Objective: To evaluate the effects of thyorotropin-releasing hormone (TRH ) on severe head injury.Methods: Eighty--seven severely head injured patients with a Glasgow Coma Scale (GCS ) score of & or less wererando...Objective: To evaluate the effects of thyorotropin-releasing hormone (TRH ) on severe head injury.Methods: Eighty--seven severely head injured patients with a Glasgow Coma Scale (GCS ) score of & or less wererandomized into TRH--treated and saline control groups. In TRH treated group. the treatment was started with abolus injection of 0. 2 mg/kg followed by continuous infusion for 2 hours at 0. 2 mg/kg/h. Such treatment wasgiven once a day for 4 times. The patients in control group were given the equivalent normal saline with the samemethod. Results: TRH, administered intravenously after head injury. promoted the recovery of consciousness andGCS score, alleviated the traumatic brain edema, controlled and lowered the intracranial pressure. decreased thelevel of lipid superoxides, decreased the mortality rate. and improved the life quality of the survivals. Nocomplications or adverse and toxic effects were noted during the course of TRH treatment. Conclusion: TRH hasbeneficial effects on patients with severe head injury.展开更多
Objective: To investigate the expression regulation of thyrotrophin-releasing hormone (TRH) and its receptor (TRH-R) in rat testis and their function in the reproduction and development. Methods: Total RNA of fat test...Objective: To investigate the expression regulation of thyrotrophin-releasing hormone (TRH) and its receptor (TRH-R) in rat testis and their function in the reproduction and development. Methods: Total RNA of fat testicular tissues was used as template. The oligonucleotide primers were designed from the sequence of rat hypothalamus prepro(pp)TRH and pituitary TRH-R cDNA for reverse transcription- polymerase chain reaction (RT- PCR ). Specific fragments of ppTRH and TRH-R cDNA were cloned and sequenced. Results: DNA sequence analysis indicated that cDNA Sequences of ppTRH and TRH-R from rat testis were consistent with those of hypothalamus ppTRH and pituitary TRH-R cDNA. Conclusion: TRH may function as a new autocrine or paracrine regulator of testicular function via a transmembrane receptor very similar or identical to that in pituitary.展开更多
The thyrotropin-releasing hormone (TRH) is a bioactive peptides Synthesized and excreted from hypoghaiamus. It is the mainphysiological action that stimulates the Synthesis of antehypophysis, release of thyroid-stimul...The thyrotropin-releasing hormone (TRH) is a bioactive peptides Synthesized and excreted from hypoghaiamus. It is the mainphysiological action that stimulates the Synthesis of antehypophysis, release of thyroid-stimulating hormone (TSH) and excretion of prolactin.Within 1980s, it was found that TRH plays a role in antishock. In this paped Synthestic method of TRH is improved.展开更多
本文报告以促甲状腺激素释放激素(TRH)治疗 West 综合征和 Lennox-Gastaut综合征各10例所取得的初步疗效。具体方法是对确诊为上述两综合征的患者在继续服用原有抗痫药外每日肌注 TRH 0.9mg,10～30天。于治疗前后均进行临床评价、脑电...本文报告以促甲状腺激素释放激素(TRH)治疗 West 综合征和 Lennox-Gastaut综合征各10例所取得的初步疗效。具体方法是对确诊为上述两综合征的患者在继续服用原有抗痫药外每日肌注 TRH 0.9mg,10～30天。于治疗前后均进行临床评价、脑电图或脑电功率谱检查以及智商或发育商测定以资对比。试用结果:部分 West 综合征和 Lennox-Gastaut 综合征患儿的临床发作,脑电图或功率谱,智商或发育商各有不同程度的好转或提高。提示 TRH 可能促进两综合征患儿的脑结构或功能的发育或成熟,从而提高了这些患儿的智能水平和抗痫能力。展开更多
本文对碘缺乏地区人群进行了 TRH 兴奋试验的研究。通过对18例无甲肿居民、18例甲肿居民和17例神经型克汀病者的 TSH 对 TRH 应答性的观察,表明经过3年的供碘,病区大部分人群的甲状腺功能得以改善,但部分人群出现 TSH 对 TRH 应答性低钝...本文对碘缺乏地区人群进行了 TRH 兴奋试验的研究。通过对18例无甲肿居民、18例甲肿居民和17例神经型克汀病者的 TSH 对 TRH 应答性的观察,表明经过3年的供碘,病区大部分人群的甲状腺功能得以改善,但部分人群出现 TSH 对 TRH 应答性低钝,其中甲肿者占38.9%,无甲肿者占44.4%。本次调查未发现现症甲状腺功能低下者,但部分无现症甲低症的神经型克汀病者有激素性甲低的实验室依据。展开更多
Diabetes mellitus or hypoinsulinemia was induced successfully in the male dwarf goats aged be-tween 2 - 3 years with 2 consecutive administrations of streptozotocin. A comparable group of intact control goats was also...Diabetes mellitus or hypoinsulinemia was induced successfully in the male dwarf goats aged be-tween 2 - 3 years with 2 consecutive administrations of streptozotocin. A comparable group of intact control goats was also maintained. In ruminants including goats unlike non-ruminants, insulin generally displays ineffectiveness or resistance in their biochemical setup to facilitate gluco-neogenesis, the only source of glucose in these animals. In present study almost in the absence of insulin through induced hypoinsulinemia the effects of thyrotropin releasing hormone (TRH) (30 μg/kg body weight) and thyroid stimulating hormone (TSH) (2.5 μg/kg body weight) on circulatory glucose and different fatty acid fractions were studied in insulin resistant ruminant model. Fatty acid fractions were estimated by gas chromatography. Both TRH and TSH administration lowered glycemia in insulin deficient goats compared to the controls but significantly with TSH dose only. In intact goats the detectable circulating long chain fatty acids (LCFAs) fractions of lauric, myristic, palmitic, stearic, oleic and linoleic acid were undetected except linoleic acid in the hypoinsulinemic state, however were found restored following TRH and TSH administrations and some of LCFAs;stearic (6417%), oleic (1676%) and linoleic acid (1225%) increased exceptionally with TSH dose. In Intact goats however the hormones variedly increased the fractions. The volatile fatty acid fractions (VFAs) of formic, acetic, propionic, iso-butyric, n-butyric, iso-valeric, n-valeric, iso-caproic, n-caproic and heptanoic acid were detected in the goats. The most VFAs fractions markedly increased in hypoinsulinemic goats compared to the control goats following TRH and TSH infusion. These results have indicated that endogenously stimulated thyroid hormones with TRH and TSH in insulin deficient state inhibit the mechanisms of utilizing the fatty acids in glucose production. Therefore the study reveals thyroid hormones inhibitory effects on gluconeogenesis in insulin resistance and hyperglycemia.展开更多
文摘Objective: To evaluate the effects of thyorotropin-releasing hormone (TRH ) on severe head injury.Methods: Eighty--seven severely head injured patients with a Glasgow Coma Scale (GCS ) score of & or less wererandomized into TRH--treated and saline control groups. In TRH treated group. the treatment was started with abolus injection of 0. 2 mg/kg followed by continuous infusion for 2 hours at 0. 2 mg/kg/h. Such treatment wasgiven once a day for 4 times. The patients in control group were given the equivalent normal saline with the samemethod. Results: TRH, administered intravenously after head injury. promoted the recovery of consciousness andGCS score, alleviated the traumatic brain edema, controlled and lowered the intracranial pressure. decreased thelevel of lipid superoxides, decreased the mortality rate. and improved the life quality of the survivals. Nocomplications or adverse and toxic effects were noted during the course of TRH treatment. Conclusion: TRH hasbeneficial effects on patients with severe head injury.
基金Supported by National Nature Science Foundation of China, No. 39870109
文摘Objective: To investigate the expression regulation of thyrotrophin-releasing hormone (TRH) and its receptor (TRH-R) in rat testis and their function in the reproduction and development. Methods: Total RNA of fat testicular tissues was used as template. The oligonucleotide primers were designed from the sequence of rat hypothalamus prepro(pp)TRH and pituitary TRH-R cDNA for reverse transcription- polymerase chain reaction (RT- PCR ). Specific fragments of ppTRH and TRH-R cDNA were cloned and sequenced. Results: DNA sequence analysis indicated that cDNA Sequences of ppTRH and TRH-R from rat testis were consistent with those of hypothalamus ppTRH and pituitary TRH-R cDNA. Conclusion: TRH may function as a new autocrine or paracrine regulator of testicular function via a transmembrane receptor very similar or identical to that in pituitary.
文摘The thyrotropin-releasing hormone (TRH) is a bioactive peptides Synthesized and excreted from hypoghaiamus. It is the mainphysiological action that stimulates the Synthesis of antehypophysis, release of thyroid-stimulating hormone (TSH) and excretion of prolactin.Within 1980s, it was found that TRH plays a role in antishock. In this paped Synthestic method of TRH is improved.
文摘本文报告以促甲状腺激素释放激素(TRH)治疗 West 综合征和 Lennox-Gastaut综合征各10例所取得的初步疗效。具体方法是对确诊为上述两综合征的患者在继续服用原有抗痫药外每日肌注 TRH 0.9mg,10～30天。于治疗前后均进行临床评价、脑电图或脑电功率谱检查以及智商或发育商测定以资对比。试用结果:部分 West 综合征和 Lennox-Gastaut 综合征患儿的临床发作,脑电图或功率谱,智商或发育商各有不同程度的好转或提高。提示 TRH 可能促进两综合征患儿的脑结构或功能的发育或成熟,从而提高了这些患儿的智能水平和抗痫能力。
文摘本文对碘缺乏地区人群进行了 TRH 兴奋试验的研究。通过对18例无甲肿居民、18例甲肿居民和17例神经型克汀病者的 TSH 对 TRH 应答性的观察,表明经过3年的供碘,病区大部分人群的甲状腺功能得以改善,但部分人群出现 TSH 对 TRH 应答性低钝,其中甲肿者占38.9%,无甲肿者占44.4%。本次调查未发现现症甲状腺功能低下者,但部分无现症甲低症的神经型克汀病者有激素性甲低的实验室依据。
文摘Diabetes mellitus or hypoinsulinemia was induced successfully in the male dwarf goats aged be-tween 2 - 3 years with 2 consecutive administrations of streptozotocin. A comparable group of intact control goats was also maintained. In ruminants including goats unlike non-ruminants, insulin generally displays ineffectiveness or resistance in their biochemical setup to facilitate gluco-neogenesis, the only source of glucose in these animals. In present study almost in the absence of insulin through induced hypoinsulinemia the effects of thyrotropin releasing hormone (TRH) (30 μg/kg body weight) and thyroid stimulating hormone (TSH) (2.5 μg/kg body weight) on circulatory glucose and different fatty acid fractions were studied in insulin resistant ruminant model. Fatty acid fractions were estimated by gas chromatography. Both TRH and TSH administration lowered glycemia in insulin deficient goats compared to the controls but significantly with TSH dose only. In intact goats the detectable circulating long chain fatty acids (LCFAs) fractions of lauric, myristic, palmitic, stearic, oleic and linoleic acid were undetected except linoleic acid in the hypoinsulinemic state, however were found restored following TRH and TSH administrations and some of LCFAs;stearic (6417%), oleic (1676%) and linoleic acid (1225%) increased exceptionally with TSH dose. In Intact goats however the hormones variedly increased the fractions. The volatile fatty acid fractions (VFAs) of formic, acetic, propionic, iso-butyric, n-butyric, iso-valeric, n-valeric, iso-caproic, n-caproic and heptanoic acid were detected in the goats. The most VFAs fractions markedly increased in hypoinsulinemic goats compared to the control goats following TRH and TSH infusion. These results have indicated that endogenously stimulated thyroid hormones with TRH and TSH in insulin deficient state inhibit the mechanisms of utilizing the fatty acids in glucose production. Therefore the study reveals thyroid hormones inhibitory effects on gluconeogenesis in insulin resistance and hyperglycemia.
