四神丸对腹泻型肠易激综合征大鼠结肠MCT、c-fos表达的影响

目的观察四神丸对腹泻型肠易激综合征(IBS-D)模型大鼠结肠MCT、c-fos表达的影响。方法将40只大鼠随机分为正常组、模型组、匹维溴铵组(15.23 mg/kg)和四神丸组(7.32 mg/kg),每组10只,采用番泻叶灌胃联合避水应激法造模,灌胃给药14 d后,观察一般状态,测定体质量、粪便含水量和AWR评分,ELISA法检测血清MCT、c-fos水平,免疫组织化学法、Western blot法分别检测结肠组织MCT、c-fos蛋白定位及表达,RT-qPCR法检测结肠组织MCT、c-fos mRNA表达。结果与模型组比较,四神丸组和匹维溴铵组大鼠一般状态明显好转,体质量升高(P<0.01),粪便含水量、AWR评分以及血清中MCT、c-fos水平均降低(P<0.05,P<0.01),结肠组织MCT、c-fos蛋白及mRNA表达均降低(P<0.05,P<0.01);四神丸组结肠组织MCT蛋白表达及c-fos蛋白表达均低于匹维溴铵组(P<0.05)。结论四神丸对IBS-D大鼠内脏敏感的保护机制可能与调节结肠肥大细胞活化指标MCT、c-fos的表达有关。

一种MCT门量子可逆线路分解与优化方法

为提高可逆线路中MCT门的分解和优化效率,提出了一种MCT门的优化分解方法,根据该方法得出MCT分解模板并验证了正确性。基于该模板给出了相应的分解与优化算法,算法对MCT门分解出的Toffoli线路进行分类,使用优化分解模板将其分解为NCV线路。该算法的时间复杂度为O(m),优于传统算法的复杂度O(m2)。通过对控制位m∈{3,10}的MCT门与Benchmark可逆线路的实验,验证了该算法优化和分解的有效性。

过敏性猝死大鼠血清IgE、MCT及咽喉和胃壁组织内P物质的检测及意义

本文旨在探讨过敏性猝死大鼠血清中的IgE、肥大细胞类胰蛋白酶(Mast cell trypsin,MCT)及咽喉、胃壁、肠壁组织中P物质(substance P,SP)的含量检测及其意义。实验选择健康清洁级SD大白鼠14只,随机分为致敏组和0.9%氯化钠溶液对照组,每组7只。采用酶联免疫吸附试验ELISA法检测大鼠血清的IgE、MCT含量,并采用免疫组化法检测咽喉和胃肠组织的P物质含量。结果显示,过敏会导致猝死大鼠血清中IgE和MCT含量升高,与对照组大鼠之间的差异具有统计学意义(P<0.05)。致敏组与对照组在咽喉黏膜、胃肠组织中P物质含量的差异具有统计学意义(P<0.05)。血清IgE、MCT和咽喉、胃肠黏膜组织的P物质含量可以作为过敏性休克大鼠法医病理学诊断的检测指标。

Macro Meso Response and Stress Wave Propagation Characteristics of MCT High-Voltage Switch Under Shock load

In order to study the dynamic and electrical coupling response characteristics of Metal Oxide Semiconductor Controlled Thyristor(MCT)high-voltage switch under the synergic action of mechanical load and high voltage,the separated Hopkinson pressure bar(SHPB)test system was used to simulate different impact load environments,and combined with the multi-layer high-voltage ceramic capacitor charging and discharging system,the instantaneous electrical signals of MCT high-voltage switch were collected.Combined with numerical simulation and theoretical analysis,the failure mode and stress wave propagation characteristics of MCT high voltage switch were determined.The mechanical and electrical coupling response characteristics and failure mechanism of MCT high voltage switch under dynamic load were revealed from macroscopic and microscopic levels.The results show that the damage modes of MCT high-voltage switches can be divided into non-functional damage,recoverable functional damage,non-recoverable damage and structural damage.Due to the gap between the metal gate and the oxide layer,the insulating oxide layer was charged.After placing for a period of time,the elastic deformation of the metal gate partially recovered and the accumulated charge disappeared,which induced the recoverable functional damage failure of the device.In addition,obvious cracks appeared on both sides of the monocrystalline silicon inside the MCT high-voltage switch,leading to unrecoverable damage of the device.

The nature and movement of thrusts in the eastern Iranian orogen:Sechengi Area on the northern border of Lut and Sistan

The eastern Iranian range,known as the Sistan suture zone in the past,has recently been identified as the Sistan orogen.This Paleogene orogeny is located between the Lut and Afghan microcontinents.The structural analysis shows that most of the thrusts dip towards the NW so that the Permo-Triassic sediments and Jurassic micro-diorites of the Lut Block overthrusted over the younger rocks.Structural studies show that the tectonic vergence was from the NW to the SE of the Sechengi area in the NW part of Sistan orogen.We recognized three deformation phases in eastern Iran.The first N-S deformation event(D1)resulted in the formation of tight E-W folds(F1)and associated cleavages(S1).The second E-W deformation event(D2),which occurred in the late Paleogene led to the bending of older structures,including the axial plane of the first-generation folds giving them a new northwest direction(F2).Additionally,the ramp of the first-phase thrusts(striking E-W)was reactivated,acquiring a new NNW orientation and exhibiting SSE tectonic vergence.The third deformation event(D3)resulted in the formation of NNE and WNW conjugate faults in eastern Iran.Such consecutive deformation events perpendicular to each other are inconsistent with the models of simple linear orogen presented for eastern Iran(i.e.rifting of eastern Iran continental crust and subsequence linear collision)and seem more consistent with the buckling orogeny(Orocline).

Performance investigation of a low-power Hall thruster fed on iodine propellant

The common propellants used for electric thrusters, such as xenon and krypton, are rare, expensive,and difficult to acquire. Solid iodine attracts much attention with the advantages of low cost,extensive availability, low vapor pressure, and ionization potential. The performance of a lowpower iodine-fed Hall thruster matched with a xenon-fed cathode is investigated across a broad range of operation conditions. Regulation of the iodine vapor's mass flow rates is stably achieved by using a temperature control method of the iodine reservoir. The thrust measurements are finished utilizing a thrust target during the tests. Results show that thrust and anode-specific impulse increase approximately linearly with the increasing iodine mass flow rate.At the nominal power of 200 W class, iodine mass flow rates are 0.62 and 0.93 mg/s, thrusts are7.19 and 7.58 m N, anode specific impulses are 1184 and 826 s, anode efficiencies are 20.8%and 14.5%, and thrust to power ratios are 35.9 and 37.9 m N/k W under the conditions of 250 V,0.8 A and 200 V, 1.0 A, respectively. The operating characteristics of iodine-fed Hall thruster are analyzed in different states. Further work on the measurements of plasma characteristics and experimental optimization will be carried out.

Petrogenesis and Tectonic Implications of the Early Triassic Nianzi Adakitic Granite Unit in the Yanshan Fold and Thrust Belt:New Constraints from U-Pb Geochronology and Sr-Nd-Hf Isotopes

The Nianzi granite unit,which includes the Nianzi,Xiaolianghou and Xiawopu granitic intrusions,is a significant component of the northern part of the North China Craton(NCC)and is situated in the Yanshan fold and thrust belt(YFTB).However,there is still debate regarding the tectonic evolutionary history of the YFTB during the late Permian to Triassic period,specifically regarding the timing of subduction and collision between the NCC and the Paleo-Asian Ocean.The Nianzi granite unit exhibits unique petrological,geochronological and geochemical signatures that shed light on the tectonic evolutionary history of the YFTB.This study presents detailed petrology,whole-rock geochemistry,together with Sr-Nd isotopic,zircon U-Pb dating and Lu-Hf isotopic data of the granites within the Nianzi granite unit.Our findings demonstrate that the granites primarily consist of subhedral K-feldspar,plagioclase,quartz,minor biotite and hornblende,with accessory titanite,apatite,magnetite and zircon.Zircon U-Pb dating indicates that the Xiaolianghou granite was emplaced at 247.5±0.62 Ma.Additionally,the adakitic characteristics of the Nianzi,Xiawopu and Xiaolianghou granitic intrusions,such as high Sr and Ba contents and high ratios of Sr/Y and(La/Yb)N,combined with negative Sr-Nd and Lu-Hf isotopes(87Sr/86Sr)i=0.705681–0.7057433,εNd(t)=−21.98 to−20.97,zirconεHf(t)=−20.26 to−9.92,as well as the I-type granite features of high SiO_(2),Na_(2)O and K_(2)O/Na_(2)O ratios,enriched Rb,K,Sr and Ba,along with depleted Th,U,Nb,Ta,P and Ti,suggest that the Nianzi granitic unit was mainly derived from the partial melting of a thickened lower crust containing hydrous,calc-alkaline to high-K calc-alkaline,mafic to intermediate metamorphic rocks.In light of these parameters,we further integrate our data with previous studies and conclude that the Nianzi granitic unit was generated in a post-collisional extensional environment during the Early Triassic.

Thrust Optimization of Flapping Wing via Gradient Descent Technologies

The current work aims at employing a gradient descent algorithm for optimizing the thrust of a flapping wing. An in-house solver has been employed, along with mesh movement methodologies to capture the dynamics of flow around the airfoil. An efficient framework for implementing the coupled solver and optimization in a multicore environment has been implemented for the generation of optimized solutionsmaximizing thrust performance & computational speed.

Solid Rocket Booster Thrust Asynchrony Identification Method for Solid Rocket Bundled Rockets With ESO

The role of the rocket attitude control system is to execute the required maneuvers for guidance and ensure the stability of the rocket's flight attitude. Attitude control technology has always been one of the key technologies for ensuring the success of rocket flights and has been a core topic in carrier rocket technology research. The Gravity-1 solid carrier rocket is the first solid rocket bundled rocket developed by China, adopting a configuration with four boosters and a core stage bundled together. During the actual flight process, the four booster engines are ignited first, and then, in the event of insufficient control force from the boosters, the core stage engine is ignited to participate in control. To address thrust asynchrony during the descent of the four boosters, an Extended State Observer(ESO) is employed in the control scheme for this flight segment. This involves real-time estimation and compensation of attitude parameters during flight, identification of thrust asynchrony among the boosters, and simultaneous determination of whether the core stage engine is ignited to participate in control.Through six degrees of freedom simulation analysis and Y1 flight test validation, this method has been proven to be correct and feasible.

Clusters of Moderate Size Earthquakes along Main Central Thrust (MCT) in Himalaya

The Main Central Thrust (MCT) in Himalaya is seismically active in segments. In recent times, strain release within these active segments produce five spatial clusters (A to E;Figure 1). The seismicity within the cluster zones occurs in two depth bands;corresponding to the base of upper and lower crust. Depth sections across the clusters illustrate gently dipping subducted Indian Plate, overriding Tibetan Plate and compressed Sedimentary Wedge in between, with mid crustal ramping of MCT. Several presumptions / hypotheses have been put forward to decipher the causes of clustering along MCT. These are segmental activation of MCT, cross fault interactions, zones of arc parallel and arc perpendicular compressions, pore pressure perturbations, low heat flow zones etc. But these hypotheses need to be evaluated in the future after more ground level data are available. The maximum size of seismic threat that MCT can produce is inferred to be around Mw 7.0 in those clusters.

乳酸及单羧酸转运蛋白MCT4在组织纤维化和肿瘤中的作用及应用

乳酸及其转运体单羧酸转运蛋白(MCTs)在多种疾病的发生发展过程中承担着非常重要的作用.肿瘤细胞通过Warburg effect产生乳酸不仅可以为其增殖、迁移、侵袭提供能量来源,还可以促进血管生成,帮助肿瘤细胞免疫逃逸.而MCTs承担着乳酸转运的职能,在维持肿瘤细胞代谢共生和代谢适应以及恶性表型方面发挥着必不可少的作用.通过综述乳酸和MCTs的一个亚型MCT4在癌症及癌症相关的疾病中研究进展,以便探讨乳酸和MCT4在疾病发生发展中的作用,同时寻求靶向乳酸及MCT4在疾病治疗的策略.

Early Cretaceous Thrust and Nappe Tectonics in North Qilian Shan,Northern Tibetan Plateau:Evidence from Field Mapping,Geochronology,and Deep Structural Analysis

The North Qilian Shan fold and thrust belt,located at the northern Tibetan Plateau and southern margin of the Hexi Corridor,is a key tectonic unit to decode the formation and expansion of the plateau.Previous studies emphasize the Cenozoic deformation due to the far-field response to the Indo-Asian collision,but the Mesozoic deformations are poorly constrained in this area.We conducted detailed field mapping,structural analysis,geochronology,and structural interpretation of deep seismic reflectional profiling and magnetotelluric(MT)sounding,to address the superposed results of the Mesozoic and Cenozoic deformation.The results recognized the North Qilian thrust and nappe system(NQTS),the root and the frontal belt are the North Qilian thrust(NQT),and the Yumu Shan klippe(YK),respectively.The middle belt is located between the NQT and the YK.Monzonitic granite zircon U-Pb dating from the middle belt yields an age of ca.415 Ma,which is similar to south NQT.The thrusting displacement is estimated at ca.48 km by structural interpretation of deep profiles.The timing is constrained in the early stage of the Early Cretaceous by the formation of simultaneous growth strata.We suggest that the NQTS has resulted from the far-field effect of the Lhasa-Qiangtang collision,and the Yumu Shan is uplifted by the superposed Cenozoic deformation.

Heterogeneity and differential hydrocarbon accumulation model of deep reservoirs in foreland thrust belts: A case study of deep Cretaceous Qingshuihe Formation clastic reservoirs in southern Junggar Basin, NW China

Using the data of drilling, logging, core, experiments and production, the heterogeneity and differential hydrocarbon accumulation model of deep reservoirs in Cretaceous Qingshuihe Formation(K1q) in the western section of the foreland thrust belt in southern Junggar Basin are investigated. The target reservoirs are characterized by superimposition of conglomerates, sandy conglomerates and sandstones, with high content of plastic clasts. The reservoir space is mainly composed of intergranular pores. The reservoirs are overall tight, and the sandy conglomerate has the best physical properties. The coupling of short deep burial period with low paleotemperature gradient and formation overpressure led to the relatively weak diagenetic strength of the reservoirs. Specifically, the sandy conglomerates show relatively low carbonate cementation, low compaction rate and high dissolution porosity. The special stress-strain mechanism of the anticline makes the reservoirs at the top of the anticline turning point more reformed by fractures than those at the limbs, and the formation overpressure makes the fractures in open state. Moreover, the sandy conglomerates have the highest oil saturation. Typical anticline reservoirs are developed in deep part of the thrust belt, but characterized by "big trap with small reservoir". Significantly, the sandy conglomerates at the top of anticline turning point have better quality, lower in-situ stress and higher structural position than those at the limbs,with the internal hydrocarbons most enriched, making them high-yield oil/gas layers. The exponential decline of fractures makes hydrocarbon accumulation difficult in the reservoirs at the limbs. Nonetheless, plane hydrocarbon distribution is more extensive at the gentle limb than the steep limb.

一步共烧法制备的异质MCT-NiZn复合基板

以Ni_(0.6)Zn_(0.4)Nd_(0.01)Sn_(0.01)Mn_(0.01)Fe_(1.95)O_(4)(NiZn)旋磁铁氧体材料为内芯、0.85(Mg_(0.7)Zn_(0.3))TiO_(3)-0.15Ca_(0.8)Sm_(0.4/3)TiO_(3)(MCT)微波陶瓷为外环,采用一步共烧法制备了环行器/隔离器用钛酸镁钙-镍锌MCT-NiZn异质复合基板。首先将NiZn粉料压制成圆柱体,作为复合基板的内芯;将MCT粉料压制成环形柱体,作为基板的外环,将内芯NiZn和外环MCT的生坯组装,并在特定温度下直接一步共烧,获得MCT-NiZn异质复合基板。研究了共烧温度对复合基板的相组成、微观组织、剪切强度的影响。此外,还研究了复合基板直接共烧结后过渡区的结构与性能。结果表明,NiZn-MCT复合基板之间发生了界面反应,在过渡区形成了新相Mg_(2)TiO_(4),复合基板的最佳共烧温度为1260℃。此外,复合材料具有高剪切强度,达到57.45 MPa。综上,采用一步共烧法制备MCT-NiZn复合基板是一种具有广阔应用前景的复合材料。

Winding Function Theory Based Thrust Calculation on Nested-loop Secondary Linear Machine Adapted to Linear Metro

With advantages of strong drive capability,nested-loop secondary linear machine(NLS-LM)has great potentiality in linear metro.For its secondary structure with multiple loops,it is difficult to calculate the electromagnetic thrust of NLS-LM reasonably.Hence,in this paper,one thrust calculation method is proposed considering variable loop inductance and transient loop current.Firstly,to establish the secondary winding function,the modeling domain is confined to a limited range,and the equivalent loop span is employed by analyzing the coupling relationship between primary and secondary.Then,in order to obtain the secondary flux density,the transient secondary current is solved based on the loop impedance and induced voltage.Finally,the electromagnetic thrust can be calculated reasonably by the given primary current sheet and the calculated secondary flux density.Comprehensive simulations and experiments have demonstrated the effectiveness of the proposed method.

MCT悬浮床加氢复合催化剂应用分析

介绍了北京海新能源科技股份有限公司自主研发的复合催化剂HS的合成及其在鹤壁华石联合能源科技有限公司MCT悬浮床加氢装置的工业应用情况。通过工业试验获得该催化剂在不同添加量、反应温度、原料及催化剂配比条件下的加氢活性,考察复合催化剂的加氢、抗结焦等性能。结果表明,悬浮床加工渣油时最佳操作条件为催化剂配比(1.0±0.2)%,该比例下可以最大量产出目的产物;悬浮床反应器内反应床层温度控制在(450~455)℃;悬浮床加工煤焦油时各项目标产物指标优于渣油;悬浮床加工渣油时选用HS复合催化剂最佳配比,粒径在(10~100)μm时,可以实现装置的平稳、安全生产,节约生产成本,提高设备、管道的使用寿命。

Study of beam divergence and thrust vector eccentricity characteristics of the Hall thruster based on dual Faraday probe array planes and its applications

The accurate knowledge of the thrust vector eccentricity and beam divergence characteristics of Hall thrusters are of significant engineering value for the beneficial integration and successful application of Hall thrusters on spacecraft.For the characteristics of the plume bipolar diffusion due to the annular discharge channel of the Hall thruster,a Gaussian-fitted method for thrust vector deviation angle and beam divergence of Hall thrusters based on dual Faraday probe array planes was proposed in respect of the Hall thruster beam characteristics.The results show that the ratios of the deviation between the maximum and minimum values of the beam divergence angle and the thrust vector eccentricity angle using a Gaussian fit to the optimized Faraday probe dual plane to the mean value are 1.4%and 11.5%,respectively.The optimized thrust vector eccentricity angle obtained has been substantially improved,by approximately 20%.The beam divergence angle calculated using a Gaussian fitting to the optimized Faraday probe dual plane is approximately identical to the non-optimized one.The beam divergence and thrust vector eccentricity angles for different anode mass flow rates were obtained by averaging the beam divergence and thrust vector eccentricity angles calculated by the dual-plane,Gaussian-fitted ion current density method for different cross-sections.The study not only allows for an immediate and effective tool for determining the design of thrust vector adjustment mechanisms of spacecraft with different power Hall thrusters but also for characterizing the 3D spatial distribution of the Hall thruster plume.

Method of SLAS’s ground track manipulation based on tangential impulse thrust

Satellites with altitudes below 400 km are called super low altitude satellites(SLAS),often used to achieve responsive imaging tasks.Therefore,it is important for the manipulation of its ground track.Aiming at the problem of ground track manipulation of SLAS,a control method based on tangential impulse thrust is proposed.First,the equation of the longitude difference between SLAS and the target point on the target latitude is derived based on Gauss’s variational equations.On this basis,the influence of the tangential impulse thrust on the ground track’s longitude is derived.Finally,the method for ground track manipulation of SLAS under the tangential impulse thrust is proposed.The simulation results verify the effective-ness of the method,after manipulation,the satellite can visit the target point and revisit it for multiple days.

Integrated Sliding Mode Velocity Control of Linear Permanent Magnet Synchronous Motor with Thrust Ripple Compensation

In this paper,a compound sliding mode velocity control scheme with a new exponential reaching law(NERL)with thrust ripple observation strategy is proposed to obtain a high performance velocity loop of the linear permanent magnet synchronous motor(LPMSM)control system.A sliding mode velocity controller based on NERL is firstly discussed to restrain chattering of the conventional exponential reaching law(CERL).Furthermore,the unavoidable thrust ripple caused by the special structure of linear motor will bring about velocity fluctuation and reduced control performance.Thus,a thrust ripple compensation strategy on the basis of extend Kalman filter(EKF)theory is proposed.The estimated thrust ripple will be introduced into the sliding mode velocity controller to optimize the control accuracy and robustness.The effectiveness of the proposal is validated with experimental results.

考虑综合性能最优的非短视快速天基雷达多目标跟踪资源调度算法

合理有效的资源调度是天基雷达效能得以充分发挥的关键。针对天基雷达多目标跟踪资源调度问题,建立了综合考虑目标威胁度、跟踪精度与低截获概率(LPI)的代价函数;考虑目标的不确定、天基平台约束以及长远期期望代价,建立了多约束下的基于部分可观测的马尔可夫决策过程(POMDP)的资源调度模型;采用拉格朗日松弛法将多约束下的多目标跟踪资源调度问题转换分解为多个无约束的子问题;针对连续状态空间、连续动作空间及连续观测空间引起的维数灾难问题,采用基于蒙特卡罗树搜索(MCTS)的在线POMDP算法—POMCPOW算法进行求解,最终提出了一种综合多指标性能的非短视快速天基雷达多目标跟踪资源调度算法。仿真表明,与已有调度算法相比,所提算法资源分配更合理,系统性能更优。