Objective:To study the trauma and bone metabolism after internal absorbable screw and metal screw fixation treatment of tibia-fibula fracture. Methods:78 patients with tibia-fibula fracture who received internal fixat...Objective:To study the trauma and bone metabolism after internal absorbable screw and metal screw fixation treatment of tibia-fibula fracture. Methods:78 patients with tibia-fibula fracture who received internal fixation surgery in our hospital between May 2013 and October 2015 were selected and randomly divided into absorbable group and metal group (n=39) who accepted internal absorbable screw fixation and internal metal screw fixation respectively. 3 d after operation, serum was collected to determine the levels of inflammatory factors, pain mediators, stress hormones and bone metabolism indexes. Results: Serum inflammatory mediators procalcitonin (PCT), Resistin, C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α), pain mediators substance P (SP), prostaglandin E2 (PGE2) and NPY, stress hormones norepinephrine (NE), epinephrine (E) and cortisol (Cor) as well as bone resorption marker molecules C-terminal telopeptides of type I collagen (CTX-I) and C-terminal telopeptides of type II collagen (CTX-II) levels of absorbable group were significantly lower than those of metal group (P<0.05) while bone formation marker molecules N-MID osteocalcin (N-MID) and N-terminal propeptide of procollagen type I (PINP) levels were significantly higher than those of metal group (P<0.05). Conclusions:The trauma degree of internal absorbable screw fixation treatment of tibia-fibula fracture is weaker than that of internal metal screw fixation, and the bone metabolism activity is better than that of internal metal screw fixation.展开更多
文摘Objective:To study the trauma and bone metabolism after internal absorbable screw and metal screw fixation treatment of tibia-fibula fracture. Methods:78 patients with tibia-fibula fracture who received internal fixation surgery in our hospital between May 2013 and October 2015 were selected and randomly divided into absorbable group and metal group (n=39) who accepted internal absorbable screw fixation and internal metal screw fixation respectively. 3 d after operation, serum was collected to determine the levels of inflammatory factors, pain mediators, stress hormones and bone metabolism indexes. Results: Serum inflammatory mediators procalcitonin (PCT), Resistin, C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α), pain mediators substance P (SP), prostaglandin E2 (PGE2) and NPY, stress hormones norepinephrine (NE), epinephrine (E) and cortisol (Cor) as well as bone resorption marker molecules C-terminal telopeptides of type I collagen (CTX-I) and C-terminal telopeptides of type II collagen (CTX-II) levels of absorbable group were significantly lower than those of metal group (P<0.05) while bone formation marker molecules N-MID osteocalcin (N-MID) and N-terminal propeptide of procollagen type I (PINP) levels were significantly higher than those of metal group (P<0.05). Conclusions:The trauma degree of internal absorbable screw fixation treatment of tibia-fibula fracture is weaker than that of internal metal screw fixation, and the bone metabolism activity is better than that of internal metal screw fixation.
