK.Furthermore,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of GNSS-PPP.Field monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN de-noising.By comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load action.The research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms. 展开更多
关键词 GNSS-PPP offshore platform dynamic deformation monitoring improved CEEMDAN de-noising
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Flow characteristics and hot workability of a typical low-alloy high-strength steel during multi-pass deformation 被引量:1
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作者 Mingjie Zhao Lihong Jiang +4 位作者 Changmin Li Liang Huang Chaoyuan Sun Jianjun Li Zhenghua Guo 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第2期323-336,共14页
Heavy components of low-alloy high-strength(LAHS) steels are generally formed by multi-pass forging. It is necessary to explore the flow characteristics and hot workability of LAHS steels during the multi-pass forging... Heavy components of low-alloy high-strength(LAHS) steels are generally formed by multi-pass forging. It is necessary to explore the flow characteristics and hot workability of LAHS steels during the multi-pass forging process, which is beneficial to the formulation of actual processing parameters. In the study, the multi-pass hot compression experiments of a typical LAHS steel are carried out at a wide range of deformation temperatures and strain rates. It is found that the work hardening rate of the experimental material depends on deformation parameters and deformation passes, which is ascribed to the impacts of static and dynamic softening behaviors. A new model is established to describe the flow characteristics at various deformation passes. Compared to the classical Arrhenius model and modified Zerilli and Armstrong model, the newly proposed model shows higher prediction accuracy with a confidence level of 0.98565. Furthermore, the connection between power dissipation efficiency(PDE) and deformation parameters is revealed by analyzing the microstructures. The PDE cannot be utilized to reflect the efficiency of energy dissipation for microstructure evolution during the entire deformation process, but only to assess the efficiency of energy dissipation for microstructure evolution in a specific deformation parameter state.As a result, an integrated processing map is proposed to better study the hot workability of the LAHS steel, which considers the effects of instability factor(IF), PDE, and distribution and size of grains. The optimized processing parameters for the multi-pass deformation process are the deformation parameters of 1223–1318 K and 0.01–0.08 s^(-1). Complete dynamic recrystallization occurs within the optimized processing parameters with an average grain size of 18.36–42.3 μm. This study will guide the optimization of the forging process of heavy components. 展开更多
关键词 low-alloy high-strength steel work hardening rate constitutive model hot workability multi-pass deformation
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Liquefaction susceptibility and deformation characteristics of saturated coral sandy soils subjected to cyclic loadings-a critical review 被引量:1
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作者 Chen Guoxing Qin You +3 位作者 Ma Weijia Liang Ke Wu Qi C.Hsein Juang 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第1期261-296,共36页
Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and respons... Coral sandy soils widely exist in coral island reefs and seashores in tropical and subtropical regions.Due to the unique marine depositional environment of coral sandy soils,the engineering characteristics and responses of these soils subjected to monotonic and cyclic loadings have been a subject of intense interest among the geotechnical and earthquake engineering communities.This paper critically reviews the progress of experimental investigations on the undrained behavior of coral sandy soils under monotonic and cyclic loadings over the last three decades.The focus of coverage includes the contractive-dilative behavior,the pattern of excess pore-water pressure(EPWP)generation and the liquefaction mechanism and liquefaction resistance,the small-strain shear modulus and strain-dependent shear modulus and damping,the cyclic softening feature,and the anisotropic characteristics of undrained responses of saturated coral sandy soils.In particular,the advances made in the past decades are reviewed from the following aspects:(1)the characterization of factors that impact the mechanism and patterns of EPWP build-up;(2)the identification of liquefaction triggering in terms of the apparent viscosity and the average flow coefficient;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefaction resistance and the number of cycles required to reach liquefaction;(4)the establishment of the invariable form of the predictive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effects of stress-induced anisotropy on liquefaction susceptibility and dynamic deformation characteristics.Insights gained through the critical review of these advances in the past decades offer a perspective for future research to further resolve the fundamental issues concerning the liquefaction mechanism and responses of coral sandy sites subjected to cyclic loadings associated with seismic events in marine environments. 展开更多
关键词 liquefaction susceptibility dynamic deformation characteristics coral sandy soil cyclic loading review and prospect
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The combined application of stem cells and three-dimensional bioprinting scaffolds for the repair of spinal cord injury 被引量:1
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作者 Dingyue Ju Chuanming Dong 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1751-1758,共8页
Spinal cord injury is considered one of the most difficult injuries to repair and has one of the worst prognoses for injuries to the nervous system.Following surgery,the poor regenerative capacity of nerve cells and t... Spinal cord injury is considered one of the most difficult injuries to repair and has one of the worst prognoses for injuries to the nervous system.Following surgery,the poor regenerative capacity of nerve cells and the generation of new scars can make it very difficult for the impaired nervous system to restore its neural functionality.Traditional treatments can only alleviate secondary injuries but cannot fundamentally repair the spinal cord.Consequently,there is a critical need to develop new treatments to promote functional repair after spinal cord injury.Over recent years,there have been seve ral developments in the use of stem cell therapy for the treatment of spinal cord injury.Alongside significant developments in the field of tissue engineering,three-dimensional bioprinting technology has become a hot research topic due to its ability to accurately print complex structures.This led to the loading of three-dimensional bioprinting scaffolds which provided precise cell localization.These three-dimensional bioprinting scaffolds co uld repair damaged neural circuits and had the potential to repair the damaged spinal cord.In this review,we discuss the mechanisms underlying simple stem cell therapy,the application of different types of stem cells for the treatment of spinal cord injury,and the different manufa cturing methods for three-dimensional bioprinting scaffolds.In particular,we focus on the development of three-dimensional bioprinting scaffolds for the treatment of spinal cord injury. 展开更多
关键词 BIOMATERIALS embryonic stem cells induced pluripotent stem cells mesenchymal stem cells nerve regeneration spinal cord injury stem cell therapy stem cells three-dimensional bioprinting
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Deformation monitoring of long-span railway bridges based on SBAS-InSAR technology
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作者 Lv Zhou Xinyi Li +4 位作者 Yuanjin Pan Jun Ma Cheng Wang Anping Shi Yukai Chen 《Geodesy and Geodynamics》 EI CSCD 2024年第2期122-132,共11页
The deformation monitoring of long-span railway bridges is significant to ensure the safety of human life and property.The interferometric synthetic aperture radar(In SAR)technology has the advantage of high accuracy ... The deformation monitoring of long-span railway bridges is significant to ensure the safety of human life and property.The interferometric synthetic aperture radar(In SAR)technology has the advantage of high accuracy in bridge deformation monitoring.This study monitored the deformation of the Ganjiang Super Bridge based on the small baseline subsets(SBAS)In SAR technology and Sentinel-1A data.We analyzed the deformation results combined with bridge structure,temperature,and riverbed sediment scouring.The results are as follows:(1)The Ganjiang Super Bridge area is stable overall,with deformation rates ranging from-15.6 mm/yr to 10.7 mm/yr(2)The settlement of the Ganjiang Super Bridge deck gradually increases from the bridge tower toward the main span,which conforms to the typical deformation pattern of a cable-stayed bridge.(3)The sediment scouring from the riverbed cause the serious settlement on the bridge’s east side compared with that on the west side.(4)The bridge deformation negatively correlates with temperature,with a faster settlement at a higher temperature and a slow rebound trend at a lower temperature.The study findings can provide scientific data support for the health monitoring of long-span railway bridges. 展开更多
关键词 SBAS-InSAR Long-span railway bridge deformation monitoring Bridge structure Time series deformation
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Development of a toroidal soft x-ray imaging system and application for investigating three-dimensional plasma on J-TEXT
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作者 赵传旭 李建超 +9 位作者 张晓卿 王能超 丁永华 杨州军 江中和 严伟 李杨波 毛飞越 任正康 the J-TEXT Team 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第3期94-99,共6页
A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on J-TEXT.This T-SXRI system consists of three sets of SXR arrays.Two sets are newly developed and locat... A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on J-TEXT.This T-SXRI system consists of three sets of SXR arrays.Two sets are newly developed and located on the vacuum chamber wall at toroidal positionsφof 126.4°and 272.6°,respectively,while one set was established previously atφ=65.50.Each set of SXR arrays consists of three arrays viewing the plasma poloidally,and hence can be used separately to obtain SXR images via the tomographic method.The sawtooth precursor oscillations are measured by T-SXRI,and the corresponding images of perturbative SXR signals are successfully reconstructed at these three toroidal positions,hence providing measurement of the 3D structure of precursor oscillations.The observed 3D structure is consistent with the helical structure of the m/n=1/1 mode.The experimental observation confirms that the T-SXRI system is able to observe 3D structures in the J-TEXT plasma. 展开更多
关键词 SXR imaging J-TEXT tokamak three-dimensional measurement MHD
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Effect of deformation parameters on the austenite dynamic recrystallization behavior of a eutectoid pearlite rail steel
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作者 Haibo Feng Shaohua Li +7 位作者 Kexiao Wang Junheng Gao Shuize Wang Haitao Zhao Zhenyu Han Yong Deng Yuhe Huang Xinping Ma 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第5期833-841,共9页
Understandings of the effect of hot deformation parameters close to the practical production line on grain refinement are crucial for enhancing both the strength and toughness of future rail steels.In this work,the au... Understandings of the effect of hot deformation parameters close to the practical production line on grain refinement are crucial for enhancing both the strength and toughness of future rail steels.In this work,the austenite dynamic recrystallization(DRX)behaviors of a eutectoid pearlite rail steel were studied using a thermo-mechanical simulator with hot deformation parameters frequently employed in rail production lines.The single-pass hot deformation results reveal that the prior austenite grain sizes(PAGSs)for samples with different deformation reductions decrease initially with an increase in deformation temperature.However,once the deformation temperature is beyond a certain threshold,the PAGSs start to increase.It can be attributed to the rise in DRX volume fraction and the increase of DRX grain with deformation temperature,respectively.Three-pass hot deformation results show that the accumulated strain generated in the first and second deformation passes can increase the extent of DRX.In the case of complete DRX,PAGS is predominantly determined by the deformation temperature of the final pass.It suggests a strategic approach during industrial production where part of the deformation reduction in low temperature range can be shifted to the medium temperature range to release rolling mill loads. 展开更多
关键词 eutectoid pearlite rail steel prior austenite grain size dynamic recrystallization single-pass hot deformation three-pass hot deformation
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Three-dimensional cell-based strategies for liver regeneration
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作者 DAN GUO XI XIA JIAN YANG 《BIOCELL》 SCIE 2024年第7期1023-1036,共14页
Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine.In recent years,the utilization of 3D cell-based strategies has emerged as a promising ap... Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine.In recent years,the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical requirements.This review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver failure.Here,we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver failure.Furthermore,we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical applications.The collective insights presented herein highlight the significance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care. 展开更多
关键词 three-dimensional Liver regeneration ORGANOIDS Stem cells Cell therapy
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Study on the vertical deformations induced by terrestrial water storage changes in Huang-Huai-Hai river basin
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作者 Liansheng Deng Yugang Xiao +2 位作者 Qusen Chen Feifei Liao Zhao Li 《Geodesy and Geodynamics》 EI CSCD 2024年第4期352-365,共14页
Terrestrial water storage(TWs)variations are associated with water mass movements,which may cause the deformation displacements of the Global Navigation Satellite System(GNSS)stations.This study investigates the spati... Terrestrial water storage(TWs)variations are associated with water mass movements,which may cause the deformation displacements of the Global Navigation Satellite System(GNSS)stations.This study investigates the spatio-temporal Tws variations and addresses the relationship between deformation variations observed in the Huang-Huai-Hai River Basin(HHHRB)and local hydrological features.Results indicate that the vertical velocities at the GNSS stations induced by TWS changes are relatively small,and the impacts of the terrestrial water storage changes are mainly reflected in the changes of seasonal characteristics.Although there is a downward TWS trend from 2011 to 2022 in most HHHRB areas,velocities from the vertical displacements of both Gravity Recovery and Climate Experiment(GRACE)and GRACE Follow-On(GFO)and the GNSS reflect that the HHHRB is undergoing an uplift process,while the magnitude of the GRACE/GFO derived velocities is much smaller than that of the GNSS solutions.Common hydrological deformations estimated from GRACE/GFO and GNSS measurements reveal that the TWS-derived displacements can explain 54.5%of the GNSS seasonal variations,with the phases of terrestrial water storage advancing by about one month relative to GNss common signal phases.Moreover,the decrease of the groundwater storage in the HHHRB has been accelerating since 2008.After reaching its lowest level around mid-2020,it began to rise rapidly,which might be closely related to the implementation of the South-North Water Transfer Central Project. 展开更多
关键词 Terrestrial waterstorage GRACE GNSS Vertical deformations Huang-Huai-Hairiverbasin
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Computer-assisted three-dimensional individualized extreme liver resection for hepatoblastoma in proximity to the major liver vasculature
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作者 Wen-Li Xiu Jie Liu +7 位作者 Jing-Li Zhang Jing-Miao Wang Xue-Feng Wang Fei-Fei Wang Jie Mi Xi-Wei Hao NanXia Qian Dong 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第4期1066-1077,共12页
BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,e... BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,extreme liver resection can be considered a potential option.AIM To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of NAC.METHODS We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June 2023.We then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of NAC.RESULTS Sixty-seven children diagnosed with HB underwent surgical resection.The age at diagnosis was 21.4±18.8 months,and 40 boys and 27 girls were included.Fifty-nine(88.1%)patients had a single tumor,39(58.2%)of which was located in the right lobe of the liver.A total of 47 patients(70.1%)had PRE-TEXT III or IV.Thirty-nine patients(58.2%)underwent delayed resection.After a full course of NAC,16 patients still had close PMV(within 1 cm in two patients,touching in 11 patients,compressing in four patients,and showing tumor thrombus in three patients).There were 6 patients of tumors in the middle lobe of the liver,and four of those patients exhibited liver anatomy variations.These 16 children underwent extreme liver resection after comprehensive preoperative evaluation.Intraoperative procedures were performed according to the preoperative plan,and the operations were successfully performed.Currently,the 3-year event-free survival of 67 children with HB is 88%.Among the 16 children who underwent extreme liver resection,three experienced recurrence,and one died due to multiple metastases.CONCLUSION Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and feasible.This approach not only reduces the necessity for liver transplantation but also results in a favorable prognosis.Individualized three-dimensional surgical planning is beneficial for accurate and complete resection of HB,particularly for assessing vascular involvement,remnant liver volume and anatomical variations. 展开更多
关键词 Children HEPATOBLASTOMA Surgery three-dimensional COMPUTER-ASSISTED
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Mechanical Behavior and Microstructure Evolution during Tensile Deformation of Twinning Induced Plasticity Steel Processed by Warm Forgings
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作者 王文 ZHAO Modi +2 位作者 WANG Xingfu 汪聃 韩福生 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第2期417-424,共8页
The mechanical behavior and microstructural evolution of an Fe-30Mn-3Al-3Si twinninginduced plasticity(TWIP)steel processed using warm forging was investigated.It is found that steel processed via warm forging improve... The mechanical behavior and microstructural evolution of an Fe-30Mn-3Al-3Si twinninginduced plasticity(TWIP)steel processed using warm forging was investigated.It is found that steel processed via warm forging improves comprehensive mechanical properties compared to the TWIP steel processed via cold rolling,with a high tensile strength(R_(m))of 793 MPa,a yield strength(R_(P))of 682 MPa,an extremely large R_(P)/R_(m)ratio as high as 0.86 as well as an excellent elongation rate of 46.8%.The microstructure observation demonstrates that steel processed by warm forging consists of large and elongated grains together with fine,equiaxed grains.Complicated micro-defect configurations were also observed within the steel,including dense dislocation networks and a few coarse deformation twins.As the plastic deformation proceeds,the densities of dislocations and deformation twins significantly increase.Moreover,a great number of slip lines could be observed in the elongated grains.These findings reveal that a much more dramatic interaction between microstructural defect and dislocations glide takes place in the forging sample,wherein the fine and equiaxed grains propagated dislocations more rapidly,together with initial defect configurations,are responsible for enhanced strength properties.Meanwhile,larger,elongated grains with more prevalently activated deformation twins result in high plasticity. 展开更多
关键词 TWIP steel TWINNING mechanical property deformation mechanism MICROSTRUCTURE
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Unraveling engineering disturbance effects on deformation in red-bed mudstone railway cuttings:incorporating crack-facilitated moisture diffusion
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作者 HUANG Kang DAI Zhangjun +3 位作者 YAN Chengzeng YAO Junkai CHI Zecheng CHEN Shanxiong 《Journal of Mountain Science》 SCIE CSCD 2024年第5期1663-1682,共20页
Red-bed mudstone, prevalent in southwest China, poses a formidable challenge due to its hydrophilic clay minerals, resulting in expansion, deformation, and cracking upon exposure to moisture. This study addresses upli... Red-bed mudstone, prevalent in southwest China, poses a formidable challenge due to its hydrophilic clay minerals, resulting in expansion, deformation, and cracking upon exposure to moisture. This study addresses uplift deformation disasters in high-speed railways by employing a moisture diffusion-deformation-fracture coupling model based on the finite-discrete element method(FDEM). The model integrates the influence of cracks on moisture diffusion. The investigation into various excavation depths reveals a direct correlation between depth and the formation of tensile cracks at the bottom of the railway cutting. These cracks expedite moisture migration, significantly impacting the temporal and spatial evolution of the moisture field. Additionally, crack expansion dominates hygroscopic deformation, with the lateral coordinate of the crack zone determining peak vertical displacement. Furthermore, key factors influencing deformation in railway cuttings, including the swelling factor and initial moisture content at the bottom of the cutting, are explored. The number of tensile and shear cracks increases with greater excavation depth, particularly concerning shear cracks. Higher swelling factors and initial moisture contents result in an increased total number of cracks, predominantly shear cracks. Numerical calculations provide valuable insights, offering a scientific foundation and directional guidance for the precise prevention, control, prediction, and comprehensive treatment of mudstone-related issues in high-speed railways. 展开更多
关键词 Red-bed mudstone Railway cutting FDEM Moisture diffusion deformation CRACK
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Kinematic deformation and intensity assessment of the 2021 Maduo M_(S)7.4 earthquake in Qinghai revealed by high-frequency GNSS
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作者 Yu Li Yuebing Wang +2 位作者 Lijiang Zhao Hongbo Shi Pingping Wang 《Geodesy and Geodynamics》 EI CSCD 2024年第3期230-240,共11页
Rapid acquisition of the kinematic deformation field and seismic intensity distribution of large earthquakes is crucial for postseismic emergency rescue,disaster assessment,and future seismic risk research.The advance... Rapid acquisition of the kinematic deformation field and seismic intensity distribution of large earthquakes is crucial for postseismic emergency rescue,disaster assessment,and future seismic risk research.The advancement of GNSS observation and data processing makes it play an important role in this field,especially the high-frequency GNSS.We used the differential positioning method to calculate the 1 HZ GNSS data from 98 sites within 1000 km of the M_(S)7.4 Maduo earthquake epicenter.The kinematic deformation field and the distribution of the seismic intensity by using the peak ground velocity derived from displacement waveforms were obtained.The results show that:1)Horizontal coseismic response deformation levels ranging from 25 mm to 301 mm can be observed within a 1000 km radius from the epicenter.Coseismic response deformation on the east and west sides shows bilateral asymmetry,which markedly differs from the symmetry presented by surface rupture.2)The seismic intensity obtained through high-frequency GNSS and field investigations exhibits good consistency of the scope and orientation in the high seismic intensity area,although the former is generally slightly smaller than the latter.3)There may exist obstacles on the eastern side of the seismogenic fault.The Maduo earthquake induced a certain tectonic stress loading effect on the western Kunlun Pass-Jiangcuo fault(KPJF)and Maqin-Maqu segment,resulting in higher seismic risk in the future. 展开更多
关键词 Maduo earthquake High-frequency GNSS Kinematic deformation Seismic intensity
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Impact of initial fluctuations and nuclear deformations in isobar collisions
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作者 Jian-Fei Wang Hao-Jie Xu Fu-Qiang Wang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第6期155-162,共8页
Relativistic isobar^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zrcollisions have revealed intricate differences in their nuclear size and shape,inspiring unconventional studies of nuclear structure using relat... Relativistic isobar^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zrcollisions have revealed intricate differences in their nuclear size and shape,inspiring unconventional studies of nuclear structure using relativistic heavy ion collisions.In this study,we investigate the relative differences in the mean multiplicityR_(<Nch>)and the secondR_(ε2)and third-order eccentricityR_(ε3)between isobar collisions using initial state Glauber models.It is found that initial fluctuations and nuclear deformations have negligible effects on R_(<Nch>)in most central collisions,while both are important for the R_(ε2)and R_(ε3),the degree of which is sensitive to the underlying nucleonic or sub-nucleonic degree of freedom.These features,compared to real data,may probe the particle production mechanism and the physics underlying nuclear structure. 展开更多
关键词 Relativistic isobar collisions Initial fluctuations Nuclear deformation
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