Clinical Effective Evaluation of Tongren Dahuoluo Pill (同仁大活络丸) on Knee Osteoarthritis by Musculoskeletal Ultrasound

Objective:To evaluate the clinical effect of Tongren Dahuoluo Pill(同仁大活络丸)on knee osteoarthritis by musculoskeletal ultrasonography.Methods:From March 2019 to December 2019,45 patients with knee osteoarthritis were collected from the outpatient department of the First Medical Center of PLA General Hospital.Tongren Dahuoluo Pill(同仁大活络丸)was given oral treatment for 12 weeks.VAS score,Lequesne score and WOMAC score were recorded before and after treatment,and the changes of knee joint effusion and synovial hyperplasia were observed by musculoskeletal ultrasonography.Results:Among the 45 patients,18 were male and 27 were female,with the average age of(62.07±9.08)years old,and average disease course of(6.83±7.01)years.The VAS score,Lequesne score and WOMAC score were significantly reduced compared with before treatment,and the difference was statistically significant(P<0.01).We observed that joint effusion range and joint synovial hyperplasia thickness of knee osteoarthritis significantly reduced with Tongren Dahuoluo Pill(同仁大活络丸)treatment by musculoskeletal ultrasonography,and the difference were statistically significant(P<0.01).Conclusion:Tongren Dahuoluo Pill(同仁大活络丸)can not only relieve the clinical symptoms of knee osteoarthritis,but also effectively inhibit synovitis hyperplasia of knee joint.

穴位注射联合同仁大活络丸治疗膝骨关节炎的随机对照试验疗效观察

目的:观察同仁大活络丸联合穴位注射治疗膝骨关节炎的临床疗效。方法:将160例中医辨证为风寒湿痹证的膝骨关节炎患者随机分为治疗组和对照组,每组80例。对照组除基础治疗外,温水送服同仁大活络丸治疗,每次2丸,早、晚各1次。治疗组在对照组的基础上联合穴位注射治疗,取双侧足三里穴位,注射用鹿瓜多肽8 mg以质量分数为0.9%的氯化钠注射液4 mL溶解,每穴注射2 mL,每周3次。2组均以4周为1个疗程。观察2组临床疗效,以及治疗前后膝关节功能评分变化。结果:治疗组治愈0例,显效1例,有效58例,无效21例,总有效率为73.75%;对照组治愈0例,显效0例,有效53例,无效27例,总有效率为66.25%。2组比较,差异有统计学意义(P<0.05)。治疗后,2组视觉模拟评分法评分、骨关节炎严重指数评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分较治疗前均显著降低(P<0.05),且治疗组低于对照组(P<0.05);WOMAC评分中关节疼痛、僵硬及日常活动评分较治疗前显著降低(P<0.05),且治疗组低于对照组(P<0.05)。结论:穴位注射联合同仁大活络丸治疗膝骨关节炎,可提高疗效,改善关节疼痛、僵硬及日常活动情况,具有简便性、安全性和有效性,值得临床推广应用。