A class of models for activity-driven networks is proposed in which nodes vary in two states: active and inactive. Only active nodes can receive links from others which represent instantaneous dynamical interactions....A class of models for activity-driven networks is proposed in which nodes vary in two states: active and inactive. Only active nodes can receive links from others which represent instantaneous dynamical interactions. The evolution of the network couples the addition of new nodes and state transitions of old ones. The active group changes with activated nodes entering and deactivated ones leaving. A general differential equation framework is developed to study the degree distribution of nodes of integrated networks where four different schemes are formulated.展开更多
This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown nonlinearities.To eli...This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown nonlinearities.To eliminate nonlinearities,neural networks are applied to approximate the inherent dynamics of the system.In addition,due to the limitations of the actual working conditions,each follower agent can only obtain the locally measurable partial state information of the leader agent.To address this problem,a neural network state observer based on the leader state information is designed.Then,a finite-time prescribed performance adaptive output feedback control strategy is proposed by restricting the sliding mode surface to a prescribed region,which ensures that the closed-loop system has practical finite-time stability and that formation errors of the multi-agent systems converge to the prescribed performance bound in finite time.Finally,a numerical simulation is provided to demonstrate the practicality and effectiveness of the developed algorithm.展开更多
The present study addresses the problem of fault estimation for a specific class of nonlinear time-varying complex networks,utilizing an unknown-input-observer approach within the framework of dynamic event-triggered ...The present study addresses the problem of fault estimation for a specific class of nonlinear time-varying complex networks,utilizing an unknown-input-observer approach within the framework of dynamic event-triggered mechanism(DETM).In order to optimize communication resource utilization,the DETM is employed to determine whether the current measurement data should be transmitted to the estimator or not.To guarantee a satisfactory estimation performance for the fault signal,an unknown-input-observer-based estimator is constructed to decouple the estimation error dynamics from the influence of fault signals.The aim of this paper is to find the suitable estimator parameters under the effects of DETM such that both the state estimates and fault estimates are confined within two sets of closed ellipsoid domains.The techniques of recursive matrix inequality are applied to derive sufficient conditions for the existence of the desired estimator,ensuring that the specified performance requirements are met under certain conditions.Then,the estimator gains are derived by minimizing the ellipsoid domain in the sense of trace and a recursive estimator parameter design algorithm is then provided.Finally,a numerical example is conducted to demonstrate the effectiveness of the designed estimator.展开更多
In this paper, a filtering method is presented to estimate time-varying parameters of a missile dual control system with tail fins and reaction jets as control variables. In this method, the long-short-term memory(LST...In this paper, a filtering method is presented to estimate time-varying parameters of a missile dual control system with tail fins and reaction jets as control variables. In this method, the long-short-term memory(LSTM) neural network is nested into the extended Kalman filter(EKF) to modify the Kalman gain such that the filtering performance is improved in the presence of large model uncertainties. To avoid the unstable network output caused by the abrupt changes of system states,an adaptive correction factor is introduced to correct the network output online. In the process of training the network, a multi-gradient descent learning mode is proposed to better fit the internal state of the system, and a rolling training is used to implement an online prediction logic. Based on the Lyapunov second method, we discuss the stability of the system, the result shows that when the training error of neural network is sufficiently small, the system is asymptotically stable. With its application to the estimation of time-varying parameters of a missile dual control system, the LSTM-EKF shows better filtering performance than the EKF and adaptive EKF(AEKF) when there exist large uncertainties in the system model.展开更多
Recent research in cross-domain intelligence fault diagnosis of machinery still has some problems,such as relatively ideal speed conditions and sample conditions.In engineering practice,the rotational speed of the mac...Recent research in cross-domain intelligence fault diagnosis of machinery still has some problems,such as relatively ideal speed conditions and sample conditions.In engineering practice,the rotational speed of the machine is often transient and time-varying,which makes the sample annotation increasingly expensive.Meanwhile,the number of samples collected from different health states is often unbalanced.To deal with the above challenges,a complementary-label(CL)adversarial domain adaptation fault diagnosis network(CLADAN)is proposed under time-varying rotational speed and weakly-supervised conditions.In the weakly supervised learning condition,machine prior information is used for sample annotation via cost-friendly complementary label learning.A diagnosticmodel learning strategywith discretized category probabilities is designed to avoidmulti-peak distribution of prediction results.In adversarial training process,we developed virtual adversarial regularization(VAR)strategy,which further enhances the robustness of the model by adding adversarial perturbations in the target domain.Comparative experiments on two case studies validated the superior performance of the proposed method.展开更多
In engineering fields,time-varying matrix inversion(TVMI)issue is often encountered.Zeroing neural network(ZNN)has been extensively employed to resolve the TVMI problem.Nevertheless,the original ZNN(OZNN)and the integ...In engineering fields,time-varying matrix inversion(TVMI)issue is often encountered.Zeroing neural network(ZNN)has been extensively employed to resolve the TVMI problem.Nevertheless,the original ZNN(OZNN)and the integral-enhanced ZNN(IEZNN)usually fail to deal with the TVMI problem under unbounded noises,such as linear noises.Therefore,a neural network model that can handle the TVMI under linear noise interference is urgently needed.This paper develops a double integral-enhanced ZNN(DIEZNN)model based on a novel integral-type design formula with inherent linear-noise tolerance.Moreover,its convergence and robustness are verified by deriva-tion strictly.For comparison and verification,the OZNN and the IEZNN models are adopted to resolve the TVMI under multiple identical noise environments.The experi-ments proved that the DIEZNN model has excellent advantages in solving TVMI problems under linear noises.In general,the DIEZNN model is an innovative work and is proposed for the first time.Satisfyingly,the errors of DIEZNN are always less than 1�10−3 under linear noises,whereas the error norms of OZNN and IEZNN models are not convergent to zero.In addition,these models are applied to the control of the controllable permanent magnet synchronous motor chaotic system to indicate the superiority of the DIEZNN.展开更多
Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment responses.AIM To predict prognosis and immunotherapy response in patients diagnose...BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment responses.AIM To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural networks.METHODS Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus.Mitochondrial genes were sourced from the MitoCarta3.0 database.The discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation cohort.Using the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were predicted.RESULTS In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy model.The average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation cohort.The average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation cohort.CONCLUSION The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.展开更多
Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network lev...Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve transfer.Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery.展开更多
A new approach to damage classification for health monitoring of a time-varylng system is presented. The functional-series time-dependent auto regressive moving average (FS-TARMA) time series model is applied to the...A new approach to damage classification for health monitoring of a time-varylng system is presented. The functional-series time-dependent auto regressive moving average (FS-TARMA) time series model is applied to the vibration signal observed in the time-varying system for estimating the TAR/TMA parameters and the innovation variance. These parameters are the functions of the time, represented by a group of projection coefficients on the certain functional subspace with specific basis functions. The estimated TAR/TMA parameters and the innovation variance are further used to calculate the latent components (LCs) as the more informative data for health monitoring evaluation, based on an eigenvalue decomposition technique. LCs are then combined and reduced to numerical values (NVs) as feature sets, which are input to a probabilistic neural network (PNN) for the damage classification. For the evaluation of the proposed method, numerical simulations of the damage classification for a tlme-varylng system are used, in which different classes of damage are modeled by the mass or stiffness reductions. It is demonstrated that the method can identify the damages in the course of operation and the change of parameters on the time-varying background of the system.展开更多
In this paper,a distributed stochastic approximation algorithm is proposed to track the dynamic root of a sum of time-varying regression functions over a network.Each agent updates its estimate by using the local obse...In this paper,a distributed stochastic approximation algorithm is proposed to track the dynamic root of a sum of time-varying regression functions over a network.Each agent updates its estimate by using the local observation,the dynamic information of the global root,and information received from its neighbors.Compared with similar works in optimization area,we allow the observation to be noise-corrupted,and the noise condition is much weaker.Furthermore,instead of the upper bound of the estimate error,we present the asymptotic convergence result of the algorithm.The consensus and convergence of the estimates are established.Finally,the algorithm is applied to a distributed target tracking problem and the numerical example is presented to demonstrate the performance of the algorithm.展开更多
In this work,a frame work for time-varying channel modeling and simulation is proposed by using neural network(NN)to overcome the shortcomings in geometry based stochastic model(GBSM)and simulation approach.Two NN mod...In this work,a frame work for time-varying channel modeling and simulation is proposed by using neural network(NN)to overcome the shortcomings in geometry based stochastic model(GBSM)and simulation approach.Two NN models are developed for modeling of path loss together with shadow fading(SF)and joint small scale channel parameters.The NN models can predict path loss plus SF and small scale channel parameters accurately compared with measurement at 26 GHz performed in an outdoor microcell.The time-varying path loss and small scale channel parameters generated by the NN models are proposed to replace the empirical path loss and channel parameter random numbers in GBSM-based framework to playback the measured channel and match with its environment.Moreover,the sparse feature of clusters,delay and angular spread,channel capacity are investigated by a virtual array measurement at 28 GHz in a large waiting hall.展开更多
Abstract--In this paper, an adaptive neural network (NN) control approach is proposed for nonlinear pure-feedback sys- tems with time-varying full state constraints. The pure-feedback systems of this paper are assum...Abstract--In this paper, an adaptive neural network (NN) control approach is proposed for nonlinear pure-feedback sys- tems with time-varying full state constraints. The pure-feedback systems of this paper are assumed to possess nonlinear function uncertainties. By using the mean value theorem, pure-feedback systems can be transformed into strict feedback forms. For the newly generated systems, NNs are employed to approximate unknown items. Based on the adaptive control scheme and backstepping algorithm, an intelligent controller is designed. At the same time, time-varying Barrier Lyapunov functions (BLFs) with error variables are adopted to avoid violating full state constraints in every step of the backstepping design. All closed- loop signals are uniformly ultimately bounded and the output tracking error converges to the neighborhood of zero, which can be verified by using the Lyapunov stability theorem. Two simulation examples reveal the performance of the adaptive NN control approach. Index TermsmAdaptive control, neural networks (NNs), non- linear pure-feedback systems, time-varying constraints.展开更多
In this paper, we present an interval model of networked control systems with time-varying sampling periods and time-varying network-induced delays and discuss the problem of stability of networked control systems usi...In this paper, we present an interval model of networked control systems with time-varying sampling periods and time-varying network-induced delays and discuss the problem of stability of networked control systems using Lyapunov stability theory. A sufficient stability condition is obtained by solving a set of linear matrix inequalities. In the end, the illustrative example demonstrates the correctness and effectiveness of the proposed approach.展开更多
Cascading failure can cause great damage to complex networks, so it is of great significance to improve the network robustness against cascading failure. Many previous existing works on load-redistribution strategies ...Cascading failure can cause great damage to complex networks, so it is of great significance to improve the network robustness against cascading failure. Many previous existing works on load-redistribution strategies require global information, which is not suitable for large scale networks, and some strategies based on local information assume that the load of a node is always its initial load before the network is attacked, and the load of the failure node is redistributed to its neighbors according to their initial load or initial residual capacity. This paper proposes a new load-redistribution strategy based on local information considering an ever-changing load. It redistributes the loads of the failure node to its nearest neighbors according to their current residual capacity, which makes full use of the residual capacity of the network. Experiments are conducted on two typical networks and two real networks, and the experimental results show that the new load-redistribution strategy can reduce the size of cascading failure efficiently.展开更多
In this paper, the global exponential robust stability of neural networks with ume-varying delays is investigated. By using nonnegative matrix theory and the Halanay inequality, a new sufficient condition for global e...In this paper, the global exponential robust stability of neural networks with ume-varying delays is investigated. By using nonnegative matrix theory and the Halanay inequality, a new sufficient condition for global exponential robust stability is presented. It is shown that the obtained result is different from or improves some existing ones reported in the literatures. Finally, some numerical examples and a simulation are given to show the effectiveness of the obtained result.展开更多
In this paper, the problem of the global exponential stability analysis is investigated for a class of recurrent neural networks (RNNs) with time-varying discrete and distributed delays. Due to a novel technique whe...In this paper, the problem of the global exponential stability analysis is investigated for a class of recurrent neural networks (RNNs) with time-varying discrete and distributed delays. Due to a novel technique when estimating the upper bound of the derivative of Lyapunov functional, we establish new exponential stability criteria in terms of LMIs. It is shown that the obtained criteria can provide less conservative results than some existing ones. Numerical examples are given to show the effectiveness of the proposed results.展开更多
This paper discusses H-infinity state feedback control for a networked control system with time-varying delays. Based on the flee-weighing matrix method, a dehy-dependent stability criterion satisfying a prescribed H-...This paper discusses H-infinity state feedback control for a networked control system with time-varying delays. Based on the flee-weighing matrix method, a dehy-dependent stability criterion satisfying a prescribed H-infinity norm bound is presented for an NCS with unknown, time-varying and bounded delays. And then, the criterion is transformed into sufficient conditions based on linear matrix inequalities for H-infinity control. The conditions thus obtained are also used to design an H-infinity state feedback controller. This design method is further extended to solve the design problem of robust H-infinity state feedback control. A numerical example demonstrates the validity of the method.展开更多
In this paper, the problem of stability analysis for neural networks with time-varying delays is considered. By constructing a new augmented Lyapunov-Krasovskii's functional and some novel analysis techniques, improv...In this paper, the problem of stability analysis for neural networks with time-varying delays is considered. By constructing a new augmented Lyapunov-Krasovskii's functional and some novel analysis techniques, improved delaydependent criteria for checking the stability of the neural networks are established. The proposed criteria are presented in terms of linear matrix inequalities (LMIs) which can be easily solved and checked by various convex optimization algorithms. Two numerical examples are included to show the superiority of our results.展开更多
The problem of passivity analysis is investigated for uncertain stochastic neural networks with discrete interval and distributed time-varying delays.The parameter uncertainties are assumed to be norm bounded and the ...The problem of passivity analysis is investigated for uncertain stochastic neural networks with discrete interval and distributed time-varying delays.The parameter uncertainties are assumed to be norm bounded and the delay is assumed to be time-varying and belongs to a given interval,which means that the lower and upper bounds of interval time-varying delays are available.By constructing proper Lyapunov-Krasovskii functional and employing a combination of the free-weighting matrix method and stochastic analysis technique,new delay-dependent passivity conditions are derived in terms of linear matrix inequalities(LMIs).Finally,numerical examples are given to show the less conservatism of the proposed conditions.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.11665009)the Natural Science Research Project of Guizhou Provincial Education Bureau(Grant No.KY[2015]355)
文摘A class of models for activity-driven networks is proposed in which nodes vary in two states: active and inactive. Only active nodes can receive links from others which represent instantaneous dynamical interactions. The evolution of the network couples the addition of new nodes and state transitions of old ones. The active group changes with activated nodes entering and deactivated ones leaving. A general differential equation framework is developed to study the degree distribution of nodes of integrated networks where four different schemes are formulated.
基金the National Natural Science Foundation of China(62203356)Fundamental Research Funds for the Central Universities of China(31020210502002)。
文摘This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown nonlinearities.To eliminate nonlinearities,neural networks are applied to approximate the inherent dynamics of the system.In addition,due to the limitations of the actual working conditions,each follower agent can only obtain the locally measurable partial state information of the leader agent.To address this problem,a neural network state observer based on the leader state information is designed.Then,a finite-time prescribed performance adaptive output feedback control strategy is proposed by restricting the sliding mode surface to a prescribed region,which ensures that the closed-loop system has practical finite-time stability and that formation errors of the multi-agent systems converge to the prescribed performance bound in finite time.Finally,a numerical simulation is provided to demonstrate the practicality and effectiveness of the developed algorithm.
基金supported in part by the National Natural Science Foundation of China (62233012,62273087)the Research Fund for the Taishan Scholar Project of Shandong Province of Chinathe Shanghai Pujiang Program of China (22PJ1400400)。
文摘The present study addresses the problem of fault estimation for a specific class of nonlinear time-varying complex networks,utilizing an unknown-input-observer approach within the framework of dynamic event-triggered mechanism(DETM).In order to optimize communication resource utilization,the DETM is employed to determine whether the current measurement data should be transmitted to the estimator or not.To guarantee a satisfactory estimation performance for the fault signal,an unknown-input-observer-based estimator is constructed to decouple the estimation error dynamics from the influence of fault signals.The aim of this paper is to find the suitable estimator parameters under the effects of DETM such that both the state estimates and fault estimates are confined within two sets of closed ellipsoid domains.The techniques of recursive matrix inequality are applied to derive sufficient conditions for the existence of the desired estimator,ensuring that the specified performance requirements are met under certain conditions.Then,the estimator gains are derived by minimizing the ellipsoid domain in the sense of trace and a recursive estimator parameter design algorithm is then provided.Finally,a numerical example is conducted to demonstrate the effectiveness of the designed estimator.
文摘In this paper, a filtering method is presented to estimate time-varying parameters of a missile dual control system with tail fins and reaction jets as control variables. In this method, the long-short-term memory(LSTM) neural network is nested into the extended Kalman filter(EKF) to modify the Kalman gain such that the filtering performance is improved in the presence of large model uncertainties. To avoid the unstable network output caused by the abrupt changes of system states,an adaptive correction factor is introduced to correct the network output online. In the process of training the network, a multi-gradient descent learning mode is proposed to better fit the internal state of the system, and a rolling training is used to implement an online prediction logic. Based on the Lyapunov second method, we discuss the stability of the system, the result shows that when the training error of neural network is sufficiently small, the system is asymptotically stable. With its application to the estimation of time-varying parameters of a missile dual control system, the LSTM-EKF shows better filtering performance than the EKF and adaptive EKF(AEKF) when there exist large uncertainties in the system model.
基金Shanxi Scholarship Council of China(2022-141)Fundamental Research Program of Shanxi Province(202203021211096).
文摘Recent research in cross-domain intelligence fault diagnosis of machinery still has some problems,such as relatively ideal speed conditions and sample conditions.In engineering practice,the rotational speed of the machine is often transient and time-varying,which makes the sample annotation increasingly expensive.Meanwhile,the number of samples collected from different health states is often unbalanced.To deal with the above challenges,a complementary-label(CL)adversarial domain adaptation fault diagnosis network(CLADAN)is proposed under time-varying rotational speed and weakly-supervised conditions.In the weakly supervised learning condition,machine prior information is used for sample annotation via cost-friendly complementary label learning.A diagnosticmodel learning strategywith discretized category probabilities is designed to avoidmulti-peak distribution of prediction results.In adversarial training process,we developed virtual adversarial regularization(VAR)strategy,which further enhances the robustness of the model by adding adversarial perturbations in the target domain.Comparative experiments on two case studies validated the superior performance of the proposed method.
基金National Natural Science Foundation of China,Grant/Award Numbers:61962023,62066015。
文摘In engineering fields,time-varying matrix inversion(TVMI)issue is often encountered.Zeroing neural network(ZNN)has been extensively employed to resolve the TVMI problem.Nevertheless,the original ZNN(OZNN)and the integral-enhanced ZNN(IEZNN)usually fail to deal with the TVMI problem under unbounded noises,such as linear noises.Therefore,a neural network model that can handle the TVMI under linear noise interference is urgently needed.This paper develops a double integral-enhanced ZNN(DIEZNN)model based on a novel integral-type design formula with inherent linear-noise tolerance.Moreover,its convergence and robustness are verified by deriva-tion strictly.For comparison and verification,the OZNN and the IEZNN models are adopted to resolve the TVMI under multiple identical noise environments.The experi-ments proved that the DIEZNN model has excellent advantages in solving TVMI problems under linear noises.In general,the DIEZNN model is an innovative work and is proposed for the first time.Satisfyingly,the errors of DIEZNN are always less than 1�10−3 under linear noises,whereas the error norms of OZNN and IEZNN models are not convergent to zero.In addition,these models are applied to the control of the controllable permanent magnet synchronous motor chaotic system to indicate the superiority of the DIEZNN.
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
基金Supported by National Key Technology Research and Developmental Program of China,No.2022YFC2704400 and No.2022YFC2704405.
文摘BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment responses.AIM To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural networks.METHODS Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus.Mitochondrial genes were sourced from the MitoCarta3.0 database.The discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation cohort.Using the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were predicted.RESULTS In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy model.The average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation cohort.The average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation cohort.CONCLUSION The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.
基金supported by the National Natural Science Foundation of China,Nos.81871836(to MZ),82172554(to XH),and 81802249(to XH),81902301(to JW)the National Key R&D Program of China,Nos.2018YFC2001600(to JX)and 2018YFC2001604(to JX)+3 种基金Shanghai Rising Star Program,No.19QA1409000(to MZ)Shanghai Municipal Commission of Health and Family Planning,No.2018YQ02(to MZ)Shanghai Youth Top Talent Development PlanShanghai“Rising Stars of Medical Talent”Youth Development Program,No.RY411.19.01.10(to XH)。
文摘Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve transfer.Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery.
文摘A new approach to damage classification for health monitoring of a time-varylng system is presented. The functional-series time-dependent auto regressive moving average (FS-TARMA) time series model is applied to the vibration signal observed in the time-varying system for estimating the TAR/TMA parameters and the innovation variance. These parameters are the functions of the time, represented by a group of projection coefficients on the certain functional subspace with specific basis functions. The estimated TAR/TMA parameters and the innovation variance are further used to calculate the latent components (LCs) as the more informative data for health monitoring evaluation, based on an eigenvalue decomposition technique. LCs are then combined and reduced to numerical values (NVs) as feature sets, which are input to a probabilistic neural network (PNN) for the damage classification. For the evaluation of the proposed method, numerical simulations of the damage classification for a tlme-varylng system are used, in which different classes of damage are modeled by the mass or stiffness reductions. It is demonstrated that the method can identify the damages in the course of operation and the change of parameters on the time-varying background of the system.
基金This work was supported by the National Key Research and Development Program of China under Grant 2018YFA0703800the National Natural Science Foundation of China under Grant 61822312This work was also supported(in part)by the Strategic Priority Research Program of Chinese Academy of Sciences under Grant No.XDA27000000.
文摘In this paper,a distributed stochastic approximation algorithm is proposed to track the dynamic root of a sum of time-varying regression functions over a network.Each agent updates its estimate by using the local observation,the dynamic information of the global root,and information received from its neighbors.Compared with similar works in optimization area,we allow the observation to be noise-corrupted,and the noise condition is much weaker.Furthermore,instead of the upper bound of the estimate error,we present the asymptotic convergence result of the algorithm.The consensus and convergence of the estimates are established.Finally,the algorithm is applied to a distributed target tracking problem and the numerical example is presented to demonstrate the performance of the algorithm.
基金supported by the National Nature Science Foundation of China(NSFC)under grant No.61771194supported by Key Program of Beijing Municipal Natural Science Foundation with No.17L20052
文摘In this work,a frame work for time-varying channel modeling and simulation is proposed by using neural network(NN)to overcome the shortcomings in geometry based stochastic model(GBSM)and simulation approach.Two NN models are developed for modeling of path loss together with shadow fading(SF)and joint small scale channel parameters.The NN models can predict path loss plus SF and small scale channel parameters accurately compared with measurement at 26 GHz performed in an outdoor microcell.The time-varying path loss and small scale channel parameters generated by the NN models are proposed to replace the empirical path loss and channel parameter random numbers in GBSM-based framework to playback the measured channel and match with its environment.Moreover,the sparse feature of clusters,delay and angular spread,channel capacity are investigated by a virtual array measurement at 28 GHz in a large waiting hall.
基金supported in part by the National Natural Science Foundation of China(61622303,61603164,61773188)the Program for Liaoning Innovative Research Team in University(LT2016006)+1 种基金the Fundamental Research Funds for the Universities of Liaoning Province(JZL201715402)the Program for Distinguished Professor of Liaoning Province
文摘Abstract--In this paper, an adaptive neural network (NN) control approach is proposed for nonlinear pure-feedback sys- tems with time-varying full state constraints. The pure-feedback systems of this paper are assumed to possess nonlinear function uncertainties. By using the mean value theorem, pure-feedback systems can be transformed into strict feedback forms. For the newly generated systems, NNs are employed to approximate unknown items. Based on the adaptive control scheme and backstepping algorithm, an intelligent controller is designed. At the same time, time-varying Barrier Lyapunov functions (BLFs) with error variables are adopted to avoid violating full state constraints in every step of the backstepping design. All closed- loop signals are uniformly ultimately bounded and the output tracking error converges to the neighborhood of zero, which can be verified by using the Lyapunov stability theorem. Two simulation examples reveal the performance of the adaptive NN control approach. Index TermsmAdaptive control, neural networks (NNs), non- linear pure-feedback systems, time-varying constraints.
基金the National Natural Science Foundation of China (No.60674043)
文摘In this paper, we present an interval model of networked control systems with time-varying sampling periods and time-varying network-induced delays and discuss the problem of stability of networked control systems using Lyapunov stability theory. A sufficient stability condition is obtained by solving a set of linear matrix inequalities. In the end, the illustrative example demonstrates the correctness and effectiveness of the proposed approach.
基金Project supported by the National Basic Research Program of China(Grant No.2013CB328903)the Special Fund of 2011 Internet of Things Development of Ministry of Industry and Information Technology,China(Grant No.2011BAJ03B13-2)+1 种基金the National Natural Science Foundation of China(Grant No.61473050)the Key Science and Technology Program of Chongqing,China(Grant No.cstc2012gg-yyjs40008)
文摘Cascading failure can cause great damage to complex networks, so it is of great significance to improve the network robustness against cascading failure. Many previous existing works on load-redistribution strategies require global information, which is not suitable for large scale networks, and some strategies based on local information assume that the load of a node is always its initial load before the network is attacked, and the load of the failure node is redistributed to its neighbors according to their initial load or initial residual capacity. This paper proposes a new load-redistribution strategy based on local information considering an ever-changing load. It redistributes the loads of the failure node to its nearest neighbors according to their current residual capacity, which makes full use of the residual capacity of the network. Experiments are conducted on two typical networks and two real networks, and the experimental results show that the new load-redistribution strategy can reduce the size of cascading failure efficiently.
基金supported by 973 Programs (No.2008CB317110)the Key Project of Chinese Ministry of Education (No.107098)+1 种基金Sichuan Province Project for Applied Basic Research (No.2008JY0052)the Project for Academic Leader and Group of UESTC
文摘In this paper, the global exponential robust stability of neural networks with ume-varying delays is investigated. By using nonnegative matrix theory and the Halanay inequality, a new sufficient condition for global exponential robust stability is presented. It is shown that the obtained result is different from or improves some existing ones reported in the literatures. Finally, some numerical examples and a simulation are given to show the effectiveness of the obtained result.
基金supported by National Natural Science Foundation of China (No.60674027,No.60974127)Key Project of Education Ministry of China (No.208074)
文摘In this paper, the problem of the global exponential stability analysis is investigated for a class of recurrent neural networks (RNNs) with time-varying discrete and distributed delays. Due to a novel technique when estimating the upper bound of the derivative of Lyapunov functional, we establish new exponential stability criteria in terms of LMIs. It is shown that the obtained criteria can provide less conservative results than some existing ones. Numerical examples are given to show the effectiveness of the proposed results.
文摘This paper discusses H-infinity state feedback control for a networked control system with time-varying delays. Based on the flee-weighing matrix method, a dehy-dependent stability criterion satisfying a prescribed H-infinity norm bound is presented for an NCS with unknown, time-varying and bounded delays. And then, the criterion is transformed into sufficient conditions based on linear matrix inequalities for H-infinity control. The conditions thus obtained are also used to design an H-infinity state feedback controller. This design method is further extended to solve the design problem of robust H-infinity state feedback control. A numerical example demonstrates the validity of the method.
基金Project supported by the MKE (The Ministry of Knowledge Economy),Koreathe ITRC (Information Technology Research Center) support program supervised by the IITA (Institute for Information Technology Advancement) (Grant No. IITA-2009-C1090-0904-0007)
文摘In this paper, the problem of stability analysis for neural networks with time-varying delays is considered. By constructing a new augmented Lyapunov-Krasovskii's functional and some novel analysis techniques, improved delaydependent criteria for checking the stability of the neural networks are established. The proposed criteria are presented in terms of linear matrix inequalities (LMIs) which can be easily solved and checked by various convex optimization algorithms. Two numerical examples are included to show the superiority of our results.
基金supported by Department of Science and Technology,New Delhi,India(SR/S4/MS:485/07)
文摘The problem of passivity analysis is investigated for uncertain stochastic neural networks with discrete interval and distributed time-varying delays.The parameter uncertainties are assumed to be norm bounded and the delay is assumed to be time-varying and belongs to a given interval,which means that the lower and upper bounds of interval time-varying delays are available.By constructing proper Lyapunov-Krasovskii functional and employing a combination of the free-weighting matrix method and stochastic analysis technique,new delay-dependent passivity conditions are derived in terms of linear matrix inequalities(LMIs).Finally,numerical examples are given to show the less conservatism of the proposed conditions.