Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of previously replication-competent cells.

Long Lasting Phosphorescence and Photo-Stimulated Long Lasting Phosphorescence in Tb^(3+)-doped Strontium Borosilicate Glasses

Long lasting phosphorescence （LLP） and photo-stimulated long lasting phosphorescence （PSLLP） were observed in Tb^3＋-doped strontium borosilicate glasses. The green phosphorescence arises fromf-f transitions of Tb^3＋ and can be observed with naked eyes in the dark for up to 10 hours after the irradiation with a UV lamp （λmax =254 nm） for 30 min at room temperature. The glass could re-emit LLP under the stimulation of a UV lamp （λmax=366 rim） for 60 seconds after the LLP disappeared. The re-emitted LLP is called PSLLP. The glass sample was characterized by the fluorescence and thermoluminescence spectra, respectively. The possible mechanism of the LLP and PSLLP was also discussed.

Photo-luminescence properties and thermo-luminescence curve analysis of a new white long-lasting phosphor: Ca_2MgSi_2O_7:Dy^(3+)

A white long-lasting phosphor Ca2MgSi2O7:Dy3+ was prepared by the solid-state reaction. A strong band peaked at 260 nm was shown in the excitation spectrum of 578 nm emission, which might be attributed to the oxygen deficiency of the host. After irradiated with 254 nm for 4 min, the white afterglow of the sample could be seen for 3 h. Moreover, the depths and frequency factors of trap centers were calculated from the thermo-luminescence curve of the sample, which indicated that the trap centers corresponding to the 414 K band were more helpful to the long-lasting phosphorescence.

Very Original Proofs of Two Famous Problems: “Are There Any Odd Perfect Numbers?” (Unsolved until to Date) and “Fermat’s Last Theorem: A New Proof of Theorem (Less than One and a Half Pages) and Its Generalization”

This article presents very original and relatively brief or very brief proofs about of two famous problems: 1) Are there any odd perfect numbers? and 2) “Fermat’s last theorem: A new proof of theorem and its generalization”. They are achieved with elementary mathematics. This is why these proofs can be easily understood by any mathematician or anyone who knows basic mathematics. Note that, in both problems, proof by contradiction was used as a method of proof. The first of the two problems to date has not been resolved. Its proof is completely original and was not based on the work of other researchers. On the contrary, it was based on a simple observation that all natural divisors of a positive integer appear in pairs. The aim of the first work is to solve one of the unsolved, for many years, problems of the mathematics which belong to the field of number theory. I believe that if the present proof is recognized by the mathematical community, it may signal a different way of solving unsolved problems. For the second problem, it is very important the fact that it is generalized to an arbitrarily large number of variables. This generalization is essentially a new theorem in the field of the number theory. To the classical problem, two solutions are given, which are presented in the chronological order in which they were achieved. Note that the second solution is very short and does not exceed one and a half pages. This leads me to believe that Fermat, as a great mathematician was not lying and that he had probably solved the problem, as he stated in his historic its letter, with a correspondingly brief solution. To win the bet on the question of whether Fermat was telling truth or lying, go immediately to the end of this article before the General Conclusions.

Tessellons, topography, and glaciations on the Qinghai-Tibet Plateau

The Qinghai-Tibet Plateau has developed into a vast fortress-like structure that has recently presented a barrier limiting the egress of moisture-bearing air masses. Lower sea levels also affected the climate. This paper examines their effects on the current evidence for the timing of past glaciations, and the development and evolution of permafrost. There are two theories regarding glaciation on the Qinghai-Tibet Plateau （QTP）. Kuhle suggested that there was a major, unified ice-cap during the Last Glacial Maximum （LGM）, whereas major Chinese glaciologists and others have not found or verified reliable evidence for this per se. There have been limited glaciations during the last 1.1 Ma B.P. but with increasing dominance of permafrost including both primary and secondary tessellons infilled with rock, sand or loess. The East Asia Monsoon was absent in this area during the main LGM, starting at 〉30 ka B.P. on the plateau, with sufficient precipitation reappearing about 19 ka B.P. to produce ice-wedges. A weak Megathermal event took place between 8.5 and 6.0 ka B.P., followed by Neoglacial events exhibiting peak cold at 5.3-4.7 ka, 3.1-1.5 ka, and the Little Ice Age （LIA） after 0.7 ka. Subsequently, mean annual air temperature has increased by 4 ℃.

Wash resistance and bio-efficacy of Olyset~? Plus, a long-lasting insecticide-treated mosquito net with synergist against malaria vector, Anopheles stephensi

Objective: To determine the wash resistance of Olyset~? Plus using World Health Organization Pesticide Evaluation Scheme standard washing procedure and to assess the value of knock down and mortality rates of Anopheles stephensi at different regimens of long lasting insecticide treated nets washings.Methods: The study was conducted at the Bioassay Laboratory of Culicidae Insectary,School of Public Health, Tehran University of Medical Sciences, Iran. The net was made of polyester impregnated with permethrin and piperonyl butoxide at a ratio of 2:1. The washing resistance was assessed using Le Chat?soap and a shaker incubator set at a speed of 155 r/min, 30℃ for 10 min. The cone bioassay test was carried out according to World Health Organization recommended guideline with tolerant field strain of female Anopheles stephensi to pyrethroids.Results: The knockdown and mortality rates of female mosquitoes exposed to Olyset~? Plus from un-washed nets to 2 washings were 79.7% and 88.8% respectively. Mortality was dropped to zero while active ingredient estimated 0.532 mg/100 cm^2 to 0.481 mg/100 cm^2 after 15 washings. A positive correlation was seen between residues of permethrin on nets, knockdown rate and mortality rate of female Anopheles stephensi exposed to different regimes of washed Olyset~? Plus(r = 0.954, P = 0.001).Conclusions: It is recommended that a preliminary survey conducted on resistance level of Anopheles vectors before the distribution of Olyset~? Plus in malaria endemic communities.

Late Pleistocene(MIS 2) climate change on the Northern Tibetan Plateau inferred from pollen and geochemical records from Lake Gomo Co

Introduction A 405-cm sediment section GM02 from Gomo Co salt lake in the northern Tibetan Plateau was used to reconstruct climate changes during marine isotope stage(MIS)2,including the Last Glacial Maximum(LGM)and last

Whole Perfect Vectors and Fermat’s Last Theorem

A naïve discussion of Fermat’s last theorem conundrum is described. The present theorem’s proof is grounded on the well-known properties of sums of powers of the sine and cosine functions, the Minkowski norm definition, and some vector-specific structures.

Contributions of the Bering Strait throughflow to oceanic meridional heat transport under modern and Last Glacial Maximum climate conditions

Paleo reconstructions and model simulations have suggested the Bering Strait plays a pivotal role in climate change. However, the contribution of the Bering Strait throughflow to oceanic meridional heat transport (OMHT) is about 100 times smaller than the OMHT at low latitudes in the modern climate and it is generally ignored. Based on model simulations under modern and Last Glacial Maximum (LGM,~21 ka;ka=thousand years ago) climate conditions, this study highlights the importance of the Bering Strait throughflow to OMHT. The interbasin OMHT induced by the Bering Strait throughflow is estimated by interbasin-intrabasin decomposition. Similar to barotropic-baroclinic-horizontal decomposition, we assume the nonzero net mass transport induced by interbasin throughflows is uniform across the entire section, and the interbasin term is separated to force zero net mass transport for the intrabasin term. Based on interbasinintrabasin decomposition, the contribution of the Bering Strait throughflow is determined as ~0.02 PW (1 PW=10 15 W) under the modern climate, and zero under the LGM climate because the closed Bering Strait blocked interbasin throughflows. The contribution of the Bering Strait throughflow to OMHT is rather small, consistent with previous studies. However, comparisons of OMHT under modern and LGM climate conditions indicate the mean absolute changes are typically 0.05 and 0.20 PWin the North Atlantic and North Pacific, respectively. Thus, the contribution of the Bering Strait throughflow should not be ignored when comparing OMHT under diff erent climate conditions.

Solutions to Beal’s Conjecture, Fermat’s Last Theorem and Riemann Hypothesis

A Simple Mathematical Solutions to Beal’s Conjecture and Fermat’s Marginal Conjecture in his diary notes, Group Theoretical and Calculus Solutions to Fermat’s Last theorem & Integral Solution to Riemann Hypothesis are discussed.

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

Retinol is an ingredient used in cosmetic products for reducing the appearance of the signs of aging and photo-damage. Currently, most of these products contain 0.1% of retinol. However, at this concentration, some irritation can occur. We have evaluated in vitro and in a clinical study the potential efficacy of a combination of actives to improve the facial skin aging signs while using low concentration of retinol. We demonstrated, in vitro, that a chromone derivative, 5,7-di-hydroxy-2-methyl chromone (DMC), is able to enhance the collagen synthesis in culture of normal human dermal fibroblasts. The enhancement of retinol anti-wrinkle efficacy by DMC was confirmed in a small scale clinical trial. Specifically, a product associating low concentration of retinol (0.04%) and DMC (0.1%) in combination with low molecular weight hyaluronic acid fragments (50,000 Dalton of average molecular weight) has been applied topically for 8 weeks. Clinical results show significant improvement of various signs of facial skin aging such as wrinkles, pigmentary spots, tone unevenness, dullness and the overall photo-damage score. Improvements were still visible 4 weeks after the cessation of the test product application. This study demonstrates that significant lasting improvement of facial skin aging can be obtained with well tolerated low concentration of retinol when adequately formulated with other anti-aging ingredients.

From Pythagoras Theorem to Fermat’s Last Theorem and the Relationship between the Equation of Degree <i>n</i>with One Unknown

The most interesting and famous problem that puzzled the mathematicians all around the world is much likely to be the Fermat’s Last Theorem. However, since the Theorem was proposed, people can’t find a way to solve the problem until Andrew Wiles proved the Fermat’s Last Theorem through a very difficult method called Modular elliptic curves in 1995. In this paper, I firstly constructed a geometric method to prove Fermat’s Last Theorem, and in this way we can easily get the conclusion below: If a and b are integer and?a = b, n ∈ Q and n > 1, the value of c satisfies the function an + bn = cn that can never be integer;if a, b and c are integer and a ≠ b, n is integer and n > 2, the function an + bn = cn cannot be established.

Decisive Factors of Conidia Release of Botryosphaeria berengeriana during Growing Season

[ Objective ] The study aimed to explore the release conditions for the conidia of Botryosphaena berengeriana and understand the release dynamic of conidia. [Method] The systematical survey on the release conditions for the conidia of B. berengeriana were conducted in two growing seasons in 2008 and 2009, combined with the collection of meteorological data around conidia release period, the weather conditions causing large amount release of B. berengedana were analyzed. [ Result] During a growing season, the conidia of pathogen appeared several large release peaks. Under the suitable temperature, when the precipitation lasted for 4 h, the conidia of B. berengeriana began to release with large amount, the amount of conidia reached the peak after release and trended to be stable during 4 - 12 h, which significantly reduced after 24 h, tended to dis- appear after 36 h, and completely disappeared after 72 h. [Conclusion] The dominant factor affecting B. berengeriana conidia release in large a- mount was precipitation, while the lasting time of precipitation played a decisive role.

Photoluminescence of Long Lasting Phosphors Ca_2MgSi_2O_7∶Eu^(2+),Dy^(3+)

The Eu (2+) and Dy (3+) codoped silicates,Ca_2MgSi_2O_7∶Eu (2+),Dy (3+),was synthesized,and its photoluminescence properties were studied with synchrotron radiation. Under synchrotron radiation excitation at 305 nm,only the characteristic emission from Eu (2+) was excited. But the characteristic emission from Dy (3+) was also found under 175 nm excitation,besides the characteristic emission of Eu (2+). The characteristic emission from Dy (3+) was detected in the Eu (2+) and Dy (3+) codoped long lasting phosphorescence materials,which indicates that Dy (3+) is still existed in the phosphors under continue excitation at 175 nm.

Long Lasting Phosphorescence in Eu^(2+) and Ce^(3+) Co-Doped Strontium Borate Glasses

Long lasting phosphorescence (LLP) was observed in Eu2+, Ce3+ co-doped strontium borate glasses prepared under the reducing atmosphere due to the emission of both Eu2 + and Ce3+ . The methods of photoluminescence, thermolu-minescence and phosphorescence were used to study the samples, and possible mechanism was suggested. The co-doping of Ce3 + ions poisoned the phosphorescence emission of Eu2 + because of the competition to obtain the trapped electron . The phosphorescence of Ce3 + in the sample decays more quickly than that of Eu2 + , which is suggested for the reason that the emission energy of Ce3 + is higher or the distance between Ce3 + and electron traps of the glasses is longer.

Synthesis and luminescence properties of Eu^(3+),Sm^(3+) doped(Y_xGd_(1-x))_2O_3:Si^(4+),Mg^(2+) long-lasting phosphor

A novel red long-lasting phosphor, （YxGd1-x）2O3：Eu3＋, Sm3＋, Si4＋, Mg2＋, was synthesized by the co-precipitation method using oxalate precipitation as the precursor. X-ray diffraction （XRD）, scanning electronic microscopy （SEM）, integrated thermal analyzer （TG）, and photoluminescence spectra （PL） as well as the ST-900PM weak light photometer were used to study the synthesis conditions, morphology, luminescence properties, and the decay time of the phosphor. The XRD results show that the products synthesized at 1400~C for 4 h have good crystallization without any detectable impurity phases. Based on the PL spectra, the optimal conditions are as the following. The molar ratios of Y3＋ to Gd3＋ and Eu3＋ to Sm3＋ are 2：8 and 3：1, respectively, and the contents of Mg2＋ and SiO2 are 5mol% and 3mol%, respectively. The decay time monitored by the ST-900PM weak light photometer is 7200 s, increasing 44% and 100%, respectively, compared with the Eu3＋ and Sm3＋ single-doped phosphors. The results indicate that the energy transfer is from Sm3＋ to Eu3＋ ion, and Sm3＋ is a good sensitizer to Eu3＋.

Comparison of Climate and Environment Change of the Last Interglacial Period and Holocene in Beijing Area, China

Research on climate changes between the last interglacial period and Holocene renders a speculation on the tendency of present climate. Fully understanding the nature of the changes will play a significant role in a better understanding of global climate change. This work discussed the climate change of the last interglacial period and Holocene in Beijing area to discover the mechanism of local palaeo-climate change. The palaeo-vegetation of the last interglacial period in Xishan Mountain of Beijing was reconstructed by pollen analysis and thermo-luminescence dating to represent the change of palaeo-climate and palaeo-environment. Palaeo-vegetation indicators demonstrated that the climate change of the last interglacial period included 6 stages and was homologous to that reflected by the records from deep sea depositions and polar ice cores, respectively corresponding to Marine Isotope Stage (MIS) 5e, 5d, 5c, 5b, 5a and the interim from MIS5 to MIS4 from the early to the late. Millennial climate abrupt events occurred in MIS 5e, which had an agreement with the records of GRIP. In addition, a climate warming event appeared in the interim from MIS5 to MIS4 and it also was found in other regions of the world. Compared with the vegetation and environment indicators of Holocene in Beijing area, it was found that the vegetation, climate and environment of the last glacial period were better than those of Holocene. The climate abrupt events not only appeared in the last interglacial period and MIS 5e, but also occurred in Holocene, whose mechanism and pattern were analogical. After analyzing the records of millennial climate abrupt change events from this work, Ice Cores and others, it was concluded that climate was instability in the interglacial period.

“Greatest lake period” and its palaeo-environment on the Tibetan Plateau

The “greatest lake period” means that the lakes are in the stage of their maximum areas. As the paleo lake shorelines are widely distributed in the lake basins on the Tibetan Plateau, the lake areas during the “greatest lake period” may be inferred by the last highest lake shorelines. They are several, even tens times larger than that at present. According to the analyses of tens of lakes on the Plateau, most dating data fell into the range of 40-25 ka BP, some lasted to 20 ka BP. It was corresponded to the stage 3 of marine isotope and interstitial of last glaciation. The occurrence of maximum areas of lakes marked the very humid period on the Plateau and was also related to the stronger summer monsoon during that period.

Cosmogenic ^(10)Be and ^(26)Al Chronology of the Last Glaciation of the Palaeo-Daocheng Ice Cap,Southeastern Qinghai-Tibetan Plateau

The glacial landforms of the Qinghai-Tibetan Plateau （QTP） provide a unique opportunity to research hemispheric and global environmental changes. In this study, we focus on the glacial history of the palaeo-Daocheng Ice Cap （p-DIC） in the southeastern QTP during the last glacial cycle. Based on field investigations, morphostratigraphy, and surface exposure dating of roche moutonnée, polished surface and moraine debris through the terrestrial cosmogenic nuclides （TCN） ^10Be and ^26Al. We identify glacial deposits of the last deglaciation, with minimum ages of 14.9±1.3-18.7±1.7 ka, the Last Glacial Maximum （LGM） of 24.7±2.2 ka, and the early part of the last glacial period （marine oxygen isotope stage （MIS） 3） of 37.1±3.4-45.2±3.9 ka. Our results show that in this region, the extent of the glacial advance during MIS 3 was larger than that during the traditional LGM （MIS 2）. These ages are consistent with prior chronologies, and the ^10Be age is consistent with the ^26Al age for the same sample. Thus, these data provide reliable constraints on climate change in the QTP, during the last glaciation.