Clinical observation of electroacupuncture"Tongmin Point"combined with heat-sensitive moxibustion on knee osteoarthritis and its influence on blood lipid level and ADAMTS-4

Objective:To observe the clinical effect of electroacupuncture"Tongmin point"combined with heat-sensitive moxibustion on knee osteoarthritis and its effect on blood lipid level,polyprotein polysaccharide enzyme-4(a disintegrin and metalloprotease with thrombospondin motifs,ADAMTS-4,matrix metalloproteinase-3(matrix metalloproteinase-3,);and MMPs-3)Impact.Methods:80 patients were randomly divided into two groups,40 cases per group,Treatment and control groups,The treatment group was given electroacupuncture combined with heat-sensitive moxibustion,Six times a week,Continuous treatment for 4 weeks;The control group was given intraarticular sodium hyaluronate,Once a week,continuous treatment for 4 weeks.Results:During the treatment period,Visual analogue scale visual analogue scale,VAS)show a downward trend,Intra-group comparisons,Differences were statistically significant(P<0.05);After 2 weeks of treatment,4 weeks of treatment and 2 weeks of follow-up,All the scores in the treatment group were lower than those in the control group(P<0.05).After treatment in two groups(The Western Ontario and Mc Master Universities Osteoarthritis Index,)of osteoarthritis index,University of Western Ontario WOMAC)The scores of each item decreased significantly,treatment group was better than the control group(P<0.05).After four weeks of treatment,(Total cholesterol,)Total cholesterol TC,triglycerides(Triglyceride,);and TG,LDL(Low density lipoprotein,);and LDL-C)A decrease in content,High density lipoprotein High density lipoprotein,HDL-C)Increased content,and the improvement was better than that of the control group(P<0.05).After treatment,the ADAMTS-4,MMPs-3 content decreased,Intergroup comparisons,Differences were statistically significant(P<0.05);The effective rate in the treatment group was 87.5%,The control rate was 60%,treatment group was more effective(P<0.05).Conclusions:Electroacupuncture"Tongmin point"combined with heat-sensitive moxibustion can obviously improve the symptoms of knee osteoarthritis patients,Regulate blood lipids,High security,It is worth popularizing in clinic.

自拟方通敏汤加减联合穴位贴敷治疗小儿过敏性鼻炎肺脾气虚证临床研究

目的研究自拟方通敏汤加减联合穴位贴敷治疗小儿过敏性鼻炎肺脾气虚证临床效果。方法选择洛阳市第三人民医院2020年1月至2022年1月收治的62例小儿过敏性鼻炎肺脾气虚证开展分析,按随机法分为两组均31例,对照组采取常规西医干预,研究组加用自拟方通敏汤加减联合穴位贴敷治疗。观察两组患者临床疗效、各项炎性因子水平、症状评分、免疫球蛋白。结果研究组治疗有效率(89.10%)高于对照组(74.19%),差异有统计学意义(P<0.05)。治疗前,两组炎性因子水平、相关症状评分、免疫球蛋白各项水平差异无统计学意义(P>0.05);治疗后,研究组超敏C-反应蛋白(hs-CRP)、白介素-4(IL-4)、白细胞介素-6(IL-6)水平均低于对照组,各项症状评分均低于对照组,免疫球蛋白水平均低于对照组,差异有统计学意义(P<0.05)。结论小儿过敏性鼻炎肺脾气虚证,通过自拟方通敏汤加减联合穴位贴敷治疗后,整体效果理想,可有效改善患儿相关症状,使得免疫球蛋白水平好转,炎症因子水平下降,值得临床应用。

电针“痛敏穴”联合热敏灸对膝骨性关节炎的临床观察及对血脂水平、ADAMTS⁃4的影响

目的:观察电针“痛敏穴”联合热敏灸对膝骨性关节炎的临床疗效及对血脂水平、聚蛋白多糖酶4(a disintegrin and metalloprotease with thrombospondin motifs,ADAMTS-4)、基质金属蛋白酶-3(matrix metalloproteinase-3,MMPs-3)影响。方法:将80例膝骨性关节炎患者随机分为治疗组40例与对照组40例。治疗组给予电针联合热敏灸,每周6次,连续治疗4周;对照组给予关节腔内注射玻璃酸钠,每周1次,连续治疗4周。结果:两组在治疗期,视觉模拟评分量表(visual analogue scale,VAS)均呈现下降趋势,组内比较,差异具有统计学意义(P<0.05);在治疗2周、治疗4周、随访2周,治疗组得分均低于对照组(P<0.05)。两组治疗后(美国西安大略麦马斯特大学骨性关节炎指标(Western Ontario and McMaster Universities osteoarthritis index,WOMAC)各项目得分均明显下降,治疗组疗效优于对照组(P<0.05)。治疗组在4周治疗后,总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(LDL-C)含量下降,高密度脂蛋白胆固醇(HDL-C)含量上升,其改善程度优于对照组(P<0.05)。两组治疗后ADAMTS-4、MMPs-3含量均下降,组间比较,差异有明显统计学意义(P<0.05);治疗组有效率为87.5%,对照组有效率为60.0%,治疗组疗效更佳(P<0.05)。结论:电针“痛敏穴”联合热敏灸能明显改善膝骨性关节炎患者的症状,调节血脂水平,安全性高,值得临床推广使用。