Objective: Adjuvant chemotherapy (AC) after curative resection is known to improve the survival of patients with non-small cell lung cancer (NSCLC); however, few studies have reported the correlation between the time ...Objective: Adjuvant chemotherapy (AC) after curative resection is known to improve the survival of patients with non-small cell lung cancer (NSCLC); however, few studies have reported the correlation between the time to initiation of AC (TTAC) and survival in NSCLC patients. Methods: The clinical data of 925 NSCLC patients who received curative resection and post-operative AC at the Cancer Hospital of Chinese Academy of Medical Sciences between 2003 and 2013 were retrospectively analyzed. TTAC was measured from the date of surgery to the initiation of AC. Disease-free survival (DFS) was defined as the duration from surgery to the time of tumor recurrence or last follow-up evaluation. The optimal cut-off value of TTAC was determined by maximally selected log-rank statistics. The DFS curve was estimated using the Kaplan-Meier method, and the Cox proportional hazards regression model was used to identify risk factors independently associated with DFS. Propensity score matching (PSM) was performed for survival analysis using the match data. Results: The optimal discriminating cut-off value of TTAC was set at d 35 after curative resection based on which the patients were assigned into two groups: group A (<= 35 d) and group B (> 35 d). There was no significant difference in the DFS between the two groups (P=0.246), indicating that the TTAC is not an independent prognostic factor for DFS. A further comparison continued to show no significant difference in the DFS among 258 PSM pairs (P=0.283). Conclusions: There was no significant correlation between the TTAC and DFS in NSCLC patients. Studies with larger samples are needed to further verify this conclusion.展开更多
AIM To investigate the safety timing of immediately postoperative chemotherapy in the patients with breast cancer. METHODS Thirty two patients with breast cancer of classification Ⅱ were admitted to our hospital, wer...AIM To investigate the safety timing of immediately postoperative chemotherapy in the patients with breast cancer. METHODS Thirty two patients with breast cancer of classification Ⅱ were admitted to our hospital, were performed on a breast radical resection. The patients were divided randomly into 2 groups and accepted chemotherapy at day 1 (group 1) and day 8 (group 2) after operation respectively, to observe the effect of healing of surgical wound, a response to chemotherapy and a change of IL 2 and sIL 2R lever in serum. RESULTS There were no significant differences between 2 groups in healing of surgical incisions. A few patients in 2 groups felt nausea and vomit but the symptoms were disappeared when they treated based on the correct diagnosis. Also there were no differences between 2 groups on the fall of the number of white blood cells and a similar tend towards in change of IL 2, sIL 2R lever in serum. CONCLUSION Early postoperative adjuvant chemotherapy with better curative effects and fewer side effects durgs will not effect the ability of surgical wound healing and increase the postoperative complications. The immunity function of the body will not depress. A positive effect occurs both on improvement of the 5 year survival rate and on reducing the recurrent rate in patients with breast cancer.展开更多
Aim:High-risk endometrial cancer has a higher risk of regional and distant recurrence.We sought to examine our institutional experience regarding the timing of adjuvant radiotherapy and local failure(LF),locoregional ...Aim:High-risk endometrial cancer has a higher risk of regional and distant recurrence.We sought to examine our institutional experience regarding the timing of adjuvant radiotherapy and local failure(LF),locoregional failure(LRF),distant failure(DF),and overall survival(OS).Methods:We retrospectively reviewed a database of patients with high-risk endometrial cancer treated with sequential chemotherapy followed by adjuvant external beam radiation therapy(EBRT)with or without brachytherapy from 2012 to 2019.Results:One hundred thirty-one patients were identified.The median age at diagnosis was 65(range 32-81).The most prevalent FIGO stages were IIIB(28.2%,n=37),IIIC1(19.8%,n=26),and IIIA(17.6%,n=23).Of the patients,29%(n=38)had positive lymph nodes and 71%(n=93)had negative lymph nodes.The most prevalent histology was endometrioid(71%,n=93),serous(12.2%,n=16),clear cell(9.2%,n=12),and other(7.6%,n=10).Moreover,100%(n=131)of the patients completed EBRT.The mean EBRT dose was 49.6 Gy(range 45-50.4).The median number of days between surgery and EBRT was 212.4 days(range 103-219).The mean brachytherapy dose was 14.7 Gy(range 12-30).The cumulative incidence of LF was 6.1%,LRF was 19%,DF was 19%,and the median survival was 33.4 months.For patients who completed EBRT 180 days after surgery,LRF(HR 3.55[1.23-10.2],P=0.013),LF(HR 1.91[0.4-8.9],P=0.429),DF(HR 0.91[0.41-2],P=0.806),and OS(HR 0.92[0.33-2.6],P=0.87).Conclusion:In our cohort of patients with high-risk endometrial cancer treated with chemotherapy followed by radiotherapy,delaying RT was associated with an increased risk of LRF but no differences in DF or OS.展开更多
文摘Objective: Adjuvant chemotherapy (AC) after curative resection is known to improve the survival of patients with non-small cell lung cancer (NSCLC); however, few studies have reported the correlation between the time to initiation of AC (TTAC) and survival in NSCLC patients. Methods: The clinical data of 925 NSCLC patients who received curative resection and post-operative AC at the Cancer Hospital of Chinese Academy of Medical Sciences between 2003 and 2013 were retrospectively analyzed. TTAC was measured from the date of surgery to the initiation of AC. Disease-free survival (DFS) was defined as the duration from surgery to the time of tumor recurrence or last follow-up evaluation. The optimal cut-off value of TTAC was determined by maximally selected log-rank statistics. The DFS curve was estimated using the Kaplan-Meier method, and the Cox proportional hazards regression model was used to identify risk factors independently associated with DFS. Propensity score matching (PSM) was performed for survival analysis using the match data. Results: The optimal discriminating cut-off value of TTAC was set at d 35 after curative resection based on which the patients were assigned into two groups: group A (<= 35 d) and group B (> 35 d). There was no significant difference in the DFS between the two groups (P=0.246), indicating that the TTAC is not an independent prognostic factor for DFS. A further comparison continued to show no significant difference in the DFS among 258 PSM pairs (P=0.283). Conclusions: There was no significant correlation between the TTAC and DFS in NSCLC patients. Studies with larger samples are needed to further verify this conclusion.
文摘AIM To investigate the safety timing of immediately postoperative chemotherapy in the patients with breast cancer. METHODS Thirty two patients with breast cancer of classification Ⅱ were admitted to our hospital, were performed on a breast radical resection. The patients were divided randomly into 2 groups and accepted chemotherapy at day 1 (group 1) and day 8 (group 2) after operation respectively, to observe the effect of healing of surgical wound, a response to chemotherapy and a change of IL 2 and sIL 2R lever in serum. RESULTS There were no significant differences between 2 groups in healing of surgical incisions. A few patients in 2 groups felt nausea and vomit but the symptoms were disappeared when they treated based on the correct diagnosis. Also there were no differences between 2 groups on the fall of the number of white blood cells and a similar tend towards in change of IL 2, sIL 2R lever in serum. CONCLUSION Early postoperative adjuvant chemotherapy with better curative effects and fewer side effects durgs will not effect the ability of surgical wound healing and increase the postoperative complications. The immunity function of the body will not depress. A positive effect occurs both on improvement of the 5 year survival rate and on reducing the recurrent rate in patients with breast cancer.
基金This retrospective study was reviewed and approved by the institutional ethics board(R-2022-1301-035).
文摘Aim:High-risk endometrial cancer has a higher risk of regional and distant recurrence.We sought to examine our institutional experience regarding the timing of adjuvant radiotherapy and local failure(LF),locoregional failure(LRF),distant failure(DF),and overall survival(OS).Methods:We retrospectively reviewed a database of patients with high-risk endometrial cancer treated with sequential chemotherapy followed by adjuvant external beam radiation therapy(EBRT)with or without brachytherapy from 2012 to 2019.Results:One hundred thirty-one patients were identified.The median age at diagnosis was 65(range 32-81).The most prevalent FIGO stages were IIIB(28.2%,n=37),IIIC1(19.8%,n=26),and IIIA(17.6%,n=23).Of the patients,29%(n=38)had positive lymph nodes and 71%(n=93)had negative lymph nodes.The most prevalent histology was endometrioid(71%,n=93),serous(12.2%,n=16),clear cell(9.2%,n=12),and other(7.6%,n=10).Moreover,100%(n=131)of the patients completed EBRT.The mean EBRT dose was 49.6 Gy(range 45-50.4).The median number of days between surgery and EBRT was 212.4 days(range 103-219).The mean brachytherapy dose was 14.7 Gy(range 12-30).The cumulative incidence of LF was 6.1%,LRF was 19%,DF was 19%,and the median survival was 33.4 months.For patients who completed EBRT 180 days after surgery,LRF(HR 3.55[1.23-10.2],P=0.013),LF(HR 1.91[0.4-8.9],P=0.429),DF(HR 0.91[0.41-2],P=0.806),and OS(HR 0.92[0.33-2.6],P=0.87).Conclusion:In our cohort of patients with high-risk endometrial cancer treated with chemotherapy followed by radiotherapy,delaying RT was associated with an increased risk of LRF but no differences in DF or OS.
