EVALUATION ON THE THERAPEUTIC EFFECT OF DEEP PUNCTURE OF TIANSHU (ST 25) FOR SLOW TRANSIT CONSTIPATION

Objective: To evaluate the short-term and middle-long-term therapeutic effects of deep puncture of Tianshu (天枢ST 25) for slow transit constipation (STC). Methods: Sixty cases of STC patients were evenly randomized into acupuncture group and medication group. In acupuncture group, electroacupuncture (EA, 20 Hz, continuous waves and tolerable strength) was applied to bilateral Tianshu (ST 25) for 30 min after deep puncture. The treatment was given once daily, 5 sessions every week, two weeks altogether. Patients of control group were ordered to take Lactulose (10 mL/time, b.i.d), two weeks altogether. Cleveland Constipation Score (CCS) and colonic transit time (CCT) were used to evaluate the therapeutic effect. Results: After treatment, both CCS and CCT showed that the therapeutic effect of acupuncture group was significantly superior to that of medication group (P<0.05). Six-months’ follow up showed that the therapeutic effect of acupuncture still maintained in 13 of the 22 cases visited, while that of control group only maintained in 1 of the 19 cases. Conclusion: The therapeutic effect of deep puncture of Tianshu (ST 25) for STC is definite and has a middle-long-term effect. The patients have no any unfavorable reactions.

Effects of Acupuncture at Tianshu(ST25)and Shangjuxu(ST37)on the Intestinal Mucosa and Metabolites of Local Skin Tissues at Tianshu(ST25)in 2,4,6-Trinitrobenzene Sulfonic Acid and Ethanol-induced Rats

Objective:To observe the effect of acupuncture on local skin tissue metabolites of Tianshu(ST25)in rats with Crohn's disease(CD)using metabolomics and to explore the mechanism of acupuncture treatment metabolites and pathway on local skin tissue of Tianshu(ST25).Materials and Methods:Thirty-eight Sprague-Dawley rats were randomly assigned to a normal group(n=14)and a CD modeling group(n=24).Rats in the CD modeling group were administered with 2,4,6-trinitrobenzene sulfonic acid and ethanol enema,in addition to the normal group.Four normal rats and four CD modeling rats were selected at random after model identification was established.Furthermore,CD modeling group rats were randomly assigned to two groups of 10 rats:the model group and acupuncture group.Rats in the acupuncture group underwent acupuncture of Tianshu(ST25)and Shangjuxu(ST37)for 7 days.After the intervention,the colon tissue was collected from each group of rats and the pathological changes were observed through hematoxylin and eosin(HE)staining.The local skin tissues at Tianshu(ST25)of the rats in each group were taken,and the proton nuclear magnetic resonance technique was used to detect the metabonomics of the local skin tissues of Tianshu(ST25)in rats.Results:Compared with the normal group,the following were observed in the model group after HE staining:irregular colon morphology and other pathological changes such as intestinal mucosal hyperemia,edema,ulcers,polyps,and inflammatory cell infiltration.In the acupuncture group,colon tissue structure was relatively complete and layered,the colon gland structure was restored,and inflammatory cell infiltration was significantly improved.The choline,glycerin,glycine,guanidoacetic acid,and proline levels were significantly higher in the model group than in the normal group(P<0.05 or P<0.01).Compared with the model group,the acupuncture group had significantly increased contents of alanine,leucine,L-phenylalanine,and tyrosine in the skin(P<0.05 or P<0.01).Valine,leucine,and L-isoleucine biosynthesis and L-phenylalanine metabolism were the main metabolic pathways involved in the changes in the local skin tissues of the rats in each group,biosynthesis of tyrosine,and tryptophan.Conclusion:The change in the metabolites in the local area of Tianshu(ST25)may be related to intestinal disease.The acupuncture of Tianshu(ST25)can improve intestinal inflammatory reaction in rats with CD,and this finding may be related to the regulation of amino acid metabolites and their pathways in the local acupoint tissues of Tianshu(ST25)by acupuncture.

电针“天枢”与“天枢”配伍“上巨虚”对肠易激综合征大鼠行为学和结肠功能的影响

目的观察并比较电针“天枢”与“天枢”配伍“上巨虚”对肠易激综合征(irritable bowel syndrome,IBS)模型大鼠情绪和结肠功能影响,初步探讨天枢配伍上巨虚是否存在协同或叠加效应。方法雄性Wistar大鼠分为空白组(10只)和造模组(45只),采用慢性和急性应激相结合方法连续干预10 d制备模型,将制备成功IBS模型大鼠随机分为模型组(8只)、天枢组(8只)、天枢配伍上巨虚组(8只);天枢组、天枢配伍上巨虚组连续电针干预治疗14 d;干预结束后,分别对各组大鼠进行高架十字迷宫实验、结肠痛敏阈值测定,检测血清5-羟色胺(5-hydroxytryptamine,5-HT)含量以及结肠5-羟色胺4受体(5-hydroxytryptamine 4 receptor,5-HT 4 R)蛋白表达。结果与模型组比较,电针天枢组、电针天枢配伍上巨虚组进入开放臂(open arm entry,OE)次数百分比和开臂停留时间(open arm time,OT)百分比增加(P<0.01);结肠痛敏阈值显著升高(P<0.01);血清5-HT含量减少(P<0.05);结肠5-HT 4 R蛋白相对表达量增加(P<0.05)。两电针组之间比较,OE%、OT%、结肠痛敏阈值、血清5-HT含量以及结肠5-HT 4 R蛋白相对表达量的差异无统计学意义。结论电针“天枢”与“天枢”配伍“上巨虚”均能调节大鼠情绪心理行为的异常和改善结肠功能紊乱症状,但电针“天枢”配伍“上巨虚”相较于电针“天枢”未表现明显的穴位协同或叠加效应。

马铃薯新品种天薯19号选育报告

为解决甘肃省乃至西北地区马铃薯专用品种缺乏的问题,天水市农业科学研究所以晋薯11号为母本、天薯9号为父本杂交,利用常规杂交育种技术选育出了晚熟鲜食菜用型马铃薯新品种天薯19号。该品种在2019—2020年进行的国家马铃薯西北晚熟组区域试验中,2 a 18点(次)平均折合产量为32490.0 kg/hm^(2),较对照品种陇薯6号增产3.0%。该品种生育期119 d左右,薯块卵圆形、黄皮黄肉、芽眼少而浅。薯块品质优良,鲜薯块茎含干物质204 g/kg、淀粉166 g/kg、维生素C 547 mg/kg、粗蛋白22.1 g/kg、还原糖3.5 g/kg。适宜在甘肃中东部、宁夏中南部、青海东部及生态类似区种植。

温针灸八髎穴与天枢穴联合养血滋阴汤对老年人功能性便秘临床症状和血清胃肠激素水平的影响

目的:探究温针灸八髎穴与天枢穴联合养血滋阴汤对老年功能性便秘(FC)临床症状和血清胃肠激素水平的影响。方法:选取108例老年FC患者,随机分为研究组和对照组各54例。对照组服用枸橼酸莫沙必利片,研究组在对照组的基础上采用温针灸八髎穴与天枢穴联合养血滋阴汤进行治疗。评估两组治疗后的疗效,治疗前后评估两组患者的排便情况(排便不尽感评分、排便费力评分、排便不成功次数)、便秘严重程度和中医证候评分,测定两组患者治疗前后的胃肠激素水平[血清胃动素(MTL)、血管活性肠肽(VIP)、胃泌素(GAS)],肛肠动力学指标[肛管静息压(ARP)、直肠静息压(RRP)],并观察不良反应。结果:治疗后,研究组的治疗总有效率高于对照组(P<0.05);两组治疗后排便不尽感评分、排便费力评分与治疗前相比均有下降,且研究组高于对照组(P<0.05);两组治疗后MTL、VIP、GAS、ARP和RRP水平均比治疗前升高,且研究组高于对照组(P<0.05);治疗期间两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:温针灸八髎穴与天枢穴联合养血滋阴汤治疗老年FC能有效提升临床疗效,改善患者的便秘情况,促进胃肠激素分泌,改善肛肠动力学指标,且安全性良好。

基于CiteSpace对天枢穴研究可视化分析

目的:基于CiteSpace软件分析我国近20年对天枢穴的研究,探索其研究现状以及热点趋势,为后续研究提供借鉴与参考。方法:基于中国期刊全文数据库(CNKI)、万方数据知识服务平台(WanFang)、维普资讯中文期刊服务平台(VIP)数据库,检索2002-2022年关于天枢穴基础研究及临床研究的相关文献。运用CiteSpace 6.1 R6软件,绘制作者、机构、关键词等可视化图谱并进行分析。结果:纳入基础研究文献131篇以及临床研究文献471篇。基础研究及临床研究分别形成了8和12个关键词聚类。结论:天枢穴基础和临床研究领域均已进入平稳发展期并且形成一些稳定的大型研究团队;天枢穴的基础研究和临床研究的研究重点、热点方面并不对称,对天枢穴的研究领域还有空白需要更多研究者来填补。

高天舒教授从厥阴湿热论治新诊断2型糖尿病经验总结

新诊断2型糖尿病(T2DM)归属于中医学“消渴”范畴,临床上常无明显“三多一少”症状,但是多表现为寒热错杂之象。高天舒教授结合当今社会-饮食-心理模式,从“厥阴湿热”角度出发,辨证论治,提出新诊断T2DM大多以厥阴阴虚为本、湿热内郁为标且具有肝郁、脾寒、胃热的病机特点;治疗方面以“疏肝理气、通腑泄热、温下实脾”为基本原则,灵活用药,取得显著效果,同时也为中草药缓解甚至逆转新诊断T2DM提供了新的诊疗思路。

基于脑-肠-菌轴探讨天枢穴治疗功能性便秘作用机制

功能性便秘(functional constipation,FC)是常见的一种胃肠功能紊乱疾病,该病发病机制复杂,脑-肠-菌轴(BGMA)在其病理生理中的作用逐渐受到关注,脑-肠与肠道菌群交互障碍可通过神经、内分泌、免疫和代谢等途径影响胃肠道运动、感觉、分泌等功能,进而引起排便异常。天枢穴具有疏调肠腑、理气行滞、健脾和胃、调神的功效,为针灸临床治疗FC的要穴。现代研究表明,针灸天枢穴对该病的影响机制可能与调节BGMA有关,包括促进中枢神经系统、肠神经系统结构与功能的正常化,改善肠道微生态失调,调节脑肠肽的分泌以及抑制促肾上腺皮质激素释放因子的过度表达等。该文从BGMA角度探究脑-肠轴、肠道菌群与FC的发病关系,总结探讨天枢穴治疗FC的内在机制,以期为针灸治疗功能性胃肠疾病提供理论依据和临床应用指导。

天舒片联合盐酸氟桂利嗪胶囊治疗偏头痛患者的效果

目的:观察天舒片联合盐酸氟桂利嗪胶囊治疗偏头痛患者的效果。方法:选取2020年3月至2022年3月该院收治的76例偏头痛患者进行前瞻性研究,按照随机数字表法分为研究组与对照组各38例。对照组采用盐酸氟桂利嗪胶囊治疗,研究组在对照组基础上联合天舒片治疗,比较两组治疗总有效率,偏头痛发作频率、每次发作持续时间、发作时视觉模拟评分法(VAS)评分,血清细胞因子[白细胞介素增强结合因子-1(ILF-1)、降钙素基因相关肽(CGRP)、内皮素-1(ET-1)]水平和不良反应发生率。结果:研究组治疗总有效率为94.74%,明显高于对照组的76.32%,差异有统计学意义(P<0.05);治疗后,两组偏头痛发作频率和VAS评分均低于治疗前,且研究组低于对照组,两组每次发作持续时间均短于治疗前,且研究组短于对照组,差异有统计学意义(P<0.05);治疗后,两组血清CGRP水平高于治疗前,且研究组高于对照组,两组血清ET-1、ILF-1水平低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:天舒片联合盐酸氟桂利嗪胶囊治疗偏头痛患者可提高治疗总有效率,缩短每次发作持续时间,改善血清细胞因子水平,降低偏头痛发作频率和VAS评分,效果优于单纯盐酸氟桂利嗪胶囊治疗。

Effect of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) for the treatment of diarrhea-dominant irritable bowel syndrome： a patient-blinded pilot trial with orthogonal design

OBJECTIVE: To investigate the effects of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV6) in patients with diarrhea-dominant irritable bowel syndrome(D-IBS) by assessing predominant factors, and determining the best factor combinations and their interactions. To identify the optimal quantity of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) to achieve optimal efficacy.METHODS: An L9(3~4) orthogonal design was applied to 233 confirmed subjects based on the three most influential factors and the three most frequently used levels. Nine programs were designed.Subjects were assigned to four subgroups according to age and gender; each subject underwent one of the nine programs randomly. We selected Tianshu(ST 25, bilateral) and Qihai(CV 6). The scores of symptoms and the IBS Quality of Life(IBS-QOL) were evaluated after the final treatment.RESULTS: After treatment, clinical symptoms of all patients were significantly improved(P = 0.001).Quality of life also improved significantly(P < 0.05).For all the participants, frequency was the dominating factor regarding symptoms(P = 0.01). Duration was the dominating factor for quality of life(P =0.0001). The best combination for improving symptoms in 30-40-year-old male and female patients was two courses of 10 min each once a day, and for41-50-year-old male and female patients it was three courses of 10 min(males) or 30 min(females)twice a day. The best combination for quality of life was three courses of 20 min once a day. No interaction was found between frequency and course, or frequency and duration.CONCLUSION: Warming moxibustion Tianshu(ST25, bilateral) and Qihai(CV 6) is a promising therapy for D-IBS. To acquire optimal efficacy, the three main factors(duration, frequency and treatment course) of the warming moxibustion should reach a specific quantity and be combined appropriately.

“天枢-带脉”电针法结合行为控制治疗代谢相关脂肪性肝病的疗效观察

目的对“天枢-带脉”电针法结合行为控制治疗代谢相关脂肪性肝病(NAFLD)的疗效观察和讨论。方法选取80例NAFLD患者,随机分为治疗组(“天枢-带脉”电针法结合行为控制)与对照组(行为控制),各40例。比较两组患者临床疗效,治疗前后体质量指数(BMI)及肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)],治疗前后血脂指标[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)]。结果治疗组患者的治疗总有效率90.0%高于对照组的60.0%,差异具有统计学意义(P<0.05)。治疗组治疗前BMI、ALT、AST分别为(26.30±1.32)kg/m^(2)、(69.42±14.89)U/L、(56.31±13.25)U/L,治疗后分别为(24.25±1.16)kg/m^(2)、(43.50±9.89)U/L、(41.05±11.87)U/L;对照组治疗前BMI、ALT、AST分别为(26.42±1.45)kg/m^(2)、(68.99±15.37)U/L、(55.89±11.08)U/L,治疗后分别为(24.85±1.13)kg/m^(2)、(56.24±13.05)U/L、(47.89±10.67)U/L。治疗后,两组患者的BMI、ALT、AST水平均较治疗前下降,治疗组的BMI、ALT、AST水平下降程度较对照组显著(P<0.05)。治疗组治疗前TC、TG、HDL-C、LDL-C分别为(6.23±0.49)、(3.29±0.47)、(0.87±0.49)、(3.57±0.59)mmol/L,治疗后分别为(4.58±0.56)、(1.05±0.61)、(1.49±0.35)、(2.49±0.48)mmol/L;对照组治疗前TC、TG、HDL-C、LDL-C分别为(6.40±0.54)、(3.41±0.83)、(0.86±0.36)、(3.58±0.62)mmol/L,治疗后分别为(5.07±0.25)、(1.31±0.58)、(1.01±0.38)、(2.95±0.41)mmol/L。治疗后,两组患者的TG、TC和LDL-C水平均较治疗前下降,治疗组的HDL-C显著较治疗前升高(P<0.05);而对照组治疗后HDL-C较治疗前差异不显著(P>0.05);治疗后,治疗组患者TC、LDL-C水平低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05);两组治疗后TG水平差异不显著(P>0.05)。结论“天枢-带脉”电针法结合行为控制治疗NAFLD的临床疗效显著,患者可获得病情逆转,同时肝功能及血脂显著受益。

Effects of acupuncture at “Tianshu”(ST25) on electro-activity and mechanical motility of migrating motor complex during jejunal digestion period in rats with detached jejunum

Objective To observe the effects of acupuncture at"Tianshu"(ST 25)on electro-activity and mechanical motility at different phases of migrating motor complex(MMC)during jejunal digestion period in rats with detached jejunum,so as to explore the effect and mechanism of acupuncture on regulating intestinal movement.Methods Sixteen adult SD rats were selected.

Effect of Tianshu capsule in treatment of migraine:a meta-analysi of randomized control trials

OBJECTIVE: To review the efficacy of Tianshu cap sule in the treatment of migraine. METHODS: Retrieving papers from Pubmed, co chrane central register of controlled trials (CEN TRAL), Weipu database (VIP) , China biology medi cine (CBM), China national knowledge infrastruc ture (CNKI), and Wanfang Data. Two reviewers retrieved and extracted the information indepen dently. Retrieval time scale is up to August 2012,Software Review Manager 5.1 was used for analysis. RESULTS: A total of 10 studies including 937 migraine patients. The merged data shows Tianshu capsule had a higher effective rate in treating migraine, and there is no significant heterogeneity between Tianshu capsule group and control group (χ2=6.33, df=9, P=0.71, I2=0% ), OR=4.18 [95% CI (2.93,5.95)]. Tianshu capsule alone compared to conventional therapy also showed advantages, and there was low heterogeneity (χ2=4.53, df=3, P=0.21, I2 = 34%), OR=3.95 [95% CI (2.32, 6.72)]. Meta-analysis results show that clinical efficacy of Tianshu capsule was better than that of the control group in the treatment of migraine and there was a significant difference (P<0.000 01). CONCLUSION: Tianshu capsule had better efficacy in the treatment of migraine with fewer adverse effects.

天枢穴主治病症及配伍规律探析:基于随机临床对照试验

目的:运用数据挖掘技术深入总结天枢穴现代主治病症及腧穴配伍规律。方法:检索自建库至2022年6月2日中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、中国生物医学文献数据库(SinoMed)、PubMed及Web of Science等数据库相关文献资料,建立天枢单穴、配伍主治病症和配伍腧穴等数据库。运用SPSS Modeler 18.0和Gephi 0.9.2等软件对纳入文献进行复杂网络分析、关联分析、聚类分析。结果:共纳入随机对照试验文献622篇,毫针刺、电针、穴位敷贴以及艾灸是天枢穴常用的干预措施。单穴主治病症12种,优势病症为便秘、腹泻等2种;配伍主治病症85种,优势病症为便秘、胃肠功能障碍、肠易激综合征、肥胖、腹泻、消化不良、溃疡性结肠炎等14种。高频配伍腧穴为足三里、中脘、上巨虚、关元等22穴,聚类分析得到4系6类天枢配伍组合,配伍经脉以任脉频次最高,阳经腧穴多于阴经。结论:天枢穴主治范围广泛,以消化系统疾病为主,便秘为核心优势病症,其高频配穴为足三里、中脘、上巨虚、关元。

鲜食马铃薯新品种‘天薯19号’的选育

‘天薯19号’是天水市农业科学研究所以‘晋薯11号’为母本,‘天薯9号’为父本杂交选育而成的晚熟鲜食菜用型马铃薯新品种,2022年通过非主要农作物品种登记,登记号为GPD马铃薯(2022)620106。生育期119 d左右。块茎卵圆形,淡黄皮淡黄肉,薯皮光滑,芽眼浅。2019~2020年国家马铃薯品种区域试验平均产量为2166 kg/667m^(2),较对照‘陇薯6号’(CK)(2103 kg/667m^(2))增产3.00%。块茎干物质含量20.40%,淀粉含量16.60%,粗蛋白含量2.21%,维生素C含量54.70 mg/100 g,还原糖含量0.35%。高抗晚疫病,中抗马铃薯X病毒病和马铃薯Y病毒病。适宜在甘肃省中东部、宁夏回族自治区中南部、青海省东部种植。

针灸对克罗恩病模型大鼠天枢穴局部皮肤中缓激肽、CGRP和NPY的影响

目的观察艾灸与针刺对克罗恩病模型大鼠天枢穴局部皮肤中缓激肽(bradykinin,BK)、降钙素基因相关肽(calcitonin gene related peptid,CGRP)、神经肽Y(neuropeptide Y,NPY)含量的影响。方法将50只SD大鼠随机分为正常组、模型组、艾灸组、针刺组和西药组,每组10只。除正常组外,其余各组应用2,4,6-三硝基苯磺酸(2,4,6-trinitrobenzenesulfonic acid,TNBS)灌肠的方法制备克罗恩病肠纤维化大鼠模型。模型制备成功后,分别采用艾灸和针刺的方法干预艾灸组和针刺组大鼠双侧天枢穴和上巨虚穴,每次15 min;西药组大鼠给予美沙拉嗪肠溶片溶液灌胃。上述干预均1次/d,连续干预7 d。干预结束后,肉眼和HE染色观察各组大鼠结肠病理形态学变化;剪取各组大鼠天枢穴局部皮肤,ELISA法检测BK的蛋白表达,Western blot法检测CGRP、NPY的蛋白表达。结果与正常组相比,模型组大鼠肠壁可见典型鹅卵石样改变、黏膜充血水肿等病理形态学损伤,天枢穴局部皮肤中BK含量显著升高(P<0.01),CGRP相对表达量显著降低(P<0.05),NPY相对表达量差异无统计学意义(P>0.05)。与模型组相比,各治疗组大鼠肠黏膜受损情况明显较轻,天枢穴局部皮肤中BK含量均显著降低(P<0.01),CGRP相对表达量均显著升高(P<0.01或P<0.05),NPY相对表达量差异无统计学意义(P>0.05)。针刺组、艾灸组和西药组3组之间相比,天枢穴局部皮肤中BK、CGRP和NPY的差异均无统计学意义(P>0.05)。结论克罗恩病大鼠天枢穴局部皮肤中BK、CGRP的变化可能是肠腑病变在体表的客观反映,艾灸、针刺对克罗恩病大鼠天枢穴局部皮肤中BK、CGRP具有调节作用。

薏苡附子败酱散联合电针治疗对AOM/DSS小鼠炎症相关性结直肠癌的防治作用及机制

目的:探究薏苡附子败酱散(Yiyi Fuzi Baijiang San,YYFZBJS)联合电针(electroacupuncture,EA)对AOM/DSS模型小鼠炎症相关性结直肠癌(colitis-associated colorectal cancer,CAC)的防治作用及对结直肠癌上皮间质转化(epithelial-mesenchymal transition,EMT)相关蛋白表达情况的影响。方法:建立AOM/DSS诱导的CAC小鼠模型,将40只小鼠随机分为模型组、针药结合组、薏苡附子败酱散组、电针组和阿司匹林组,于实验第2周开始干预治疗,治疗过程中记录各组小鼠一般情况,统计体质量变化、疾病活动指数(disease activity index,DAI)评分及生存情况,于实验末比较各组小鼠结直肠长度、成瘤数量及肿瘤大小,通过HE染色观察结直肠组织及肿瘤组织的病理变化,免疫组织化学染色观察结直肠肿瘤Ki-67、PCNA、p-NF-κB、NF-κB、E-cadherin、ZO-1、Occludin、Vimentin和N-cadherin蛋白的表达。结果:与模型组相比,针药结合组小鼠体质量显著升高(P<0.05),DAI分值降低(P<0.05),生存率为87.5%,结直肠长度显著增加(P<0.01),直径小于2 mm的肿瘤数量减少(P<0.05),直径介于2~4 mm之间和大于4 mm的肿瘤数量显著减少(P<0.01),总成瘤数量明显下降(P<0.01),结直肠形态明显改善;肿瘤组织病理评分降低(P<0.01),肿瘤组织中Ki-67、PCNA、p-NF-κB、NF-κB、Vimentin和N-cadherin蛋白表达量降低(P<0.01),E-cadherin、ZO-1和Occludin蛋白表达量升高(P<0.05)。结论:薏苡附子败酱散联合电针对AOM/DSS模型小鼠的CAC发生发展有防治作用,其机制可能与下调NF-κB信号通路,减缓EMT进程有关。

《针灸大成》中天枢穴的临床应用浅析

通过整理《针灸大成》中有关天枢穴的记载,探讨其临床应用。天枢穴不仅是足阳明胃经输穴、又是大肠募穴,还因其特殊的位置,从而具有广泛的临床应用。而其临床应用中不仅有常见的脾胃疾病与肠腑疾病,还在妇科疾病、奔豚证、肥胖症、腰痛等疾病中有相应的疗效。

中频电刺激天枢穴治疗脊髓损伤后神经源性肠道功能障碍的疗效

目的:观察中频电刺激天枢穴治疗脊髓损伤后神经源性肠道功能障碍(NBD)的有效性。方法:选取2020年9月—2022年9月入住粤北人民医院脊柱外科的60例脊髓损伤后NBD病人,随机分为对照组和观察组,每组30例。对照组采用常规治疗措施,观察组在常规治疗的基础上使用中频电刺激治疗。比较两组治疗前和治疗后1个月的肠道功能和生活质量。结果:治疗后1个月,观察组便秘、腹胀、药物依赖发生率及排便时间、排便频率评分均低于对照组(P<0.05),日常活动能力评分和生活质量评分均高于对照组,差异有统计学意义(P<0.05)。结论:中频电刺激天枢穴能有效缓解脊髓损伤后NBD,提高病人自理能力和生活质量。

天舒胶囊联合盐酸氟桂利嗪胶囊治疗偏头痛患者的效果

目的:观察天舒胶囊联合盐酸氟桂利嗪胶囊治疗偏头痛患者的效果。方法:回顾性分析2020年6月至2022年6月该院收治的92例偏头痛患者的临床资料,按照治疗方法不同将其分为对照组和观察组各46例。对照组采用盐酸氟桂利嗪胶囊治疗,观察组在对照组基础上联合天舒胶囊治疗,比较两组治疗前后头痛改善情况、临床疗效、治疗前后颅内动脉血流动力学指标[基底动脉(BA)、椎动脉(VA)、脑前动脉(ACA)、脑后动脉(PCA)和脑中动脉(MCA)血流速度]水平、血清学指标[降钙素基因相关肽(CGRP)、5-羟色胺(5-HT)和内皮素-1(ET-1)]水平和不良反应发生率。结果:治疗后,观察组头痛发作次数少于对照组,头痛发作持续时间短于对照组,头痛发作强度低于对照组,差异均有统计学意义(P<0.05);观察组治疗总有效率为91.30%,高于对照组的71.74%,差异有统计学意义(P<0.05);治疗后,观察组BA、VA、ACA、PCA及MCA血流速度均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组CGRP、5-HT及ET-1水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:天舒胶囊联合盐酸氟桂利嗪胶囊治疗偏头痛患者,可改善头痛发作情况,提高临床疗效,降低颅内动脉血流速度和血清学指标水平,其效果优于单纯盐酸氟桂利嗪胶囊治疗。