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Time-dependent dilatancy for brittle rocks 被引量:2
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作者 Jie Li Mingyang Wang +2 位作者 Kaiwen Xia Ning Zhang Houxu Huang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2017年第6期1054-1070,共17页
This paper presents a theoretical study on time-dependent dilatancy behaviors for brittle rocks. The theory employs a well-accepted postulation that macroscopically observed dilatancy originates from the expansion of ... This paper presents a theoretical study on time-dependent dilatancy behaviors for brittle rocks. The theory employs a well-accepted postulation that macroscopically observed dilatancy originates from the expansion of microcracks. The mechanism and dynamic process that microcracks initiate from local stress concentration and grow due to localized tensile stress are analyzed. Then, by generalizing the results from the analysis of single cracks, a parameter and associated equations for its evolution are developed to describe the behaviors of the microcracks. In this circumstance, the relationship between microcracking and dilatancy can be established, and the theoretical equations for characterizing the process of rock dilatancy behaviors are derived. Triaxial compression and creep tests are conducted to validate the developed theory. With properly chosen model parameters, the theory yields a satisfactory accuracy in comparison with the experimental results. 展开更多
关键词 time-dependent dilatancy Microcracking Subcritical crack growth Rock deformation and failure
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Study of hydro-mechanical behaviours of rough rock fracture with shear dilatancy and asperities using shear-flow model 被引量:1
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作者 Luyu Wang Weizhong Chen Qun Sui 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第10期4004-4016,共13页
The geometric properties of fracture surfaces significantly influence shear-seepage in rock fractures,introducing complexities to fracture modelling.The present study focuses on the hydro-mechanical behaviours of roug... The geometric properties of fracture surfaces significantly influence shear-seepage in rock fractures,introducing complexities to fracture modelling.The present study focuses on the hydro-mechanical behaviours of rough rock fractures during shear-seepage processes to reveal how dilatancy and fracture asperities affect these phenomena.To achieve this,an improved shear-flow model(SFM)is proposed with the incorporation of dilatancy effect and asperities.In particular,shear dilatancy is accounted for in both the elastic and plastic stages,in contrast to some existing models that only consider it in the elastic stage.Depending on the computation approaches for the peak dilatancy angle,three different versions of the SFM are derived based on Mohr-Coulomb,joint roughness coefficient-joint compressive strength(JRC-JCS),and Grasselli’s theories.Notably,this is a new attempt that utilizes Grasselli’s model in shearseepage analysis.An advanced parameter optimization method is introduced to accurately determine model parameters,addressing the issue of local optima inherent in some conventional methods.Then,model performance is evaluated against existing experimental results.The findings demonstrate that the SFM effectively reproduces the shear-seepage characteristics of rock fracture across a wide range of stress levels.Further sensitivity analysis reveals how dilatancy and asperity affect hydraulic properties.The relation between hydro-mechanical properties(dilatancy displacement and hydraulic conductivity)and asperity parameters is analysed.Several profound understandings of the shear-seepage process are obtained by exploring the phenomenon under various conditions. 展开更多
关键词 Rock fracture Stress-seepage coupling Shear-flow model Fracture asperity Shear dilatancy
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Modeling time-dependent mechanical behavior of hard rock considering excavation-induced damage and complex 3D stress states 被引量:1
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作者 Peiyang Yu Xiuli Ding +3 位作者 Peng-Zhi Pan Shuting Miao Zhaofeng Wang Shuling Huang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第10期4046-4065,共20页
To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main compon... To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main components:a 3D viscoplastic isotropic constitutive relation that considers excavation damage and complex stress state,a quantitative relationship between critical irreversible deformation and complex stress state,and evolution characteristics of strength parameters.The proposed model is implemented in a self-developed numerical code,i.e.CASRock.The reliability of the model is validated through experiments.It is indicated that the time-dependent fracturing potential index(xTFPI)at a given time during the attenuation creep stage shows a negative correlation with the extent of excavationinduced damage.The time-dependent fracturing process of rock demonstrates a distinct interval effect of the intermediate principal stress,thereby highlighting the 3D stress-dependent characteristic of the model.Finally,the influence of excavation-induced damage and intermediate principal stress on the time-dependent fracturing characteristics of the surrounding rocks around the tunnel is discussed. 展开更多
关键词 Hard rock Excavation damage Complex stress state Three-dimensional(3D)time-dependent model
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Mechanical response and dilatancy characteristics of deep marble under different stress paths:A sight from energy dissipation
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作者 LIU Xiao-hui HAO Qi-jun +2 位作者 ZHENG Yu ZHANG Zhao-peng XUE Yang 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第6期2070-2086,共17页
Dilatancy is a fundamental volumetric growth behavior observed during loading and serves as a key index to comprehending the intricate nonlinear behavior and constitutive equation structure of rock.This study focuses ... Dilatancy is a fundamental volumetric growth behavior observed during loading and serves as a key index to comprehending the intricate nonlinear behavior and constitutive equation structure of rock.This study focuses on Jinping marble obtained from the Jinping Underground Laboratory in China at a depth of 2400 m.Various uniaxial and triaxial tests at different strain rates,along with constant confining pressure tests and reduced confining pressure tests under different confining pressures were conducted to analyze the mechanical response and dilatancy characteristics of the marble under four stress paths.Subsequently,a new empirical dilatancy coefficient is proposed based on the energy dissipation method.The results show that brittle failure characteristics of marble under uniaxial compression are more obvious with the strain rate increasing,and plastic failure characteristics of marble under triaxial compression are gradually strengthened.Furthermore,compared to the constant confining pressure,the volume expansion is relatively lower under unloading condition.The energy dissipation is closely linked to the process of dilatancy,with a rapid increase of dissipated energy coinciding with the beginning of dilatancy.A new empirical dilatancy coefficient is defined according to the change trend of energy dissipation rate curve,of which change trend is consistent with the actual dilatancy response in marble under different stress paths.The existing empirical and theoretical dilatancy models are analyzed,which shows that the empirical dilatancy coefficient based on the energy background is more universal. 展开更多
关键词 deep marble stress paths dilatancy energy dissipation empirical dilatancy coefficient
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Impact of different interaction behavior on epidemic spreading in time-dependent social networks
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作者 黄帅 陈杰 +2 位作者 李梦玉 徐元昊 胡茂彬 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期190-195,共6页
We investigate the impact of pairwise and group interactions on the spread of epidemics through an activity-driven model based on time-dependent networks.The effects of pairwise/group interaction proportion and pairwi... We investigate the impact of pairwise and group interactions on the spread of epidemics through an activity-driven model based on time-dependent networks.The effects of pairwise/group interaction proportion and pairwise/group interaction intensity are explored by extensive simulation and theoretical analysis.It is demonstrated that altering the group interaction proportion can either hinder or enhance the spread of epidemics,depending on the relative social intensity of group and pairwise interactions.As the group interaction proportion decreases,the impact of reducing group social intensity diminishes.The ratio of group and pairwise social intensity can affect the effect of group interaction proportion on the scale of infection.A weak heterogeneous activity distribution can raise the epidemic threshold,and reduce the scale of infection.These results benefit the design of epidemic control strategy. 展开更多
关键词 epidemic transmission complex network time-dependent networks social interaction
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A process-oriented approach for identifying potential landslides considering time-dependent behaviors beyond geomorphological features
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作者 Xiang Sun Guoqing Chen +4 位作者 Xing Yang Zhengxuan Xu Jingxi Yang Zhiheng Lin Yunpeng Liu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期961-978,共18页
Geomorphological features are commonly used to identify potential landslides.Nevertheless,overemphasis on these features could lead to misjudgment.This research proposes a process-oriented approach for potential lands... Geomorphological features are commonly used to identify potential landslides.Nevertheless,overemphasis on these features could lead to misjudgment.This research proposes a process-oriented approach for potential landslide identification that considers time-dependent behaviors.The method integrates comprehensive remote sensing and geological analysis to qualitatively assess slope stability,and employs numerical analysis to quantitatively calculate aging stability.Specifically,a time-dependent stability calculation method for anticlinal slopes is developed and implemented in discrete element software,incorporating time-dependent mechanical and strength reduction calculations.By considering the time-dependent evolution of slopes,this method highlights the importance of both geomorphological features and time-dependent behaviors in landslide identification.This method has been applied to the Jiarishan slope(JRS)on the Qinghai-Tibet Plateau as a case study.The results show that the JRS,despite having landslide geomorphology,is a stable slope,highlighting the risk of misjudgment when relying solely on geomorphological features.This work provides insights into the geomorphological characterization and evolution history of the JRS and offers valuable guidance for studying slopes with similar landslide geomorphology.Furthermore,the process-oriented method incorporating timedependent evolution provides a means to evaluate potential landslides,reducing misjudgment due to excessive reliance on geomorphological features. 展开更多
关键词 Geomorphological features Evolution history time-dependent stability calculation Landslides identification Qinghai-Tibet Plateau
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A GENERALIZED SCALAR AUXILIARY VARIABLE METHOD FOR THE TIME-DEPENDENT GINZBURG-LANDAU EQUATIONS
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作者 司智勇 《Acta Mathematica Scientia》 SCIE CSCD 2024年第2期650-670,共21页
This paper develops a generalized scalar auxiliary variable(SAV)method for the time-dependent Ginzburg-Landau equations.The backward Euler method is used for discretizing the temporal derivative of the time-dependent ... This paper develops a generalized scalar auxiliary variable(SAV)method for the time-dependent Ginzburg-Landau equations.The backward Euler method is used for discretizing the temporal derivative of the time-dependent Ginzburg-Landau equations.In this method,the system is decoupled and linearized to avoid solving the non-linear equation at each step.The theoretical analysis proves that the generalized SAV method can preserve the maximum bound principle and energy stability,and this is confirmed by the numerical result,and also shows that the numerical algorithm is stable. 展开更多
关键词 time-dependent Ginzburg-Landau equation generalized scalar auxiliary variable algorithm maximum bound principle energy stability
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Thermomechanical Dynamics (TMD) and Bifurcation-Integration Solutions in Nonlinear Differential Equations with Time-Dependent Coefficients
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作者 Hiroshi Uechi Lisa Uechi Schun T. Uechi 《Journal of Applied Mathematics and Physics》 2024年第5期1733-1743,共11页
The new independent solutions of the nonlinear differential equation with time-dependent coefficients (NDE-TC) are discussed, for the first time, by employing experimental device called a drinking bird whose simple ba... The new independent solutions of the nonlinear differential equation with time-dependent coefficients (NDE-TC) are discussed, for the first time, by employing experimental device called a drinking bird whose simple back-and-forth motion develops into water drinking motion. The solution to a drinking bird equation of motion manifests itself the transition from thermodynamic equilibrium to nonequilibrium irreversible states. The independent solution signifying a nonequilibrium thermal state seems to be constructed as if two independent bifurcation solutions are synthesized, and so, the solution is tentatively termed as the bifurcation-integration solution. The bifurcation-integration solution expresses the transition from mechanical and thermodynamic equilibrium to a nonequilibrium irreversible state, which is explicitly shown by the nonlinear differential equation with time-dependent coefficients (NDE-TC). The analysis established a new theoretical approach to nonequilibrium irreversible states, thermomechanical dynamics (TMD). The TMD method enables one to obtain thermodynamically consistent and time-dependent progresses of thermodynamic quantities, by employing the bifurcation-integration solutions of NDE-TC. We hope that the basic properties of bifurcation-integration solutions will be studied and investigated further in mathematics, physics, chemistry and nonlinear sciences in general. 展开更多
关键词 The Nonlinear Differential Equation with time-dependent Coefficients The Bifurcation-Integration Solution Nonequilibrium Irreversible States Thermomechanical Dynamics (TMD)
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A post-peak dilatancy model for soft rock and its application in deep tunnel excavation 被引量:5
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作者 Wuqiang Cai Hehua Zhu +3 位作者 Wenhao Liang Xiaojun Wang Chenlong Su Xiangyang Wei 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第3期683-701,共19页
The dilation angle is the most commonly used parameter to study nonlinear post-peak dilatancy(PPD)behavior and simulate surrounding rock deformation;however,simplified or constant dilatancy models are often used in nu... The dilation angle is the most commonly used parameter to study nonlinear post-peak dilatancy(PPD)behavior and simulate surrounding rock deformation;however,simplified or constant dilatancy models are often used in numerical calculations owing to their simple mathematical forms.This study developed a PPD model for rocks(rock masses)based on the Alejanoe-Alonso(A-A)dilatancy model.The developed model comprehensively reflects the influences of confining pressure(σ_(3))and plastic shear strain(γ^(p)),with the advantages of a simple mathematical form,while requiring fewer parameters and demonstrating a clear physical significance.The overall fitting accuracy of the PPD model for 11 different rocks was found to be higher than that of the A-A model,particularly for Witwatersrand quartzite and jointed granite.The applicability and reliability of the PPD model to jointed granites and different scaled Moura coals were also investigated,and the model was found to be more suitable for the soft and large-scale rocks,e.g.deep rock mass.The PPD model was also successfully applied in studying the mechanical response of a circular tunnel excavated in strain-softening rock mass,and the developed semi-analytical solution was compared and verified with existing analytical solutions.The sensitivities of the rock dilatancy to γ^(p) and σ_(3) showed significant spatial variabilities along the radial direction of the surrounding rock,and the dilation angle did not exhibit a monotonical increasing or decreasing law from the elasticeplastic boundary to the tunnel wall,thereby presenting the σ3-or γ^(p)-dominated differential effects of rock dilatancy.Tunnel deformation parabolically or exponentially increased with increasing in situ stress(buried depth).The developed PPD model is promising to conduct refined numerical and analytical analyses for deep tunneling,which produces extensive plastic deformation and exhibits significant nonlinear post-peak behavior. 展开更多
关键词 Deep excavation Post-peak dilatancy(PPD)model AlejanoeAlonso(AeA)dilatancy model Soft rock
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Sample size adaptive strategy for time-dependent Monte Carlo particle transport simulation 被引量:3
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作者 Dan-Hua ShangGuan Wei-Hua Yan +3 位作者 Jun-Xia Wei Zhi-Ming Gao Yi-Bing Chen Zhi-Cheng Ji 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2023年第4期127-134,共8页
When multiphysics coupling calculations contain time-dependent Monte Carlo particle transport simulations, these simulations often account for the largest part of the calculation time, which is insufferable in certain... When multiphysics coupling calculations contain time-dependent Monte Carlo particle transport simulations, these simulations often account for the largest part of the calculation time, which is insufferable in certain important cases. This study proposes an adaptive strategy for automatically adjusting the sample size to fulfil more reasonable simulations. This is realized based on an extension of the Shannon entropy concept and is essentially different from the popular methods in timeindependent Monte Carlo particle transport simulations, such as controlling the sample size according to the relative error of a target tally or by experience. The results of the two models show that this strategy can yield almost similar results while significantly reducing the calculation time. Considering the efficiency, the sample size should not be increased blindly if the efficiency cannot be enhanced further. The strategy proposed herein satisfies this requirement. 展开更多
关键词 time-dependent Monte Carlo particle transport simulation Shannon entropy Adaptive strategy
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Failure transition of shear-to-dilation band of rock salt under triaxial stresses 被引量:3
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作者 Jianfeng Liu Xiaosong Qiu +3 位作者 Jianxiong Yang Chao Liang Jingjing Dai Yu Bian 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期56-64,共9页
Great potential of underground gas/energy storage in salt caverns seems to be a promising solution to support renewable energy.In the underground storage method,the operating cycle unfortunately may reach up to daily ... Great potential of underground gas/energy storage in salt caverns seems to be a promising solution to support renewable energy.In the underground storage method,the operating cycle unfortunately may reach up to daily or even hourly,which generates complicated pressures on the salt cavern.Furthermore,the mechanical behavior of rock salt may change and present distinct failure characteristics under different stress states,which affects the performance of salt cavern during the time period of full service.To reproduce a similar loading condition on the cavern surrounding rock mass,the cyclic triaxial loading/unloading tests are performed on the rock salt to explore the mechanical transition behavior and failure characteristics under different confinement.Experimental results show that the rock salt samples pre-sent a diffused shear failure band with significant bulges at certain locations in low confining pressure conditions(e.g.5 MPa,10 MPa and 15 MPa),which is closely related to crystal misorientation and grain boundary sliding.Under the elevated confinement(e.g.20 MPa,30 MPa and 40 MPa),the dilation band dominates the failure mechanism,where the large-size halite crystals are crushed to be smaller size and new pores are developing.The failure transition mechanism revealed in the paper provides additional insight into the mechanical performance of salt caverns influenced by complicated stress states. 展开更多
关键词 Rock salt Cyclic mechanical loading Shear band dilation band Underground gas storage(UGS)
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Time-dependent variational approach to solve multi-dimensional time-dependent Schr?dinger equation
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作者 何明睿 王哲 +1 位作者 姚陆锋 李洋 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第12期361-366,共6页
We present an efficient approach to solve multi-dimensional time-dependent Schr?dinger equation(TDSE)in an intense laser field.In this approach,each spatial degree of freedom is treated as a distinguishable quasi-part... We present an efficient approach to solve multi-dimensional time-dependent Schr?dinger equation(TDSE)in an intense laser field.In this approach,each spatial degree of freedom is treated as a distinguishable quasi-particle.The non-separable Coulomb potential is regarded as a two-body operator between different quasi-particles.The time-dependent variational principle is used to derive the equations of motion.Then the high-order multi-dimensional problem is broken down into several lower-order coupled equations,which can be efficiently solved.As a demonstration,we apply this method to solve the two-dimensional TDSE.The accuracy is tested by comparing the direct solutions of TDSE using several examples such as the strong-field ionization and the high harmonic generation.The results show that the present method is much more computationally efficient than the conventional one without sacrificing accuracy.The present method can be straightforwardly extended to three-dimensional problems.Our study provides a flexible method to investigate the laser-atom interaction in the nonperturbative regime. 展开更多
关键词 time-dependent variational approach above-threshold ionization high harmonic generation
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Non-harmonic resonance of viscoelastic structures subjected to time-dependent exponentially decreasing transverse distributed loads
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作者 Nasrin Jafari 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2023年第3期825-840,共16页
In this paper,the non-harmonic resonance of Bernoulli viscoelastic beams,Kirchhoff viscoelastic plates,Timoshenko viscoelastic beams,and Mindlin viscoelastic plates subjected to time-dependent exponentially decreasing... In this paper,the non-harmonic resonance of Bernoulli viscoelastic beams,Kirchhoff viscoelastic plates,Timoshenko viscoelastic beams,and Mindlin viscoelastic plates subjected to time-dependent exponentially decreasing transverse distributed load is investigated for the first time.The constitutive equations are expressed utilizing Boltzmann integral law with a constant bulk modulus.The displacement vector is approximated by employing the separation of variables method.The Laplace transformation is used to transfer equations from the time domain to the Laplace domain and vice versa.The novel point of the proposed method is to express,prove and calculate the critical time in which the displacement will be several times the displacement at time zero.In addition,this new method calculates the maximum deflection at the critical time,explicitly and exactly,without any need to follow the time-displacement curve with a low computational cost.Additionally,the proposed method introduces the critical range of time so that the responses are greater than the responses at time zero. 展开更多
关键词 Bernoulli and Timoshenko viscoelastic beams critical time non-harmonic resonance time-dependent decreasing exponential load Kirchhoff and Mindlin viscoelastic plates
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Blowup of Solutions to the Non-Isentropic Compressible Euler Equations with Time-Dependent Damping and Vacuum
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作者 Yuping Feng Huimin Yu Wanfang Shen 《Journal of Applied Mathematics and Physics》 2023年第7期1881-1894,共14页
This paper mainly studies the blowup phenomenon of solutions to the compressible Euler equations with general time-dependent damping for non-isentropic fluids in two and three space dimensions. When the initial data i... This paper mainly studies the blowup phenomenon of solutions to the compressible Euler equations with general time-dependent damping for non-isentropic fluids in two and three space dimensions. When the initial data is assumed to be radially symmetric and the initial density contains vacuum, we obtain that classical solution, especially the density, will blow up on finite time. The results also reveal that damping can really delay the singularity formation. 展开更多
关键词 Compressible Euler Equations BLOWUP General time-dependent Damping VACUUM
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Long-term outcomes of urethral balloon dilation for anterior urethral stricture: A prospective cohort study
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作者 Ahmed M.Abdel Gawad Abhijit Patil +3 位作者 Abhishek Singh Arvind P.Ganpule Ravindra B.Sabnis Mahesh R.Desai 《Asian Journal of Urology》 CSCD 2024年第3期480-485,共6页
Objective:To prospectively follow up a cohort of anterior urethral stricture disease patients managed with balloon dilation(BD)for 3 years to evaluate the long-term outcomes and to study factors that contribute to rec... Objective:To prospectively follow up a cohort of anterior urethral stricture disease patients managed with balloon dilation(BD)for 3 years to evaluate the long-term outcomes and to study factors that contribute to recurrence.Methods:This study included men who had urethral BD for significant anterior urethral stricture disease between January 2017 and March 2019.Data about the patient age,stricture characteristics,and recurrence date were recorded,along with information on postoperative indwelling catheter use and operative complications.Furthermore,information about the self-calibration procedure was collected and where available,free flow(FF)measurements during the follow-up period were recorded and analyzed.Success was defined as a lack of symptoms and acceptable FF rates(maximum flow rate>12 mL/s).Results:The final analysis was conducted on 187 patients.The mean follow-up period was 37 months.The long-term overall success rate at the end of our study was 66.8%.Our recurrence rate was 7.4%at 12 months,24.7%at 24 months,and reached 33.2%at the end of our study.The time to recurrence ranged from 91 days to 1635 days,with a mean of 670 days.The stricture-free survival was significantly shorter with lengthy peno-bulbar(p=0.031)and multiple strictures(p=0.015),and in the group of patients who were not committed to self-calibration protocol(p<0.011).However,post-procedural self-calibration was the most important factor that may have decreased the incidence of recurrence(odds ratioZ5.85).Adjuvant self-calibration after BD not only reduced the recurrence rate from 85.4%in the non-self-calibration group to 15.1%in the self-calibration one(p<0.001),but also improved the overall stricture-free survival and FF parameters. 展开更多
关键词 Balloon dilation Internal urethrotomy RECURRENCE SELF-CALIBRATION Urethral stricture
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Dilation,discrimination and Uhlmann's theorem of link products of quantum channels
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作者 雷强 操刘桁 +1 位作者 Asutosh Kumar 武俊德 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期201-206,共6页
We establish the Stinespring dilation theorem of the link product of quantum channels in two different ways,discuss the discrimination of quantum channels,and show that the distinguishability can be improved by self-l... We establish the Stinespring dilation theorem of the link product of quantum channels in two different ways,discuss the discrimination of quantum channels,and show that the distinguishability can be improved by self-linking each quantum channel n times as n grows.We also find that the maximum value of Uhlmann's theorem can be achieved for diagonal channels. 展开更多
关键词 quantum channels link products Stinespring dilation theorem Uhlmann's theorem
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Bioinformatics Analysis of the Relationship between Dilated Cardiomyopathy and Chronic Heart Failure
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作者 Lanqing Yu Haidong Zhou +8 位作者 Bailu Deng Jiaochang Wei Mei Zhang Chongyao Xu Guiyun Wei Junxiu Zhou Jun Huang Qi Lu Shaowu Ye 《Journal of Biosciences and Medicines》 2024年第8期333-346,共14页
Objective: To screen and analyze the differentially expressed genes between dilated cardiomyopathy (DCM) and chronic heart failure (CHF) based on bioinformatics methods. Methods: The Gene Expression Omnibus (GEO) data... Objective: To screen and analyze the differentially expressed genes between dilated cardiomyopathy (DCM) and chronic heart failure (CHF) based on bioinformatics methods. Methods: The Gene Expression Omnibus (GEO) database was used for data retrieval, and the chip data GSE3585 was downloaded, which was the original data of DCM and normal control group. At the same time, the chip data GSE76701 was downloaded, which was the original data of CHF and control group. Differentially expressed mRNAs (DEmRNAs) were screened by R language limma package, the data were standardized, and the common differentially expressed genes were screened. GO function and KEGG pathway enrichment analysis were performed on the common differentially expressed genes. String11.0 online tool was used for data analysis to obtain differentially expressed genes, and the results were imported into Cytoscape 3.9.1 software. The results were imported into Cytoscape 3.9.1 software, and the common expression gene module was obtained by MOCDE algorithm. Nine Hub genes were obtained by 10 algorithms such as MCC. Results: A total of 248 differentially expressed genes were screened. GO analysis showed that differentially expressed genes were mainly concentrated in 9 different physiological and pathological processes. KEGG analysis showed that the main signaling pathways involved in differentially expressed genes were 2, and 9 key differentially expressed genes were predicted: NPPB, NPPA, MYH6, FRZB, ASPN, SFRP4, RPS4Y1, DDX3Y. Conclusion: This study preliminarily explored the molecular mechanism of DCM and CHF, and obtained the common differentially expressed genes of the two diseases. Further experimental studies are needed to verify the correlation between gene expression and clinicopathological features. Provide new ideas for clinical drug treatment research. 展开更多
关键词 dilated Cardiomyopathy Chronic Heart Failure Bioinformatics Analysis Differentially Expressed Genes
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An improved deep dilated convolutional neural network for seismic facies interpretation
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作者 Na-Xia Yang Guo-Fa Li +2 位作者 Ting-Hui Li Dong-Feng Zhao Wei-Wei Gu 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期1569-1583,共15页
With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural network... With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural networks.These intelligent and automated methods significantly reduce manual labor,particularly in the laborious task of manually labeling seismic facies.However,the extensive demand for training data imposes limitations on their wider application.To overcome this challenge,we adopt the UNet architecture as the foundational network structure for seismic facies classification,which has demonstrated effective segmentation results even with small-sample training data.Additionally,we integrate spatial pyramid pooling and dilated convolution modules into the network architecture to enhance the perception of spatial information across a broader range.The seismic facies classification test on the public data from the F3 block verifies the superior performance of our proposed improved network structure in delineating seismic facies boundaries.Comparative analysis against the traditional UNet model reveals that our method achieves more accurate predictive classification results,as evidenced by various evaluation metrics for image segmentation.Obviously,the classification accuracy reaches an impressive 96%.Furthermore,the results of seismic facies classification in the seismic slice dimension provide further confirmation of the superior performance of our proposed method,which accurately defines the range of different seismic facies.This approach holds significant potential for analyzing geological patterns and extracting valuable depositional information. 展开更多
关键词 Seismic facies interpretation dilated convolution Spatial pyramid pooling Internal feature maps Compound loss function
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Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes syndrome with dilated cardiomyopathy: A case report
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作者 Jia-Rong Li Lei-Yu Feng +2 位作者 Jian-Wei Li Yu Liao Fei-Qi Liu 《World Journal of Clinical Cases》 SCIE 2024年第3期601-606,共6页
BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,skin changes(POEMS)syndrome is a rare paraneoplastic syndrome that encompass multiple systems.The most common clinical symptoms of POEMS syndrome are pro... BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,skin changes(POEMS)syndrome is a rare paraneoplastic syndrome that encompass multiple systems.The most common clinical symptoms of POEMS syndrome are pro-gressive sensorimotor polyneuropathy,organ enlargement,endocrine disorders,darkening skin,a monoclonal plasma cell proliferative disorder,and lymph node hyperplasia.The organomegaly consists of hepatosplenomegaly and/or lym-phadenopathy;cases of cardiomyopathy are rare.Diagnoses are often delayed because of the atypical nature of the syndrome,exposing patients to possibly severe disability.Therefore,identifying atypical symptoms can improve the prognosis and quality of life among POEMS syndrome patients.lenalidomide and dexamethasone.CONCLUSION When patients with cardiomyopathy have systemic manifestations such as numb limbs and darkening skin,the POEMS syndrome is the most possible diagnosis. 展开更多
关键词 POLYNEUROPATHY organomegaly ENDOCRINOPATHY M-PROTEIN skin changes syndrome dilated cardiomyopathy LENALIDOMIDE Dexamethasone Case report
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Extra Time Dimension: Deriving Relativistic Space-Time Transformations, Kinematics, and Example of Dimensional Compactification Using Time-Dependent Non-Relativistic Quantum Mechanics
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作者 Sajjad Zahir 《Journal of Modern Physics》 2023年第10期1333-1354,共22页
We consider a five-dimensional Minkowski space with two time dimensions characterized by distinct speeds of causality and three space dimensions. Formulas for relativistic coordinate and velocity transformations are d... We consider a five-dimensional Minkowski space with two time dimensions characterized by distinct speeds of causality and three space dimensions. Formulas for relativistic coordinate and velocity transformations are derived, leading to a new expression for the speed limit. Extending the ideas of Einstein’s Theory of Special Relativity, concepts of five-velocity and five-momenta are introduced. We get a new formula for the rest energy of a massive object. Based on a non-relativistic limit, a two-time dependent Schrödinger-like equation for infinite square-well potential is developed and solved. The extra time dimension is compactified on a closed loop topology with a period matching the Planck time. It generates interference of additional quantum states with an ultra-small period of oscillation. Some cosmological implications of the concept of four-dimensional versus five-dimensional masses are briefly discussed, too. 展开更多
关键词 Two-Time Physics Special Theory of Relativity Kaluza-Klein Theory time-dependent Schrödinger Equation COMPACTIFICATION
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