A network intrusion detection system is critical for cyber security against llegitimate attacks.In terms of feature perspectives,network traffic may include a variety of elements such as attack reference,attack type,a...A network intrusion detection system is critical for cyber security against llegitimate attacks.In terms of feature perspectives,network traffic may include a variety of elements such as attack reference,attack type,a subcategory of attack,host information,malicious scripts,etc.In terms of network perspectives,network traffic may contain an imbalanced number of harmful attacks when compared to normal traffic.It is challenging to identify a specific attack due to complex features and data imbalance issues.To address these issues,this paper proposes an Intrusion Detection System using transformer-based transfer learning for Imbalanced Network Traffic(IDS-INT).IDS-INT uses transformer-based transfer learning to learn feature interactions in both network feature representation and imbalanced data.First,detailed information about each type of attack is gathered from network interaction descriptions,which include network nodes,attack type,reference,host information,etc.Second,the transformer-based transfer learning approach is developed to learn detailed feature representation using their semantic anchors.Third,the Synthetic Minority Oversampling Technique(SMOTE)is implemented to balance abnormal traffic and detect minority attacks.Fourth,the Convolution Neural Network(CNN)model is designed to extract deep features from the balanced network traffic.Finally,the hybrid approach of the CNN-Long Short-Term Memory(CNN-LSTM)model is developed to detect different types of attacks from the deep features.Detailed experiments are conducted to test the proposed approach using three standard datasets,i.e.,UNsWNB15,CIC-IDS2017,and NSL-KDD.An explainable AI approach is implemented to interpret the proposed method and develop a trustable model.展开更多
The study of machine learning has revealed that it can unleash new applications in a variety of disciplines.Many limitations limit their expressiveness,and researchers are working to overcome them to fully exploit the...The study of machine learning has revealed that it can unleash new applications in a variety of disciplines.Many limitations limit their expressiveness,and researchers are working to overcome them to fully exploit the power of data-driven machine learning(ML)and deep learning(DL)techniques.The data imbalance presents major hurdles for classification and prediction problems in machine learning,restricting data analytics and acquiring relevant insights in practically all real-world research domains.In visual learning,network information security,failure prediction,digital marketing,healthcare,and a variety of other domains,raw data suffers from a biased data distribution of one class over the other.This article aims to present a taxonomy of the approaches for handling imbalanced data problems and their comparative study on the classification metrics and their application areas.We have explored very recent trends of techniques employed for solutions to class imbalance problems in datasets and have also discussed their limitations.This article has also identified open challenges for further research in the direction of class data imbalance.展开更多
A rotating packed bed is a typical chemical process enhancement equipment that can strengthen micromixing and mass transfer.During the operation of the rotating packed bed,the nonreactants and products irregularly adh...A rotating packed bed is a typical chemical process enhancement equipment that can strengthen micromixing and mass transfer.During the operation of the rotating packed bed,the nonreactants and products irregularly adhere to the wire mesh packing in the rotor,thus resulting in an imbalance in the vibration of the rotor,which may cause serious damage to the bearing and material leakage.This study proposes a model prediction for estimating the bearing residual life of a rotating packed bed based on rotor imbalance response analysis.This method is used to determine the influence of the mass on the imbalance in the vibration of the rotor on bearing damage.The major influence on rotor vibration was found to be exerted by the imbalanced mass and its distribution radius,as revealed by the results of orthogonal experiments.Through implementing finite element analysis,the imbalance response curve for the rotating packed bed rotor was obtained,and a correlation among rotor imbalance mass,distribution radius of imbalance mass,and bearing residue life was established via data fitting.The predicted value of the bearing life can be used as the reference basis for an early safety warning of a rotating packed bed to effectively avoid accidents.展开更多
In this paper,a control scheme based on current optimization is proposed for dual three-phase permanent-magnet synchronous motor(DTP-PMSM)drive to reduce the low-frequency temperature swing.The reduction of temperatur...In this paper,a control scheme based on current optimization is proposed for dual three-phase permanent-magnet synchronous motor(DTP-PMSM)drive to reduce the low-frequency temperature swing.The reduction of temperature swing can be equivalent to reducing maximum instantaneous phase copper loss in this paper.First,a two-level optimization aiming at minimizing maximum instantaneous phase copper loss at each electrical angle is proposed.Then,the optimization is transformed to a singlelevel optimization by introducing the auxiliary variable for easy solving.Considering that singleobjective optimization trades a great total copper loss for a small reduction of maximum phase copper loss,the optimization considering both instantaneous total copper loss and maximum phase copper loss is proposed,which has the same performance of temperature swing reduction but with lower total loss.In this way,the proposed control scheme can reduce maximum junction temperature by 11%.Both simulation and experimental results are presented to prove the effectiveness and superiority of the proposed control scheme for low-frequency temperature swing reduction.展开更多
Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings.Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia.Dynamin-related protein 1(Drp1)regulates ...Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings.Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia.Dynamin-related protein 1(Drp1)regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications,which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic injury.However,there is active controversy and gaps in knowledge regarding the modification,protein interaction,and functions of Drp1,which both hinder and promote development of Drp1 as a novel therapeutic target.Here,we summarize recent findings on the oligomeric changes,modification types,and protein interactions of Drp1 in various hypoxic-ischemic diseases,as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and hypoxia.Additionally,potential clinical translation prospects for targeting Drp1 are discussed.This review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.展开更多
A system model is developed to describe the translational and rotational motion of an active-magnetic-bearing-suspended rigid rotor in a single-gimbal control moment gyro onboard a rigid satellite. This model strictly...A system model is developed to describe the translational and rotational motion of an active-magnetic-bearing-suspended rigid rotor in a single-gimbal control moment gyro onboard a rigid satellite. This model strictly reflects the motion characteristics of the rotor by considering the dynamic and static imbalance as well as the coupling between the gimbal's and the rotor's motion on a satellite platform. Adaptive auto-centering control is carefully constructed for the rotor with unknown dynamic and static imbalance. The rotor makes its rotation about the principal axis of inertia through identifying the small rotational angles between the geometric axis and the principal axis as well as the displacements from the geometric center to the mass center so as to tune a stabilizing controller composed of a decentralized PD controller with cross-axis proportional gains and high- and low-pass filters. The main disturbance in the wheel spinning can thereby be completely removed and the vibration acting on the satellite attenuated.展开更多
Unlike previous theories with velocity and/or elastic modulus averaging, we use a three-phase porous rock physics model developed by Santos for analyzing the seismic response of two immiscible fluids in saturated poro...Unlike previous theories with velocity and/or elastic modulus averaging, we use a three-phase porous rock physics model developed by Santos for analyzing the seismic response of two immiscible fluids in saturated porous media. Considering reservoir reference pressure and coupling drag of two fluids in pores, the effects of frequency, porosity, and gas saturation on the phase velocities of the P-and S-waves are discussed in detail under field conditions. The effects of porosity and gas saturation on Vp/Vs are also provided. The data for our numerical experiments are from a sample of deep volcanic rock from Daqing. The numerical results show that the frequency dispersion effect can be ignored for deep volcanic rocks with low porosity and low permeability. It is concluded that for deep volcanic rocks the effect of gas content in pores on Vp/Vs is negligible but the effect of porosity is significant when there is a certain amount of water contained in the pores. The accurate estimate of lithology and porosity in this case is relatively more important.展开更多
A pilot pattern across two orthogonal frequency division multiplexing OFDM symbols with a special structure is designed for the channel estimation of OFDM systems with inphase and quadrature IQ imbalances at the recei...A pilot pattern across two orthogonal frequency division multiplexing OFDM symbols with a special structure is designed for the channel estimation of OFDM systems with inphase and quadrature IQ imbalances at the receiver.A high-efficiency time-domain TD least square LS channel estimator and a low-complexity frequency-domain Gaussian elimination GE equalizer are proposed to eliminate IQ distortion.The former estimator can significantly suppress channel noise by a factor N/L+1 over the existing frequency-domain FD LS where N and L+1 are the total number of subcarriers and the length of cyclic prefix and the proposed GE requires only 2N complex multiplications per OFDM symbol.Simulation results show that by exploiting the TD property of the channel the proposed TD-LS channel estimator obtains a significant signal-to-noise ratio gain over the existing FD-LS one whereas the proposed low-complexity GE compensation achieves the same bit error rate BER performance as the existing LS one.展开更多
For three phase four-wire active power filters (APFs), several typical power theories and corresponding current reference generation strategies are induced, p-q, d-q, unify power factor (UPF) and instantaneous act...For three phase four-wire active power filters (APFs), several typical power theories and corresponding current reference generation strategies are induced, p-q, d-q, unify power factor (UPF) and instantaneous active current (IAC) methods are analyzed and compared with each other. The interpretation of active and reactive currents in non-sinusoidal and unbalanced three-phase four-wire systems is given based on the generalized instantaneous reactive power theory. The performance and the characteristic are evaluated, and the application conditions of current reference generation strategies are concluded. Simulation results under different source voltages and loads verify the evaluation result.展开更多
The three-phase bridge inverter is used as the converter topology in the power controller for a 9 kW doubly salient permanent magnet (DSPM) motor. Compared with common three-phase bridge inverters, the proposed inve...The three-phase bridge inverter is used as the converter topology in the power controller for a 9 kW doubly salient permanent magnet (DSPM) motor. Compared with common three-phase bridge inverters, the proposed inverter works under more complicated conditions with different principles for special winding back EMFs, position signals of hall sensors, and the given mode of switches. The ideal steady driving principles of the inverter for the motor are given. The working state with asymmetric winding back EMFs, inaccurate position signals of hall sensors, and the changing input voltage is analyzed. Finally, experimental results vertify that the given anal ysis is correct.展开更多
Objective To investigate the co-effect of Demand-control-support (DCS) model and Effort-reward Imbalance (ERI) model on the risk estimation of depression in humans in comparison with the effects when they are used...Objective To investigate the co-effect of Demand-control-support (DCS) model and Effort-reward Imbalance (ERI) model on the risk estimation of depression in humans in comparison with the effects when they are used respectively. Methods A total of 3 632 males and 1 706 females from 13 factories and companies in Henan province were recruited in this cross-sectional study. Perceived job stress was evaluated with the Job Content Questionnaire and Effort-Reward Imbalance Questionnaire (Chinese version). Depressive symptoms were assessed by using the Center for Epidemiological Studies Depression Scale (CES-D). Results DC (demands/job control ratio) and ERI were shown to be independently associated with depressive symptoms. The outcome of low social support and overcommitment were similar. High DC and low social support (SS), high ERI and high overcommitment, and high DC and high ERI posed greater risks of depressive symptoms than each of them did alone. ERI model and SS model seem to be effective in estimating the risk of depressive symptoms if they are used respectively. Conclusion The DC had better performance when it was used in combination with low SS. The effect on physical demands was better than on psychological demands. The combination of DCS and ERI models could improve the risk estimate of depressive symptoms in humans.展开更多
Oestrogens are not exclusive to the female gender but occur in moderate circulating levels of 25-70 pg ml^-1 in men, compared to 44- 153 pg ml^-1 in women. Arising from aromatisation of testosterone (T), oestrogen i...Oestrogens are not exclusive to the female gender but occur in moderate circulating levels of 25-70 pg ml^-1 in men, compared to 44- 153 pg ml^-1 in women. Arising from aromatisation of testosterone (T), oestrogen is considered to have many opposing physiological functions and the progressive T decline in the aging male is associated with relative and/or absolute increase in serum oestradiol (E2). Sexual disinterest and erectile dysfunction (ED) in the elderly may well be due to pathophysiological E2-T imbalance; the altered hormonal ratio may also explain the higher incidence of ED in hyperestrogenism or following exposure to environmental/plant oestrogens.展开更多
China’s financial conundrum arises from two sources: (1) its large trade (saving) surplus results in a currency mismatch because it is an immature creditor that cannot lend in its own currency. Instead foreign curren...China’s financial conundrum arises from two sources: (1) its large trade (saving) surplus results in a currency mismatch because it is an immature creditor that cannot lend in its own currency. Instead foreign currency claims (largely dollars) build up within domestic financial institutions. And (2) economists – both American and Chinese – mistakenly attribute the surpluses to an undervalued renminbi. To placate the United States, the result is a gradual appreciation of the renminbi against the dollar of 6% or more per year. This predictable appreciation since 2004, and the fall in US interest rates since mid 2007, not only attracts hot money inflows but inhibits private capital outflows from financing China’s huge trade surplus. This one-way bet in the foreign exchange markets can no longer be offset by relatively low interest rates in China compared to the United States, as had been the case in 2005-06. Thus, the People’s Bank of China (PBOC) now must intervene heavily to prevent the renminbi from ratcheting upwards – and so becomes the country’s sole international financial intermediary. Despite massive efforts by the PBOC to sterilize the monetary consequences of the reserve buildup, inflation in China is increasing, with excess liquidity that spills over into the world economy. China has been transformed from a deflationary force on American and European price levels into an inflationary one. Because of the currency mismatch, floating the RMB is neither feasible nor desirable – and a higher RMB would not reduce China’s trade surplus. Instead, monetary control and normal private-sector finance for the trade surplus require a return to a credibly fixed nominal yuan/dollar rate similar to that which existed between 1995 and 2004. But for any newly reset yuan/dollar rate to be credible as a monetary anchor, foreign "China bashing" to get the RMB up must end. Currency stabilization would allow the PBOC to regain monetary control and quash inflation. Only then can the Chinese government take decisive steps to reduce the trade (saving) surplus by tax cuts, increased social expenditures, and higher dividend payouts. But as long as the economy remains overheated, the government hesitates to take these trade-surplus-reduction measures because of their near-term inflationary consequences.展开更多
A better understanding of the regional disparity and imbalance characteristics of China's urbanization development is the important premise for constituting correct policy and strategy and promoting the healthy an...A better understanding of the regional disparity and imbalance characteristics of China's urbanization development is the important premise for constituting correct policy and strategy and promoting the healthy and sustainable development of urbanization in the 21st century. The regional differences of China's urbanization level have close relations with natural conditions of landform and climate etc.,the urbanization level reduces with the eleva-tion of topography and decrease of precipitation. According to the statistical data set of ur-banization in 1950-2006,the temporal change course of inter-provincial disparity of Chinese urbanization level since the founding of New China in 1949 was studied,and then the inter-regional and intra-regional disparities of urbanization development were analyzed by the Theil index and its nested decomposition method,to grasp the dynamic change of spatial disparities of China's urbanization level on the whole. Using the imbalance index model,the imbalance status of urban population distribution relative to total population,grain output,total agricultural output value,gross output value of industry,tertiary industrial output value as well as gross regional product was discussed,to hold the balance characteristics of urbanization development relative to the regional development conditions from the macroscopic scales.展开更多
In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30% glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase(AR) and sorbitol dehydrogenase, respectivel...In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30% glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase(AR) and sorbitol dehydrogenase, respectively. AR reduces glucose to sorbitol at the expense of NADPH, while sorbitol dehydrogenase converts sorbitol to fructose at the expense of NAD+, leading to NADH production. Consumption of NADPH, accumulation of sorbitol, and generation of fructose and NADH have all been implicated in the pathogenesis of diabetes and its complications. In this review, the roles of this pathway in NADH/NAD+redox imbalance stress and oxidative stress in diabetes are highlighted. A potential intervention using nicotinamide riboside to restore redox balance as an approach to fighting diabetes is also discussed.展开更多
Generally, most soil slope failures are induced by rainfall infiltration, a process that involves interactions between the liquid phase, gas phase,and solid skeleton in an unsaturated soil slope. In this study, a loos...Generally, most soil slope failures are induced by rainfall infiltration, a process that involves interactions between the liquid phase, gas phase,and solid skeleton in an unsaturated soil slope. In this study, a loosely coupled liquid-gas-solid three-phase model, linking two numerical codes,TOUGH2/EOS3, which is used for water-air two-phase flow analysis, and FLAC^(3D), which is used for mechanical analysis, was established. The model was validated through a documented water drainage experiment over a sandy column and a comparison of the results with measured data and simulated results from other researchers. The proposed model was used to investigate the features of water-air two-phase flow and stress fields in an unsaturated soil slope during rainfall infiltration. The slope stability analysis was then performed based on the simulated water-air two-phase seepage and stress fields on a given slip surface. The results show that the safety factor for the given slip surface decreases first, then increases, and later decreases until the rainfall stops. Subsequently, a sudden rise occurs. After that, the safety factor decreases continually and reaches its lowest value, and then increases slowly to a steady value. The lowest value does not occur when the rainfall stops, indicating a delayed effect of the safety factor. The variations of the safety factor for the given slip surface are therefore caused by a combination of pore-air pressure, matric suction, normal stress, and net normal stress.展开更多
An efficient compensation scheme combining a timedomain Gaussian elimination(GE) channel estimator and a frequency-domain GE equalizer is proposed for orthogonal frequency division multiplexing(OFDM) systems with ...An efficient compensation scheme combining a timedomain Gaussian elimination(GE) channel estimator and a frequency-domain GE equalizer is proposed for orthogonal frequency division multiplexing(OFDM) systems with frequencydependent in-phase and quadrature-phase(IQ) imbalances at both transmitter and receiver.Compared with the traditional least square and least mean square compensation schemes,the proposed compensation scheme achieves the same bit error rate as the ideal IQ branches by using only two training OFDM symbols instead of about 20 OFDM symbols.展开更多
In the hydraulic transporting process of cutter-suction mining natural gas hydrate, when the temperature-pressure equilibrium of gas hydrate is broken, gas hydrates dissociate into gas. As a result, solid-liquid two-p...In the hydraulic transporting process of cutter-suction mining natural gas hydrate, when the temperature-pressure equilibrium of gas hydrate is broken, gas hydrates dissociate into gas. As a result, solid-liquid two-phase flow(hydrate and water) transforms into gas-solid-liquid three-phase flow(methane, hydrate and water) inside the pipeline. The Euler model and CFD-PBM model were used to simulate gas-solid-liquid three-phase flow. Numerical simulation results show that the gas and solid phase gradually accumulate to the center of the pipe. Flow velocity decreases from center to boundary of the pipe along the radial direction. Comparison of numerical simulation results of two models reveals that the flow state simulated by CFD-PBM model is more uniform than that simulated by Euler model, and the main behavior of the bubble is small bubbles coalescence to large one. Comparison of numerical simulation and experimental investigation shows that the values of flow velocity and gas fraction in CFD-PBM model agree with experimental data better than those in Euler model. The proposed PBM model provides a more accurate and effective way to estimate three-phase flow state of transporting gas hydrate within the submarine pipeline.展开更多
An innovative green process of producing ε-caprolactam was proposed by integrating ammoximation and Beckmann rearrangement effectively. As a first part of the new process, TS-1 molecular sieve-catalyzed synthesis of ...An innovative green process of producing ε-caprolactam was proposed by integrating ammoximation and Beckmann rearrangement effectively. As a first part of the new process, TS-1 molecular sieve-catalyzed synthesis of cyclohexanone oxime from cyclohexanone, ammonia and hydrogen peroxide was carried out in a batch plant. Cyclohexane was used as the solvent in the three-phase reaction system. The influences of essential process parameters on ammoximation were investigated. Under the reaction conditions as catalyst content of 2.5% (by mass); H 2 O 2 /yclohexanone molar ratio of 1.10; NH 3 /cyclohexanone molar ratio of 2.20; reaction temperature of 343 K; reaction time of 5 h, high conversion of cyclohexanone and selectivity to oxime (both>99%) were obtained. Thus, the three-phase ammoximation process showed equal catalytic activity as TS-1 but much more convenient and simpler for the separation of catalyst in comparison to the industrial two-phase system with t-butanol used as solvent.展开更多
Based on the momentum theorem, the fluid governing equation in a lifting pipe is proposed by use of the method combining theoretical analysis with empirical correlations related to the previous research, and the perfo...Based on the momentum theorem, the fluid governing equation in a lifting pipe is proposed by use of the method combining theoretical analysis with empirical correlations related to the previous research, and the performance of an airlift pump can be clearly characterized by the triangular relationship among the volumetric flux of air, water and solid particles, which are obtained respectively by using numerical calculation. The meso-scale river sand is used as tested particles to examine the theoretical model. Results of the model are compared with the data in three-phase flow obtained prior to the development of the present model, by an independent experimental team that used the physical conditions of the present approach. The analytical error can be controlled within 12% for predicting the volumetric flux of water and is smaller than that (±16%) of transporting solid particles in three-phase flow. The experimental results and computations are in good agreement for air-water two-phase flow within a margin of ±8%. Reasonable agreement justifies the use of the present model for engineering design purposes.展开更多
文摘A network intrusion detection system is critical for cyber security against llegitimate attacks.In terms of feature perspectives,network traffic may include a variety of elements such as attack reference,attack type,a subcategory of attack,host information,malicious scripts,etc.In terms of network perspectives,network traffic may contain an imbalanced number of harmful attacks when compared to normal traffic.It is challenging to identify a specific attack due to complex features and data imbalance issues.To address these issues,this paper proposes an Intrusion Detection System using transformer-based transfer learning for Imbalanced Network Traffic(IDS-INT).IDS-INT uses transformer-based transfer learning to learn feature interactions in both network feature representation and imbalanced data.First,detailed information about each type of attack is gathered from network interaction descriptions,which include network nodes,attack type,reference,host information,etc.Second,the transformer-based transfer learning approach is developed to learn detailed feature representation using their semantic anchors.Third,the Synthetic Minority Oversampling Technique(SMOTE)is implemented to balance abnormal traffic and detect minority attacks.Fourth,the Convolution Neural Network(CNN)model is designed to extract deep features from the balanced network traffic.Finally,the hybrid approach of the CNN-Long Short-Term Memory(CNN-LSTM)model is developed to detect different types of attacks from the deep features.Detailed experiments are conducted to test the proposed approach using three standard datasets,i.e.,UNsWNB15,CIC-IDS2017,and NSL-KDD.An explainable AI approach is implemented to interpret the proposed method and develop a trustable model.
文摘The study of machine learning has revealed that it can unleash new applications in a variety of disciplines.Many limitations limit their expressiveness,and researchers are working to overcome them to fully exploit the power of data-driven machine learning(ML)and deep learning(DL)techniques.The data imbalance presents major hurdles for classification and prediction problems in machine learning,restricting data analytics and acquiring relevant insights in practically all real-world research domains.In visual learning,network information security,failure prediction,digital marketing,healthcare,and a variety of other domains,raw data suffers from a biased data distribution of one class over the other.This article aims to present a taxonomy of the approaches for handling imbalanced data problems and their comparative study on the classification metrics and their application areas.We have explored very recent trends of techniques employed for solutions to class imbalance problems in datasets and have also discussed their limitations.This article has also identified open challenges for further research in the direction of class data imbalance.
基金the High-Performance Computing Platform of Beijing University of Chemical Technology(BUCT)for supporting this papersupported by the Fundamental Research Funds for the Central Universities(JD2319)+2 种基金the CNOOC Technical Cooperation Project(ZX2022ZCTYF7612)the National Natural Science Foundation of China(51775029,52004014)the Chinese Universities Scientific Fund(XK2020-04)。
文摘A rotating packed bed is a typical chemical process enhancement equipment that can strengthen micromixing and mass transfer.During the operation of the rotating packed bed,the nonreactants and products irregularly adhere to the wire mesh packing in the rotor,thus resulting in an imbalance in the vibration of the rotor,which may cause serious damage to the bearing and material leakage.This study proposes a model prediction for estimating the bearing residual life of a rotating packed bed based on rotor imbalance response analysis.This method is used to determine the influence of the mass on the imbalance in the vibration of the rotor on bearing damage.The major influence on rotor vibration was found to be exerted by the imbalanced mass and its distribution radius,as revealed by the results of orthogonal experiments.Through implementing finite element analysis,the imbalance response curve for the rotating packed bed rotor was obtained,and a correlation among rotor imbalance mass,distribution radius of imbalance mass,and bearing residue life was established via data fitting.The predicted value of the bearing life can be used as the reference basis for an early safety warning of a rotating packed bed to effectively avoid accidents.
基金supported by the National Natural Science Foundation of China(No.62271109)。
文摘In this paper,a control scheme based on current optimization is proposed for dual three-phase permanent-magnet synchronous motor(DTP-PMSM)drive to reduce the low-frequency temperature swing.The reduction of temperature swing can be equivalent to reducing maximum instantaneous phase copper loss in this paper.First,a two-level optimization aiming at minimizing maximum instantaneous phase copper loss at each electrical angle is proposed.Then,the optimization is transformed to a singlelevel optimization by introducing the auxiliary variable for easy solving.Considering that singleobjective optimization trades a great total copper loss for a small reduction of maximum phase copper loss,the optimization considering both instantaneous total copper loss and maximum phase copper loss is proposed,which has the same performance of temperature swing reduction but with lower total loss.In this way,the proposed control scheme can reduce maximum junction temperature by 11%.Both simulation and experimental results are presented to prove the effectiveness and superiority of the proposed control scheme for low-frequency temperature swing reduction.
基金This work was supported by the National Natural Science Foundation of China(82272252,82270378)the Senior Medical Talents Program of Chongqing for Young and Middle-agedthe Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University.
文摘Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings.Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia.Dynamin-related protein 1(Drp1)regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications,which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic injury.However,there is active controversy and gaps in knowledge regarding the modification,protein interaction,and functions of Drp1,which both hinder and promote development of Drp1 as a novel therapeutic target.Here,we summarize recent findings on the oligomeric changes,modification types,and protein interactions of Drp1 in various hypoxic-ischemic diseases,as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and hypoxia.Additionally,potential clinical translation prospects for targeting Drp1 are discussed.This review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.
文摘A system model is developed to describe the translational and rotational motion of an active-magnetic-bearing-suspended rigid rotor in a single-gimbal control moment gyro onboard a rigid satellite. This model strictly reflects the motion characteristics of the rotor by considering the dynamic and static imbalance as well as the coupling between the gimbal's and the rotor's motion on a satellite platform. Adaptive auto-centering control is carefully constructed for the rotor with unknown dynamic and static imbalance. The rotor makes its rotation about the principal axis of inertia through identifying the small rotational angles between the geometric axis and the principal axis as well as the displacements from the geometric center to the mass center so as to tune a stabilizing controller composed of a decentralized PD controller with cross-axis proportional gains and high- and low-pass filters. The main disturbance in the wheel spinning can thereby be completely removed and the vibration acting on the satellite attenuated.
文摘Unlike previous theories with velocity and/or elastic modulus averaging, we use a three-phase porous rock physics model developed by Santos for analyzing the seismic response of two immiscible fluids in saturated porous media. Considering reservoir reference pressure and coupling drag of two fluids in pores, the effects of frequency, porosity, and gas saturation on the phase velocities of the P-and S-waves are discussed in detail under field conditions. The effects of porosity and gas saturation on Vp/Vs are also provided. The data for our numerical experiments are from a sample of deep volcanic rock from Daqing. The numerical results show that the frequency dispersion effect can be ignored for deep volcanic rocks with low porosity and low permeability. It is concluded that for deep volcanic rocks the effect of gas content in pores on Vp/Vs is negligible but the effect of porosity is significant when there is a certain amount of water contained in the pores. The accurate estimate of lithology and porosity in this case is relatively more important.
基金The Open Research Fund of National Mobile Communications Research Laboratory of Southeast University(No.2013D02)the Fundamental Research Funds for the Central Universities(No.30920130122004)the National Natural Science Foundation of China(No.61271230,61472190)
文摘A pilot pattern across two orthogonal frequency division multiplexing OFDM symbols with a special structure is designed for the channel estimation of OFDM systems with inphase and quadrature IQ imbalances at the receiver.A high-efficiency time-domain TD least square LS channel estimator and a low-complexity frequency-domain Gaussian elimination GE equalizer are proposed to eliminate IQ distortion.The former estimator can significantly suppress channel noise by a factor N/L+1 over the existing frequency-domain FD LS where N and L+1 are the total number of subcarriers and the length of cyclic prefix and the proposed GE requires only 2N complex multiplications per OFDM symbol.Simulation results show that by exploiting the TD property of the channel the proposed TD-LS channel estimator obtains a significant signal-to-noise ratio gain over the existing FD-LS one whereas the proposed low-complexity GE compensation achieves the same bit error rate BER performance as the existing LS one.
文摘For three phase four-wire active power filters (APFs), several typical power theories and corresponding current reference generation strategies are induced, p-q, d-q, unify power factor (UPF) and instantaneous active current (IAC) methods are analyzed and compared with each other. The interpretation of active and reactive currents in non-sinusoidal and unbalanced three-phase four-wire systems is given based on the generalized instantaneous reactive power theory. The performance and the characteristic are evaluated, and the application conditions of current reference generation strategies are concluded. Simulation results under different source voltages and loads verify the evaluation result.
文摘The three-phase bridge inverter is used as the converter topology in the power controller for a 9 kW doubly salient permanent magnet (DSPM) motor. Compared with common three-phase bridge inverters, the proposed inverter works under more complicated conditions with different principles for special winding back EMFs, position signals of hall sensors, and the given mode of switches. The ideal steady driving principles of the inverter for the motor are given. The working state with asymmetric winding back EMFs, inaccurate position signals of hall sensors, and the changing input voltage is analyzed. Finally, experimental results vertify that the given anal ysis is correct.
基金funded by Henan Provincial Health Science and Technology Key Projects(201001009)National Science and Technology Infrastructure Program(2006BAI06B 08),China
文摘Objective To investigate the co-effect of Demand-control-support (DCS) model and Effort-reward Imbalance (ERI) model on the risk estimation of depression in humans in comparison with the effects when they are used respectively. Methods A total of 3 632 males and 1 706 females from 13 factories and companies in Henan province were recruited in this cross-sectional study. Perceived job stress was evaluated with the Job Content Questionnaire and Effort-Reward Imbalance Questionnaire (Chinese version). Depressive symptoms were assessed by using the Center for Epidemiological Studies Depression Scale (CES-D). Results DC (demands/job control ratio) and ERI were shown to be independently associated with depressive symptoms. The outcome of low social support and overcommitment were similar. High DC and low social support (SS), high ERI and high overcommitment, and high DC and high ERI posed greater risks of depressive symptoms than each of them did alone. ERI model and SS model seem to be effective in estimating the risk of depressive symptoms if they are used respectively. Conclusion The DC had better performance when it was used in combination with low SS. The effect on physical demands was better than on psychological demands. The combination of DCS and ERI models could improve the risk estimate of depressive symptoms in humans.
文摘Oestrogens are not exclusive to the female gender but occur in moderate circulating levels of 25-70 pg ml^-1 in men, compared to 44- 153 pg ml^-1 in women. Arising from aromatisation of testosterone (T), oestrogen is considered to have many opposing physiological functions and the progressive T decline in the aging male is associated with relative and/or absolute increase in serum oestradiol (E2). Sexual disinterest and erectile dysfunction (ED) in the elderly may well be due to pathophysiological E2-T imbalance; the altered hormonal ratio may also explain the higher incidence of ED in hyperestrogenism or following exposure to environmental/plant oestrogens.
文摘China’s financial conundrum arises from two sources: (1) its large trade (saving) surplus results in a currency mismatch because it is an immature creditor that cannot lend in its own currency. Instead foreign currency claims (largely dollars) build up within domestic financial institutions. And (2) economists – both American and Chinese – mistakenly attribute the surpluses to an undervalued renminbi. To placate the United States, the result is a gradual appreciation of the renminbi against the dollar of 6% or more per year. This predictable appreciation since 2004, and the fall in US interest rates since mid 2007, not only attracts hot money inflows but inhibits private capital outflows from financing China’s huge trade surplus. This one-way bet in the foreign exchange markets can no longer be offset by relatively low interest rates in China compared to the United States, as had been the case in 2005-06. Thus, the People’s Bank of China (PBOC) now must intervene heavily to prevent the renminbi from ratcheting upwards – and so becomes the country’s sole international financial intermediary. Despite massive efforts by the PBOC to sterilize the monetary consequences of the reserve buildup, inflation in China is increasing, with excess liquidity that spills over into the world economy. China has been transformed from a deflationary force on American and European price levels into an inflationary one. Because of the currency mismatch, floating the RMB is neither feasible nor desirable – and a higher RMB would not reduce China’s trade surplus. Instead, monetary control and normal private-sector finance for the trade surplus require a return to a credibly fixed nominal yuan/dollar rate similar to that which existed between 1995 and 2004. But for any newly reset yuan/dollar rate to be credible as a monetary anchor, foreign "China bashing" to get the RMB up must end. Currency stabilization would allow the PBOC to regain monetary control and quash inflation. Only then can the Chinese government take decisive steps to reduce the trade (saving) surplus by tax cuts, increased social expenditures, and higher dividend payouts. But as long as the economy remains overheated, the government hesitates to take these trade-surplus-reduction measures because of their near-term inflationary consequences.
基金National Science and Technology Supporting Program of "the Eleventh Five-Year Plan",No.2006BAJ05A06 2006BAJ14B03-01Innovation Project of CAS, No.KZCX2-YW-307-02
文摘A better understanding of the regional disparity and imbalance characteristics of China's urbanization development is the important premise for constituting correct policy and strategy and promoting the healthy and sustainable development of urbanization in the 21st century. The regional differences of China's urbanization level have close relations with natural conditions of landform and climate etc.,the urbanization level reduces with the eleva-tion of topography and decrease of precipitation. According to the statistical data set of ur-banization in 1950-2006,the temporal change course of inter-provincial disparity of Chinese urbanization level since the founding of New China in 1949 was studied,and then the inter-regional and intra-regional disparities of urbanization development were analyzed by the Theil index and its nested decomposition method,to grasp the dynamic change of spatial disparities of China's urbanization level on the whole. Using the imbalance index model,the imbalance status of urban population distribution relative to total population,grain output,total agricultural output value,gross output value of industry,tertiary industrial output value as well as gross regional product was discussed,to hold the balance characteristics of urbanization development relative to the regional development conditions from the macroscopic scales.
基金National Institutes of Health,Grant/Award Number:R01NS079792UNTHSC Seed Grants,Grant/Award Number:RI10015 and RI10039
文摘In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30% glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase(AR) and sorbitol dehydrogenase, respectively. AR reduces glucose to sorbitol at the expense of NADPH, while sorbitol dehydrogenase converts sorbitol to fructose at the expense of NAD+, leading to NADH production. Consumption of NADPH, accumulation of sorbitol, and generation of fructose and NADH have all been implicated in the pathogenesis of diabetes and its complications. In this review, the roles of this pathway in NADH/NAD+redox imbalance stress and oxidative stress in diabetes are highlighted. A potential intervention using nicotinamide riboside to restore redox balance as an approach to fighting diabetes is also discussed.
基金supported by the National Natural Science Foundation of China(Grants No.51579170 and 51179118)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(Grant No.51321065)
文摘Generally, most soil slope failures are induced by rainfall infiltration, a process that involves interactions between the liquid phase, gas phase,and solid skeleton in an unsaturated soil slope. In this study, a loosely coupled liquid-gas-solid three-phase model, linking two numerical codes,TOUGH2/EOS3, which is used for water-air two-phase flow analysis, and FLAC^(3D), which is used for mechanical analysis, was established. The model was validated through a documented water drainage experiment over a sandy column and a comparison of the results with measured data and simulated results from other researchers. The proposed model was used to investigate the features of water-air two-phase flow and stress fields in an unsaturated soil slope during rainfall infiltration. The slope stability analysis was then performed based on the simulated water-air two-phase seepage and stress fields on a given slip surface. The results show that the safety factor for the given slip surface decreases first, then increases, and later decreases until the rainfall stops. Subsequently, a sudden rise occurs. After that, the safety factor decreases continually and reaches its lowest value, and then increases slowly to a steady value. The lowest value does not occur when the rainfall stops, indicating a delayed effect of the safety factor. The variations of the safety factor for the given slip surface are therefore caused by a combination of pore-air pressure, matric suction, normal stress, and net normal stress.
基金supported by the National Natural Science Fundation of China(6127123061172073)the Open Research Fund of National Mobile Communications Research Lab(2010D13)
文摘An efficient compensation scheme combining a timedomain Gaussian elimination(GE) channel estimator and a frequency-domain GE equalizer is proposed for orthogonal frequency division multiplexing(OFDM) systems with frequencydependent in-phase and quadrature-phase(IQ) imbalances at both transmitter and receiver.Compared with the traditional least square and least mean square compensation schemes,the proposed compensation scheme achieves the same bit error rate as the ideal IQ branches by using only two training OFDM symbols instead of about 20 OFDM symbols.
基金Project(51375498) supported by the National Natural Science Foundation of China
文摘In the hydraulic transporting process of cutter-suction mining natural gas hydrate, when the temperature-pressure equilibrium of gas hydrate is broken, gas hydrates dissociate into gas. As a result, solid-liquid two-phase flow(hydrate and water) transforms into gas-solid-liquid three-phase flow(methane, hydrate and water) inside the pipeline. The Euler model and CFD-PBM model were used to simulate gas-solid-liquid three-phase flow. Numerical simulation results show that the gas and solid phase gradually accumulate to the center of the pipe. Flow velocity decreases from center to boundary of the pipe along the radial direction. Comparison of numerical simulation results of two models reveals that the flow state simulated by CFD-PBM model is more uniform than that simulated by Euler model, and the main behavior of the bubble is small bubbles coalescence to large one. Comparison of numerical simulation and experimental investigation shows that the values of flow velocity and gas fraction in CFD-PBM model agree with experimental data better than those in Euler model. The proposed PBM model provides a more accurate and effective way to estimate three-phase flow state of transporting gas hydrate within the submarine pipeline.
基金Supported by the National Natural Science Foundation of China and Sinopec (20736009)
文摘An innovative green process of producing ε-caprolactam was proposed by integrating ammoximation and Beckmann rearrangement effectively. As a first part of the new process, TS-1 molecular sieve-catalyzed synthesis of cyclohexanone oxime from cyclohexanone, ammonia and hydrogen peroxide was carried out in a batch plant. Cyclohexane was used as the solvent in the three-phase reaction system. The influences of essential process parameters on ammoximation were investigated. Under the reaction conditions as catalyst content of 2.5% (by mass); H 2 O 2 /yclohexanone molar ratio of 1.10; NH 3 /cyclohexanone molar ratio of 2.20; reaction temperature of 343 K; reaction time of 5 h, high conversion of cyclohexanone and selectivity to oxime (both>99%) were obtained. Thus, the three-phase ammoximation process showed equal catalytic activity as TS-1 but much more convenient and simpler for the separation of catalyst in comparison to the industrial two-phase system with t-butanol used as solvent.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.51374101 and 51474158)the National Basic Research Program of China(973 Program,Grant No.2014CB239203)the Scientific Research Project of Education Department of Hunan Province(Grant No.14B047)
文摘Based on the momentum theorem, the fluid governing equation in a lifting pipe is proposed by use of the method combining theoretical analysis with empirical correlations related to the previous research, and the performance of an airlift pump can be clearly characterized by the triangular relationship among the volumetric flux of air, water and solid particles, which are obtained respectively by using numerical calculation. The meso-scale river sand is used as tested particles to examine the theoretical model. Results of the model are compared with the data in three-phase flow obtained prior to the development of the present model, by an independent experimental team that used the physical conditions of the present approach. The analytical error can be controlled within 12% for predicting the volumetric flux of water and is smaller than that (±16%) of transporting solid particles in three-phase flow. The experimental results and computations are in good agreement for air-water two-phase flow within a margin of ±8%. Reasonable agreement justifies the use of the present model for engineering design purposes.