满山香化学成分的研究

目的 :从满山香茎藤中分离鉴定化学成分。方法 :溶剂提取及柱色谱法分离 ,光谱技术鉴定结构。结果 :分得 6个联苯环辛二烯木脂素 ,tigloylgomisinP(1) ,angeloylgomisinO(2 ) ,angeloylisogomisinO(3) ,kadsulignanL(4) ,(± ) 5 ,8 epoxyl 6 ,7 dimethyl 2′ ,3′ ,2″ ,3″ dimethylenedioxy 4′ ,1″ dimethyl 1,2∶3,4 dibenzo 1,3 cyclooctadiene(5 )和五味子丙素 (6 )。结论 :化合物 4和 5为首次自五味子属植物中发现的 6 ,9位形成氧桥环的木脂素 。

Dibenzocyclooctadiene Lignans with Platelet-Activating Factor (PAF) Antagonist Activity from Kadsura heteroclita

Seven known dibenzocyclooctadiene lignans,tigloylgomisin P(1), angeloylgomisin P(2),gomisin A(3),Schizandrin(4),angeloylgomisin H(5),gomisin B(6) and R(+)-gomisin M_1(7)were isolated from Kadsura heteroclita.The conformation of tiglolylgomisin P(1)was established by 2D NMR techniques.Using[~3H]platelet activating factor(PAF)binding to human platelet membrane assay,(1),(2)and(7)showed PAF receptor antagonistic activities.