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Modeling time-dependent mechanical behavior of hard rock considering excavation-induced damage and complex 3D stress states 被引量:1
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作者 Peiyang Yu Xiuli Ding +3 位作者 Peng-Zhi Pan Shuting Miao Zhaofeng Wang Shuling Huang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第10期4046-4065,共20页
To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main compon... To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main components:a 3D viscoplastic isotropic constitutive relation that considers excavation damage and complex stress state,a quantitative relationship between critical irreversible deformation and complex stress state,and evolution characteristics of strength parameters.The proposed model is implemented in a self-developed numerical code,i.e.CASRock.The reliability of the model is validated through experiments.It is indicated that the time-dependent fracturing potential index(xTFPI)at a given time during the attenuation creep stage shows a negative correlation with the extent of excavationinduced damage.The time-dependent fracturing process of rock demonstrates a distinct interval effect of the intermediate principal stress,thereby highlighting the 3D stress-dependent characteristic of the model.Finally,the influence of excavation-induced damage and intermediate principal stress on the time-dependent fracturing characteristics of the surrounding rocks around the tunnel is discussed. 展开更多
关键词 Hard rock Excavation damage Complex stress state Three-dimensional(3D)time-dependent model
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Impact of different interaction behavior on epidemic spreading in time-dependent social networks
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作者 黄帅 陈杰 +2 位作者 李梦玉 徐元昊 胡茂彬 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期190-195,共6页
We investigate the impact of pairwise and group interactions on the spread of epidemics through an activity-driven model based on time-dependent networks.The effects of pairwise/group interaction proportion and pairwi... We investigate the impact of pairwise and group interactions on the spread of epidemics through an activity-driven model based on time-dependent networks.The effects of pairwise/group interaction proportion and pairwise/group interaction intensity are explored by extensive simulation and theoretical analysis.It is demonstrated that altering the group interaction proportion can either hinder or enhance the spread of epidemics,depending on the relative social intensity of group and pairwise interactions.As the group interaction proportion decreases,the impact of reducing group social intensity diminishes.The ratio of group and pairwise social intensity can affect the effect of group interaction proportion on the scale of infection.A weak heterogeneous activity distribution can raise the epidemic threshold,and reduce the scale of infection.These results benefit the design of epidemic control strategy. 展开更多
关键词 epidemic transmission complex network time-dependent networks social interaction
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A process-oriented approach for identifying potential landslides considering time-dependent behaviors beyond geomorphological features
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作者 Xiang Sun Guoqing Chen +4 位作者 Xing Yang Zhengxuan Xu Jingxi Yang Zhiheng Lin Yunpeng Liu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期961-978,共18页
Geomorphological features are commonly used to identify potential landslides.Nevertheless,overemphasis on these features could lead to misjudgment.This research proposes a process-oriented approach for potential lands... Geomorphological features are commonly used to identify potential landslides.Nevertheless,overemphasis on these features could lead to misjudgment.This research proposes a process-oriented approach for potential landslide identification that considers time-dependent behaviors.The method integrates comprehensive remote sensing and geological analysis to qualitatively assess slope stability,and employs numerical analysis to quantitatively calculate aging stability.Specifically,a time-dependent stability calculation method for anticlinal slopes is developed and implemented in discrete element software,incorporating time-dependent mechanical and strength reduction calculations.By considering the time-dependent evolution of slopes,this method highlights the importance of both geomorphological features and time-dependent behaviors in landslide identification.This method has been applied to the Jiarishan slope(JRS)on the Qinghai-Tibet Plateau as a case study.The results show that the JRS,despite having landslide geomorphology,is a stable slope,highlighting the risk of misjudgment when relying solely on geomorphological features.This work provides insights into the geomorphological characterization and evolution history of the JRS and offers valuable guidance for studying slopes with similar landslide geomorphology.Furthermore,the process-oriented method incorporating timedependent evolution provides a means to evaluate potential landslides,reducing misjudgment due to excessive reliance on geomorphological features. 展开更多
关键词 Geomorphological features Evolution history time-dependent stability calculation Landslides identification Qinghai-Tibet Plateau
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A GENERALIZED SCALAR AUXILIARY VARIABLE METHOD FOR THE TIME-DEPENDENT GINZBURG-LANDAU EQUATIONS
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作者 司智勇 《Acta Mathematica Scientia》 SCIE CSCD 2024年第2期650-670,共21页
This paper develops a generalized scalar auxiliary variable(SAV)method for the time-dependent Ginzburg-Landau equations.The backward Euler method is used for discretizing the temporal derivative of the time-dependent ... This paper develops a generalized scalar auxiliary variable(SAV)method for the time-dependent Ginzburg-Landau equations.The backward Euler method is used for discretizing the temporal derivative of the time-dependent Ginzburg-Landau equations.In this method,the system is decoupled and linearized to avoid solving the non-linear equation at each step.The theoretical analysis proves that the generalized SAV method can preserve the maximum bound principle and energy stability,and this is confirmed by the numerical result,and also shows that the numerical algorithm is stable. 展开更多
关键词 time-dependent Ginzburg-Landau equation generalized scalar auxiliary variable algorithm maximum bound principle energy stability
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Thermomechanical Dynamics (TMD) and Bifurcation-Integration Solutions in Nonlinear Differential Equations with Time-Dependent Coefficients
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作者 Hiroshi Uechi Lisa Uechi Schun T. Uechi 《Journal of Applied Mathematics and Physics》 2024年第5期1733-1743,共11页
The new independent solutions of the nonlinear differential equation with time-dependent coefficients (NDE-TC) are discussed, for the first time, by employing experimental device called a drinking bird whose simple ba... The new independent solutions of the nonlinear differential equation with time-dependent coefficients (NDE-TC) are discussed, for the first time, by employing experimental device called a drinking bird whose simple back-and-forth motion develops into water drinking motion. The solution to a drinking bird equation of motion manifests itself the transition from thermodynamic equilibrium to nonequilibrium irreversible states. The independent solution signifying a nonequilibrium thermal state seems to be constructed as if two independent bifurcation solutions are synthesized, and so, the solution is tentatively termed as the bifurcation-integration solution. The bifurcation-integration solution expresses the transition from mechanical and thermodynamic equilibrium to a nonequilibrium irreversible state, which is explicitly shown by the nonlinear differential equation with time-dependent coefficients (NDE-TC). The analysis established a new theoretical approach to nonequilibrium irreversible states, thermomechanical dynamics (TMD). The TMD method enables one to obtain thermodynamically consistent and time-dependent progresses of thermodynamic quantities, by employing the bifurcation-integration solutions of NDE-TC. We hope that the basic properties of bifurcation-integration solutions will be studied and investigated further in mathematics, physics, chemistry and nonlinear sciences in general. 展开更多
关键词 The Nonlinear Differential Equation with time-dependent Coefficients The Bifurcation-Integration Solution Nonequilibrium Irreversible States Thermomechanical Dynamics (TMD)
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Sample size adaptive strategy for time-dependent Monte Carlo particle transport simulation 被引量:3
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作者 Dan-Hua ShangGuan Wei-Hua Yan +3 位作者 Jun-Xia Wei Zhi-Ming Gao Yi-Bing Chen Zhi-Cheng Ji 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2023年第4期127-134,共8页
When multiphysics coupling calculations contain time-dependent Monte Carlo particle transport simulations, these simulations often account for the largest part of the calculation time, which is insufferable in certain... When multiphysics coupling calculations contain time-dependent Monte Carlo particle transport simulations, these simulations often account for the largest part of the calculation time, which is insufferable in certain important cases. This study proposes an adaptive strategy for automatically adjusting the sample size to fulfil more reasonable simulations. This is realized based on an extension of the Shannon entropy concept and is essentially different from the popular methods in timeindependent Monte Carlo particle transport simulations, such as controlling the sample size according to the relative error of a target tally or by experience. The results of the two models show that this strategy can yield almost similar results while significantly reducing the calculation time. Considering the efficiency, the sample size should not be increased blindly if the efficiency cannot be enhanced further. The strategy proposed herein satisfies this requirement. 展开更多
关键词 time-dependent Monte Carlo particle transport simulation Shannon entropy Adaptive strategy
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Time-dependent variational approach to solve multi-dimensional time-dependent Schr?dinger equation
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作者 何明睿 王哲 +1 位作者 姚陆锋 李洋 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第12期361-366,共6页
We present an efficient approach to solve multi-dimensional time-dependent Schr?dinger equation(TDSE)in an intense laser field.In this approach,each spatial degree of freedom is treated as a distinguishable quasi-part... We present an efficient approach to solve multi-dimensional time-dependent Schr?dinger equation(TDSE)in an intense laser field.In this approach,each spatial degree of freedom is treated as a distinguishable quasi-particle.The non-separable Coulomb potential is regarded as a two-body operator between different quasi-particles.The time-dependent variational principle is used to derive the equations of motion.Then the high-order multi-dimensional problem is broken down into several lower-order coupled equations,which can be efficiently solved.As a demonstration,we apply this method to solve the two-dimensional TDSE.The accuracy is tested by comparing the direct solutions of TDSE using several examples such as the strong-field ionization and the high harmonic generation.The results show that the present method is much more computationally efficient than the conventional one without sacrificing accuracy.The present method can be straightforwardly extended to three-dimensional problems.Our study provides a flexible method to investigate the laser-atom interaction in the nonperturbative regime. 展开更多
关键词 time-dependent variational approach above-threshold ionization high harmonic generation
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Construction of Split-Plot Designs with General Minimum Lower Order Confounding
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作者 Kexin Li Beichen Han Zhenzhen Niu 《Open Journal of Applied Sciences》 CAS 2023年第3期261-274,共14页
Fractional factorial split-plot design has been widely used in many fields due to its advantage of saving experimental cost. The general minimum lower order confounding criterion is usually used as one of the attracti... Fractional factorial split-plot design has been widely used in many fields due to its advantage of saving experimental cost. The general minimum lower order confounding criterion is usually used as one of the attractive design criterion for selecting fractional factorial split-plot design. In this paper, we are interested in the theoretical construction methods of the optimal fractional factorial split-plot designs under the general minimum lower order confounding criterion. We present the theoretical construction methods of optimal fractional factorial split-plot designs under general minimum lower order confounding criterion under several conditions. 展开更多
关键词 Fractional Factorial Design General Minimum Lower Order confounding Criterion Split-Plot Design
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Non-harmonic resonance of viscoelastic structures subjected to time-dependent exponentially decreasing transverse distributed loads
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作者 Nasrin Jafari 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2023年第3期825-840,共16页
In this paper,the non-harmonic resonance of Bernoulli viscoelastic beams,Kirchhoff viscoelastic plates,Timoshenko viscoelastic beams,and Mindlin viscoelastic plates subjected to time-dependent exponentially decreasing... In this paper,the non-harmonic resonance of Bernoulli viscoelastic beams,Kirchhoff viscoelastic plates,Timoshenko viscoelastic beams,and Mindlin viscoelastic plates subjected to time-dependent exponentially decreasing transverse distributed load is investigated for the first time.The constitutive equations are expressed utilizing Boltzmann integral law with a constant bulk modulus.The displacement vector is approximated by employing the separation of variables method.The Laplace transformation is used to transfer equations from the time domain to the Laplace domain and vice versa.The novel point of the proposed method is to express,prove and calculate the critical time in which the displacement will be several times the displacement at time zero.In addition,this new method calculates the maximum deflection at the critical time,explicitly and exactly,without any need to follow the time-displacement curve with a low computational cost.Additionally,the proposed method introduces the critical range of time so that the responses are greater than the responses at time zero. 展开更多
关键词 Bernoulli and Timoshenko viscoelastic beams critical time non-harmonic resonance time-dependent decreasing exponential load Kirchhoff and Mindlin viscoelastic plates
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Blowup of Solutions to the Non-Isentropic Compressible Euler Equations with Time-Dependent Damping and Vacuum
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作者 Yuping Feng Huimin Yu Wanfang Shen 《Journal of Applied Mathematics and Physics》 2023年第7期1881-1894,共14页
This paper mainly studies the blowup phenomenon of solutions to the compressible Euler equations with general time-dependent damping for non-isentropic fluids in two and three space dimensions. When the initial data i... This paper mainly studies the blowup phenomenon of solutions to the compressible Euler equations with general time-dependent damping for non-isentropic fluids in two and three space dimensions. When the initial data is assumed to be radially symmetric and the initial density contains vacuum, we obtain that classical solution, especially the density, will blow up on finite time. The results also reveal that damping can really delay the singularity formation. 展开更多
关键词 Compressible Euler Equations BLOWUP General time-dependent Damping VACUUM
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Extra Time Dimension: Deriving Relativistic Space-Time Transformations, Kinematics, and Example of Dimensional Compactification Using Time-Dependent Non-Relativistic Quantum Mechanics
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作者 Sajjad Zahir 《Journal of Modern Physics》 2023年第10期1333-1354,共22页
We consider a five-dimensional Minkowski space with two time dimensions characterized by distinct speeds of causality and three space dimensions. Formulas for relativistic coordinate and velocity transformations are d... We consider a five-dimensional Minkowski space with two time dimensions characterized by distinct speeds of causality and three space dimensions. Formulas for relativistic coordinate and velocity transformations are derived, leading to a new expression for the speed limit. Extending the ideas of Einstein’s Theory of Special Relativity, concepts of five-velocity and five-momenta are introduced. We get a new formula for the rest energy of a massive object. Based on a non-relativistic limit, a two-time dependent Schrödinger-like equation for infinite square-well potential is developed and solved. The extra time dimension is compactified on a closed loop topology with a period matching the Planck time. It generates interference of additional quantum states with an ultra-small period of oscillation. Some cosmological implications of the concept of four-dimensional versus five-dimensional masses are briefly discussed, too. 展开更多
关键词 Two-Time Physics Special Theory of Relativity Kaluza-Klein Theory time-dependent Schrödinger Equation COMPACTIFICATION
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Time-dependent magnetometric resistivity anomalies of groundwater contamination: Synthetic results from computational hydro-geophysical modeling 被引量:5
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作者 朱凯光 杨建文 《Applied Geophysics》 SCIE CSCD 2008年第4期322-330,共9页
We present a forward-modeling investigation of time-dependent ground magnetometric resistivity (MMR) anomalies associated with transient leachate transport in groundwater systems. Numerical geo-electrical models are... We present a forward-modeling investigation of time-dependent ground magnetometric resistivity (MMR) anomalies associated with transient leachate transport in groundwater systems. Numerical geo-electrical models are constructed based on the hydrological simulation results of leachate plumes from a highly conceptualized landfill system and the resultant MMR responses are computed using a modified finite difference software MMR2DFD. Three transmitter configurations (i.e., single source, MMR-TE, and MMR-TM modes) and two hydrological models (i.e., uniform and faulted porous media) are considered. Our forward modeling results for the uniform porous medium indicates that the magnetic field components perpendicular to the dominant current flow contain the most information of the underground targets and the MMR-TE mode is an appropriate configuration for detecting contaminant plumes. The modeling experiments for the faulted porous medium also confirm that the MMR method is capable of mapping and monitoring the extent of contaminant plumes in aroundwater systems. 展开更多
关键词 time-dependent magnetometric resistivity leachate plumes hydro-geophysicalmodeling
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Meta-analysis of potentially confounding effect of class size on associations between object-oriented metrics and maintainability
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作者 卢红敏 周毓明 徐宝文 《Journal of Southeast University(English Edition)》 EI CAS 2008年第3期281-283,共3页
This paper uses three size metrics,which are collectable during the design phase,to analyze the potentially confounding effect of class size on the associations between object-oriented(OO)metrics and maintainability... This paper uses three size metrics,which are collectable during the design phase,to analyze the potentially confounding effect of class size on the associations between object-oriented(OO)metrics and maintainability.To draw as many general conclusions as possible,the confounding effect of class size is analyzed on 127 C++ systems and 113 Java systems.For each OO metric,the indirect effect that represents the distortion of the association caused by class size and its variance for individual systems is first computed.Then,a statistical meta-analysis technique is used to compute the average indirect effect over all the systems and to determine if it is significantly different from zero.The experimental results show that the confounding effects of class size on the associations between OO metrics and maintainability generally exist,regardless of whatever size metric is used.Therefore,empirical studies validating OO metrics on maintainability should consider class size as a confounding variable. 展开更多
关键词 OBJECT-ORIENTED metrics VALIDATION class size confounding MAINTAINABILITY
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Numerical investigation into pillar failure induced by time-dependent skin degradation 被引量:10
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作者 Sainoki Atsushi Mitri Hani S. 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2017年第4期591-597,共7页
This paper focuses on the instability mechanism of an isolated pillar, caused by time-dependent skin degradation and strength heterogeneity. The time-dependent skin degradation is simulated with a non-linear rheologic... This paper focuses on the instability mechanism of an isolated pillar, caused by time-dependent skin degradation and strength heterogeneity. The time-dependent skin degradation is simulated with a non-linear rheological model capable of simulating tertiary creep, whereby two different pillar failure cases are investigated. The first case is of an isolated pillar in a deep hard rock underground mine and subjected to high stresses. The results show that pillar degradation is limited to the regions near the surface or the skin until two months after ore extraction. Afterwards degradation starts to extend deeper into the pillar, eventually leaving a highly-stressed pillar core due to stress transfer from the failed skin.Rockburst potential indices show that the risk increases exponentially at the core as time goes by. It is then demonstrated that the progressive skin degradation cannot be simulated with conventional strain-softening model assuming brittle failure. The parametric study with respect to the degree of heterogeneity reveals that heterogeneity is key to the occurrence of progressive skin degradation. The second case investigated in this study is pillar failure taking place in a very long period. Such failure becomes significantly important when assessing the risk for ground subsidence caused by pillar collapse in an abandoned mine. The analysis results demonstrate that the employed non-linear rheological model can simulate gradual skin degradation taking place over several hundred years. The percentage of damage zone volume within the pillar is merely 1% after a lapse of one days and increases to 50% after one hundred years, indicating a high risk for pillar collapse in the long term. The vertical displacements within the pillar also indicate the risk of subsidence. The proposed method is suitable for evaluating the risk of ground surface subsidence above an abandoned mine. 展开更多
关键词 Pillar stability Underground mine Skin degradation Rheological model time-dependent failure
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THE FINITE DIFFERENCE STREAMLINE DIFFUSION METHODS FOR TIME-DEPENDENT CONVECTION-DIFFUSION EQUATIONS 被引量:6
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作者 孙澈 沈慧 《Numerical Mathematics A Journal of Chinese Universities(English Series)》 SCIE 1998年第1期72-85,共14页
In this paper, two finite difference streamline diffusion (FDSD) schemes for solving two-dimensional time-dependent convection-diffusion equations are constructed. Stability and optimal order error estimati-ions for c... In this paper, two finite difference streamline diffusion (FDSD) schemes for solving two-dimensional time-dependent convection-diffusion equations are constructed. Stability and optimal order error estimati-ions for considered schemes are derived in the norm stronger than L^2-norm. 展开更多
关键词 time-dependent CONVECTION-DIFFUSION equations STREAMLINE diffusion methods Euler-FDSD SCHEME Crank-Nicolson-FDSD scheme.
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Time-dependent safety of lining structures of circular tunnels in weak rock strata 被引量:7
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作者 Baoguo Liu Yu Song Zhaofei Chu 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2022年第2期323-334,共12页
Following tunnel excavation and lining completion,fractured surrounding rock deforms gradually over time;this results in a time-dependent evolution of the pressure applied to the lining structure by the surrounding ro... Following tunnel excavation and lining completion,fractured surrounding rock deforms gradually over time;this results in a time-dependent evolution of the pressure applied to the lining structure by the surrounding rock.Thus,the safety of the tunnel lining in weak strata is strongly correlated with time.In this study,we developed an analytical method for determining the time-dependent pressure in the surrounding rock and lining structure of a circular tunnel under a hydrostatic stress field.Under the proposed method,the stress–strain relationship of the fractured surrounding rock is assumed to conform to that of the Burgers viscoelastic component,and the lining structure is assumed to be an elastomer.Based on these assumptions,the viscoelastic deformation of the surrounding rock,the elastic deformation of the lining structure,and the coordinated deformation between the surrounding rock and lining structure were derived.The proposed analytical method,which employs a time-dependent safety coefficient,was subsequently used to estimate the durability of the lining structure of the Foling Tunnel in China.The derived attenuation curve of the safety coefficient with respect to time can assist engineers in predicting the remaining viable life of the lining structure.Unlike existing analytical methods,the method derived in this study considers the time dependency of the interaction between the surrounding rock and tunnel lining;hence,it is more suitable for the evaluation of lining lifetime. 展开更多
关键词 Tunnel lining Surrounding rock pressure Rheological characteristics Weak rock strata time-dependent safety
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The characterization of the time-dependent nonlinear viscoelastic of an LDPE melt using a simple thixotropy model 被引量:6
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作者 Shuxin Huang Chuanjing Lu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2005年第4期330-335,共6页
A new simple thixotropy model was proposed in the present paper to characterize the thixotropy-loop experiments and the start-up experiment of an LDPE (PE-FSB23D0221Q200) melt. The thixotropy model is a combination ... A new simple thixotropy model was proposed in the present paper to characterize the thixotropy-loop experiments and the start-up experiment of an LDPE (PE-FSB23D0221Q200) melt. The thixotropy model is a combination of a viscoelastic-component and a postulated kinetics process of structure change, which is constituted in terms of the indirect microstructural approach usually adopted in the characterization of thixotropy. The descriptions of the thixotropy model on both the thixotropy-loop tests and the startup test show good agreement with the experimental values, indicating the good capability of the model in characterizing the time-dependent nonlinear viscoelastic. The stress overshoot phenomenon and the stress relaxation after cessation of the thixotropy loop test can be described well by the model, whereas both of the typical viscoelastic phenomena could not be described in our previous work with a variant Huang model. 展开更多
关键词 time-dependent viscoelastic Stressovershoot Stress relaxation A simple thixotropy model
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Exact Wave Function of a Quantum Oscillator with Time-Dependent Frequency and Driving
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作者 彭彦泽 彭松清 范天佑 《Journal of Beijing Institute of Technology》 EI CAS 2001年第3期246-249,共4页
The harmonic oscillator with time? dependent frequency and driving is studied by means of a new, simple method. By means of simple transformations of variables, the time dependent Schrdinger equation is first tr... The harmonic oscillator with time? dependent frequency and driving is studied by means of a new, simple method. By means of simple transformations of variables, the time dependent Schrdinger equation is first transformed into the time independent one. And then exact wave function is found in terms of solutions of the classical equation of motion of the oscillator. 展开更多
关键词 time-dependent harmonic oscillator wave function classical equation of motion
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Approximate solution to the time-dependent Kratzer plus screened Coulomb potential in the Feinberg–Horodecki equation 被引量:2
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作者 Mahmoud Farout Ramazan Sever Sameer MIkhdair 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第6期90-97,共8页
We obtain the quantized momentum eigenvalues Pn together with space-like coherent eigenstates for the space-like counterpart of the Schr¨odinger equation,the Feinberg–Horodecki equation,with a combined Kratzer p... We obtain the quantized momentum eigenvalues Pn together with space-like coherent eigenstates for the space-like counterpart of the Schr¨odinger equation,the Feinberg–Horodecki equation,with a combined Kratzer potential plus screened coulomb potential which is constructed by temporal counterpart of the spatial form of these potentials.The present work is illustrated with two special cases of the general form:the time-dependent modified Kratzer potential and the time-dependent screened Coulomb potential. 展开更多
关键词 quantized momentum states Feinberg-Horodecki equation the time-dependent screened Coulomb potential and time-dependent modified Kratzer potential
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Confounding factors affect the pathophysiology of eosinophilic esophagitis 被引量:6
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作者 Yoram Elitsur 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第33期4466-4469,共4页
Eosinophilic esophagitis is a newly diagnosed esophageal disease in adult and children. The clinical and pathological characteristics of this disease have been established and were recently summarized in the expert cl... Eosinophilic esophagitis is a newly diagnosed esophageal disease in adult and children. The clinical and pathological characteristics of this disease have been established and were recently summarized in the expert clinical guideline published in 2011. In spite of the wide knowledge accumulated on this disease, there are many areas where scientific data are missing, especially in regard to the disease's pathophysiology. Recent publications have suggested that other confounding factors modify the disease and may affect its clinicalphenotypic presentation. Those factors may include place of living, air pollution, race, genetic factors and other. In the present report we discussed and review those confounding factors, the new developments, and what direction we should go to further advance our knowledge of this disease. 展开更多
关键词 Eosinophilic esophagitis confounding factors Race Gender Environment
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