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Effect of Tianhuang Granule(田黄冲剂) on Intracranial Pressure and Serum Matrix Metalloproteinase-9 in Patients with Acute Cerebral Hemorrhage 被引量:5
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作者 廖辉 徐杰 +2 位作者 林展增 杨家玥 陈强 《Chinese Journal of Integrative Medicine》 SCIE CAS 2010年第4期304-308,共5页
Objective: To study the effect and mechanism of Tianhuang Granule (田黄冲剂, THG) on hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring, serum matr... Objective: To study the effect and mechanism of Tianhuang Granule (田黄冲剂, THG) on hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring, serum matrix metalloproteinase-9 (MMP-9) level observation, and National Institutes of Health Stroke Scale (NIHSS) scoring (for nerve function deficit). Methods: Sixty patients with ACH were equally randomized into two groups by lottery, the control group and the THG group; all were treated with conventional therapy, but to the patients in the THG group, THG was given orally in addition for 28 days. Changes of ICP, MMP-9 expression, and NIHSS scores, as well as the degree of cerebral hematoma and hydrocephalus (by cranial CT scanning) in the patients, were estimated and compared. Results: (1) ICP was lowered more significantly in the THG group, showing a significant difference between groups on day 7 (P〈0.05). (2) MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group. (3) The degrees of cerebral hematoma and hydrocephalus in the THG group on day 7 were reduced significantly as compared with those on day 3 (P〈0.05), but in the control group, the day of significant reduction was delayed to day 14, and the degrees on day 7 and day 14 in the two groups were significantly different (P〈0.05 and P〈0.01). (4) NIHSS score was significantly lower in the THG group than that in the control group on day 14 and day 28 (P〈0.05 and P〈0.01). Conclusion: THG can effectively lower ICP, down-regulate MMP-9 expression, promote the absorption of cerebral hematoma and hydrocephalus, and improve the nerve function, showing a clinical effectiveness than conventional therapy. 展开更多
关键词 acute cerebral hemorrhage intracranial pressure matrix metalloproteinase-9 HYDROCEPHALUS Chinese medicinal therapy tianhuang granule
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