The myocilin mt. 1 genotype (TIGR/MYOC mt.1, -1000 C/G) found in approximately 15% of subjects was evaluated for its potential effects on disease progression in patients that were followed at the Wills Eye Hospital gl...The myocilin mt. 1 genotype (TIGR/MYOC mt.1, -1000 C/G) found in approximately 15% of subjects was evaluated for its potential effects on disease progression in patients that were followed at the Wills Eye Hospital glaucoma clinic. 147 POAG patients over 35 years of age with an average follow-up of approximately 15 years were studied. Optic disc and visual field展开更多
This study presents the first stage of a multi-scale numerical framework designed to predict the non-linear constitutive behavior of metal-composite interfaces in titanium-graphite fiber metal laminates. Scanning elec...This study presents the first stage of a multi-scale numerical framework designed to predict the non-linear constitutive behavior of metal-composite interfaces in titanium-graphite fiber metal laminates. Scanning electron microscopy and x-ray diffraction techniques are used to characterize the baseline physical and chemical state of the interface. The physics of adhesion between the metal and polymer matrix composite components are then evaluated on the atomistic scale using molecular dynamics simulations. Interfacial mechanical properties are subsequently derived from these simulations using classical mechanics and thermodynamics. These molecular-level property predictions are used in a companion study to parameterize a continuum-level finite element model of the interface by means of a traction-separation constitutive law. Extension of the proposed approach to other dissimilar metal- or metal oxide-polymer interfaces is also discussed.展开更多
文摘The myocilin mt. 1 genotype (TIGR/MYOC mt.1, -1000 C/G) found in approximately 15% of subjects was evaluated for its potential effects on disease progression in patients that were followed at the Wills Eye Hospital glaucoma clinic. 147 POAG patients over 35 years of age with an average follow-up of approximately 15 years were studied. Optic disc and visual field
文摘This study presents the first stage of a multi-scale numerical framework designed to predict the non-linear constitutive behavior of metal-composite interfaces in titanium-graphite fiber metal laminates. Scanning electron microscopy and x-ray diffraction techniques are used to characterize the baseline physical and chemical state of the interface. The physics of adhesion between the metal and polymer matrix composite components are then evaluated on the atomistic scale using molecular dynamics simulations. Interfacial mechanical properties are subsequently derived from these simulations using classical mechanics and thermodynamics. These molecular-level property predictions are used in a companion study to parameterize a continuum-level finite element model of the interface by means of a traction-separation constitutive law. Extension of the proposed approach to other dissimilar metal- or metal oxide-polymer interfaces is also discussed.
