Objective To investigate the relationship between SNPs reported in previous studies and the blood lipid level in the Tibetan population. Methods Random cluster sampling was employed in 5 areas （Lhasa, Shigatse, Shann...Objective To investigate the relationship between SNPs reported in previous studies and the blood lipid level in the Tibetan population. Methods Random cluster sampling was employed in 5 areas （Lhasa, Shigatse, Shannan, Nagqu, and Nyingchi）. The levels of cholesterol （TC）, triglyceride {TG）, high-density lipoprotein cholesterol （HDL-C）, and low-density lipoprotein cholesterol （LDL-C） from blood samples were determined and DNA was extracted for genotyping and statistical analyses. Results Among 1 318 subjects aged 〉18 years enrolled in this study, 367 had dyslipidemia with a prevalence of 27.8%, of whom dyslipidemia males accounted for 33.1% and dyslipidemia females - 24.5%. Results of the correlation analysis between all SNPs and TG showed that the SNPs of rs714052 and rs964184 were related to the serum TG level. Subjects with rs714052 CC genotype had the lowest TG level, and the highest TG level was found in those with rs714052 TT genotype. The serum TG level in individuals with TC genotype lied in between the above two population groups. Subjects with rs964184 CC genotype had the lowest TG level, and the highest serum TG level was noted in those with rs964184 GG genotype. Conclusion Several SNPs were found to be related to the serum TG level in the Tibetan population. The APOA5 gene and MLXlPL gene may be closely associated with the serum TG level in this ethnic population group.展开更多
Arjinshan National Nature Reserve(ANNR) is one of 3 refuges of the endemic ungulates Tibetan wild ass(Equus kiang),Chiru(Pantholops hodgsonii) and wild yak(Bos mutus) that are endangered by natural and anthropogenic f...Arjinshan National Nature Reserve(ANNR) is one of 3 refuges of the endemic ungulates Tibetan wild ass(Equus kiang),Chiru(Pantholops hodgsonii) and wild yak(Bos mutus) that are endangered by natural and anthropogenic factors in the Qinghai-Tibetan Plateau(QTP).Identifying habitat suitability is critical for species protection management.We used a GIS-based niche model to delimit and classify habitat suitability using an integrated assessment system,which included 9 biotic and abiotic factors.We divided the research area into 4 habitat types for these ungulates:(1) high suitability habitat;(2) moderate suitability habitat;(3) low suitability habitat;and(4) unsuitable area.Results suggested that chiru have the most areas of high and moderate suitability habitats while Tibetan wild ass had the largest areas of low suitability habitat and unsuitable area.Wild yak had the largest area of moderate and low suitability habitat,but high suitability habitats for wild yak were smaller than those of other 2 ungulates.There was overlap of high-quality habitat for the three kinds of ungulates in the vicinity of Kardun inspection station,which could be regarded as the core area for the coexistence and conservation of these endangered ungulate populations.展开更多
文摘Objective To investigate the relationship between SNPs reported in previous studies and the blood lipid level in the Tibetan population. Methods Random cluster sampling was employed in 5 areas （Lhasa, Shigatse, Shannan, Nagqu, and Nyingchi）. The levels of cholesterol （TC）, triglyceride {TG）, high-density lipoprotein cholesterol （HDL-C）, and low-density lipoprotein cholesterol （LDL-C） from blood samples were determined and DNA was extracted for genotyping and statistical analyses. Results Among 1 318 subjects aged 〉18 years enrolled in this study, 367 had dyslipidemia with a prevalence of 27.8%, of whom dyslipidemia males accounted for 33.1% and dyslipidemia females - 24.5%. Results of the correlation analysis between all SNPs and TG showed that the SNPs of rs714052 and rs964184 were related to the serum TG level. Subjects with rs714052 CC genotype had the lowest TG level, and the highest TG level was found in those with rs714052 TT genotype. The serum TG level in individuals with TC genotype lied in between the above two population groups. Subjects with rs964184 CC genotype had the lowest TG level, and the highest serum TG level was noted in those with rs964184 GG genotype. Conclusion Several SNPs were found to be related to the serum TG level in the Tibetan population. The APOA5 gene and MLXlPL gene may be closely associated with the serum TG level in this ethnic population group.
基金provided by School of Environment,Beijing Normal Universitysupported by grants from Ministry of Environmental Protection of China (201209033)grants from the Ministry of Science and Technology of China (2012BAC01B02)
文摘Arjinshan National Nature Reserve(ANNR) is one of 3 refuges of the endemic ungulates Tibetan wild ass(Equus kiang),Chiru(Pantholops hodgsonii) and wild yak(Bos mutus) that are endangered by natural and anthropogenic factors in the Qinghai-Tibetan Plateau(QTP).Identifying habitat suitability is critical for species protection management.We used a GIS-based niche model to delimit and classify habitat suitability using an integrated assessment system,which included 9 biotic and abiotic factors.We divided the research area into 4 habitat types for these ungulates:(1) high suitability habitat;(2) moderate suitability habitat;(3) low suitability habitat;and(4) unsuitable area.Results suggested that chiru have the most areas of high and moderate suitability habitats while Tibetan wild ass had the largest areas of low suitability habitat and unsuitable area.Wild yak had the largest area of moderate and low suitability habitat,but high suitability habitats for wild yak were smaller than those of other 2 ungulates.There was overlap of high-quality habitat for the three kinds of ungulates in the vicinity of Kardun inspection station,which could be regarded as the core area for the coexistence and conservation of these endangered ungulate populations.
