AIM:To verify if subclinical hypothyroidism(SCH) could be associated to atopy in children.METHODS:Seven hundred and thirty-two Caucasian children from South Italy presenting symptoms of allergic disease were enrolled ...AIM:To verify if subclinical hypothyroidism(SCH) could be associated to atopy in children.METHODS:Seven hundred and thirty-two Caucasian children from South Italy presenting symptoms of allergic disease were enrolled and submitted to atopy,obesity,chronic low grade inflammation,and SCH work up.RESULTS:Four hundred and forty-five out of 705(63.12%) children affected by allergic disease were diagnosed as atopic and 260(36.88%) as not atopic.The SCH prevalence was 6.3%.Significant higher prevalence of SCH among atopic children with average(group 2) and high(group 3) low grade chronic inflammation compared to atopic children with mild(group 1)low grade chronic inflammation was present.Moreover,group 1 and group 2 presented an OR to show SCH of2.57(95%CI:1.55-6.26) and 2.96(95%CI:1.01-8.65),respectively.Both in atopic and not atopic children we found C3 serum levels significantly higher in group 3respect to group 2 and group 1.Noteworthy,among atopic patients,also total immunoglobulin E(IgE) serum levels,were significantly higher in group 3 compared to group 2 and group 1 children.In atopic children,C3 and total IgE serum values increased in parallel with the increase of C-reactive protein values,while in not atopic children this phenomenon was not evident.CONCLUSION:The possibility exists that an increasing atopic inflammation contributes to SCH occurrence.So far this is the first report in literature showing an association between SCH and atopy but further studies are needed to confirm our data.展开更多
甲状腺结节风险评估系统在甲状腺结节的临床管理中发挥着重要作用,其分为分级系统和评分系统两大类。甲状腺影像报告与数据分级系统(Thyroid Imaging Reporting and Data System,TI-RADS)作为一种定量分级系统,在21世纪初被首次提出,并...甲状腺结节风险评估系统在甲状腺结节的临床管理中发挥着重要作用,其分为分级系统和评分系统两大类。甲状腺影像报告与数据分级系统(Thyroid Imaging Reporting and Data System,TI-RADS)作为一种定量分级系统,在21世纪初被首次提出,并不断更新、完善。TI-RADS最大的贡献在于建立了甲状腺结节超声标准化诊断的体系,为临床医师和超声医师搭建了有效沟通的桥梁。就甲状腺结节超声风险分层的发展历史及各版本的优缺点加以总结分析,并讨论TI-RADS在甲状腺结节的个体化、精细化治疗中的发展方向。展开更多
文摘AIM:To verify if subclinical hypothyroidism(SCH) could be associated to atopy in children.METHODS:Seven hundred and thirty-two Caucasian children from South Italy presenting symptoms of allergic disease were enrolled and submitted to atopy,obesity,chronic low grade inflammation,and SCH work up.RESULTS:Four hundred and forty-five out of 705(63.12%) children affected by allergic disease were diagnosed as atopic and 260(36.88%) as not atopic.The SCH prevalence was 6.3%.Significant higher prevalence of SCH among atopic children with average(group 2) and high(group 3) low grade chronic inflammation compared to atopic children with mild(group 1)low grade chronic inflammation was present.Moreover,group 1 and group 2 presented an OR to show SCH of2.57(95%CI:1.55-6.26) and 2.96(95%CI:1.01-8.65),respectively.Both in atopic and not atopic children we found C3 serum levels significantly higher in group 3respect to group 2 and group 1.Noteworthy,among atopic patients,also total immunoglobulin E(IgE) serum levels,were significantly higher in group 3 compared to group 2 and group 1 children.In atopic children,C3 and total IgE serum values increased in parallel with the increase of C-reactive protein values,while in not atopic children this phenomenon was not evident.CONCLUSION:The possibility exists that an increasing atopic inflammation contributes to SCH occurrence.So far this is the first report in literature showing an association between SCH and atopy but further studies are needed to confirm our data.
文摘甲状腺结节风险评估系统在甲状腺结节的临床管理中发挥着重要作用,其分为分级系统和评分系统两大类。甲状腺影像报告与数据分级系统(Thyroid Imaging Reporting and Data System,TI-RADS)作为一种定量分级系统,在21世纪初被首次提出,并不断更新、完善。TI-RADS最大的贡献在于建立了甲状腺结节超声标准化诊断的体系,为临床医师和超声医师搭建了有效沟通的桥梁。就甲状腺结节超声风险分层的发展历史及各版本的优缺点加以总结分析,并讨论TI-RADS在甲状腺结节的个体化、精细化治疗中的发展方向。
